iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.80e-83	279.0	442	916

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtCY+NSvLQ+L++ +++r+++l+     l e+    ++++l+++lq lf+ l +s++ a+sp+++l+a +   + fs   qq
   Q: 442  GLINLGNTCYVNSVLQALFMASDFRHCVLR-----LTEN----NSQPLMTKLQWLFAFLEHSQRPAISPENFLSASW--TPWFSPGTQQ 519
           9*****************************.....4433....3579***************************998..677******* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           D++E+l++lld+l+ee      k+ ++ +++ k+++  + +e+ +++n + ++++F+g++ ++i cl+c nvssree f+dlsl++p  
   Q: 520  DCSEYLKYLLDRLHEEE-----KTGTRICQKLKQSSLPSPQEELPSSNATSVERMFGGKIVTRICCLHCLNVSSREEAFTDLSLAFPPP 603
           *****************.....667777777777777778999********************************************88 PP
   S: 180  eetkke................................................................................... 185
           e + ++                                                                                   
   Q: 604  ERSRHRrlgsvmlptedvraqeltlaprapgaqrqrkhcitgdaprtgldiegvdtvgnggqsgqekvereqagkekevaedreeegpr 692
           87766689********************************************************************************* PP
   S: 186  .........................................................slqdcLesftkeeelegenkyycekckkkqea 217
                                                                    s+ d+ + f ++e+l+ en+yyce+c ++q+a
   Q: 693  eeekeegeekdkekkedekekeaedgkekegdslgpgtrkdaatppreqacgpegsrSVLDLVNYFLSPERLTAENRYYCESCASLQDA 781
           ***************************************************************************************** PP
   S: 218  ekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvkn.... 301
           ek ++l++ P +Lil L Rfsf+ ++++r+ki + v++pl L l     +        + Y+L++vvvHsG s++sGHY++y+++    
   Q: 782  EKVVELSQGPCYLILTLLRFSFDLRTMRRRKILDDVTIPLLLRLPLAGGQ-------GQAYDLCSVVVHSGvSSESGHYYCYAREgaar 863
           ***************************************99999844444.......89**************************9999 PP
   S: 302  ............ekgkWllfdDskVtevkeeevleetg....staYvlfYkrr 338
                        +++W+lf+D++V+ ++ e+v + t+    +taYvlfY++r
   Q: 864  papvlgsterpePENQWYLFNDTRVSFSSFESVSNVTSffpkDTAYVLFYRQR 916
           9999999998888999*******************999************985 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MDKILEAVVT SSYPASVKQG LVRRVLEAAR QPLEREQCLA LLALGARLYV GGTDELPRRV 60
GCQLLHVAGR HHPDVFAEFF SARRVLRLLQ GGAGPPGARA LACVQLGLQL LPDGPAADEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACAAGA TCCTGGAGGC CGTGGTGACT TCGTCCTACC CTGCGAGTGT GAAGCAAGGG 60
CTGGTGCGGC GCGTGCTGGA GGCTGCACGG CAGCCCTTGG AGCGGGAGCA GTGCCTGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:308834

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001744	Ailuropoda melanoleuca	82.24	0.00e+00	1306.00
IUUC-Apl-004121	Anas platyrhynchos	60.94	0.00e+00	1113.00
IUUC-Aca-005070	Anolis carolinensis	72.41	5.00e-167	581.00
IUUC-Bta-012545	Bos taurus	92.32	0.00e+00	1167.00
IUUC-Cja-019731	Callithrix jacchus	92.72	0.00e+00	1172.00
IUUC-Cfa-020095	Canis familiaris	87.57	0.00e+00	1493.00
IUUC-Cpo-021961	Cavia porcellus	89.64	0.00e+00	1176.00
IUUC-Csa-023167	Chlorocebus sabaeus	91.19	0.00e+00	1167.00
IUUC-Dno-029186	Dasypus novemcinctus	81.42	0.00e+00	833.00
IUUC-Dor-030538	Dipodomys ordii	82.20	0.00e+00	1385.00
IUUC-Dme-031871	Drosophila melanogaster	31.93	9.00e-46	178.00
IUUC-Ete-032512	Echinops telfairi	87.75	4.00e-102	365.00
IUUC-Eca-033279	Equus caballus	95.72	0.00e+00	912.00
IUUC-Eeu-035120	Erinaceus europaeus	72.24	0.00e+00	838.00
IUUC-Fca-035969	Felis catus	84.95	0.00e+00	1228.00
IUUC-Fal-037625	Ficedula albicollis	70.68	0.00e+00	904.00
IUUC-Gga-040767	Gallus gallus	68.55	0.00e+00	910.00
IUUC-Ggo-045323	Gorilla gorilla	90.65	0.00e+00	939.00
IUUC-Hsa-046124	Homo sapiens	92.37	0.00e+00	1161.00
IUUC-Itr-048704	Ictidomys tridecemlineatus	87.03	0.00e+00	1563.00
IUUC-Lch-049513	Latimeria chalumnae	55.84	0.00e+00	1003.00
IUUC-Laf-053999	Loxodonta africana	88.13	0.00e+00	1134.00
IUUC-Mcc-055266	Macaca mulatta	91.23	0.00e+00	1144.00
IUUC-Meu-056906	Macropus eugenii	74.96	0.00e+00	999.00
IUUC-Mga-059595	Meleagris gallopavo	71.29	0.00e+00	885.00
IUUC-Mmr-061720	Microcebus murinus	84.89	0.00e+00	1095.00
IUUC-Mdo-062167	Monodelphis domestica	74.00	0.00e+00	1003.00
IUUC-Mmu-063298	Mus musculus	95.54	0.00e+00	1753.00
IUUC-Mpu-066195	Mustela putorius furo	86.97	0.00e+00	1434.00
IUUC-Mlu-067583	Myotis lucifugus	78.45	0.00e+00	1070.00
IUUC-Opr-070454	Ochotona princeps	91.33	2.00e-161	563.00
IUUC-Ocu-074121	Oryctolagus cuniculus	85.28	0.00e+00	953.00
IUUC-Oga-088593	Otolemur garnettii	92.56	0.00e+00	1153.00
IUUC-Oar-090140	Ovis aries	92.02	0.00e+00	1152.00
IUUC-Pan-092168	Papio anubis	91.48	0.00e+00	1170.00
IUUC-Psi-093707	Pelodiscus sinensis	62.44	0.00e+00	1159.00
IUUC-Pab-097614	Pongo abelii	91.67	0.00e+00	1157.00
IUUC-Pca-100683	Procavia capensis	87.18	0.00e+00	1130.00
IUUC-Pva-103146	Pteropus vampyrus	78.73	0.00e+00	1338.00
IUUC-Sha-106686	Sarcophilus harrisii	72.31	0.00e+00	970.00
IUUC-Tgu-117024	Taeniopygia guttata	70.91	0.00e+00	910.00
IUUC-Tsy-119505	Tarsius syrichta	74.66	0.00e+00	659.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence