iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046849

UUCD1 version

UUC-HoS-00187

Ensembl Protein ID

ENSP00000316291.4

UniProt Accession

Q7Z6E9; Q147T5; Q15290; Q6DKH4; Q6P4C2; Q6YNC9; Q7Z6E8; Q8N0V2; Q96PH3; Q9H3I8; Q9H5M5; Q9NPX4; RBBP6_HUMAN

Genbank Protein ID

BAC77636.1; BAC77637.1; EAW55789.1; AAH29352.1; AAH63524.1; AAH73938.1; AAI01140.1; AAI01141.1; AAI01142.1; AAI01143.1; AAI14354.1; AAI14355.1; AAI18668.1; AAI39831.1; AAG43155.1; AAL68925.1; AAL05625.1; CAA59445.1; BAB15600.1; CAB94869.1

Protein Name

E3 ubiquitin-protein ligase RBBP6; Proliferation potential-related protein; Protein P2P-R; RING-type E3 ubiquitin transferase RBBP6; Retinoblastoma-binding Q protein 1; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis

Genbank Nucleotide ID

AB112074; AB112075; CH471145; BC029352; BC063524; BC073938; BC101139; BC101140; BC101141; BC101142; BC114353; BC114354; BC118667; BC139830; AF063596; AY072922; AF352051; X85133; AK026954; AL359564

Gene Name

RBBP6; P2PR; PACT; RBQ1; My038

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000122257.18	ENST00000319715.8	ENSP00000317872.4
ENSG00000122257.18	ENST00000452655.6	ENSP00000390537.2
ENSG00000122257.18	ENST00000381039.7	ENSP00000370427.3
ENSG00000122257.18	ENST00000348022.6	ENSP00000316291.4
ENSG00000122257.18	ENST00000562683.2	ENSP00000481477.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18851979; 20210701
ULD/UDP/UFD/DWNN	DWNN	16396680

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	2.10e-09	38.9	253	326
E3 activity/RING/RING	0.085	15.1	259	299
ULD/UDP/UFD/DWNN	8.30e-42	143.0	4	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlp.sGitydrssIekwl.asggktcPvtrqpl.teedlvPnltlrrliqawceen 72
           +p+e+lC I +++M+d vv+p +G +y  ++I+  l +s+++tcP+++q   +++ l+ n++lr+ ++++ +e 
   Q: 253  IPDELLCLICKDIMTDAVVIPcCGNSYCDECIRTALlESDEHTCPTCHQNDvSPDALIANKFLRQAVNNFKNET 326
           8********************************998677777*****9975599999*********99998765 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlp.CgHvfhadClqkwpglknssskefrCPlC 45
           C+iC++ + d  +v p Cg  ++ +C+        ++s e +CP+C
   Q: 259  CLICKDIMTD-AVVIPcCGNSYCDECIRTA----LLESDEHTCPTC 299
           ********99.55566589********544....57********** PP

ULD/UDP/UFD/DWNN

   S: 1    vhykfksklnydtitfDGlhisvfDLkreiiqrekLgkaaDfdLqitnaqtkeeykDDafliPkntsvivkriP 74
           vhykf+sklnydt+tfDGlhis++DLk++i++rekL kaaD+dLqitnaqtkeey+DD++liPkn+sviv+riP
   Q: 4    VHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKL-KAADCDLQITNAQTKEEYTDDNALIPKNSSVIVRRIP 76
           8***********************************.************************************9 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).

Protein Sequence
(Fasta)

MSCVHYKFSS KLNYDTVTFD GLHISLCDLK KQIMGREKLK AADCDLQITN AQTKEEYTDD 60
NALIPKNSSV IVRRIPIGGV KSTSKTYVIS RTEPAMATTK AIDDSSASIS LAQLTKTANL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATGCACC ACGCTGATTA AATTAGGCAT TCAGTATATA AAGGGGTCGG CCACAGACGG 60
GCAAAAGGAA CAGATTCACC GCTTCGGAGT GAATTCCATG ACGGCTTGCA ATTTTCTCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0235--DNA replication
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR014891--DWNN_domain
IPR033489--RBBP6
IPR003613--Ubox_domain
IPR025829--Zn_knuckle_CX2CX3GHX4C
IPR001878--Znf_CCHC
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51282--DWNN
PS50158--ZF_CCHC
PS50089--ZF_RING_2

Pfam

PF08783--DWNN
PF04564--U-box
PF13696--zf-CCHC_2

SMART

SM01180--DWNN
SM00184--RING
SM00343--ZnF_C2HC

Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0005815--C:microtubule organizing center
GO:0005730--C:nucleolus
GO:0003723--F:RNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006260--P:DNA replication
GO:0048568--P:embryonic organ development
GO:0001701--P:in utero embryonic development
GO:0006397--P:mRNA processing
GO:0035264--P:multicellular organism growth
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006275--P:regulation of DNA replication
GO:0061053--P:somite development

KEGG

hsa:5930

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000195	Aegilops tauschii	35.71	3.00e-16	80.50
IUUC-Aml-001655	Ailuropoda melanoleuca	88.68	0.00e+00	1210.00
IUUC-Atr-002768	Amborella trichopoda	38.69	1.00e-17	85.50
IUUC-Apl-004100	Anas platyrhynchos	68.53	0.00e+00	887.00
IUUC-Aca-004345	Anolis carolinensis	67.69	1.00e-114	408.00
IUUC-Aly-006036	Arabidopsis lyrata	29.89	1.00e-32	135.00
IUUC-Ath-007648	Arabidopsis thaliana	32.00	2.00e-40	161.00
IUUC-Ago-007949	Ashbya gossypii	30.48	2.00e-34	140.00
IUUC-Acl-008118	Aspergillus clavatus	31.59	9.00e-27	115.00
IUUC-Afl-008408	Aspergillus flavus	32.08	6.00e-16	79.00
IUUC-Afu-008777	Aspergillus fumigatus	31.97	2.00e-35	143.00
IUUC-Ani-009426	Aspergillus nidulans	30.83	4.00e-36	146.00
IUUC-Ang-009735	Aspergillus niger	30.39	8.00e-33	135.00
IUUC-Aor-010213	Aspergillus oryzae	32.47	6.00e-35	142.00
IUUC-Ate-010474	Aspergillus terreus	30.56	2.00e-33	137.00
IUUC-Ame-010679	Astyanax mexicanus	69.62	3.00e-166	580.00
IUUC-Bgr-012229	Blumeria graminis	32.24	5.00e-37	149.00
IUUC-Bta-012672	Bos taurus	90.31	0.00e+00	1353.00
IUUC-Bci-013880	Botrytis cinerea	31.12	2.00e-34	140.00
IUUC-Bdi-014250	Brachypodium distachyon	28.00	7.00e-35	142.00
IUUC-Bol-015602	Brassica oleracea	31.55	8.00e-40	159.00
IUUC-Bra-016670	Brassica rapa	31.28	3.00e-39	157.00
IUUC-Cel-018532	Caenorhabditis elegans	37.17	3.00e-53	204.00
IUUC-Cja-018843	Callithrix jacchus	97.06	0.00e+00	1490.00
IUUC-Cfa-021107	Canis familiaris	91.08	0.00e+00	1330.00
IUUC-Cre-022712	Chlamydomonas reinhardtii	27.62	1.00e-12	67.80
IUUC-Csa-023397	Chlorocebus sabaeus	98.04	0.00e+00	1527.00
IUUC-Cho-024327	Choloepus hoffmanni	97.84	0.00e+00	961.00
IUUC-Cin-025439	Ciona intestinalis	48.44	2.00e-49	189.00
IUUC-Csv-026162	Ciona savignyi	54.98	3.00e-55	208.00
IUUC-Cgl-026629	Colletotrichum gloeosporioides	30.40	1.00e-28	121.00
IUUC-Cne-026921	Cryptococcus neoformans	29.34	2.00e-39	157.00
IUUC-Cme-027244	Cyanidioschyzon merolae	45.05	4.00e-18	87.40
IUUC-Dre-028023	Danio rerio	82.99	2.00e-162	567.00
IUUC-Dno-029430	Dasypus novemcinctus	90.08	0.00e+00	1339.00
IUUC-Dor-030406	Dipodomys ordii	86.15	0.00e+00	1261.00
IUUC-Dse-031312	Dothistroma septosporum	31.21	1.00e-37	151.00
IUUC-Dme-032133	Drosophila melanogaster	43.07	1.00e-73	271.00
IUUC-Ete-032466	Echinops telfairi	84.93	0.00e+00	1221.00
IUUC-Eca-034174	Equus caballus	91.13	0.00e+00	1111.00
IUUC-Eeu-034677	Erinaceus europaeus	95.22	0.00e+00	828.00
IUUC-Fca-035439	Felis catus	91.14	0.00e+00	1294.00
IUUC-Fal-037230	Ficedula albicollis	65.55	0.00e+00	758.00
IUUC-Fox-037976	Fusarium oxysporum	30.50	5.00e-35	142.00
IUUC-Fso-038202	Fusarium solani	29.17	3.00e-35	143.00
IUUC-Gmo-038618	Gadus morhua	70.15	3.00e-77	281.00
IUUC-Ggr-040035	Gaeumannomyces graminis	26.52	6.00e-31	129.00
IUUC-Gga-040908	Gallus gallus	68.55	0.00e+00	769.00
IUUC-Gac-041718	Gasterosteus aculeatus	71.04	5.00e-87	313.00
IUUC-Gma-044229	Glycine max	31.79	1.00e-38	155.00
IUUC-Ggo-044567	Gorilla gorilla	99.02	0.00e+00	1495.00
IUUC-Hvu-047050	Hordeum vulgare	26.05	6.00e-23	102.00
IUUC-Itr-048832	Ictidomys tridecemlineatus	91.21	0.00e+00	1271.00
IUUC-Kpa-049323	Komagataella pastoris	31.01	2.00e-35	143.00
IUUC-Lch-050524	Latimeria chalumnae	67.38	0.00e+00	708.00
IUUC-Lpe-050947	Leersia perrieri	26.46	3.00e-25	110.00
IUUC-Loc-052709	Lepisosteus oculatus	82.49	2.00e-167	584.00
IUUC-Lma-053186	Leptosphaeria maculans	32.83	8.00e-34	138.00
IUUC-Laf-054472	Loxodonta africana	89.20	0.00e+00	1320.00
IUUC-Mcc-055743	Macaca mulatta	97.82	0.00e+00	1522.00
IUUC-Meu-056399	Macropus eugenii	78.23	0.00e+00	744.00
IUUC-Mor-057073	Magnaporthe oryzae	29.55	1.00e-31	131.00
IUUC-Mpo-057378	Magnaporthe poae	26.22	5.00e-31	129.00
IUUC-Mtr-058761	Medicago truncatula	31.64	1.00e-33	138.00
IUUC-Mla-058840	Melampsora laricipopulina	36.73	1.00e-24	108.00
IUUC-Mga-060129	Meleagris gallopavo	67.47	0.00e+00	856.00
IUUC-Mvi-060424	Microbotryum violaceum	33.55	1.00e-24	108.00
IUUC-Mmr-061295	Microcebus murinus	93.22	0.00e+00	1386.00
IUUC-Mdo-062295	Monodelphis domestica	78.48	0.00e+00	1102.00
IUUC-Mmu-064009	Mus musculus	80.53	0.00e+00	1175.00
IUUC-Mac-065479	Musa acuminata	27.50	5.00e-32	133.00
IUUC-Mpu-065875	Mustela putorius furo	90.31	0.00e+00	1313.00
IUUC-Mlu-066941	Myotis lucifugus	88.79	0.00e+00	1241.00
IUUC-Nfi-068518	Neosartorya fischeri	31.30	3.00e-36	146.00
IUUC-Ncr-068886	Neurospora crassa	28.77	2.00e-31	130.00
IUUC-Nle-069717	Nomascus leucogenys	98.61	0.00e+00	1062.00
IUUC-Opr-070280	Ochotona princeps	95.83	0.00e+00	706.00
IUUC-Ont-071462	Oreochromis niloticus	66.67	8.00e-143	502.00
IUUC-Oan-073300	Ornithorhynchus anatinus	75.68	0.00e+00	993.00
IUUC-Ocu-074124	Oryctolagus cuniculus	90.43	0.00e+00	1418.00
IUUC-Oba-075756	Oryza barthii	30.81	5.00e-30	126.00
IUUC-Obr-076809	Oryza brachyantha	25.75	3.00e-17	84.00
IUUC-Ogl-077759	Oryza glaberrima	32.43	6.00e-36	146.00
IUUC-Ogu-078657	Oryza glumaepatula	30.81	1.00e-29	125.00
IUUC-Oin-079481	Oryza indica	32.76	3.00e-31	130.00
IUUC-Olo-081062	Oryza longistaminata	36.31	7.00e-23	102.00
IUUC-Ome-081813	Oryza meridionalis	29.82	2.00e-29	124.00
IUUC-Oni-083007	Oryza nivara	30.81	2.00e-29	124.00
IUUC-Opu-083385	Oryza punctata	29.89	2.00e-29	124.00
IUUC-Oru-084861	Oryza rufipogon	30.81	2.00e-29	124.00
IUUC-Osa-085896	Oryza sativa	32.26	8.00e-36	144.00
IUUC-Ola-086693	Oryzias latipes	63.37	7.00e-129	454.00
IUUC-Olu-087631	Ostreococcus lucimarinus	48.65	1.00e-14	70.50
IUUC-Oga-088262	Otolemur garnettii	94.10	0.00e+00	1378.00
IUUC-Oar-089658	Ovis aries	89.15	0.00e+00	1423.00
IUUC-Ptr-091311	Pan troglodytes	99.35	0.00e+00	1494.00
IUUC-Pan-091925	Papio anubis	98.26	0.00e+00	1532.00
IUUC-Psi-093605	Pelodiscus sinensis	69.96	0.00e+00	872.00
IUUC-Pma-094163	Petromyzon marinus	73.13	4.00e-99	353.00
IUUC-Pno-094790	Phaeosphaeria nodorum	28.27	8.00e-24	105.00
IUUC-Ppa-095943	Physcomitrella patens	30.68	2.00e-45	177.00
IUUC-Pfo-096581	Poecilia formosa	70.12	7.00e-137	482.00
IUUC-Pab-098229	Pongo abelii	98.15	0.00e+00	1485.00
IUUC-Pop-099160	Populus trichocarpa	35.88	4.00e-24	106.00
IUUC-Pca-100875	Procavia capensis	83.57	0.00e+00	868.00
IUUC-Ppe-101658	Prunus persica	36.47	3.00e-17	84.30
IUUC-Pva-102343	Pteropus vampyrus	92.83	0.00e+00	939.00
IUUC-Pgr-103275	Puccinia graminis	36.24	6.00e-18	86.70
IUUC-Ptt-104004	Puccinia triticina	40.00	4.00e-10	60.10
IUUC-Pte-104161	Pyrenophora teres	31.78	1.00e-29	124.00
IUUC-Pyt-104576	Pyrenophora triticirepentis	32.20	4.00e-30	126.00
IUUC-Rno-105264	Rattus norvegicus	78.71	0.00e+00	1111.00
IUUC-Sce-106138	Saccharomyces cerevisiae	30.70	8.00e-38	151.00
IUUC-Sha-107497	Sarcophilus harrisii	77.86	0.00e+00	1120.00
IUUC-Sja-107991	Schizosaccharomyces japonicus	32.83	2.00e-43	170.00
IUUC-Spo-108257	Schizosaccharomyces pombe	34.23	1.00e-46	180.00
IUUC-Ssl-108581	Sclerotinia sclerotiorum	30.03	3.00e-37	150.00
IUUC-Smo-109358	Selaginella moellendorffii	29.49	7.00e-33	134.00
IUUC-Sit-109920	Setaria italica	30.93	4.00e-37	150.00
IUUC-Sly-111616	Solanum lycopersicum	30.31	5.00e-40	160.00
IUUC-Stu-112648	Solanum tuberosum	32.37	4.00e-11	62.80
IUUC-Sar-113120	Sorex araneus	81.82	0.00e+00	1154.00
IUUC-Sbi-113881	Sorghum bicolor	30.21	1.00e-37	152.00
IUUC-Sre-115127	Sporisorium reilianum	31.47	6.00e-49	188.00
IUUC-Ssc-116147	Sus scrofa	89.11	0.00e+00	1325.00
IUUC-Tgu-117215	Taeniopygia guttata	73.75	0.00e+00	639.00
IUUC-Tru-118525	Takifugu rubripes	64.27	2.00e-134	472.00
IUUC-Tsy-119160	Tarsius syrichta	92.35	0.00e+00	1393.00
IUUC-Tni-119816	Tetraodon nigroviridis	68.84	2.00e-83	301.00
IUUC-Tca-121727	Theobroma cacao	30.89	3.00e-31	130.00
IUUC-Tre-122181	Trichoderma reesei	29.54	2.00e-35	144.00
IUUC-Tvi-122316	Trichoderma virens	28.27	3.00e-35	143.00
IUUC-Tae-125227	Triticum aestivum	36.31	3.00e-17	84.30
IUUC-Tur-126827	Triticum urartu	36.31	2.00e-16	81.30
IUUC-Tme-126984	Tuber melanosporum	30.96	4.00e-44	172.00
IUUC-Tbe-127263	Tupaia belangeri	89.90	0.00e+00	1061.00
IUUC-Ttr-128498	Tursiops truncatus	89.14	0.00e+00	1388.00
IUUC-Uma-129457	Ustilago maydis	30.38	1.00e-44	174.00
IUUC-Vda-129986	Verticillium dahliae	29.45	1.00e-35	144.00
IUUC-Vpa-130795	Vicugna pacos	91.64	0.00e+00	770.00
IUUC-Vvi-131146	Vitis vinifera	36.31	8.00e-17	82.80
IUUC-Xtr-132789	Xenopus tropicalis	65.19	0.00e+00	656.00
IUUC-Xma-133011	Xiphophorus maculatus	69.21	5.00e-134	471.00
IUUC-Yli-134516	Yarrowia lipolytica	32.49	2.00e-39	156.00
IUUC-Zma-134699	Zea mays	29.79	5.00e-36	146.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence