iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000116661.9	ENST00000354287.4	ENSP00000346240.4
ENSG00000116661.9	ENST00000465901.1	ENSP00000473649.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWAS Central	OMIM
Post-translational Modifications (PTMs)
PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	21135578; 20854419

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.014	17.1	24	88

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 80   aaaapapapaptptpeegpdaglldrlpeeilveilklldkee.llraarvcrrwqelasqkalw 143
            a+a    p      e  + a  ld+lpe +l+++l  l++ e ++++++vc rw+el +   lw
   Q: 24   EASAEEERPEDQQEEEAAAAAAYLDELPEPLLLRVLAALPAAElVQACRLVCLRWKELVDGAPLW 88
           44455555555555666678899****************8888688999*******998866665 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).

Protein Sequence
(Fasta)

MDGDGDPESV GQPEEASPEE QPEEASAEEE RPEDQQEEEA AAAAAYLDEL PEPLLLRVLA 60
ALPAAELVQA CRLVCLRWKE LVDGAPLWLL KCQQEGLVPE GGVEEERDHW QQFYFLSKRR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCCTCATC CCTGCTCTGC CATTTATCTC GGGAGAGCAT GGTGCCTCTC CCAGCCTGTT 60
TCCTTCTCTG TAAATGGATG CCTTACCTCC AGGGGTCACT GGGGCGGTCC AAGGAGCTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0430--Lectin
KW-0472--Membrane
KW-0492--Microsome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR007397--F-box-assoc_dom
IPR001810--F-box_dom
IPR008979--Galactose-bd-like

PROSITE

PS51114--FBA
PS50181--FBOX

Pfam

PF00646--F-box
PF04300--FBA

SMART

SM01198--FBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0031090--C:organelle membrane
GO:0019005--C:SCF ubiquitin ligase complex
GO:0001540--F:beta-amyloid binding
GO:0030246--F:carbohydrate binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0006516--P:glycoprotein catabolic process
GO:0008285--P:negative regulation of cell proliferation
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0006508--P:proteolysis
GO:0031396--P:regulation of protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

hsa:26232

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001683	Ailuropoda melanoleuca	84.46	4.00e-130	457.00
IUUC-Apl-003298	Anas platyrhynchos	69.58	7.00e-100	356.00
IUUC-Aca-005151	Anolis carolinensis	65.83	6.00e-89	320.00
IUUC-Ame-011216	Astyanax mexicanus	56.76	6.00e-58	216.00
IUUC-Bta-013523	Bos taurus	88.89	4.00e-132	464.00
IUUC-Cja-019449	Callithrix jacchus	88.18	2.00e-130	458.00
IUUC-Cfa-021011	Canis familiaris	93.75	7.00e-132	463.00
IUUC-Cpo-021870	Cavia porcellus	85.33	7.00e-127	446.00
IUUC-Csa-024225	Chlorocebus sabaeus	98.23	5.00e-131	460.00
IUUC-Dre-028718	Danio rerio	56.90	2.00e-55	207.00
IUUC-Dno-029067	Dasypus novemcinctus	93.48	6.00e-100	357.00
IUUC-Dor-030945	Dipodomys ordii	81.54	5.00e-125	440.00
IUUC-Ete-032537	Echinops telfairi	90.88	1.00e-119	422.00
IUUC-Eca-033888	Equus caballus	95.13	1.00e-126	446.00
IUUC-Eeu-034498	Erinaceus europaeus	88.59	2.00e-74	271.00
IUUC-Fca-035793	Felis catus	80.27	3.00e-124	437.00
IUUC-Fal-037415	Ficedula albicollis	70.00	1.00e-94	338.00
IUUC-Gmo-039430	Gadus morhua	57.80	1.00e-49	188.00
IUUC-Gga-040818	Gallus gallus	70.42	7.00e-101	359.00
IUUC-Gac-042060	Gasterosteus aculeatus	54.86	1.00e-52	198.00
IUUC-Ggo-045653	Gorilla gorilla	99.56	4.00e-124	437.00
IUUC-Itr-048593	Ictidomys tridecemlineatus	94.32	4.00e-126	443.00
IUUC-Lch-049839	Latimeria chalumnae	54.17	5.00e-80	290.00
IUUC-Laf-053956	Loxodonta africana	79.21	2.00e-129	454.00
IUUC-Mcc-054799	Macaca mulatta	98.67	5.00e-132	463.00
IUUC-Mtr-057935	Medicago truncatula	30.14	7.90e-02	31.20
IUUC-Mga-059915	Meleagris gallopavo	69.58	2.00e-100	358.00
IUUC-Mdo-062296	Monodelphis domestica	64.86	2.00e-106	378.00
IUUC-Mmu-064264	Mus musculus	90.95	1.00e-123	435.00
IUUC-Mpu-066032	Mustela putorius furo	93.94	2.00e-128	451.00
IUUC-Mlu-066950	Myotis lucifugus	77.05	4.00e-120	424.00
IUUC-Nle-069626	Nomascus leucogenys	91.89	2.00e-131	461.00
IUUC-Opr-070783	Ochotona princeps	93.97	8.00e-129	452.00
IUUC-Ont-071289	Oreochromis niloticus	56.57	4.00e-54	204.00
IUUC-Oan-073742	Ornithorhynchus anatinus	74.17	2.00e-93	335.00
IUUC-Ola-086328	Oryzias latipes	54.02	2.00e-51	194.00
IUUC-Oga-088822	Otolemur garnettii	90.88	7.00e-125	439.00
IUUC-Oar-089801	Ovis aries	87.27	5.00e-129	453.00
IUUC-Ptr-091637	Pan troglodytes	100.00	8.00e-125	439.00
IUUC-Pan-092330	Papio anubis	98.67	2.00e-131	461.00
IUUC-Psi-093974	Pelodiscus sinensis	69.58	7.00e-99	353.00
IUUC-Ppa-095869	Physcomitrella patens	21.75	6.00e-12	65.10
IUUC-Pab-097688	Pongo abelii	92.57	2.00e-132	464.00
IUUC-Pca-100828	Procavia capensis	92.62	1.00e-78	285.00
IUUC-Ppe-101228	Prunus persica	25.97	3.50e-01	29.60
IUUC-Pva-102795	Pteropus vampyrus	95.20	9.00e-129	452.00
IUUC-Rno-106103	Rattus norvegicus	92.24	4.00e-126	444.00
IUUC-Smo-108894	Selaginella moellendorffii	20.49	1.00e-07	50.80
IUUC-Stu-112658	Solanum tuberosum	40.54	3.50e-02	29.30
IUUC-Ssc-115796	Sus scrofa	93.07	4.00e-126	444.00
IUUC-Tgu-116848	Taeniopygia guttata	70.00	5.00e-93	333.00
IUUC-Tre-121870	Trichoderma reesei	50.00	5.90e-01	28.90
IUUC-Tvi-122582	Trichoderma virens	24.68	2.00e-01	30.00
IUUC-Tbe-127621	Tupaia belangeri	96.36	6.00e-91	327.00
IUUC-Ttr-128809	Tursiops truncatus	90.35	1.00e-113	402.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence