iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.80e-22	77.5	146	181

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlrtgvll 36
           gH+++v++l + d+ll++GsdD + k+WD++tg ++
   Q: 146  GHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCV 181
           8********8877********************997 PP

Organism

Rattus norvegicus

Functional Description
(View)

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Protein Sequence
(Fasta)

MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET LLKRDFLKLL 60
PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT ACKNLGWQID DSVQDALHWK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCCTTTCC CCGCAGGCGC CATGGCTGCG GAGCGGACCC GGCCGCTGCG ACGCTCTGGC 60
GGCCCGAGCG CGCCTAGTCG GTGTGAGCCC GGCGCGAGGT CCCGGGCCCC GGGGCGCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

KEGG

rno:311881

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001726	Ailuropoda melanoleuca	98.68	0.00e+00	884.00
IUUC-Apl-003329	Anas platyrhynchos	93.39	0.00e+00	845.00
IUUC-Aca-004491	Anolis carolinensis	91.10	7.00e-154	536.00
IUUC-Ame-011713	Astyanax mexicanus	80.66	0.00e+00	739.00
IUUC-Bta-012538	Bos taurus	98.24	0.00e+00	879.00
IUUC-Cja-018833	Callithrix jacchus	98.68	0.00e+00	884.00
IUUC-Cfa-020233	Canis familiaris	98.68	0.00e+00	884.00
IUUC-Cpo-021662	Cavia porcellus	98.68	0.00e+00	883.00
IUUC-Csa-023818	Chlorocebus sabaeus	98.68	0.00e+00	884.00
IUUC-Cin-025489	Ciona intestinalis	30.94	2.00e-41	162.00
IUUC-Dre-028713	Danio rerio	79.34	0.00e+00	720.00
IUUC-Dno-029701	Dasypus novemcinctus	97.80	0.00e+00	874.00
IUUC-Dor-030944	Dipodomys ordii	98.68	0.00e+00	882.00
IUUC-Ete-033151	Echinops telfairi	96.92	0.00e+00	858.00
IUUC-Eca-033984	Equus caballus	98.24	0.00e+00	880.00
IUUC-Eeu-034517	Erinaceus europaeus	82.76	2.00e-137	481.00
IUUC-Fca-035678	Felis catus	98.68	0.00e+00	884.00
IUUC-Fal-036805	Ficedula albicollis	93.61	0.00e+00	848.00
IUUC-Gmo-039517	Gadus morhua	78.63	0.00e+00	726.00
IUUC-Gga-040872	Gallus gallus	92.73	0.00e+00	843.00
IUUC-Gac-042579	Gasterosteus aculeatus	77.09	0.00e+00	696.00
IUUC-Ggo-045157	Gorilla gorilla	98.46	0.00e+00	882.00
IUUC-Hsa-045668	Homo sapiens	98.68	0.00e+00	884.00
IUUC-Itr-048301	Ictidomys tridecemlineatus	98.68	0.00e+00	881.00
IUUC-Lch-049887	Latimeria chalumnae	87.00	0.00e+00	785.00
IUUC-Loc-052187	Lepisosteus oculatus	83.26	0.00e+00	755.00
IUUC-Laf-053958	Loxodonta africana	98.24	0.00e+00	880.00
IUUC-Mcc-054903	Macaca mulatta	98.46	0.00e+00	883.00
IUUC-Meu-056564	Macropus eugenii	94.05	0.00e+00	838.00
IUUC-Mga-060169	Meleagris gallopavo	92.95	0.00e+00	844.00
IUUC-Mdo-061997	Monodelphis domestica	95.81	0.00e+00	863.00
IUUC-Mmu-063709	Mus musculus	99.56	0.00e+00	886.00
IUUC-Mpu-066578	Mustela putorius furo	98.68	0.00e+00	884.00
IUUC-Mlu-067555	Myotis lucifugus	98.46	0.00e+00	880.00
IUUC-Nle-069408	Nomascus leucogenys	98.46	0.00e+00	882.00
IUUC-Opr-070771	Ochotona princeps	76.33	2.00e-158	551.00
IUUC-Ont-072597	Oreochromis niloticus	81.72	0.00e+00	721.00
IUUC-Oan-072768	Ornithorhynchus anatinus	98.68	4.00e-121	426.00
IUUC-Ocu-074312	Oryctolagus cuniculus	98.68	0.00e+00	884.00
IUUC-Ola-086660	Oryzias latipes	81.50	0.00e+00	715.00
IUUC-Oga-088471	Otolemur garnettii	87.61	0.00e+00	763.00
IUUC-Oar-089744	Ovis aries	97.14	0.00e+00	866.00
IUUC-Ptr-090977	Pan troglodytes	98.68	0.00e+00	884.00
IUUC-Pan-092850	Papio anubis	98.46	0.00e+00	883.00
IUUC-Psi-093875	Pelodiscus sinensis	92.73	0.00e+00	838.00
IUUC-Pma-094257	Petromyzon marinus	69.52	0.00e+00	629.00
IUUC-Pfo-096359	Poecilia formosa	81.72	0.00e+00	719.00
IUUC-Pab-097730	Pongo abelii	98.46	0.00e+00	882.00
IUUC-Pca-101089	Procavia capensis	97.87	2.00e-79	289.00
IUUC-Pva-102555	Pteropus vampyrus	98.90	0.00e+00	884.00
IUUC-Sha-107582	Sarcophilus harrisii	95.82	0.00e+00	861.00
IUUC-Sar-112994	Sorex araneus	76.82	2.00e-138	485.00
IUUC-Ssc-115254	Sus scrofa	98.68	0.00e+00	882.00
IUUC-Tgu-117122	Taeniopygia guttata	93.39	0.00e+00	848.00
IUUC-Tru-118198	Takifugu rubripes	81.94	0.00e+00	746.00
IUUC-Tsy-119295	Tarsius syrichta	98.02	0.00e+00	879.00
IUUC-Tni-120193	Tetraodon nigroviridis	80.62	0.00e+00	709.00
IUUC-Tbe-127929	Tupaia belangeri	98.02	0.00e+00	841.00
IUUC-Ttr-128816	Tursiops truncatus	98.68	0.00e+00	884.00
IUUC-Vpa-130198	Vicugna pacos	99.16	0.00e+00	688.00
IUUC-Xtr-132551	Xenopus tropicalis	88.11	0.00e+00	799.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence