iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000116455.13	ENST00000235090.9	ENSP00000235090.5
ENSG00000116455.13	ENST00000449340.1	ENSP00000409300.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-16	61.4	124	160

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           H d v+ ++  s+ t  vsGs D  ikvWDl ++v+l
   Q: 124  HDDIVSTVSVlSSgTQAVSGSKDICIKVWDLAQQVVL 160
           89999999977555*****************999987 PP

Organism

Homo sapiens

Functional Description
(View)

Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Protein Sequence
(Fasta)

MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLGASSLS GRCWAGSLWL 60
FKDPCAAPNE GFCSAGVQTE AGVADLTWVG ERGILVASDS GAVELWELDE NETLIVSKFC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCAAGTAA CGCTGAGAGC CTATCGCATG AGGGCGACAG CCGGAAAGCA GGATGGAGCC 60
ATAGAAGCAA TTCTCGCGAG AAGTAGAGTT GCGGTTCCCT CGGGAGAGGG GCGGAGGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0034709--C:methylosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0008327--F:methyl-CpG binding
GO:0016274--F:protein-arginine N-methyltransferase activity
GO:0060770--P:negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0008284--P:positive regulation of cell proliferation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0060528--P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0000387--P:spliceosomal snRNP assembly

KEGG

hsa:79084

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002192	Ailuropoda melanoleuca	91.55	3.00e-179	620.00
IUUC-Apl-003921	Anas platyrhynchos	62.63	7.00e-66	243.00
IUUC-Aca-004870	Anolis carolinensis	70.25	5.00e-119	420.00
IUUC-Ame-011872	Astyanax mexicanus	47.22	4.00e-38	150.00
IUUC-Bta-013325	Bos taurus	92.11	0.00e+00	628.00
IUUC-Cja-019059	Callithrix jacchus	97.08	0.00e+00	650.00
IUUC-Cfa-021036	Canis familiaris	91.41	1.00e-157	549.00
IUUC-Cpo-022369	Cavia porcellus	90.06	1.00e-177	615.00
IUUC-Csa-023585	Chlorocebus sabaeus	98.25	0.00e+00	659.00
IUUC-Cho-024470	Choloepus hoffmanni	82.99	7.00e-115	406.00
IUUC-Dno-029867	Dasypus novemcinctus	89.18	7.00e-178	616.00
IUUC-Dor-030834	Dipodomys ordii	64.43	3.00e-114	404.00
IUUC-Ete-032245	Echinops telfairi	83.16	3.00e-140	491.00
IUUC-Eca-033360	Equus caballus	91.52	2.00e-173	602.00
IUUC-Eeu-035353	Erinaceus europaeus	89.77	5.00e-177	613.00
IUUC-Fca-036277	Felis catus	92.69	0.00e+00	629.00
IUUC-Fal-037383	Ficedula albicollis	67.05	3.00e-102	364.00
IUUC-Gmo-038575	Gadus morhua	54.65	2.00e-100	358.00
IUUC-Gga-040658	Gallus gallus	69.33	2.00e-128	452.00
IUUC-Gac-041463	Gasterosteus aculeatus	52.04	5.00e-85	307.00
IUUC-Ggo-045120	Gorilla gorilla	99.12	0.00e+00	664.00
IUUC-Itr-048292	Ictidomys tridecemlineatus	94.15	4.00e-180	624.00
IUUC-Lch-049741	Latimeria chalumnae	65.51	1.00e-112	399.00
IUUC-Loc-052695	Lepisosteus oculatus	59.28	2.00e-106	379.00
IUUC-Laf-054535	Loxodonta africana	88.79	2.00e-175	608.00
IUUC-Mcc-054699	Macaca mulatta	98.25	0.00e+00	659.00
IUUC-Meu-056053	Macropus eugenii	76.09	1.00e-138	486.00
IUUC-Mga-059672	Meleagris gallopavo	64.43	6.00e-71	259.00
IUUC-Mmr-060963	Microcebus murinus	93.27	0.00e+00	637.00
IUUC-Mdo-062694	Monodelphis domestica	73.76	1.00e-132	466.00
IUUC-Mmu-064031	Mus musculus	89.77	1.00e-176	612.00
IUUC-Mpu-066408	Mustela putorius furo	92.11	0.00e+00	627.00
IUUC-Mlu-068184	Myotis lucifugus	90.09	2.00e-175	608.00
IUUC-Nle-069251	Nomascus leucogenys	97.95	0.00e+00	658.00
IUUC-Opr-071156	Ochotona princeps	85.09	9.00e-165	572.00
IUUC-Ont-072683	Oreochromis niloticus	57.32	2.00e-97	349.00
IUUC-Oan-073042	Ornithorhynchus anatinus	75.52	3.00e-126	444.00
IUUC-Ocu-074843	Oryctolagus cuniculus	93.29	9.00e-177	612.00
IUUC-Ola-086929	Oryzias latipes	53.54	3.00e-89	322.00
IUUC-Oga-088237	Otolemur garnettii	92.11	0.00e+00	626.00
IUUC-Oar-089312	Ovis aries	91.77	2.00e-165	575.00
IUUC-Ptr-091625	Pan troglodytes	99.42	0.00e+00	667.00
IUUC-Pan-091902	Papio anubis	93.31	3.00e-179	620.00
IUUC-Psi-094035	Pelodiscus sinensis	71.53	6.00e-126	443.00
IUUC-Pma-094565	Petromyzon marinus	64.04	3.00e-57	214.00
IUUC-Pfo-097070	Poecilia formosa	54.49	1.00e-92	332.00
IUUC-Pab-098007	Pongo abelii	99.42	0.00e+00	666.00
IUUC-Pca-100513	Procavia capensis	74.06	7.00e-104	369.00
IUUC-Pva-102821	Pteropus vampyrus	86.55	2.00e-165	574.00
IUUC-Rno-105836	Rattus norvegicus	88.79	4.00e-177	613.00
IUUC-Sha-106847	Sarcophilus harrisii	69.80	2.00e-88	318.00
IUUC-Sar-113451	Sorex araneus	85.42	4.00e-168	583.00
IUUC-Ssc-115978	Sus scrofa	90.94	1.00e-173	602.00
IUUC-Tgu-116745	Taeniopygia guttata	69.30	6.00e-95	339.00
IUUC-Tru-117945	Takifugu rubripes	52.80	1.00e-81	296.00
IUUC-Tsy-119059	Tarsius syrichta	88.70	6.00e-91	326.00
IUUC-Tni-120414	Tetraodon nigroviridis	54.60	9.00e-95	340.00
IUUC-Tbe-127559	Tupaia belangeri	95.03	0.00e+00	643.00
IUUC-Ttr-128505	Tursiops truncatus	89.77	2.00e-174	605.00
IUUC-Vpa-130350	Vicugna pacos	93.96	2.00e-100	358.00
IUUC-Xtr-132939	Xenopus tropicalis	61.83	5.00e-113	400.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence