iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	15640526
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	15640526

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.049	15.3	55	101
E3 adaptor/Cullin RING/DCX/DWD	9.80e-23	80.9	224	261

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 101  glldrlpeeilveilklldkeellraarvcrrwqelas.qkalwktv 146
           + l+ lp+e+ +  lk ld+++ll++ +v+++w++++s  +++w+t+
   Q: 55   DFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISaCTEVWQTA 101
           567889****************************6666479999987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gHt+ v+++++ ++ ++lvsGs D t+kvW l+ g++l
   Q: 224  GHTGAVFSVDYnDElDILVSGSADFTVKVWALSAGTCL 261
           8**********555999*****************9997 PP

Organism

Homo sapiens

Functional Description
(View)

Directly interacts with SKP1 and CUL1.

Protein Sequence
(Fasta)

MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET LLKRDFLKLL 60
PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT ACKNLGWQID DSVQDALHWK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCACCGGAA GCCGCTCCCC TGTGAGGCTG CGGACCGGGA GCAGCGGCCG CAGGTCCGGG 60
TCTGTATGCG AGGCGGGGCC GGTCGGGGAG GGGACTCTTA GGCGCCCGCG GCTCTGCTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0000209--P:protein polyubiquitination
GO:0006508--P:proteolysis

KEGG

hsa:26190

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001726	Ailuropoda melanoleuca	100.00	0.00e+00	892.00
IUUC-Apl-003329	Anas platyrhynchos	94.49	0.00e+00	854.00
IUUC-Aca-004491	Anolis carolinensis	92.12	3.00e-154	537.00
IUUC-Ame-011713	Astyanax mexicanus	80.66	0.00e+00	740.00
IUUC-Bta-012538	Bos taurus	99.56	0.00e+00	888.00
IUUC-Cja-018833	Callithrix jacchus	100.00	0.00e+00	892.00
IUUC-Cfa-020233	Canis familiaris	100.00	0.00e+00	892.00
IUUC-Cpo-021662	Cavia porcellus	99.12	0.00e+00	889.00
IUUC-Csa-023818	Chlorocebus sabaeus	100.00	0.00e+00	892.00
IUUC-Cin-025489	Ciona intestinalis	31.65	2.00e-42	166.00
IUUC-Dre-028713	Danio rerio	79.56	0.00e+00	722.00
IUUC-Dno-029701	Dasypus novemcinctus	99.12	0.00e+00	883.00
IUUC-Dor-030944	Dipodomys ordii	99.12	0.00e+00	889.00
IUUC-Ete-033151	Echinops telfairi	97.80	0.00e+00	863.00
IUUC-Eca-033984	Equus caballus	99.56	0.00e+00	889.00
IUUC-Eeu-034517	Erinaceus europaeus	83.45	5.00e-138	483.00
IUUC-Fca-035678	Felis catus	100.00	0.00e+00	892.00
IUUC-Fal-036805	Ficedula albicollis	94.71	0.00e+00	857.00
IUUC-Gmo-039517	Gadus morhua	78.63	0.00e+00	726.00
IUUC-Gga-040872	Gallus gallus	93.83	0.00e+00	853.00
IUUC-Gac-042579	Gasterosteus aculeatus	77.09	0.00e+00	696.00
IUUC-Ggo-045157	Gorilla gorilla	99.78	0.00e+00	890.00
IUUC-Itr-048301	Ictidomys tridecemlineatus	99.56	0.00e+00	889.00
IUUC-Lch-049887	Latimeria chalumnae	87.22	0.00e+00	788.00
IUUC-Loc-052187	Lepisosteus oculatus	83.48	0.00e+00	757.00
IUUC-Laf-053958	Loxodonta africana	99.56	0.00e+00	889.00
IUUC-Mcc-054903	Macaca mulatta	99.78	0.00e+00	891.00
IUUC-Meu-056564	Macropus eugenii	94.71	0.00e+00	842.00
IUUC-Mga-060169	Meleagris gallopavo	94.05	0.00e+00	853.00
IUUC-Mdo-061997	Monodelphis domestica	96.92	0.00e+00	872.00
IUUC-Mmu-063709	Mus musculus	98.68	0.00e+00	880.00
IUUC-Mpu-066578	Mustela putorius furo	100.00	0.00e+00	892.00
IUUC-Mlu-067555	Myotis lucifugus	99.34	0.00e+00	889.00
IUUC-Nle-069408	Nomascus leucogenys	99.78	0.00e+00	891.00
IUUC-Opr-070771	Ochotona princeps	76.60	9.00e-159	552.00
IUUC-Ont-072597	Oreochromis niloticus	81.72	0.00e+00	721.00
IUUC-Oan-072768	Ornithorhynchus anatinus	98.68	4.00e-121	427.00
IUUC-Ocu-074312	Oryctolagus cuniculus	100.00	0.00e+00	892.00
IUUC-Ola-086660	Oryzias latipes	81.50	0.00e+00	715.00
IUUC-Oga-088471	Otolemur garnettii	88.91	0.00e+00	772.00
IUUC-Oar-089744	Ovis aries	98.46	0.00e+00	875.00
IUUC-Ptr-090977	Pan troglodytes	100.00	0.00e+00	892.00
IUUC-Pan-092850	Papio anubis	99.78	0.00e+00	892.00
IUUC-Psi-093875	Pelodiscus sinensis	93.61	0.00e+00	844.00
IUUC-Pma-094257	Petromyzon marinus	69.30	0.00e+00	627.00
IUUC-Pfo-096359	Poecilia formosa	81.72	0.00e+00	721.00
IUUC-Pab-097730	Pongo abelii	99.78	0.00e+00	891.00
IUUC-Pca-101089	Procavia capensis	100.00	6.00e-81	294.00
IUUC-Pva-102555	Pteropus vampyrus	99.78	0.00e+00	891.00
IUUC-Rno-104837	Rattus norvegicus	98.68	0.00e+00	884.00
IUUC-Sha-107582	Sarcophilus harrisii	96.92	0.00e+00	869.00
IUUC-Sar-112994	Sorex araneus	77.09	7.00e-139	486.00
IUUC-Ssc-115254	Sus scrofa	100.00	0.00e+00	889.00
IUUC-Tgu-117122	Taeniopygia guttata	94.49	0.00e+00	857.00
IUUC-Tru-118198	Takifugu rubripes	82.16	0.00e+00	748.00
IUUC-Tsy-119295	Tarsius syrichta	99.34	0.00e+00	888.00
IUUC-Tni-120193	Tetraodon nigroviridis	80.62	0.00e+00	709.00
IUUC-Tbe-127929	Tupaia belangeri	98.90	0.00e+00	849.00
IUUC-Ttr-128816	Tursiops truncatus	100.00	0.00e+00	892.00
IUUC-Vpa-130198	Vicugna pacos	100.00	0.00e+00	693.00
IUUC-Xtr-132551	Xenopus tropicalis	88.77	0.00e+00	801.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence