iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046653

UUCD1 version

UUC-HoS-00103

Ensembl Protein ID

ENSP00000363095.1

UniProt Accession

Q13049; Q9NQP8; TRI32_HUMAN

Genbank Protein ID

AAA86474.1; AAH03154.1

Protein Name

E3 ubiquitin-protein ligase TRIM32; 72 kDa Tat-interacting protein; RING-type E3 ubiquitin transferase TRIM32; Tripartite motif-containing protein 32; Zinc finger protein HT2A

Genbank Nucleotide ID

U18543; AL133284

Gene Name

TRIM32; HT2A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000119401.10	ENST00000373983.2	ENSP00000363095.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18632609; 19349376; 19269368; 19155210; 16816390; 15316618

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.60e-07	32.7	20	64

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg...plvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C+iC+e+f ++   p++l CgH+++++Cl+k+     ss +  rCP C
   Q: 20   CPICMESFTEEqlrPKLLHCGHTICRQCLEKL---LASSINGVRCPFC 64
           ********76667799*************888...67799999***** PP

Organism

Homo sapiens

Functional Description
(View)

Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.

Protein Sequence
(Fasta)

MAAAAASHLN LDALREVLEC PICMESFTEE QLRPKLLHCG HTICRQCLEK LLASSINGVR 60
CPFCSKITRI TSLTQLTDNL TVLKIIDTAG LSEAVGLLMC RSCGRRLPRQ FCRSCGLVLC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGCTCAAC GGCGCGTGCG CAGAGGGAGG CAGGCGGGTG GGCTGCCGGC GGTGGACTCG 60
TCGGAGCCGC GGGCGGTCAG GTAGGGGGCG GGAAGGAGGG TTGGGGACTG GGGACCGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0083--Bardet-Biedl syndrome
KW-1186--Ciliopathy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0947--Limb-girdle muscular dystrophy
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0550--Obesity
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR033569--TRIM32
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01436--NHL
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005863--C:striated muscle myosin thick filament
GO:0042802--F:identical protein binding
GO:0017022--F:myosin binding
GO:0043621--F:protein self-association
GO:0003723--F:RNA binding
GO:0030957--F:Tat protein binding
GO:0003713--F:transcription coactivator activity
GO:0031369--F:translation initiation factor binding
GO:0043130--F:ubiquitin binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007014--P:actin ubiquitination
GO:0061564--P:axon development
GO:0045444--P:fat cell differentiation
GO:0045087--P:innate immune response
GO:0046716--P:muscle cell cellular homeostasis
GO:0048147--P:negative regulation of fibroblast proliferation
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0045787--P:positive regulation of cell cycle
GO:0030307--P:positive regulation of cell growth
GO:0030335--P:positive regulation of cell migration
GO:2000147--P:positive regulation of cell motility
GO:1903886--P:positive regulation of chemokine (C-C motif) ligand 20 production
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903883--P:positive regulation of interleukin-17-mediated signaling pathway
GO:0050769--P:positive regulation of neurogenesis
GO:0045666--P:positive regulation of neuron differentiation
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0045862--P:positive regulation of proteolysis
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051155--P:positive regulation of striated muscle cell differentiation
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032479--P:regulation of type I interferon production
GO:0034612--P:response to tumor necrosis factor
GO:0009411--P:response to UV
GO:0001894--P:tissue homeostasis

KEGG

hsa:22954

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000568	Aegilops tauschii	36.51	3.00e-06	45.40
IUUC-Aml-001554	Ailuropoda melanoleuca	96.75	0.00e+00	1228.00
IUUC-Aca-004290	Anolis carolinensis	83.87	0.00e+00	1108.00
IUUC-Aly-006480	Arabidopsis lyrata	34.25	1.00e-08	56.60
IUUC-Ame-011474	Astyanax mexicanus	62.21	0.00e+00	844.00
IUUC-Bta-013335	Bos taurus	93.26	0.00e+00	1196.00
IUUC-Bol-015127	Brassica oleracea	34.04	2.00e-09	55.80
IUUC-Cja-019836	Callithrix jacchus	98.47	0.00e+00	1259.00
IUUC-Cfa-020126	Canis familiaris	97.84	0.00e+00	1244.00
IUUC-Cpo-021619	Cavia porcellus	97.70	0.00e+00	1250.00
IUUC-Cre-022845	Chlamydomonas reinhardtii	43.40	1.00e-05	40.80
IUUC-Csa-023381	Chlorocebus sabaeus	99.54	0.00e+00	1264.00
IUUC-Cho-024696	Choloepus hoffmanni	95.71	0.00e+00	1215.00
IUUC-Dre-028768	Danio rerio	63.33	0.00e+00	864.00
IUUC-Dno-029162	Dasypus novemcinctus	97.55	0.00e+00	1244.00
IUUC-Dor-030490	Dipodomys ordii	96.45	0.00e+00	1224.00
IUUC-Ete-032250	Echinops telfairi	92.80	0.00e+00	1167.00
IUUC-Eca-033392	Equus caballus	97.70	0.00e+00	1246.00
IUUC-Fca-035512	Felis catus	97.99	0.00e+00	1244.00
IUUC-Fal-036745	Ficedula albicollis	85.54	0.00e+00	1110.00
IUUC-Fox-038006	Fusarium oxysporum	41.27	2.00e-05	43.50
IUUC-Gmo-038737	Gadus morhua	60.15	0.00e+00	788.00
IUUC-Gga-040258	Gallus gallus	83.54	0.00e+00	1092.00
IUUC-Gac-041657	Gasterosteus aculeatus	60.42	0.00e+00	798.00
IUUC-Ggo-045473	Gorilla gorilla	99.85	0.00e+00	1272.00
IUUC-Itr-048947	Ictidomys tridecemlineatus	97.70	0.00e+00	1253.00
IUUC-Lch-049791	Latimeria chalumnae	69.68	0.00e+00	919.00
IUUC-Loc-052573	Lepisosteus oculatus	65.59	0.00e+00	870.00
IUUC-Laf-054514	Loxodonta africana	97.24	0.00e+00	1243.00
IUUC-Mcc-055244	Macaca mulatta	99.54	0.00e+00	1264.00
IUUC-Meu-056655	Macropus eugenii	82.46	0.00e+00	1098.00
IUUC-Mtr-058731	Medicago truncatula	34.67	1.00e-10	61.20
IUUC-Mga-059343	Meleagris gallopavo	79.88	0.00e+00	1020.00
IUUC-Mmr-061774	Microcebus murinus	97.86	0.00e+00	1246.00
IUUC-Mmu-063743	Mus musculus	95.52	0.00e+00	1229.00
IUUC-Mpu-066801	Mustela putorius furo	97.99	0.00e+00	1246.00
IUUC-Nle-069880	Nomascus leucogenys	99.54	0.00e+00	1264.00
IUUC-Ont-071805	Oreochromis niloticus	58.41	0.00e+00	780.00
IUUC-Oan-073221	Ornithorhynchus anatinus	82.78	0.00e+00	1050.00
IUUC-Ocu-074609	Oryctolagus cuniculus	97.86	0.00e+00	1209.00
IUUC-Olo-080692	Oryza longistaminata	38.10	6.00e-07	47.80
IUUC-Osa-086244	Oryza sativa	39.39	5.00e-08	52.40
IUUC-Oga-088597	Otolemur garnettii	98.16	0.00e+00	1251.00
IUUC-Oar-089322	Ovis aries	91.99	0.00e+00	751.00
IUUC-Ptr-091638	Pan troglodytes	99.85	0.00e+00	1274.00
IUUC-Pan-092001	Papio anubis	99.54	0.00e+00	1264.00
IUUC-Psi-093112	Pelodiscus sinensis	84.46	0.00e+00	1125.00
IUUC-Ppa-095766	Physcomitrella patens	37.35	1.00e-11	63.50
IUUC-Pfo-097226	Poecilia formosa	59.53	0.00e+00	810.00
IUUC-Pab-098115	Pongo abelii	99.69	0.00e+00	1266.00
IUUC-Rno-104950	Rattus norvegicus	96.76	0.00e+00	1247.00
IUUC-Sha-106842	Sarcophilus harrisii	84.23	0.00e+00	1108.00
IUUC-Smo-109517	Selaginella moellendorffii	38.81	2.00e-10	56.60
IUUC-Ssc-115577	Sus scrofa	96.94	0.00e+00	1233.00
IUUC-Tgu-116636	Taeniopygia guttata	85.08	0.00e+00	1107.00
IUUC-Tsy-119479	Tarsius syrichta	98.93	0.00e+00	1257.00
IUUC-Tni-120872	Tetraodon nigroviridis	58.02	0.00e+00	765.00
IUUC-Tae-124168	Triticum aestivum	36.51	4.00e-06	45.10
IUUC-Tur-126036	Triticum urartu	36.51	3.00e-06	45.40
IUUC-Ttr-129170	Tursiops truncatus	96.78	0.00e+00	1265.00
IUUC-Xtr-132839	Xenopus tropicalis	71.36	0.00e+00	956.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence