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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046030
Ensembl Protein ID ENSP00000361800.2
UniProt Accession Q96EX3; Q5VXV4; Q9BV46; WDR34_HUMAN
Genbank Protein ID AAH01614.3; AAH11874.2
Protein Name WD repeat-containing protein 34
Genbank Nucleotide ID AL356481; BC011874
Gene Name WDR34
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000119333.11 ENST00000372715.6 ENSP00000361800.2
ENSG00000119333.11 ENST00000451652.5 ENSP00000411370.1
ENSG00000119333.11 ENST00000419989.1 ENSP00000415421.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-19 70.8 482 514
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 3    tdsvtclaf...sdtllvsGsdDgtikvWDlrt 32
           +++v+cl+f   ++ ll++G   gt+kvW l+t
   Q: 482  ESPVYCLEFnsqQTQLLAAGDAQGTVKVWQLST 514
           689******974338899999********9877 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.
 Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.
Protein Sequence
(Fasta)
MATRAQPGPL SQAGSAGVAA LATVGVASGP GPGRPGPLQD ETLGVASVPS QWRAVQGIRW 60
ETKSCQTASI ATASASAQAR NHVDAQVQTE APVPVSVQPP SQYDIPRLAA FLRRVEAMVI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046030|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGGCGTAG GGGCGGAGGT CGCGCCTGAG TGCGTCCGCA CGAGAGGGCG GAACCGTCTC 60
CATGGCAACC CGCGCGCAGC CGGGGCCACT CAGCCAGGCG GGAAGCGCTG GTGTTGCGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046030|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0966--Cell projection
KW-1186--Ciliopathy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005930--C:axoneme
GO:0005814--C:centriole
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005929--C:cilium
GO:0005868--C:cytoplasmic dynein complex
GO:0005829--C:cytosol
GO:0045503--F:dynein light chain binding
GO:0060271--P:cilium assembly
GO:0035735--P:intraciliary transport involved in cilium assembly
KEGG hsa:89891
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002326 Ailuropoda melanoleuca 88.04 0.00e+00 843.00
IUUC-Apl-004015 Anas platyrhynchos 67.23 4.00e-177 614.00
IUUC-Ame-010762 Astyanax mexicanus 51.81 7.00e-140 490.00
IUUC-Bta-013392 Bos taurus 85.57 0.00e+00 857.00
IUUC-Cja-019374 Callithrix jacchus 93.78 0.00e+00 897.00
IUUC-Cfa-020365 Canis familiaris 87.85 0.00e+00 835.00
IUUC-Csa-023810 Chlorocebus sabaeus 94.94 0.00e+00 948.00
IUUC-Cho-024515 Choloepus hoffmanni 80.70 2.00e-167 582.00
IUUC-Cin-025690 Ciona intestinalis 28.54 1.00e-50 194.00
IUUC-Csv-026220 Ciona savignyi 29.07 2.00e-47 183.00
IUUC-Dre-028439 Danio rerio 50.90 5.00e-138 484.00
IUUC-Dno-029916 Dasypus novemcinctus 86.95 0.00e+00 843.00
IUUC-Dor-030853 Dipodomys ordii 84.30 0.00e+00 870.00
IUUC-Eca-033204 Equus caballus 86.47 0.00e+00 806.00
IUUC-Fca-036470 Felis catus 87.48 0.00e+00 842.00
IUUC-Fal-037484 Ficedula albicollis 63.18 0.00e+00 629.00
IUUC-Gmo-039252 Gadus morhua 47.69 1.00e-130 459.00
IUUC-Gga-040701 Gallus gallus 64.51 1.00e-171 596.00
IUUC-Gac-041440 Gasterosteus aculeatus 49.11 2.00e-131 462.00
IUUC-Ggo-044509 Gorilla gorilla 98.88 0.00e+00 965.00
IUUC-Itr-048001 Ictidomys tridecemlineatus 86.57 0.00e+00 855.00
IUUC-Lch-050603 Latimeria chalumnae 58.32 4.00e-164 571.00
IUUC-Loc-052914 Lepisosteus oculatus 50.11 1.00e-121 429.00
IUUC-Laf-053957 Loxodonta africana 81.59 0.00e+00 700.00
IUUC-Mcc-054805 Macaca mulatta 94.77 0.00e+00 957.00
IUUC-Meu-056115 Macropus eugenii 79.76 0.00e+00 803.00
IUUC-Mga-059377 Meleagris gallopavo 65.25 1.00e-178 619.00
IUUC-Mmr-061203 Microcebus murinus 88.39 0.00e+00 873.00
IUUC-Mdo-062646 Monodelphis domestica 79.76 0.00e+00 781.00
IUUC-Mmu-063156 Mus musculus 85.34 0.00e+00 806.00
IUUC-Mpu-065923 Mustela putorius furo 84.46 0.00e+00 824.00
IUUC-Mlu-067705 Myotis lucifugus 85.98 0.00e+00 864.00
IUUC-Nle-069635 Nomascus leucogenys 97.81 0.00e+00 912.00
IUUC-Opr-070939 Ochotona princeps 68.80 1.00e-148 519.00
IUUC-Ont-072205 Oreochromis niloticus 47.41 8.00e-125 440.00
IUUC-Oan-073427 Ornithorhynchus anatinus 73.80 0.00e+00 672.00
IUUC-Ocu-074234 Oryctolagus cuniculus 86.54 0.00e+00 861.00
IUUC-Ola-086461 Oryzias latipes 48.13 7.00e-129 454.00
IUUC-Oga-088616 Otolemur garnettii 90.26 0.00e+00 724.00
IUUC-Ptr-090563 Pan troglodytes 98.69 0.00e+00 955.00
IUUC-Pan-092105 Papio anubis 95.13 0.00e+00 950.00
IUUC-Psi-093169 Pelodiscus sinensis 64.50 0.00e+00 653.00
IUUC-Pma-094688 Petromyzon marinus 38.88 5.00e-85 308.00
IUUC-Pfo-096136 Poecilia formosa 49.50 2.00e-117 416.00
IUUC-Pab-098286 Pongo abelii 96.45 0.00e+00 956.00
IUUC-Pca-100577 Procavia capensis 78.69 0.00e+00 773.00
IUUC-Pva-103194 Pteropus vampyrus 86.54 0.00e+00 903.00
IUUC-Rno-105958 Rattus norvegicus 84.54 0.00e+00 820.00
IUUC-Sha-107438 Sarcophilus harrisii 81.65 0.00e+00 788.00
IUUC-Ssc-116210 Sus scrofa 84.50 0.00e+00 851.00
IUUC-Tgu-116704 Taeniopygia guttata 63.34 6.00e-180 624.00
IUUC-Tru-117530 Takifugu rubripes 47.01 2.00e-117 416.00
IUUC-Tni-120848 Tetraodon nigroviridis 44.86 6.00e-99 354.00
IUUC-Ttr-128697 Tursiops truncatus 88.21 0.00e+00 707.00
IUUC-Xtr-132843 Xenopus tropicalis 59.01 1.00e-168 585.00
Created Date 25-Jun-2017

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