iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046239

UUCD1 version

UUC-HoS-01067

Ensembl Protein ID

ENSP00000265339.2

UniProt Accession

P63146; B2R503; D3DQA2; P23567; Q4PJ15; Q9D0J6; UBE2B_HUMAN

Genbank Protein ID

AAA35982.1; CAA37339.1; AAP35734.1; CAG28562.1; AAY68224.1; BAG34950.1; EAW62257.1; EAW62258.1; AAH05979.1; AAH08404.1; AAH08470.1

Protein Name

Ubiquitin-conjugating enzyme E2 B; E2 ubiquitin-conjugating enzyme B; RAD6 homolog B; Ubiquitin carrier protein B; Ubiquitin-conjugating enzyme E2-17 kDa; Ubiquitin-protein ligase B

Genbank Nucleotide ID

M74525; X53251; BT007071; CR407634; DQ090910; AK312012; CH471062; CH471062; BC005979; BC008404; BC008470

Gene Name

UBE2B; RAD6B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000119048.7	ENST00000265339.6	ENSP00000265339.2
ENSG00000119048.7	ENST00000510021.5	ENSP00000425237.1
ENSG00000119048.7	ENST00000506787.5	ENSP00000426364.1
ENSG00000119048.7	ENST00000507277.1	ENSP00000425137.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20675655; 20145714; 20080676; 17462990

Classification

Family	E-value	Score	Start	End
E2/UBC	2.30e-54	184.6	8	142

Active Site

Position(s)	Description	Evidence
88	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
           Rl++++k+l++dpp g+s  p+++ ++++w+++i+Gpe+tp+e+g+Fkl ief+e+YP kPP+v+fl+k+fhPnvy++G++Cl+il+  ++W
   Q: 8    RLMRDFKRLQEDPPVGVSGAPSEN-NIMQWNAVIFGPEGTPFEDGTFKLVIEFSEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQ--NRW 96
           9**********************9.9************************************************************9..*** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           sp+++v+s+l+siqsll+epnp+sp+n++aa+l+++n++ey+k+v+
   Q: 97   SPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVS 142
           *******************************************996 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.

Protein Sequence
(Fasta)

MSTPARRRLM RDFKRLQEDP PVGVSGAPSE NNIMQWNAVI FGPEGTPFED GTFKLVIEFS 60
EEYPNKPPTV RFLSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTCCCTCTT TCTCCACCCC GCCGAGCCTA AACTAGTGAC GGGGAGGGAG ACGGGATAGT 60
GTTTCTGTTT CGTGGTCTTT GAATCCACAA CCTCTAGTCT GAACACAGAG AACACAAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0000785--C:chromatin
GO:0005737--C:cytoplasm
GO:0033503--C:HULC complex
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005657--C:replication fork
GO:0001741--C:XY body
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0060070--P:canonical Wnt signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0051026--P:chiasma assembly
GO:0042769--P:DNA damage response, detection of DNA damage
GO:0006281--P:DNA repair
GO:0033522--P:histone H2A ubiquitination
GO:0070076--P:histone lysine demethylation
GO:0001701--P:in utero embryonic development
GO:0006344--P:maintenance of chromatin silencing
GO:0045141--P:meiotic telomere clustering
GO:0043066--P:negative regulation of apoptotic process
GO:0043951--P:negative regulation of cAMP-mediated signaling
GO:0033128--P:negative regulation of histone phosphorylation
GO:0010845--P:positive regulation of reciprocal meiotic recombination
GO:0006301--P:postreplication repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:0042493--P:response to drug
GO:0009411--P:response to UV
GO:0007288--P:sperm axoneme assembly
GO:0007283--P:spermatogenesis
GO:0070193--P:synaptonemal complex organization
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:7320

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002120	Ailuropoda melanoleuca	100.00	6.00e-88	315.00
IUUC-Apl-004063	Anas platyrhynchos	92.62	2.00e-76	277.00
IUUC-Aca-005001	Anolis carolinensis	99.34	8.00e-88	315.00
IUUC-Acl-008139	Aspergillus clavatus	68.87	9.00e-64	235.00
IUUC-Ame-010743	Astyanax mexicanus	96.71	1.00e-84	305.00
IUUC-Bta-012840	Bos taurus	100.00	6.00e-88	315.00
IUUC-Cja-019737	Callithrix jacchus	100.00	6.00e-88	315.00
IUUC-Cfa-020244	Canis familiaris	100.00	6.00e-88	315.00
IUUC-Cpo-022192	Cavia porcellus	100.00	6.00e-88	315.00
IUUC-Cre-022822	Chlamydomonas reinhardtii	75.97	1.00e-57	215.00
IUUC-Csa-023430	Chlorocebus sabaeus	100.00	6.00e-88	315.00
IUUC-Cho-024773	Choloepus hoffmanni	79.61	1.00e-64	238.00
IUUC-Dno-029661	Dasypus novemcinctus	100.00	6.00e-88	315.00
IUUC-Dor-030452	Dipodomys ordii	100.00	2.00e-78	283.00
IUUC-Ete-032595	Echinops telfairi	96.71	3.00e-85	306.00
IUUC-Eca-033377	Equus caballus	100.00	6.00e-88	315.00
IUUC-Fca-036336	Felis catus	100.00	6.00e-88	315.00
IUUC-Fox-037808	Fusarium oxysporum	68.87	5.00e-64	236.00
IUUC-Fso-038232	Fusarium solani	68.87	6.00e-64	236.00
IUUC-Ggr-039875	Gaeumannomyces graminis	69.13	2.00e-63	234.00
IUUC-Gga-040494	Gallus gallus	100.00	6.00e-88	315.00
IUUC-Itr-048960	Ictidomys tridecemlineatus	100.00	6.00e-88	315.00
IUUC-Kpa-049225	Komagataella pastoris	69.33	2.00e-62	231.00
IUUC-Lch-050283	Latimeria chalumnae	97.35	1.00e-85	308.00
IUUC-Loc-051962	Lepisosteus oculatus	98.03	2.00e-86	310.00
IUUC-Laf-053380	Loxodonta africana	100.00	6.00e-88	315.00
IUUC-Mcc-054819	Macaca mulatta	100.00	3.00e-88	317.00
IUUC-Mor-057087	Magnaporthe oryzae	67.16	2.00e-54	204.00
IUUC-Mla-058876	Melampsora laricipopulina	72.85	2.00e-58	217.00
IUUC-Mga-059863	Meleagris gallopavo	98.57	4.00e-79	286.00
IUUC-Mmr-060630	Microcebus murinus	100.00	6.00e-88	315.00
IUUC-Mdo-062676	Monodelphis domestica	100.00	6.00e-88	315.00
IUUC-Mmu-063491	Mus musculus	100.00	6.00e-88	315.00
IUUC-Mpu-065803	Mustela putorius furo	100.00	6.00e-88	315.00
IUUC-Mlu-067147	Myotis lucifugus	100.00	6.00e-88	315.00
IUUC-Nle-070105	Nomascus leucogenys	100.00	6.00e-88	315.00
IUUC-Opr-070935	Ochotona princeps	100.00	6.00e-88	315.00
IUUC-Oan-072706	Ornithorhynchus anatinus	94.63	2.00e-80	291.00
IUUC-Ocu-074130	Oryctolagus cuniculus	100.00	6.00e-88	315.00
IUUC-Oga-088836	Otolemur garnettii	100.00	6.00e-88	315.00
IUUC-Oar-090141	Ovis aries	100.00	6.00e-88	315.00
IUUC-Ptr-091453	Pan troglodytes	100.00	6.00e-88	315.00
IUUC-Pan-092511	Papio anubis	100.00	6.00e-88	315.00
IUUC-Psi-093968	Pelodiscus sinensis	99.34	8.00e-88	315.00
IUUC-Pno-094935	Phaeosphaeria nodorum	68.87	3.00e-64	236.00
IUUC-Pab-098121	Pongo abelii	100.00	6.00e-88	315.00
IUUC-Pgr-103611	Puccinia graminis	72.19	1.00e-58	218.00
IUUC-Ptt-103971	Puccinia triticina	72.88	3.00e-44	170.00
IUUC-Pte-104378	Pyrenophora teres	69.54	1.00e-64	238.00
IUUC-Pyt-104757	Pyrenophora triticirepentis	69.54	1.00e-64	238.00
IUUC-Rno-105772	Rattus norvegicus	100.00	2.00e-88	317.00
IUUC-Sce-106283	Saccharomyces cerevisiae	69.80	1.00e-62	232.00
IUUC-Sha-107650	Sarcophilus harrisii	98.68	5.00e-86	309.00
IUUC-Sar-113429	Sorex araneus	100.00	6.00e-88	315.00
IUUC-Ssc-115257	Sus scrofa	98.03	7.00e-86	308.00
IUUC-Tgu-116604	Taeniopygia guttata	93.83	1.00e-85	308.00
IUUC-Tru-118576	Takifugu rubripes	94.74	1.00e-83	301.00
IUUC-Tsy-119000	Tarsius syrichta	100.00	6.00e-88	315.00
IUUC-Tni-119745	Tetraodon nigroviridis	94.74	8.00e-84	301.00
IUUC-Tbe-127921	Tupaia belangeri	98.03	1.00e-83	301.00
IUUC-Ttr-129121	Tursiops truncatus	100.00	6.00e-88	315.00
IUUC-Uma-129561	Ustilago maydis	74.17	5.00e-60	223.00
IUUC-Vpa-130570	Vicugna pacos	93.43	2.00e-71	260.00
IUUC-Xtr-131824	Xenopus tropicalis	98.68	9.00e-87	311.00
IUUC-Yli-134660	Yarrowia lipolytica	66.23	7.00e-63	232.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence