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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046891
Ensembl Protein ID ENSP00000239878.4
UniProt Accession P61960; Q14346; Q5VXS0; Q6IAG6; Q9CPX2; Q9NZF2; UFM1_HUMAN
Genbank Protein ID BAD15373.1; AAF64258.1; CAG33470.1; CAH70411.1; CAH70414.1; AAH05193.1; CAA94181.1
Protein Name Ubiquitin-fold modifier 1
Genbank Nucleotide ID AB154404; AF208844; CR457189; DA664581; AL356863; BC005193; Z70222
Gene Name UFM1; C13orf20; BM-002
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000120686.11 ENST00000379649.5 ENSP00000368970.1
ENSG00000120686.11 ENST00000239878.8 ENSP00000239878.4
ENSG00000120686.11 ENST00000437952.1 ENSP00000402378.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UBQ/UBQ_Other UBQ_Other 16527251; 23109884; 24603482
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable).
 Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable).
Protein Sequence
(Fasta)
MSKVSFKITL TSDPRLPYKV LSVPESTPFT AVLKFAAEEF KVPAATSAII TNDGIGINPA 60
QTAGNVFLKH GSELRIIPRD RVGSC 85
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046891|ULD,UBQ_Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
CCAGCACACT AGAGGAAGTC GTGCTACCCC CGCGGAGTTG TCGTGTGTTC TGGATTCATT 60
CCGGCACCAC CATGTAAGTG TTTGCTTACC GACTGCCATA ATTCCTGGTC CAGCTGCCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046891|ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR029071--Ubiquitin-rel_dom
IPR005375--UFM1
Pfam

PF03671--Ufm1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043066--P:negative regulation of apoptotic process
GO:1990592--P:protein K69-linked ufmylation
GO:0071569--P:protein ufmylation
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0034976--P:response to endoplasmic reticulum stress
KEGG hsa:51569
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002340 Ailuropoda melanoleuca 100.00 8.00e-45 171.00
IUUC-Atr-002692 Amborella trichopoda 83.13 8.00e-38 148.00
IUUC-Apl-003216 Anas platyrhynchos 95.24 7.00e-43 164.00
IUUC-Aca-004340 Anolis carolinensis 95.12 1.00e-41 160.00
IUUC-Aly-005396 Arabidopsis lyrata 83.33 6.00e-38 148.00
IUUC-Ath-007254 Arabidopsis thaliana 83.33 6.00e-38 148.00
IUUC-Bdi-014766 Brachypodium distachyon 82.93 3.00e-37 145.00
IUUC-Bol-015854 Brassica oleracea 83.33 9.00e-38 147.00
IUUC-Bra-017056 Brassica rapa 83.33 9.00e-38 147.00
IUUC-Cel-018224 Caenorhabditis elegans 90.24 1.00e-40 156.00
IUUC-Cja-019654 Callithrix jacchus 100.00 8.00e-45 171.00
IUUC-Cfa-020773 Canis familiaris 100.00 9.00e-45 171.00
IUUC-Cre-022911 Chlamydomonas reinhardtii 81.93 5.00e-38 148.00
IUUC-Csa-023159 Chlorocebus sabaeus 100.00 9.00e-45 171.00
IUUC-Cin-025175 Ciona intestinalis 89.16 7.00e-40 154.00
IUUC-Csv-025838 Ciona savignyi 85.54 3.00e-38 149.00
IUUC-Dre-028404 Danio rerio 98.80 1.00e-43 166.00
IUUC-Dno-029917 Dasypus novemcinctus 97.56 9.00e-43 164.00
IUUC-Dme-031742 Drosophila melanogaster 87.95 2.00e-39 153.00
IUUC-Eca-034203 Equus caballus 98.82 5.00e-45 171.00
IUUC-Fca-035910 Felis catus 100.00 9.00e-45 171.00
IUUC-Fal-036934 Ficedula albicollis 94.05 1.00e-42 163.00
IUUC-Gga-040278 Gallus gallus 95.29 1.00e-43 167.00
IUUC-Gma-043236 Glycine max 84.15 7.00e-38 147.00
IUUC-Hvu-047577 Hordeum vulgare 81.93 2.00e-37 146.00
IUUC-Itr-048991 Ictidomys tridecemlineatus 98.81 2.00e-44 169.00
IUUC-Lpe-051293 Leersia perrieri 83.13 2.00e-37 146.00
IUUC-Loc-051783 Lepisosteus oculatus 97.56 2.00e-42 163.00
IUUC-Meu-056072 Macropus eugenii 98.46 4.00e-33 132.00
IUUC-Mtr-058403 Medicago truncatula 83.13 7.00e-38 147.00
IUUC-Mga-059440 Meleagris gallopavo 97.78 3.00e-21 92.80
IUUC-Mmr-061477 Microcebus murinus 87.50 2.00e-36 143.00
IUUC-Mdo-062878 Monodelphis domestica 98.81 4.00e-44 168.00
IUUC-Mmu-063120 Mus musculus 100.00 1.00e-45 173.00
IUUC-Mac-065340 Musa acuminata 84.15 6.00e-38 148.00
IUUC-Mpu-066256 Mustela putorius furo 100.00 1.00e-45 173.00
IUUC-Mlu-067449 Myotis lucifugus 100.00 1.00e-45 173.00
IUUC-Nle-069109 Nomascus leucogenys 100.00 9.00e-45 171.00
IUUC-Opr-070387 Ochotona princeps 78.12 5.00e-23 98.60
IUUC-Ocu-074677 Oryctolagus cuniculus 100.00 2.00e-44 169.00
IUUC-Oba-075987 Oryza barthii 83.13 2.00e-37 146.00
IUUC-Obr-076359 Oryza brachyantha 83.13 2.00e-37 146.00
IUUC-Ogl-077776 Oryza glaberrima 83.13 2.00e-37 146.00
IUUC-Ogu-078176 Oryza glumaepatula 83.13 2.00e-37 146.00
IUUC-Oin-079729 Oryza indica 83.13 2.00e-37 146.00
IUUC-Ome-082009 Oryza meridionalis 83.13 2.00e-37 146.00
IUUC-Oni-082503 Oryza nivara 83.13 2.00e-37 146.00
IUUC-Opu-084099 Oryza punctata 83.13 2.00e-37 147.00
IUUC-Oru-084912 Oryza rufipogon 83.13 2.00e-37 146.00
IUUC-Osa-085481 Oryza sativa 83.13 2.00e-37 146.00
IUUC-Ola-086978 Oryzias latipes 96.34 2.00e-42 163.00
IUUC-Oga-088728 Otolemur garnettii 100.00 1.00e-33 133.00
IUUC-Ptr-091085 Pan troglodytes 100.00 9.00e-45 171.00
IUUC-Pan-092802 Papio anubis 100.00 9.00e-45 171.00
IUUC-Psi-093487 Pelodiscus sinensis 97.62 2.00e-43 167.00
IUUC-Ppa-095524 Physcomitrella patens 85.19 1.00e-37 147.00
IUUC-Pfo-097061 Poecilia formosa 97.59 2.00e-43 166.00
IUUC-Pab-098717 Pongo abelii 97.65 8.00e-43 164.00
IUUC-Ppe-101618 Prunus persica 82.93 2.00e-37 146.00
IUUC-Rno-104980 Rattus norvegicus 98.82 3.00e-45 172.00
IUUC-Smo-109095 Selaginella moellendorffii 82.72 2.00e-37 147.00
IUUC-Sit-110509 Setaria italica 83.13 3.00e-37 146.00
IUUC-Sly-110926 Solanum lycopersicum 84.15 5.00e-38 148.00
IUUC-Stu-112759 Solanum tuberosum 84.15 7.00e-38 148.00
IUUC-Sbi-114543 Sorghum bicolor 81.93 3.00e-37 145.00
IUUC-Ssc-116296 Sus scrofa 100.00 1.00e-33 133.00
IUUC-Tgu-117443 Taeniopygia guttata 95.18 2.00e-42 163.00
IUUC-Tru-117917 Takifugu rubripes 95.29 5.00e-42 161.00
IUUC-Tca-121412 Theobroma cacao 84.15 7.00e-38 147.00
IUUC-Tre-122096 Trichoderma reesei 41.67 7.90e+00 24.60
IUUC-Tae-123384 Triticum aestivum 82.93 2.00e-37 146.00
IUUC-Vpa-130061 Vicugna pacos 100.00 1.00e-33 133.00
IUUC-Vvi-131618 Vitis vinifera 84.15 5.00e-38 148.00
IUUC-Xtr-132556 Xenopus tropicalis 94.05 5.00e-43 164.00
IUUC-Xma-133325 Xiphophorus maculatus 96.34 4.00e-42 162.00
Created Date 25-Jun-2017

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