iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	23661552

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	7.60e-19	69.5	63	138
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	3.10e-10	39.2	170	201

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvv.......g.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv+++v       g g+ f++ + vLaa++++F+++f++++ es+ +  v+++dv++e+f++l++++Ytg+++++e
   Q: 63   CDVTIEVvtpgsgpGtGRLFSCNRNVLAAACPYFKSMFTGGMYESQ-QASVTMHDVDAESFEVLVDYCYTGRVSLSE 138
           8999999999998867*****************************9.**************************9876 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           l Nc++il fAd++d ++L+++a+++i ++Fk
   Q: 170  LTNCTAILKFADAFDHHKLRSQAQSYIAHNFK 201
           58*****************************7 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MQSREDVPRS RRLASPRGGR RPKRISKPSV SAFFTGPEEL KDTAHSAALL AQLKSFYDAR 60
LLCDVTIEVV TPGSGPGTGR LFSCNRNVLA AACPYFKSMF TGGMYESQQA SVTMHDVDAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTCTCCCG GGCGCCTAGC GGGATCGCCA GCGCGGCAGT GGGGGCTTCC GCGGCTGCAA 60
GCCAGCGGGT CCTGTGAGGG CGAGCGGAGG CGGAGAAAGG GCGCGGGAGT GAGAGAGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0000165--P:MAPK cascade
GO:0016567--P:protein ubiquitination

KEGG

hsa:84078

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002412	Ailuropoda melanoleuca	95.58	0.00e+00	1253.00
IUUC-Ame-010652	Astyanax mexicanus	50.00	0.00e+00	657.00
IUUC-Bta-013332	Bos taurus	95.47	0.00e+00	1244.00
IUUC-Cja-019774	Callithrix jacchus	97.51	0.00e+00	1276.00
IUUC-Cfa-021128	Canis familiaris	94.01	0.00e+00	1233.00
IUUC-Cpo-021647	Cavia porcellus	92.11	0.00e+00	1264.00
IUUC-Csa-024241	Chlorocebus sabaeus	98.10	0.00e+00	1268.00
IUUC-Dre-028122	Danio rerio	50.16	0.00e+00	635.00
IUUC-Dno-029373	Dasypus novemcinctus	93.86	0.00e+00	1237.00
IUUC-Dor-030153	Dipodomys ordii	83.49	0.00e+00	845.00
IUUC-Eca-034128	Equus caballus	95.91	0.00e+00	1274.00
IUUC-Fca-036082	Felis catus	95.32	0.00e+00	1253.00
IUUC-Gmo-039541	Gadus morhua	46.94	1.00e-168	587.00
IUUC-Gac-042257	Gasterosteus aculeatus	48.23	3.00e-170	592.00
IUUC-Ggo-045173	Gorilla gorilla	98.54	0.00e+00	1306.00
IUUC-Itr-048955	Ictidomys tridecemlineatus	95.91	0.00e+00	1262.00
IUUC-Lch-050676	Latimeria chalumnae	62.03	0.00e+00	821.00
IUUC-Loc-052358	Lepisosteus oculatus	55.92	0.00e+00	759.00
IUUC-Laf-054091	Loxodonta africana	95.74	0.00e+00	1269.00
IUUC-Mcc-055345	Macaca mulatta	98.54	0.00e+00	1278.00
IUUC-Meu-056183	Macropus eugenii	76.82	0.00e+00	794.00
IUUC-Mmr-061693	Microcebus murinus	97.37	0.00e+00	1278.00
IUUC-Mdo-062879	Monodelphis domestica	76.05	0.00e+00	984.00
IUUC-Mmu-063250	Mus musculus	93.62	0.00e+00	1233.00
IUUC-Mlu-068069	Myotis lucifugus	93.27	0.00e+00	1244.00
IUUC-Nle-070164	Nomascus leucogenys	99.42	0.00e+00	1283.00
IUUC-Ont-071957	Oreochromis niloticus	46.42	2.00e-164	572.00
IUUC-Oan-073515	Ornithorhynchus anatinus	68.75	0.00e+00	878.00
IUUC-Ocu-074774	Oryctolagus cuniculus	85.90	0.00e+00	1134.00
IUUC-Ola-086695	Oryzias latipes	46.78	1.00e-157	550.00
IUUC-Oga-088566	Otolemur garnettii	95.20	0.00e+00	1253.00
IUUC-Oar-090137	Ovis aries	95.61	0.00e+00	1256.00
IUUC-Ptr-090662	Pan troglodytes	100.00	0.00e+00	1290.00
IUUC-Pan-092452	Papio anubis	97.95	0.00e+00	1298.00
IUUC-Pfo-097430	Poecilia formosa	46.03	2.00e-165	575.00
IUUC-Pab-097925	Pongo abelii	99.71	0.00e+00	1286.00
IUUC-Pca-100592	Procavia capensis	89.47	0.00e+00	1170.00
IUUC-Pyt-104491	Pyrenophora triticirepentis	32.08	1.00e-05	43.90
IUUC-Rno-106015	Rattus norvegicus	80.12	0.00e+00	737.00
IUUC-Sha-107610	Sarcophilus harrisii	69.34	0.00e+00	938.00
IUUC-Ssc-115906	Sus scrofa	95.17	0.00e+00	1223.00
IUUC-Tru-118563	Takifugu rubripes	45.93	2.00e-153	535.00
IUUC-Tni-120867	Tetraodon nigroviridis	45.11	1.00e-132	466.00
IUUC-Tbe-127591	Tupaia belangeri	91.23	0.00e+00	1140.00
IUUC-Ttr-128977	Tursiops truncatus	96.20	0.00e+00	1275.00
IUUC-Vpa-130491	Vicugna pacos	95.91	0.00e+00	1268.00
IUUC-Xtr-132498	Xenopus tropicalis	65.71	0.00e+00	863.00
IUUC-Xma-133681	Xiphophorus maculatus	47.10	2.00e-169	589.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence