iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020675

Ensembl Protein ID

ENSCAFP00000018474.4

UniProt Accession

F1PU93; F1PU93_CANLF

Genbank Protein ID

ENSCAFP00000018474

Protein Name

Coatomer subunit alpha

Genbank Nucleotide ID

AAEX03018465

Gene Name

COPA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000012544.4	ENSCAFT00000019919.4	ENSCAFP00000018474.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.00e-33	113.3	40	70
UBD/Beta-Prp	9.70e-72	241.9	3	314

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDl 30
           H ++v++++f  + +l+vsG+dD +ikvW++
   Q: 40   HDGPVRGIDFhkQQPLFVSGGDDYKIKVWNY 70
           99********97449**************96 PP

UBD/Beta-Prp

   S: 14   tcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsf 102
           + + f+p++++++++  +g i++w +   +l+ ++ +h+++v+ ++f+++++++v+g++D+ ikvw+++ + c+ tl gh d+++++ f
   Q: 3    KRLSFHPKRPWILSSLHNGVIQLWTTGWCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFF 91
           6688************************************************************************************* PP
   S: 103  spsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl......................... 166
           + +  +++s+s+d+tirvw++++++c+  +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+                         
   Q: 92   HHEYPWILSASDDQTIRVWNWQSRTCVC-VLTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDIsglrkknlspgavesdvrgitgvdl 179
           ****************************.************************************************************ PP
   S: 167  ..ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDgsiriWdl 251
              t+ ++++  +gh++ v++ +f+++++ +vsg++d++vk+w + +++   v+t++gh +nv++  f+p++e+++s s+D+sir+Wd+
   Q: 180  fgTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAweVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDM 268
           **888888888777********************************888888************************************* PP
   S: 252  rsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
            +++ ++t+ + +++++  a+ +++ n +++g  d+   ++kl++++p
   Q: 269  SKRTGVQTFRRDHDRFWVLAA-HPNLNLFAAG-HDGGMIVFKLERERP 314
           *********************.5554444444.589999999988765 PP

Organism

Canis familiaris

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MLKRLSFHPK RPWILSSLHN GVIQLWTTGW CTLIDKFDEH DGPVRGIDFH KQQPLFVSGG 60
DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF FHHEYPWILS ASDDQTIRVW NWQSRTCVCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCAAGAGCG CGCGGGTCAA AGGTAGTGGC GCGGGCCCGG GGGCGCAGCG GGCGCGGGGG 60
GTGGGCCGCG GCGCTGTGGC GGGGGGCGAG AGAGGCCGAG CGGGGCCCGG GGCCCGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0030157--P:pancreatic juice secretion
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	53.02	0.00e+00	1287.00
IUUC-Aml-001758	Ailuropoda melanoleuca	98.28	0.00e+00	2459.00
IUUC-Atr-002493	Amborella trichopoda	53.33	0.00e+00	1281.00
IUUC-Apl-003385	Anas platyrhynchos	95.95	0.00e+00	2062.00
IUUC-Aca-005154	Anolis carolinensis	93.37	1.00e-109	388.00
IUUC-Aly-006020	Arabidopsis lyrata	60.60	0.00e+00	1061.00
IUUC-Ath-007058	Arabidopsis thaliana	60.87	0.00e+00	1056.00
IUUC-Ago-007992	Ashbya gossypii	44.34	0.00e+00	1003.00
IUUC-Acl-008027	Aspergillus clavatus	56.34	0.00e+00	971.00
IUUC-Afl-008644	Aspergillus flavus	48.61	0.00e+00	1155.00
IUUC-Afu-008964	Aspergillus fumigatus	48.69	0.00e+00	1160.00
IUUC-Ani-009379	Aspergillus nidulans	55.73	0.00e+00	978.00
IUUC-Ang-009756	Aspergillus niger	49.26	0.00e+00	1179.00
IUUC-Aor-010174	Aspergillus oryzae	56.48	0.00e+00	969.00
IUUC-Ate-010302	Aspergillus terreus	48.98	0.00e+00	1192.00
IUUC-Ame-011229	Astyanax mexicanus	85.82	0.00e+00	2154.00
IUUC-Bgr-012300	Blumeria graminis	48.35	0.00e+00	1133.00
IUUC-Bta-012524	Bos taurus	98.76	0.00e+00	2442.00
IUUC-Bci-013781	Botrytis cinerea	48.12	0.00e+00	1164.00
IUUC-Bdi-014549	Brachypodium distachyon	53.71	0.00e+00	1311.00
IUUC-Bol-015925	Brassica oleracea	60.51	0.00e+00	1048.00
IUUC-Bra-016978	Brassica rapa	59.81	0.00e+00	1043.00
IUUC-Cel-018115	Caenorhabditis elegans	63.30	0.00e+00	1092.00
IUUC-Cja-019107	Callithrix jacchus	95.17	0.00e+00	2380.00
IUUC-Cpo-021813	Cavia porcellus	98.19	0.00e+00	2451.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	63.49	0.00e+00	1077.00
IUUC-Csa-023523	Chlorocebus sabaeus	98.43	0.00e+00	2470.00
IUUC-Cho-024704	Choloepus hoffmanni	84.10	0.00e+00	1886.00
IUUC-Cin-025572	Ciona intestinalis	72.20	0.00e+00	1843.00
IUUC-Csv-025864	Ciona savignyi	74.36	0.00e+00	1259.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	56.49	0.00e+00	989.00
IUUC-Cne-027053	Cryptococcus neoformans	51.63	0.00e+00	1222.00
IUUC-Cme-027222	Cyanidioschyzon merolae	32.34	7.00e-164	572.00
IUUC-Dre-027421	Danio rerio	85.91	0.00e+00	2196.00
IUUC-Dno-029303	Dasypus novemcinctus	98.19	0.00e+00	2450.00
IUUC-Dor-030290	Dipodomys ordii	97.52	0.00e+00	1115.00
IUUC-Dse-031543	Dothistroma septosporum	45.85	0.00e+00	1090.00
IUUC-Dme-031945	Drosophila melanogaster	75.36	0.00e+00	1262.00
IUUC-Ete-032873	Echinops telfairi	91.92	0.00e+00	2107.00
IUUC-Eca-033773	Equus caballus	96.30	0.00e+00	2385.00
IUUC-Eeu-034874	Erinaceus europaeus	85.24	0.00e+00	1498.00
IUUC-Fca-035739	Felis catus	97.55	0.00e+00	2376.00
IUUC-Fal-037263	Ficedula albicollis	87.58	0.00e+00	2116.00
IUUC-Fox-037738	Fusarium oxysporum	47.82	0.00e+00	1182.00
IUUC-Fso-038153	Fusarium solani	48.33	0.00e+00	1171.00
IUUC-Gmo-039602	Gadus morhua	81.58	0.00e+00	2014.00
IUUC-Ggr-039931	Gaeumannomyces graminis	55.57	0.00e+00	981.00
IUUC-Gga-040590	Gallus gallus	96.21	0.00e+00	2384.00
IUUC-Gac-041318	Gasterosteus aculeatus	85.59	0.00e+00	2172.00
IUUC-Gma-043567	Glycine max	54.08	0.00e+00	1302.00
IUUC-Ggo-045029	Gorilla gorilla	97.55	0.00e+00	2457.00
IUUC-Hsa-046078	Homo sapiens	97.55	0.00e+00	2457.00
IUUC-Hvu-047556	Hordeum vulgare	54.45	0.00e+00	1324.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	97.38	0.00e+00	1732.00
IUUC-Kpa-049256	Komagataella pastoris	44.33	0.00e+00	1052.00
IUUC-Lch-049706	Latimeria chalumnae	92.42	0.00e+00	2278.00
IUUC-Lpe-051316	Leersia perrieri	61.77	0.00e+00	1075.00
IUUC-Loc-051867	Lepisosteus oculatus	70.85	0.00e+00	1179.00
IUUC-Lma-053138	Leptosphaeria maculans	56.05	0.00e+00	996.00
IUUC-Laf-053510	Loxodonta africana	97.44	0.00e+00	2440.00
IUUC-Mcc-055836	Macaca mulatta	97.22	0.00e+00	2440.00
IUUC-Meu-056238	Macropus eugenii	92.37	0.00e+00	1169.00
IUUC-Mor-057172	Magnaporthe oryzae	48.21	0.00e+00	1165.00
IUUC-Mpo-057300	Magnaporthe poae	47.74	0.00e+00	1149.00
IUUC-Mtr-058248	Medicago truncatula	54.46	0.00e+00	1330.00
IUUC-Mla-059019	Melampsora laricipopulina	51.87	0.00e+00	1263.00
IUUC-Mga-059499	Meleagris gallopavo	96.05	0.00e+00	2377.00
IUUC-Mvi-060336	Microbotryum violaceum	52.45	0.00e+00	1247.00
IUUC-Mmr-061102	Microcebus murinus	97.71	0.00e+00	2413.00
IUUC-Mdo-062594	Monodelphis domestica	97.11	0.00e+00	2473.00
IUUC-Mmu-063736	Mus musculus	96.97	0.00e+00	2435.00
IUUC-Mac-065398	Musa acuminata	51.35	0.00e+00	1207.00
IUUC-Mpu-066701	Mustela putorius furo	98.36	0.00e+00	2412.00
IUUC-Mlu-067392	Myotis lucifugus	96.87	0.00e+00	2414.00
IUUC-Nfi-068270	Neosartorya fischeri	56.71	0.00e+00	974.00
IUUC-Ncr-068892	Neurospora crassa	48.54	0.00e+00	1152.00
IUUC-Nle-069634	Nomascus leucogenys	98.15	0.00e+00	1335.00
IUUC-Opr-070952	Ochotona princeps	85.85	0.00e+00	1795.00
IUUC-Ont-072488	Oreochromis niloticus	87.55	0.00e+00	2183.00
IUUC-Ocu-074211	Oryctolagus cuniculus	98.35	0.00e+00	2456.00
IUUC-Oba-075761	Oryza barthii	61.65	0.00e+00	1073.00
IUUC-Obr-076429	Oryza brachyantha	61.65	0.00e+00	1073.00
IUUC-Ogl-077364	Oryza glaberrima	61.65	0.00e+00	1075.00
IUUC-Ogu-078257	Oryza glumaepatula	61.91	0.00e+00	1074.00
IUUC-Oin-080029	Oryza indica	61.67	0.00e+00	1067.00
IUUC-Olo-080466	Oryza longistaminata	61.55	0.00e+00	1060.00
IUUC-Ome-081668	Oryza meridionalis	62.41	0.00e+00	932.00
IUUC-Oni-082874	Oryza nivara	61.91	0.00e+00	1074.00
IUUC-Opu-083697	Oryza punctata	53.14	0.00e+00	1298.00
IUUC-Oru-084274	Oryza rufipogon	61.65	0.00e+00	1074.00
IUUC-Osa-085565	Oryza sativa	61.65	0.00e+00	1074.00
IUUC-Ola-086921	Oryzias latipes	86.27	0.00e+00	2162.00
IUUC-Olu-087639	Ostreococcus lucimarinus	55.57	0.00e+00	1332.00
IUUC-Oga-087991	Otolemur garnettii	92.93	0.00e+00	2310.00
IUUC-Oar-089590	Ovis aries	98.85	0.00e+00	2466.00
IUUC-Ptr-090808	Pan troglodytes	97.63	0.00e+00	2459.00
IUUC-Pan-092475	Papio anubis	98.18	0.00e+00	2460.00
IUUC-Psi-093044	Pelodiscus sinensis	79.57	0.00e+00	1679.00
IUUC-Pno-094839	Phaeosphaeria nodorum	48.17	0.00e+00	1116.00
IUUC-Ppa-095254	Physcomitrella patens	56.04	0.00e+00	1370.00
IUUC-Pfo-097493	Poecilia formosa	87.14	0.00e+00	2158.00
IUUC-Pab-098497	Pongo abelii	98.43	0.00e+00	2471.00
IUUC-Pop-099992	Populus trichocarpa	55.71	0.00e+00	1310.00
IUUC-Pca-100413	Procavia capensis	88.57	0.00e+00	996.00
IUUC-Ppe-101899	Prunus persica	53.81	0.00e+00	1296.00
IUUC-Pva-102126	Pteropus vampyrus	94.03	0.00e+00	2335.00
IUUC-Pgr-103376	Puccinia graminis	52.42	0.00e+00	1279.00
IUUC-Ptt-103978	Puccinia triticina	48.09	0.00e+00	1083.00
IUUC-Pte-104126	Pyrenophora teres	56.46	0.00e+00	971.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	47.08	1.00e-179	624.00
IUUC-Rno-105428	Rattus norvegicus	97.77	0.00e+00	2446.00
IUUC-Sce-106464	Saccharomyces cerevisiae	42.89	0.00e+00	982.00
IUUC-Sha-107301	Sarcophilus harrisii	97.36	0.00e+00	2435.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	45.00	0.00e+00	1060.00
IUUC-Spo-108217	Schizosaccharomyces pombe	46.36	0.00e+00	1105.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	48.21	0.00e+00	1169.00
IUUC-Smo-109582	Selaginella moellendorffii	64.81	0.00e+00	1124.00
IUUC-Sit-109697	Setaria italica	61.17	0.00e+00	1066.00
IUUC-Sly-111447	Solanum lycopersicum	54.26	0.00e+00	1330.00
IUUC-Stu-112564	Solanum tuberosum	54.13	0.00e+00	1327.00
IUUC-Sar-113313	Sorex araneus	88.26	0.00e+00	1483.00
IUUC-Sbi-114388	Sorghum bicolor	61.77	0.00e+00	1073.00
IUUC-Sre-115209	Sporisorium reilianum	57.16	0.00e+00	1021.00
IUUC-Ssc-115933	Sus scrofa	98.76	0.00e+00	2464.00
IUUC-Tgu-117109	Taeniopygia guttata	81.71	0.00e+00	748.00
IUUC-Tru-117772	Takifugu rubripes	85.99	0.00e+00	2142.00
IUUC-Tsy-119105	Tarsius syrichta	83.39	0.00e+00	2055.00
IUUC-Tni-120556	Tetraodon nigroviridis	72.15	0.00e+00	1652.00
IUUC-Tca-121046	Theobroma cacao	53.79	0.00e+00	1338.00
IUUC-Tre-121951	Trichoderma reesei	56.32	0.00e+00	985.00
IUUC-Tvi-122359	Trichoderma virens	56.59	0.00e+00	992.00
IUUC-Tae-125527	Triticum aestivum	53.15	0.00e+00	1293.00
IUUC-Tur-126754	Triticum urartu	60.92	0.00e+00	1067.00
IUUC-Tme-127170	Tuber melanosporum	49.88	0.00e+00	1201.00
IUUC-Tbe-127882	Tupaia belangeri	97.71	0.00e+00	845.00
IUUC-Ttr-128217	Tursiops truncatus	95.83	0.00e+00	2382.00
IUUC-Uma-129337	Ustilago maydis	56.46	0.00e+00	1018.00
IUUC-Vda-129828	Verticillium dahliae	47.85	0.00e+00	1151.00
IUUC-Vpa-130537	Vicugna pacos	97.63	0.00e+00	2418.00
IUUC-Vvi-130958	Vitis vinifera	62.14	0.00e+00	1080.00
IUUC-Xtr-132857	Xenopus tropicalis	89.56	0.00e+00	2253.00
IUUC-Xma-133138	Xiphophorus maculatus	87.06	0.00e+00	2159.00
IUUC-Yli-134399	Yarrowia lipolytica	50.12	0.00e+00	837.00
IUUC-Zma-135612	Zea mays	53.71	0.00e+00	1308.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence