iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/APC_C/CDC20	CDC20	18662541; 19339280; 19167333; 17908926; 17015473; 20937767; 21439932; 11742988

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/APC_C/CDC20	2.10e-147	491.9	172	478
E3 adaptor/Cullin RING/DCX/DWD	4.90e-28	97.6	307	336

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkkvrt 91
           p+++ldape+r+d+ylnL+dWss nvlavaL++svylwsa++gd+ +l ++ +++++++sv+wi+eg++lavGt+++ev+++Dv+++k++r+
   Q: 172  PDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMeQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRN 263
           689************************************************899************************************** PP
   S: 92   ltghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdassse....Plkkfkehk 179
           +t+hsarvg+LsWn+++lssGsr+g+i+h+dvrv+e++++tl++h+qevCGl+w+ d+++LasGGnDn v+vw ++  e    Pl++f++h+
   Q: 264  MTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggwvPLQTFTQHQ 355
           *****************************************************************************9999*********** PP
   S: 180  aavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvaelkgheaRvl 271
           +avka+aw+Pwq+++La+GGGt+Dr+i++wn+++ga+l+++d++sqvcs+lws+++kel+s+hGfa+n++++wkyp+++kvaelkgh++Rvl
   Q: 356  GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 447
           ******************************************************************************************** PP
   S: 272  slalspdgeaivtaagDetlrfwklfdkkka 302
           sl++spdg+++++aa+Detlr+w++f+ ++a
   Q: 448  SLTMSPDGATVASAAADETLRLWRCFELDPA 478
           **************************99876 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvW 28
           gH+ +v++l++ +d ++l+sG++D+ + vW
   Q: 307  GHSQEVCGLRWaPDgRHLASGGNDNLVNVW 336
           8***********999*************** PP

Organism

Homo sapiens

Functional Description
(View)

Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

Protein Sequence
(Fasta)

MAQFAFESDL HSLLQLDAPI PNAPPARWQR KAKEAAGPAP SPMRAANRSH SAGRTPGRTP 60
GKSSSKVQTT PSKPGGDRYI PHRSAAQMEV ASFLLSKENQ PENSQTPTKK EHQKAWALNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGCGTAAG CCAGGCGTGT TAAAGCCGGT CGGAACTGCT CCGGAGGGCA CGGTGAGAGG 60
TGGTGGGGCT GAGCCGAGGT GGGGCCGTGG CCAGGGGGAG GGGGTGCTAG GCCGGAAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0221--Differentiation
KW-1017--Isopeptide bond
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033187--CDC20
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0005819--C:spindle
GO:0000922--C:spindle pole
GO:0019899--F:enzyme binding
GO:0008022--F:protein C-terminus binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0007064--P:mitotic sister chromatid cohesion
GO:0090307--P:mitotic spindle assembly
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0008284--P:positive regulation of cell proliferation
GO:0090129--P:positive regulation of synapse maturation
GO:0031915--P:positive regulation of synaptic plasticity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0050773--P:regulation of dendrite development
GO:0040020--P:regulation of meiotic nuclear division
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0007062--P:sister chromatid cohesion

KEGG

hsa:991

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000638	Aegilops tauschii	46.77	2.00e-111	395.00
IUUC-Aml-001545	Ailuropoda melanoleuca	97.39	0.00e+00	947.00
IUUC-Atr-003103	Amborella trichopoda	46.92	2.00e-109	389.00
IUUC-Apl-003255	Anas platyrhynchos	80.23	0.00e+00	754.00
IUUC-Aca-004920	Anolis carolinensis	76.23	0.00e+00	778.00
IUUC-Aly-006012	Arabidopsis lyrata	49.02	2.00e-109	389.00
IUUC-Ath-006795	Arabidopsis thaliana	46.71	6.00e-108	384.00
IUUC-Ate-010479	Aspergillus terreus	50.78	3.00e-92	332.00
IUUC-Ame-010850	Astyanax mexicanus	60.70	3.00e-91	328.00
IUUC-Bgr-012059	Blumeria graminis	49.84	2.00e-95	343.00
IUUC-Bta-012625	Bos taurus	97.60	0.00e+00	951.00
IUUC-Bci-013607	Botrytis cinerea	47.95	6.00e-99	355.00
IUUC-Bdi-014344	Brachypodium distachyon	48.67	3.00e-110	392.00
IUUC-Bol-015368	Brassica oleracea	45.88	1.00e-106	381.00
IUUC-Bra-016738	Brassica rapa	46.36	5.00e-106	379.00
IUUC-Cja-019132	Callithrix jacchus	98.80	0.00e+00	964.00
IUUC-Cfa-020780	Canis familiaris	97.60	0.00e+00	947.00
IUUC-Cpo-022223	Cavia porcellus	97.19	0.00e+00	901.00
IUUC-Cre-022701	Chlamydomonas reinhardtii	50.00	2.00e-116	412.00
IUUC-Csa-023666	Chlorocebus sabaeus	99.60	0.00e+00	965.00
IUUC-Cho-024920	Choloepus hoffmanni	96.81	6.00e-161	560.00
IUUC-Cin-025675	Ciona intestinalis	51.39	5.00e-136	478.00
IUUC-Csv-026019	Ciona savignyi	51.13	2.00e-131	462.00
IUUC-Cgl-026465	Colletotrichum gloeosporioides	40.78	4.00e-97	348.00
IUUC-Cme-027234	Cyanidioschyzon merolae	51.91	1.00e-105	377.00
IUUC-Dre-028026	Danio rerio	59.96	0.00e+00	631.00
IUUC-Dno-028865	Dasypus novemcinctus	96.60	0.00e+00	935.00
IUUC-Dor-030958	Dipodomys ordii	96.19	0.00e+00	943.00
IUUC-Dse-031391	Dothistroma septosporum	49.40	5.00e-97	348.00
IUUC-Dme-031905	Drosophila melanogaster	49.44	1.00e-143	503.00
IUUC-Ete-032387	Echinops telfairi	91.98	0.00e+00	903.00
IUUC-Eca-033522	Equus caballus	87.58	0.00e+00	852.00
IUUC-Eeu-035059	Erinaceus europaeus	84.80	0.00e+00	796.00
IUUC-Fca-036346	Felis catus	98.19	0.00e+00	869.00
IUUC-Fal-037558	Ficedula albicollis	80.36	0.00e+00	800.00
IUUC-Fox-037850	Fusarium oxysporum	45.31	3.00e-98	352.00
IUUC-Fso-038375	Fusarium solani	44.56	5.00e-99	355.00
IUUC-Gmo-039284	Gadus morhua	62.30	0.00e+00	632.00
IUUC-Ggr-039864	Gaeumannomyces graminis	48.55	5.00e-99	355.00
IUUC-Gga-040790	Gallus gallus	79.96	0.00e+00	815.00
IUUC-Gac-041431	Gasterosteus aculeatus	61.43	9.00e-180	623.00
IUUC-Gma-043489	Glycine max	46.97	4.00e-107	381.00
IUUC-Ggo-045052	Gorilla gorilla	100.00	0.00e+00	967.00
IUUC-Hvu-047476	Hordeum vulgare	46.03	8.00e-111	394.00
IUUC-Itr-048461	Ictidomys tridecemlineatus	97.60	0.00e+00	905.00
IUUC-Lch-050174	Latimeria chalumnae	61.39	1.00e-173	602.00
IUUC-Lpe-050954	Leersia perrieri	48.29	1.00e-101	363.00
IUUC-Loc-052638	Lepisosteus oculatus	63.12	0.00e+00	634.00
IUUC-Lma-052998	Leptosphaeria maculans	43.50	8.00e-101	361.00
IUUC-Laf-053742	Loxodonta africana	97.80	0.00e+00	949.00
IUUC-Mcc-054948	Macaca mulatta	99.60	0.00e+00	965.00
IUUC-Meu-056013	Macropus eugenii	86.22	1.00e-142	499.00
IUUC-Mor-057277	Magnaporthe oryzae	45.93	2.00e-96	346.00
IUUC-Mpo-057624	Magnaporthe poae	51.47	5.00e-97	348.00
IUUC-Mtr-057725	Medicago truncatula	46.28	2.00e-100	359.00
IUUC-Mga-060102	Meleagris gallopavo	80.20	0.00e+00	817.00
IUUC-Mmr-061615	Microcebus murinus	98.96	0.00e+00	955.00
IUUC-Mdo-061982	Monodelphis domestica	89.12	0.00e+00	778.00
IUUC-Mmu-063864	Mus musculus	94.79	0.00e+00	934.00
IUUC-Mac-064861	Musa acuminata	47.70	1.00e-110	393.00
IUUC-Mpu-066502	Mustela putorius furo	97.60	0.00e+00	938.00
IUUC-Mlu-067277	Myotis lucifugus	89.62	0.00e+00	884.00
IUUC-Ncr-068951	Neurospora crassa	45.87	1.00e-95	343.00
IUUC-Nle-070149	Nomascus leucogenys	99.60	0.00e+00	961.00
IUUC-Opr-070778	Ochotona princeps	95.54	0.00e+00	689.00
IUUC-Ont-071660	Oreochromis niloticus	61.16	1.00e-178	619.00
IUUC-Oan-073677	Ornithorhynchus anatinus	77.49	0.00e+00	711.00
IUUC-Ocu-073797	Oryctolagus cuniculus	97.38	0.00e+00	947.00
IUUC-Oba-075514	Oryza barthii	48.52	2.00e-101	362.00
IUUC-Obr-076018	Oryza brachyantha	46.83	4.00e-109	388.00
IUUC-Ogl-077254	Oryza glaberrima	48.52	6.00e-102	364.00
IUUC-Ogu-078521	Oryza glumaepatula	48.40	9.00e-109	388.00
IUUC-Oin-080094	Oryza indica	48.52	6.00e-102	364.00
IUUC-Olo-080449	Oryza longistaminata	48.52	6.00e-102	364.00
IUUC-Ome-081186	Oryza meridionalis	48.16	1.00e-108	388.00
IUUC-Oni-082243	Oryza nivara	48.52	6.00e-102	364.00
IUUC-Opu-084007	Oryza punctata	48.29	1.00e-101	363.00
IUUC-Oru-084562	Oryza rufipogon	48.40	2.00e-108	387.00
IUUC-Osa-086094	Oryza sativa	48.29	1.00e-101	363.00
IUUC-Ola-086907	Oryzias latipes	60.83	3.00e-166	578.00
IUUC-Olu-087647	Ostreococcus lucimarinus	49.07	2.00e-119	422.00
IUUC-Oga-088184	Otolemur garnettii	97.40	0.00e+00	944.00
IUUC-Oar-090023	Ovis aries	92.28	0.00e+00	843.00
IUUC-Ptr-090935	Pan troglodytes	98.94	0.00e+00	899.00
IUUC-Pan-091845	Papio anubis	99.60	0.00e+00	965.00
IUUC-Psi-093188	Pelodiscus sinensis	80.93	0.00e+00	844.00
IUUC-Pma-094187	Petromyzon marinus	54.36	8.00e-149	520.00
IUUC-Pno-094809	Phaeosphaeria nodorum	41.39	2.00e-101	363.00
IUUC-Ppa-095457	Physcomitrella patens	47.22	6.00e-111	394.00
IUUC-Pfo-097429	Poecilia formosa	58.57	1.00e-160	559.00
IUUC-Pab-098603	Pongo abelii	99.80	0.00e+00	966.00
IUUC-Pop-099654	Populus trichocarpa	46.39	3.00e-103	369.00
IUUC-Pca-101062	Procavia capensis	96.79	0.00e+00	926.00
IUUC-Ppe-101865	Prunus persica	46.76	3.00e-97	348.00
IUUC-Pva-102925	Pteropus vampyrus	95.99	0.00e+00	969.00
IUUC-Pte-104142	Pyrenophora teres	42.64	6.00e-99	355.00
IUUC-Pyt-104693	Pyrenophora triticirepentis	42.48	7.00e-99	354.00
IUUC-Rno-106005	Rattus norvegicus	94.99	0.00e+00	933.00
IUUC-Sha-107472	Sarcophilus harrisii	89.60	0.00e+00	893.00
IUUC-Sja-107919	Schizosaccharomyces japonicus	42.82	2.00e-94	339.00
IUUC-Spo-108075	Schizosaccharomyces pombe	45.34	5.00e-97	348.00
IUUC-Ssl-108507	Sclerotinia sclerotiorum	49.27	3.00e-98	352.00
IUUC-Smo-108922	Selaginella moellendorffii	49.46	7.00e-124	437.00
IUUC-Sit-110732	Setaria italica	47.69	3.00e-110	392.00
IUUC-Sly-111202	Solanum lycopersicum	44.65	4.00e-106	378.00
IUUC-Stu-112676	Solanum tuberosum	45.32	1.00e-97	350.00
IUUC-Sar-113092	Sorex araneus	90.98	0.00e+00	879.00
IUUC-Sbi-114558	Sorghum bicolor	46.24	3.00e-110	392.00
IUUC-Ssc-115710	Sus scrofa	98.20	0.00e+00	955.00
IUUC-Tgu-117100	Taeniopygia guttata	79.56	0.00e+00	800.00
IUUC-Tru-118184	Takifugu rubripes	57.34	2.00e-139	489.00
IUUC-Tsy-118892	Tarsius syrichta	97.87	4.00e-164	570.00
IUUC-Tni-120474	Tetraodon nigroviridis	59.01	1.00e-168	585.00
IUUC-Tca-120949	Theobroma cacao	46.51	4.00e-107	381.00
IUUC-Tre-122211	Trichoderma reesei	40.94	1.00e-97	350.00
IUUC-Tvi-122531	Trichoderma virens	41.19	5.00e-98	352.00
IUUC-Tae-123017	Triticum aestivum	46.24	2.00e-111	395.00
IUUC-Tur-126193	Triticum urartu	46.24	5.00e-111	395.00
IUUC-Tbe-127384	Tupaia belangeri	98.99	1.00e-177	615.00
IUUC-Ttr-128511	Tursiops truncatus	97.60	0.00e+00	946.00
IUUC-Vda-129993	Verticillium dahliae	41.04	1.00e-98	354.00
IUUC-Vvi-131245	Vitis vinifera	47.17	1.00e-94	340.00
IUUC-Xtr-131993	Xenopus tropicalis	73.68	0.00e+00	759.00
IUUC-Xma-133332	Xiphophorus maculatus	61.74	3.00e-177	615.00
IUUC-Zma-135135	Zea mays	47.64	3.00e-108	385.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence