iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000119771.14	ENST00000486442.5	ENSP00000420659.1
ENSG00000119771.14	ENST00000288548.5	ENSP00000288548.5

Annotation

Cancer Mutation
ICGC	COSMIC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
AREsite	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha	InWeb_IM
Disease-associated Variation
GWASdb	GWAS Central
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	7.00e-11	44.0	329	398

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmelees....ksklmveikdvqpevfrallkFlYtgkld 66
           +D  +vv+g+ef++h  vLa++S +F++l++    +s    ++kl+ +++ +q++v++ ll+F+Ytg+l 
   Q: 329  TDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSgqggREKLELVLSNLQADVLELLLEFVYTGSLV 398
           6999*******************************998999889999999*****************996 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSRHHSRFER DYRVGWDRRE WSVNGTHGTT SICSVTSGAG GGTASSLSVR PGLLPLPVVP 60
SRLPTPATAP APCTTGSSEA ITSLVASSAS AVTTKAPGIS KGDSQSQGLA TSIRWGQTPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTCCCCGCG CCGCGGCCGC GCCAGCCCCC GCGCCGCCGC CGCCGTCCCC GCCACCGCGG 60
ATCTCGCCGC AGCTCCAGCC CCGGCCCCGG CTCCGCAGCG CCCGTCCGCA GCCCCGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:114818

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001301	Ailuropoda melanoleuca	97.83	0.00e+00	1593.00
IUUC-Apl-003802	Anas platyrhynchos	92.23	0.00e+00	1105.00
IUUC-Aca-004780	Anolis carolinensis	82.49	0.00e+00	1478.00
IUUC-Ame-011528	Astyanax mexicanus	71.54	0.00e+00	1216.00
IUUC-Bta-013195	Bos taurus	96.46	0.00e+00	1564.00
IUUC-Cja-019495	Callithrix jacchus	99.82	0.00e+00	1176.00
IUUC-Cfa-020382	Canis familiaris	97.49	0.00e+00	1565.00
IUUC-Cpo-021314	Cavia porcellus	98.02	0.00e+00	1303.00
IUUC-Csa-023205	Chlorocebus sabaeus	99.43	0.00e+00	1603.00
IUUC-Dre-027939	Danio rerio	72.37	0.00e+00	1237.00
IUUC-Dno-029132	Dasypus novemcinctus	94.88	0.00e+00	1412.00
IUUC-Dor-030888	Dipodomys ordii	98.02	0.00e+00	1274.00
IUUC-Ete-033180	Echinops telfairi	80.50	0.00e+00	724.00
IUUC-Eca-033974	Equus caballus	98.52	0.00e+00	1316.00
IUUC-Fca-035437	Felis catus	97.71	0.00e+00	1587.00
IUUC-Fal-036876	Ficedula albicollis	92.69	0.00e+00	1106.00
IUUC-Gmo-038723	Gadus morhua	84.52	0.00e+00	1022.00
IUUC-Gga-040632	Gallus gallus	77.65	0.00e+00	875.00
IUUC-Gac-042153	Gasterosteus aculeatus	85.77	0.00e+00	1031.00
IUUC-Ggo-045183	Gorilla gorilla	99.89	0.00e+00	1612.00
IUUC-Itr-048141	Ictidomys tridecemlineatus	98.40	0.00e+00	1160.00
IUUC-Lch-050392	Latimeria chalumnae	66.56	0.00e+00	741.00
IUUC-Loc-052643	Lepisosteus oculatus	74.05	0.00e+00	1304.00
IUUC-Laf-054191	Loxodonta africana	98.47	0.00e+00	1303.00
IUUC-Mcc-054706	Macaca mulatta	99.77	0.00e+00	1610.00
IUUC-Meu-056801	Macropus eugenii	87.64	0.00e+00	1154.00
IUUC-Mga-059534	Meleagris gallopavo	78.39	0.00e+00	1184.00
IUUC-Mmr-061753	Microcebus murinus	98.51	0.00e+00	1588.00
IUUC-Mmu-063249	Mus musculus	97.03	0.00e+00	1540.00
IUUC-Mpu-066139	Mustela putorius furo	88.69	0.00e+00	1383.00
IUUC-Mlu-066963	Myotis lucifugus	85.60	0.00e+00	1380.00
IUUC-Nle-069821	Nomascus leucogenys	98.17	0.00e+00	1575.00
IUUC-Opr-071121	Ochotona princeps	97.85	1.00e-139	490.00
IUUC-Ont-072254	Oreochromis niloticus	67.13	0.00e+00	1034.00
IUUC-Oan-073038	Ornithorhynchus anatinus	83.48	0.00e+00	975.00
IUUC-Ocu-074777	Oryctolagus cuniculus	97.60	0.00e+00	1574.00
IUUC-Ola-086924	Oryzias latipes	86.27	0.00e+00	1037.00
IUUC-Oga-087940	Otolemur garnettii	98.63	0.00e+00	1327.00
IUUC-Oar-089961	Ovis aries	96.69	0.00e+00	1565.00
IUUC-Ptr-091255	Pan troglodytes	99.89	0.00e+00	1612.00
IUUC-Pan-092921	Papio anubis	99.54	0.00e+00	1608.00
IUUC-Psi-092981	Pelodiscus sinensis	76.72	0.00e+00	1268.00
IUUC-Pma-094318	Petromyzon marinus	57.31	0.00e+00	711.00
IUUC-Pfo-097258	Poecilia formosa	71.85	0.00e+00	1240.00
IUUC-Pab-097790	Pongo abelii	99.66	0.00e+00	1604.00
IUUC-Pca-101041	Procavia capensis	84.02	0.00e+00	734.00
IUUC-Pva-102339	Pteropus vampyrus	95.12	7.00e-125	441.00
IUUC-Ptt-103969	Puccinia triticina	26.39	7.40e-01	28.50
IUUC-Pte-104154	Pyrenophora teres	24.07	2.00e-04	41.60
IUUC-Pyt-104553	Pyrenophora triticirepentis	43.75	4.00e-11	63.20
IUUC-Rno-106023	Rattus norvegicus	97.83	0.00e+00	1569.00
IUUC-Ssc-116165	Sus scrofa	88.57	0.00e+00	1353.00
IUUC-Tgu-117177	Taeniopygia guttata	88.40	0.00e+00	1146.00
IUUC-Tru-118053	Takifugu rubripes	77.74	0.00e+00	1061.00
IUUC-Tsy-119016	Tarsius syrichta	99.12	3.00e-137	481.00
IUUC-Tni-119908	Tetraodon nigroviridis	77.89	0.00e+00	1085.00
IUUC-Tbe-127908	Tupaia belangeri	93.93	4.00e-133	468.00
IUUC-Ttr-128581	Tursiops truncatus	96.95	0.00e+00	1286.00
IUUC-Xtr-132088	Xenopus tropicalis	73.39	0.00e+00	1125.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence