iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012840

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2 B; E2 ubiquitin-conjugating enzyme B; Ubiquitin carrier protein B; Ubiquitin-protein ligase B

Genbank Nucleotide ID

BC108202

Gene Name

UBE2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000010982.5	ENSBTAT00000043235.1	ENSBTAP00000040823.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	7.90e-55	184.6	8	142

Active Site

Position(s)	Description	Evidence
88	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           Rl++++k+l++dpp g+s  p+++ ++++w+++i+Gpe+tp+e+g+Fkl ief+e+YP kPP+v+fl+k+fhPnvy++G++Cl+il+  
   Q: 8    RLMRDFKRLQEDPPVGVSGAPSEN-NIMQWNAVIFGPEGTPFEDGTFKLVIEFSEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQ-- 93
           9**********************9.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++Wsp+++v+s+l+siqsll+epnp+sp+n++aa+l+++n++ey+k+v+
   Q: 94   NRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVS 142
           **********************************************996 PP

Organism

Bos taurus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.

Protein Sequence
(Fasta)

MSTPARRRLM RDFKRLQEDP PVGVSGAPSE NNIMQWNAVI FGPEGTPFED GTFKLVIEFS 60
EEYPNKPPTV RFLSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGATTCGG CCGCCGCGCC GGGGGGTGGG GGGGCTGCGC GGGACTCTTT TCTTTCAGAC 60
TGACCGCGGG GCTGCTGGGG AGCATGTCGA CCCCGGCCCG GAGGAGGCTT ATGCGGGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0033503--C:HULC complex
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0005657--C:replication fork
GO:0001741--C:XY body
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0060070--P:canonical Wnt signaling pathway
GO:0051026--P:chiasma assembly
GO:0033522--P:histone H2A ubiquitination
GO:0070076--P:histone lysine demethylation
GO:0001701--P:in utero embryonic development
GO:0006344--P:maintenance of chromatin silencing
GO:0045141--P:meiotic telomere clustering
GO:0043066--P:negative regulation of apoptotic process
GO:0043951--P:negative regulation of cAMP-mediated signaling
GO:0033128--P:negative regulation of histone phosphorylation
GO:0010845--P:positive regulation of reciprocal meiotic recombination
GO:0006301--P:postreplication repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0050821--P:protein stabilization
GO:0042493--P:response to drug
GO:0009411--P:response to UV
GO:0007288--P:sperm axoneme assembly
GO:0070193--P:synaptonemal complex organization

KEGG

bta:512207

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001001	Aegilops tauschii	74.50	2.00e-68	250.00
IUUC-Aml-002120	Ailuropoda melanoleuca	100.00	5.00e-88	315.00
IUUC-Atr-002862	Amborella trichopoda	76.67	2.00e-70	257.00
IUUC-Apl-004063	Anas platyrhynchos	92.62	2.00e-76	277.00
IUUC-Aca-005001	Anolis carolinensis	99.34	8.00e-88	315.00
IUUC-Aly-005584	Arabidopsis lyrata	76.51	1.00e-69	254.00
IUUC-Ath-007149	Arabidopsis thaliana	76.51	1.00e-69	254.00
IUUC-Ago-007745	Ashbya gossypii	69.80	1.00e-62	231.00
IUUC-Acl-008139	Aspergillus clavatus	68.87	8.00e-64	235.00
IUUC-Afl-008551	Aspergillus flavus	68.87	1.00e-63	234.00
IUUC-Afu-008980	Aspergillus fumigatus	68.87	1.00e-63	234.00
IUUC-Ang-009554	Aspergillus niger	68.87	1.00e-63	234.00
IUUC-Aor-010242	Aspergillus oryzae	68.87	1.00e-63	234.00
IUUC-Ate-010390	Aspergillus terreus	68.87	1.00e-63	234.00
IUUC-Ame-010743	Astyanax mexicanus	96.71	9.00e-85	305.00
IUUC-Bgr-012039	Blumeria graminis	66.91	8.00e-56	208.00
IUUC-Bci-013919	Botrytis cinerea	69.08	2.00e-64	238.00
IUUC-Bdi-015010	Brachypodium distachyon	75.84	4.00e-69	253.00
IUUC-Bol-015726	Brassica oleracea	76.51	3.00e-69	256.00
IUUC-Bra-018026	Brassica rapa	76.51	7.00e-70	255.00
IUUC-Cel-018244	Caenorhabditis elegans	84.56	2.00e-76	278.00
IUUC-Cja-019737	Callithrix jacchus	100.00	5.00e-88	315.00
IUUC-Cfa-020244	Canis familiaris	100.00	5.00e-88	315.00
IUUC-Cpo-022192	Cavia porcellus	100.00	5.00e-88	315.00
IUUC-Cre-022822	Chlamydomonas reinhardtii	75.97	9.00e-58	215.00
IUUC-Csa-023430	Chlorocebus sabaeus	100.00	5.00e-88	315.00
IUUC-Cho-024773	Choloepus hoffmanni	79.61	9.00e-65	238.00
IUUC-Cin-025537	Ciona intestinalis	80.92	2.00e-61	227.00
IUUC-Csv-025846	Ciona savignyi	82.00	1.00e-66	244.00
IUUC-Cgl-026381	Colletotrichum gloeosporioides	68.87	3.00e-64	236.00
IUUC-Cne-026864	Cryptococcus neoformans	69.80	5.00e-64	236.00
IUUC-Cme-027284	Cyanidioschyzon merolae	66.67	4.00e-54	204.00
IUUC-Dre-028774	Danio rerio	95.39	8.00e-85	305.00
IUUC-Dno-029661	Dasypus novemcinctus	100.00	5.00e-88	315.00
IUUC-Dor-030452	Dipodomys ordii	100.00	2.00e-78	283.00
IUUC-Dse-031487	Dothistroma septosporum	68.87	7.00e-64	235.00
IUUC-Dme-031863	Drosophila melanogaster	86.09	2.00e-76	277.00
IUUC-Ete-032595	Echinops telfairi	96.71	3.00e-85	306.00
IUUC-Eca-033377	Equus caballus	100.00	5.00e-88	315.00
IUUC-Eeu-035191	Erinaceus europaeus	77.12	2.00e-61	227.00
IUUC-Fca-036336	Felis catus	100.00	5.00e-88	315.00
IUUC-Fal-037474	Ficedula albicollis	94.96	7.00e-65	238.00
IUUC-Fox-037808	Fusarium oxysporum	68.87	5.00e-64	236.00
IUUC-Fso-038232	Fusarium solani	68.87	6.00e-64	236.00
IUUC-Gmo-038517	Gadus morhua	95.39	2.00e-84	303.00
IUUC-Ggr-039875	Gaeumannomyces graminis	69.13	2.00e-63	234.00
IUUC-Gga-040494	Gallus gallus	100.00	5.00e-88	315.00
IUUC-Gac-042471	Gasterosteus aculeatus	95.39	3.00e-85	306.00
IUUC-Gma-043865	Glycine max	76.51	3.00e-70	256.00
IUUC-Ggo-044896	Gorilla gorilla	95.39	2.00e-84	303.00
IUUC-Hsa-046239	Homo sapiens	100.00	5.00e-88	315.00
IUUC-Hvu-047054	Hordeum vulgare	74.50	2.00e-68	250.00
IUUC-Itr-048960	Ictidomys tridecemlineatus	100.00	5.00e-88	315.00
IUUC-Kpa-049225	Komagataella pastoris	69.33	2.00e-62	231.00
IUUC-Lch-050283	Latimeria chalumnae	97.35	1.00e-85	308.00
IUUC-Lpe-051301	Leersia perrieri	76.51	8.00e-70	255.00
IUUC-Loc-051962	Lepisosteus oculatus	98.03	2.00e-86	310.00
IUUC-Laf-053380	Loxodonta africana	100.00	5.00e-88	315.00
IUUC-Mcc-054819	Macaca mulatta	100.00	3.00e-88	317.00
IUUC-Meu-056231	Macropus eugenii	95.39	2.00e-84	303.00
IUUC-Mor-057087	Magnaporthe oryzae	67.16	2.00e-54	204.00
IUUC-Mpo-057498	Magnaporthe poae	69.13	2.00e-63	234.00
IUUC-Mtr-058305	Medicago truncatula	76.51	5.00e-70	256.00
IUUC-Mla-058876	Melampsora laricipopulina	72.85	2.00e-58	217.00
IUUC-Mga-059863	Meleagris gallopavo	98.57	4.00e-79	286.00
IUUC-Mvi-060330	Microbotryum violaceum	72.85	4.00e-58	216.00
IUUC-Mmr-060630	Microcebus murinus	100.00	5.00e-88	315.00
IUUC-Mdo-062676	Monodelphis domestica	100.00	5.00e-88	315.00
IUUC-Mmu-063491	Mus musculus	100.00	5.00e-88	315.00
IUUC-Mac-064774	Musa acuminata	76.51	1.00e-69	254.00
IUUC-Mpu-065803	Mustela putorius furo	100.00	5.00e-88	315.00
IUUC-Mlu-067147	Myotis lucifugus	100.00	5.00e-88	315.00
IUUC-Nfi-068580	Neosartorya fischeri	68.87	1.00e-63	234.00
IUUC-Ncr-068913	Neurospora crassa	68.87	3.00e-64	236.00
IUUC-Nle-070105	Nomascus leucogenys	100.00	5.00e-88	315.00
IUUC-Opr-070935	Ochotona princeps	100.00	5.00e-88	315.00
IUUC-Ont-071335	Oreochromis niloticus	95.39	4.00e-85	306.00
IUUC-Oan-072706	Ornithorhynchus anatinus	94.63	2.00e-80	291.00
IUUC-Ocu-074130	Oryctolagus cuniculus	100.00	5.00e-88	315.00
IUUC-Oba-075896	Oryza barthii	75.84	3.00e-69	253.00
IUUC-Obr-076713	Oryza brachyantha	76.51	8.00e-70	255.00
IUUC-Ogl-077116	Oryza glaberrima	76.51	8.00e-70	255.00
IUUC-Ogu-078696	Oryza glumaepatula	76.51	8.00e-70	255.00
IUUC-Oin-079099	Oryza indica	76.51	8.00e-70	255.00
IUUC-Olo-081018	Oryza longistaminata	64.85	2.00e-60	224.00
IUUC-Ome-081285	Oryza meridionalis	76.51	8.00e-70	255.00
IUUC-Oni-082088	Oryza nivara	76.51	8.00e-70	255.00
IUUC-Opu-083310	Oryza punctata	76.51	8.00e-70	255.00
IUUC-Oru-084449	Oryza rufipogon	76.51	8.00e-70	255.00
IUUC-Osa-085923	Oryza sativa	76.51	8.00e-70	255.00
IUUC-Ola-087160	Oryzias latipes	95.39	4.00e-85	306.00
IUUC-Olu-087830	Ostreococcus lucimarinus	78.52	2.00e-61	227.00
IUUC-Oga-088836	Otolemur garnettii	100.00	5.00e-88	315.00
IUUC-Oar-090141	Ovis aries	100.00	5.00e-88	315.00
IUUC-Ptr-091453	Pan troglodytes	100.00	5.00e-88	315.00
IUUC-Pan-092511	Papio anubis	100.00	5.00e-88	315.00
IUUC-Psi-093968	Pelodiscus sinensis	99.34	8.00e-88	315.00
IUUC-Pma-094376	Petromyzon marinus	92.76	5.00e-83	299.00
IUUC-Pno-094935	Phaeosphaeria nodorum	68.87	3.00e-64	236.00
IUUC-Ppa-095689	Physcomitrella patens	76.51	9.00e-61	225.00
IUUC-Pfo-096656	Poecilia formosa	94.74	3.00e-84	303.00
IUUC-Pab-098121	Pongo abelii	100.00	5.00e-88	315.00
IUUC-Pop-099517	Populus trichocarpa	76.51	6.00e-70	255.00
IUUC-Pca-100906	Procavia capensis	88.82	2.00e-76	277.00
IUUC-Ppe-101949	Prunus persica	76.51	2.00e-69	255.00
IUUC-Pva-102380	Pteropus vampyrus	94.08	2.00e-81	293.00
IUUC-Pgr-103611	Puccinia graminis	72.19	1.00e-58	218.00
IUUC-Ptt-103971	Puccinia triticina	72.88	2.00e-44	170.00
IUUC-Pte-104378	Pyrenophora teres	69.54	1.00e-64	238.00
IUUC-Pyt-104757	Pyrenophora triticirepentis	69.54	1.00e-64	238.00
IUUC-Rno-105772	Rattus norvegicus	100.00	2.00e-88	317.00
IUUC-Sce-106283	Saccharomyces cerevisiae	69.80	1.00e-62	232.00
IUUC-Sha-107650	Sarcophilus harrisii	98.68	4.00e-86	309.00
IUUC-Sja-107790	Schizosaccharomyces japonicus	71.81	2.00e-58	217.00
IUUC-Spo-108073	Schizosaccharomyces pombe	71.81	2.00e-58	218.00
IUUC-Ssl-108432	Sclerotinia sclerotiorum	69.08	2.00e-64	238.00
IUUC-Smo-109512	Selaginella moellendorffii	76.51	4.00e-70	256.00
IUUC-Sit-110731	Setaria italica	76.51	8.00e-70	255.00
IUUC-Sly-111506	Solanum lycopersicum	77.18	3.00e-70	256.00
IUUC-Stu-112080	Solanum tuberosum	77.18	3.00e-70	256.00
IUUC-Sar-113429	Sorex araneus	100.00	5.00e-88	315.00
IUUC-Sbi-114289	Sorghum bicolor	76.51	8.00e-70	255.00
IUUC-Sre-115106	Sporisorium reilianum	74.17	8.00e-60	222.00
IUUC-Ssc-115257	Sus scrofa	98.03	6.00e-86	308.00
IUUC-Tgu-116604	Taeniopygia guttata	93.83	9.00e-86	308.00
IUUC-Tru-118576	Takifugu rubripes	94.74	1.00e-83	301.00
IUUC-Tsy-119000	Tarsius syrichta	100.00	5.00e-88	315.00
IUUC-Tni-119745	Tetraodon nigroviridis	94.74	7.00e-84	301.00
IUUC-Tca-121827	Theobroma cacao	76.51	5.00e-70	256.00
IUUC-Tre-122002	Trichoderma reesei	68.87	7.00e-64	235.00
IUUC-Tvi-122331	Trichoderma virens	68.87	7.00e-64	235.00
IUUC-Tae-124461	Triticum aestivum	75.17	3.00e-69	254.00
IUUC-Tur-126866	Triticum urartu	75.17	4.00e-69	253.00
IUUC-Tme-127148	Tuber melanosporum	71.14	2.00e-64	237.00
IUUC-Tbe-127921	Tupaia belangeri	98.03	1.00e-83	301.00
IUUC-Ttr-129121	Tursiops truncatus	100.00	5.00e-88	315.00
IUUC-Uma-129561	Ustilago maydis	74.17	4.00e-60	223.00
IUUC-Vda-129711	Verticillium dahliae	68.87	3.00e-64	236.00
IUUC-Vpa-130570	Vicugna pacos	93.43	2.00e-71	260.00
IUUC-Vvi-131108	Vitis vinifera	77.85	2.00e-70	257.00
IUUC-Xtr-131824	Xenopus tropicalis	98.68	8.00e-87	311.00
IUUC-Xma-133667	Xiphophorus maculatus	95.39	4.00e-85	306.00
IUUC-Yli-134660	Yarrowia lipolytica	66.23	6.00e-63	232.00
IUUC-Zma-135584	Zea mays	75.17	8.00e-69	252.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence