iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000021668.14	ENSMUST00000022172.10	ENSMUSP00000022172.4
ENSMUSG00000021668.14	ENSMUST00000091387.3	ENSMUSP00000088950.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/UBZ	UBZ	18162470

Classification

Family	E-value	Score	Start	End
UBD/ZnF/UBZ	1.60e-16	61.2	620	645

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/UBZ

   S: 2    lvCPvC...qkmvdqtdfeeHlDeCl 24
           + CPvC   q+ v++++f+eH+DeCl
   Q: 620  FICPVCfreQEGVSLEAFNEHVDECL 645
           68*****98888*************8 PP

Organism

Mus musculus

Functional Description
(View)

DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity).

Protein Sequence
(Fasta)

MDNTKEKDNF KDDLLLRMGL NDNKAGMEGL DKEKINKIIM EATKGSRFYG NELKKEKQVN 60
QRIENMMQQK AQITSQQLRK AQLQVDKFAM ELERNRNLNN TIVHVDMDAF YAAVEMRDNP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTCCTGGG CGCGCCTAAA GGCTGGTTGC CTAGGGGAAC CTTCTGAAGG CAAGTGGGCT 60
TCTTTTGAGA GTTGCGTGCC CCTTTCCGTC CAGCCTGGCT TCCGATTCTG CCTTGCGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0235--DNA replication
KW-0237--DNA synthesis
KW-0238--DNA-binding
KW-0239--DNA-directed DNA polymerase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0515--Mutator protein
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0704--Schiff base
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR017061--DNA_pol_eta/kappa
IPR017961--DNA_pol_Y-fam_little_finger
IPR022880--DNApol_IV
IPR001126--UmuC
IPR006642--Znf_Rad18_put

PROSITE

PS50173--UMUC

Pfam

PF00817--IMS
PF11799--IMS_C

SMART

SM00734--ZnF_Rad18

Gene Ontology

GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003684--F:damaged DNA binding
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0046872--F:metal ion binding
GO:0006281--P:DNA repair
GO:0006260--P:DNA replication
GO:0006297--P:nucleotide-excision repair, DNA gap filling

KEGG

mmu:27015

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001908	Ailuropoda melanoleuca	74.77	0.00e+00	1288.00
IUUC-Apl-003228	Anas platyrhynchos	53.93	0.00e+00	813.00
IUUC-Aca-005080	Anolis carolinensis	58.49	0.00e+00	870.00
IUUC-Afl-008688	Aspergillus flavus	31.49	2.00e-38	153.00
IUUC-Afu-008792	Aspergillus fumigatus	32.89	2.00e-51	196.00
IUUC-Aor-010225	Aspergillus oryzae	45.23	7.00e-44	172.00
IUUC-Ame-011889	Astyanax mexicanus	52.66	0.00e+00	740.00
IUUC-Bta-013127	Bos taurus	74.91	0.00e+00	1305.00
IUUC-Bra-017144	Brassica rapa	53.40	1.00e-58	221.00
IUUC-Cel-018629	Caenorhabditis elegans	41.62	2.00e-99	356.00
IUUC-Cja-019598	Callithrix jacchus	75.37	0.00e+00	1262.00
IUUC-Cfa-020661	Canis familiaris	73.68	0.00e+00	1267.00
IUUC-Cpo-022040	Cavia porcellus	70.23	0.00e+00	1156.00
IUUC-Csa-023669	Chlorocebus sabaeus	75.83	0.00e+00	1283.00
IUUC-Cho-024910	Choloepus hoffmanni	56.91	4.00e-169	588.00
IUUC-Csv-026293	Ciona savignyi	52.02	4.00e-138	484.00
IUUC-Dre-028317	Danio rerio	49.50	0.00e+00	741.00
IUUC-Dno-029973	Dasypus novemcinctus	73.88	0.00e+00	1255.00
IUUC-Dor-030667	Dipodomys ordii	76.07	0.00e+00	1315.00
IUUC-Dse-031339	Dothistroma septosporum	46.80	2.00e-49	190.00
IUUC-Ete-033030	Echinops telfairi	71.13	0.00e+00	1197.00
IUUC-Eca-033959	Equus caballus	76.12	0.00e+00	1303.00
IUUC-Fca-036160	Felis catus	72.18	0.00e+00	1239.00
IUUC-Fal-037116	Ficedula albicollis	56.71	0.00e+00	835.00
IUUC-Gmo-039003	Gadus morhua	51.81	0.00e+00	741.00
IUUC-Gga-040431	Gallus gallus	55.86	0.00e+00	849.00
IUUC-Gac-042455	Gasterosteus aculeatus	52.74	0.00e+00	750.00
IUUC-Gma-043303	Glycine max	53.26	3.00e-56	213.00
IUUC-Ggo-045024	Gorilla gorilla	74.94	0.00e+00	1296.00
IUUC-Hsa-046294	Homo sapiens	75.57	0.00e+00	1313.00
IUUC-Itr-048670	Ictidomys tridecemlineatus	74.79	0.00e+00	1243.00
IUUC-Lch-050251	Latimeria chalumnae	51.74	0.00e+00	804.00
IUUC-Loc-051939	Lepisosteus oculatus	52.14	0.00e+00	748.00
IUUC-Laf-054562	Loxodonta africana	69.94	0.00e+00	1168.00
IUUC-Mcc-055653	Macaca mulatta	75.57	0.00e+00	1318.00
IUUC-Meu-055994	Macropus eugenii	74.79	1.00e-143	503.00
IUUC-Mga-059228	Meleagris gallopavo	45.24	1.00e-179	623.00
IUUC-Mvi-060383	Microbotryum violaceum	36.63	8.00e-38	152.00
IUUC-Mmr-061202	Microcebus murinus	75.55	0.00e+00	1319.00
IUUC-Mdo-062829	Monodelphis domestica	62.57	0.00e+00	989.00
IUUC-Mpu-066825	Mustela putorius furo	74.60	0.00e+00	1272.00
IUUC-Mlu-067316	Myotis lucifugus	75.55	0.00e+00	1295.00
IUUC-Nle-069272	Nomascus leucogenys	75.89	0.00e+00	1312.00
IUUC-Opr-070616	Ochotona princeps	68.41	0.00e+00	1142.00
IUUC-Ont-072011	Oreochromis niloticus	55.01	0.00e+00	699.00
IUUC-Oan-073343	Ornithorhynchus anatinus	61.89	0.00e+00	998.00
IUUC-Ocu-073766	Oryctolagus cuniculus	67.13	0.00e+00	1029.00
IUUC-Ogl-077190	Oryza glaberrima	49.59	4.00e-50	192.00
IUUC-Ogu-078415	Oryza glumaepatula	41.07	1.00e-89	323.00
IUUC-Osa-085963	Oryza sativa	49.59	4.00e-50	192.00
IUUC-Ola-087034	Oryzias latipes	51.04	0.00e+00	716.00
IUUC-Oga-088157	Otolemur garnettii	72.67	0.00e+00	1265.00
IUUC-Oar-089218	Ovis aries	74.46	0.00e+00	1323.00
IUUC-Ptr-091552	Pan troglodytes	75.69	0.00e+00	1318.00
IUUC-Pan-092646	Papio anubis	74.94	0.00e+00	1300.00
IUUC-Psi-093608	Pelodiscus sinensis	57.45	0.00e+00	893.00
IUUC-Pma-094381	Petromyzon marinus	50.00	0.00e+00	714.00
IUUC-Pno-095081	Phaeosphaeria nodorum	39.47	5.00e-44	171.00
IUUC-Pfo-096545	Poecilia formosa	51.88	0.00e+00	771.00
IUUC-Pab-097613	Pongo abelii	71.01	0.00e+00	1248.00
IUUC-Pca-101071	Procavia capensis	58.94	2.00e-139	489.00
IUUC-Pva-102252	Pteropus vampyrus	75.20	0.00e+00	1291.00
IUUC-Pgr-103567	Puccinia graminis	31.93	4.00e-43	169.00
IUUC-Ptt-103934	Puccinia triticina	31.42	8.00e-27	115.00
IUUC-Rno-105793	Rattus norvegicus	88.29	0.00e+00	1489.00
IUUC-Sha-107230	Sarcophilus harrisii	64.97	0.00e+00	1070.00
IUUC-Spo-108028	Schizosaccharomyces pombe	43.81	8.00e-43	168.00
IUUC-Sly-111390	Solanum lycopersicum	54.74	6.00e-60	225.00
IUUC-Stu-112284	Solanum tuberosum	54.97	1.00e-60	228.00
IUUC-Sar-113594	Sorex araneus	65.94	0.00e+00	1082.00
IUUC-Sre-115078	Sporisorium reilianum	31.73	1.00e-42	167.00
IUUC-Ssc-116013	Sus scrofa	73.01	0.00e+00	1293.00
IUUC-Tgu-117442	Taeniopygia guttata	54.77	0.00e+00	829.00
IUUC-Tru-117935	Takifugu rubripes	56.47	0.00e+00	672.00
IUUC-Tsy-119489	Tarsius syrichta	59.41	5.00e-175	608.00
IUUC-Tni-120543	Tetraodon nigroviridis	56.62	0.00e+00	644.00
IUUC-Tbe-128112	Tupaia belangeri	77.07	0.00e+00	813.00
IUUC-Ttr-128371	Tursiops truncatus	68.89	0.00e+00	1170.00
IUUC-Uma-129377	Ustilago maydis	32.40	4.00e-46	179.00
IUUC-Vpa-130243	Vicugna pacos	75.46	0.00e+00	1318.00
IUUC-Xtr-132453	Xenopus tropicalis	54.07	0.00e+00	816.00
IUUC-Xma-133255	Xiphophorus maculatus	51.75	0.00e+00	763.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence