iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000116679.15	ENST00000367498.7	ENSP00000356468.3
ENSG00000116679.15	ENST00000422754.1	ENSP00000401826.1
ENSG00000116679.15	ENST00000367497.1	ENSP00000356467.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Disease-associated Variation
GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.70e-11	46.0	32	96

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +Dv l+v g e  ah++vLa +S+++   f+++ +     + v+++d+ pe++++ll++ Yt +l+
   Q: 32   CDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHG-ISHVKFDDLNPEAVEVLLNYAYTAQLK 96
           8**********************************776.9************************97 PP

Organism

Homo sapiens

Functional Description
(View)

Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.

Protein Sequence
(Fasta)

MIPNGYLMFE DENFIESSVA KLNALRKSGQ FCDVRLQVCG HEMLAHRAVL ACCSPYLFEI 60
FNSDSDPHGI SHVKFDDLNP EAVEVLLNYA YTAQLKADKE LVKDVYSAAK KLKMDRVKQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGCGGGCT GGGAGGCGTC GGCGGCGGCA GCGCACGTGG TGACGTGCGA GGGGGTGCGG 60
CGCGAGCGGT CGGCGGCGGC GGAGGCAGTG TCTCCCGGTC GCGCGTGGAG GTCGGTCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0945--Host-virus interaction
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR029849--NS1BP
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005681--C:spliceosomal complex
GO:0005667--C:transcription factor complex
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0009615--P:response to virus
GO:0008380--P:RNA splicing
GO:0006383--P:transcription from RNA polymerase III promoter

KEGG

hsa:10625

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001227	Ailuropoda melanoleuca	98.13	0.00e+00	1317.00
IUUC-Apl-003244	Anas platyrhynchos	90.06	0.00e+00	1209.00
IUUC-Aca-005134	Anolis carolinensis	89.56	0.00e+00	1196.00
IUUC-Ame-011309	Astyanax mexicanus	76.95	0.00e+00	1042.00
IUUC-Bta-013020	Bos taurus	97.20	0.00e+00	1286.00
IUUC-Cel-018672	Caenorhabditis elegans	27.71	5.00e-80	292.00
IUUC-Cja-018717	Callithrix jacchus	98.44	0.00e+00	1274.00
IUUC-Cfa-021209	Canis familiaris	97.98	0.00e+00	1291.00
IUUC-Cpo-022465	Cavia porcellus	97.20	0.00e+00	1290.00
IUUC-Csa-023264	Chlorocebus sabaeus	99.69	0.00e+00	1288.00
IUUC-Cho-024407	Choloepus hoffmanni	96.77	0.00e+00	1095.00
IUUC-Dre-027945	Danio rerio	77.73	0.00e+00	1057.00
IUUC-Dno-028942	Dasypus novemcinctus	92.21	0.00e+00	1207.00
IUUC-Ete-032283	Echinops telfairi	96.26	0.00e+00	1274.00
IUUC-Eca-033877	Equus caballus	97.20	0.00e+00	996.00
IUUC-Eeu-034923	Erinaceus europaeus	89.25	0.00e+00	1160.00
IUUC-Fca-036378	Felis catus	97.82	0.00e+00	1293.00
IUUC-Fal-037161	Ficedula albicollis	87.10	0.00e+00	997.00
IUUC-Gmo-039396	Gadus morhua	69.77	0.00e+00	870.00
IUUC-Gga-040338	Gallus gallus	94.55	6.00e-123	432.00
IUUC-Gac-042553	Gasterosteus aculeatus	74.96	0.00e+00	966.00
IUUC-Ggo-045612	Gorilla gorilla	99.84	0.00e+00	1289.00
IUUC-Hvu-047224	Hordeum vulgare	33.21	2.00e-38	154.00
IUUC-Itr-048475	Ictidomys tridecemlineatus	98.13	0.00e+00	1321.00
IUUC-Lch-050220	Latimeria chalumnae	78.70	0.00e+00	1022.00
IUUC-Loc-051950	Lepisosteus oculatus	80.00	0.00e+00	1089.00
IUUC-Laf-053878	Loxodonta africana	96.88	0.00e+00	1283.00
IUUC-Mcc-055598	Macaca mulatta	99.53	0.00e+00	1288.00
IUUC-Meu-056133	Macropus eugenii	98.80	1.00e-145	509.00
IUUC-Mga-059538	Meleagris gallopavo	89.13	0.00e+00	1174.00
IUUC-Mmr-061279	Microcebus murinus	97.66	0.00e+00	1263.00
IUUC-Mdo-062952	Monodelphis domestica	94.86	0.00e+00	1267.00
IUUC-Mmu-063566	Mus musculus	97.04	0.00e+00	1255.00
IUUC-Mpu-065828	Mustela putorius furo	97.98	0.00e+00	1295.00
IUUC-Mlu-067313	Myotis lucifugus	96.58	0.00e+00	1242.00
IUUC-Nle-069890	Nomascus leucogenys	99.84	0.00e+00	1290.00
IUUC-Ont-072649	Oreochromis niloticus	76.33	0.00e+00	998.00
IUUC-Oan-073447	Ornithorhynchus anatinus	93.94	0.00e+00	1217.00
IUUC-Ocu-074680	Oryctolagus cuniculus	90.91	0.00e+00	1156.00
IUUC-Obr-076181	Oryza brachyantha	32.17	2.00e-35	145.00
IUUC-Ogu-078293	Oryza glumaepatula	29.05	3.00e-12	66.60
IUUC-Ome-081207	Oryza meridionalis	29.05	2.00e-12	66.60
IUUC-Oni-082785	Oryza nivara	29.05	3.00e-12	66.20
IUUC-Oru-084871	Oryza rufipogon	29.05	3.00e-12	66.20
IUUC-Ola-086588	Oryzias latipes	75.27	0.00e+00	994.00
IUUC-Oga-088982	Otolemur garnettii	97.98	0.00e+00	1298.00
IUUC-Oar-090409	Ovis aries	97.35	0.00e+00	1289.00
IUUC-Ptr-091365	Pan troglodytes	99.69	0.00e+00	1289.00
IUUC-Pan-092753	Papio anubis	99.69	0.00e+00	1288.00
IUUC-Pma-094393	Petromyzon marinus	71.95	3.00e-89	320.00
IUUC-Pfo-096772	Poecilia formosa	76.52	0.00e+00	1011.00
IUUC-Pab-098516	Pongo abelii	99.84	0.00e+00	1290.00
IUUC-Pca-100604	Procavia capensis	87.46	0.00e+00	1113.00
IUUC-Pva-102388	Pteropus vampyrus	97.35	0.00e+00	1258.00
IUUC-Rno-105464	Rattus norvegicus	97.51	0.00e+00	1261.00
IUUC-Sha-107436	Sarcophilus harrisii	94.73	0.00e+00	1254.00
IUUC-Tgu-116590	Taeniopygia guttata	84.89	0.00e+00	1132.00
IUUC-Tru-117699	Takifugu rubripes	76.49	0.00e+00	1039.00
IUUC-Tsy-119465	Tarsius syrichta	96.57	0.00e+00	1247.00
IUUC-Tni-120314	Tetraodon nigroviridis	75.86	0.00e+00	1028.00
IUUC-Tbe-127336	Tupaia belangeri	95.95	0.00e+00	1226.00
IUUC-Ttr-128624	Tursiops truncatus	90.50	0.00e+00	1139.00
IUUC-Vpa-130453	Vicugna pacos	97.66	0.00e+00	1248.00
IUUC-Xtr-132900	Xenopus tropicalis	77.78	0.00e+00	1051.00
IUUC-Xma-133881	Xiphophorus maculatus	75.74	0.00e+00	1002.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence