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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045790
UUCD1 version UUC-HoS-00391
Ensembl Protein ID ENSP00000357297.1
UniProt Accession Q9NTX7; E1P572; Q6FIB2; Q7L8H4; Q96K03; Q96T06; Q9NTX6; RN146_HUMAN
Genbank Protein ID CAC85986.1; CAB66763.1; BAB55196.1; BAB55108.1; BAB55359.1; CAG38545.1; CAB76254.1; CAB76255.1; EAW48109.1; EAW48111.1; AAH08235.1
Protein Name E3 ubiquitin-protein ligase RNF146; Dactylidin; Iduna; RING finger protein 146; RING-type E3 ubiquitin transferase RNF146
Genbank Nucleotide ID AJ315122; AL136829; AK027558; AK027436; AK027776; CR533514; AL109939; AL109939; CH471051; CH471051; BC008235
Gene Name RNF146
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000118518.15 ENST00000368314.5 ENSP00000357297.1
ENSG00000118518.15 ENST00000476956.5 ENSP00000477204.1
ENSG00000118518.15 ENST00000609447.5 ENSP00000477019.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
BioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 15813938; 18326623
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.00075 21.6 37 75
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl..qkwpglknssskefrCPlCr 46
           CaiCl+ + + p++lpC+Hvf+  C+           s    rC lCr
   Q: 37   CAICLQTCVH-PVSLPCKHVFCYLCVkgA--------SWLGKRCALCR 75
           ********99.**************9444........44777899997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.
 E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.
Protein Sequence
(Fasta)
MMAGCGEIDH SINMLPTNRK ANESCSNTAP SLTVPECAIC LQTCVHPVSL PCKHVFCYLC 60
VKGASWLGKR CALCRQEIPE DFLDKPTLLS PEELKAASRG NGEYAWYYEG RNGWWQYDER 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045790|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
TGGAACTGCA CTCTTTCAGA GCCTCTGGGC CCTAATACAA AGCAAGCACA CTCTAAAGAA 60
GCCAGAAGAA TGCAAGCAGC GAAGTCGCCG CTCCCCACAG GCAAGAGAGT ACCGGCAGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045790|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR033509--RNF146
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50918--WWE
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF02825--WWE
SMART

SM00184--RING
SM00678--WWE
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0072572--F:poly-ADP-D-ribose binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0051865--P:protein autoubiquitination
GO:0016579--P:protein deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0016055--P:Wnt signaling pathway
KEGG hsa:81847
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002237 Ailuropoda melanoleuca 91.36 7.00e-155 540.00
IUUC-Apl-004143 Anas platyrhynchos 84.72 2.00e-134 472.00
IUUC-Aca-004557 Anolis carolinensis 81.44 1.00e-127 449.00
IUUC-Ame-011088 Astyanax mexicanus 61.09 2.00e-83 302.00
IUUC-Bta-012639 Bos taurus 92.76 2.00e-150 525.00
IUUC-Cel-018462 Caenorhabditis elegans 28.35 7.00e-19 87.40
IUUC-Cja-019397 Callithrix jacchus 99.72 5.00e-167 580.00
IUUC-Cfa-021140 Canis familiaris 91.64 1.00e-166 579.00
IUUC-Cpo-021387 Cavia porcellus 90.53 1.00e-166 578.00
IUUC-Csa-023503 Chlorocebus sabaeus 94.15 5.00e-157 546.00
IUUC-Cho-024895 Choloepus hoffmanni 93.75 8.00e-145 506.00
IUUC-Cin-025455 Ciona intestinalis 51.92 5.00e-43 167.00
IUUC-Dre-028824 Danio rerio 45.99 1.00e-82 300.00
IUUC-Dno-029269 Dasypus novemcinctus 95.26 1.00e-161 562.00
IUUC-Dor-030592 Dipodomys ordii 94.17 2.00e-164 571.00
IUUC-Dme-031618 Drosophila melanogaster 57.33 1.00e-55 210.00
IUUC-Ete-032478 Echinops telfairi 92.48 8.00e-163 566.00
IUUC-Eca-033389 Equus caballus 96.37 1.00e-180 625.00
IUUC-Fca-035488 Felis catus 96.09 3.00e-163 567.00
IUUC-Fal-037087 Ficedula albicollis 83.89 4.00e-154 537.00
IUUC-Gga-040401 Gallus gallus 85.83 1.00e-138 486.00
IUUC-Gac-042412 Gasterosteus aculeatus 64.53 1.00e-87 316.00
IUUC-Ggo-045417 Gorilla gorilla 99.07 1.00e-159 555.00
IUUC-Itr-048820 Ictidomys tridecemlineatus 94.97 2.00e-165 575.00
IUUC-Lch-049493 Latimeria chalumnae 69.08 1.00e-110 392.00
IUUC-Loc-052927 Lepisosteus oculatus 60.00 7.00e-102 363.00
IUUC-Laf-053904 Loxodonta africana 93.87 5.00e-160 556.00
IUUC-Mcc-055427 Macaca mulatta 94.17 1.00e-163 569.00
IUUC-Mmr-060580 Microcebus murinus 96.94 3.00e-159 554.00
IUUC-Mdo-062094 Monodelphis domestica 96.97 1.00e-78 284.00
IUUC-Mmu-063363 Mus musculus 92.48 6.00e-165 573.00
IUUC-Mpu-066816 Mustela putorius furo 95.26 4.00e-158 550.00
IUUC-Mlu-067433 Myotis lucifugus 95.26 2.00e-180 624.00
IUUC-Nle-068986 Nomascus leucogenys 99.16 1.00e-180 625.00
IUUC-Ont-072670 Oreochromis niloticus 58.42 4.00e-81 295.00
IUUC-Oan-073330 Ornithorhynchus anatinus 87.06 4.00e-107 380.00
IUUC-Ocu-074161 Oryctolagus cuniculus 93.61 4.00e-164 570.00
IUUC-Ola-086902 Oryzias latipes 58.91 4.00e-84 305.00
IUUC-Oga-089159 Otolemur garnettii 94.43 0.00e+00 638.00
IUUC-Oar-089586 Ovis aries 94.15 3.00e-146 511.00
IUUC-Ptr-090987 Pan troglodytes 100.00 1.00e-167 582.00
IUUC-Pan-091867 Papio anubis 94.15 6.00e-163 566.00
IUUC-Psi-094024 Pelodiscus sinensis 85.28 4.00e-142 497.00
IUUC-Pma-094453 Petromyzon marinus 63.91 5.00e-65 241.00
IUUC-Pfo-097108 Poecilia formosa 70.73 1.00e-83 303.00
IUUC-Pab-097997 Pongo abelii 98.04 2.00e-173 602.00
IUUC-Pca-100260 Procavia capensis 92.46 2.00e-164 571.00
IUUC-Pva-103140 Pteropus vampyrus 94.72 2.00e-165 574.00
IUUC-Rno-105795 Rattus norvegicus 86.67 5.00e-163 566.00
IUUC-Sha-107033 Sarcophilus harrisii 88.61 1.00e-155 542.00
IUUC-Ssc-116395 Sus scrofa 97.21 0.00e+00 627.00
IUUC-Tgu-116685 Taeniopygia guttata 81.06 5.00e-135 474.00
IUUC-Tru-118014 Takifugu rubripes 74.88 7.00e-84 303.00
IUUC-Tsy-119326 Tarsius syrichta 90.00 6.00e-177 613.00
IUUC-Tni-120322 Tetraodon nigroviridis 69.95 4.00e-82 298.00
IUUC-Tbe-128067 Tupaia belangeri 95.83 2.00e-171 594.00
IUUC-Ttr-128530 Tursiops truncatus 96.67 1.00e-164 572.00
IUUC-Vpa-130322 Vicugna pacos 97.49 2.00e-171 595.00
IUUC-Xtr-132606 Xenopus tropicalis 66.20 3.00e-118 418.00
Created Date 25-Jun-2017

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