iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064009

Ensembl Protein ID

ENSMUSP00000071519.5

UniProt Accession

P97868; P70287; Q3TTR9; Q3TUM7; Q3UMP7; Q4U217; Q7TT06; Q8BNY8; Q8R399; RBBP6_MOUSE

Genbank Protein ID

BAC32441.1; BAC37553.1; BAC38179.1; BAE26051.1; BAE35944.1; BAE36255.1; AAH25874.1; AAC72432.1; AAB49620.1

Protein Name

E3 ubiquitin-protein ligase RBBP6; Proliferation potential-related protein; Protein P2P-R; RING-type E3 ubiquitin transferase RBBP6; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis

Genbank Nucleotide ID

AK045635; AK079129; AK081261; AK144758; AK160656; AK161231; AC125221; U83913; U28789

Gene Name

Rbbp6; P2pr; Pact

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000030779.15	ENSMUST00000052135.13	ENSMUSP00000049528.7
ENSMUSG00000030779.15	ENSMUST00000098062.8	ENSMUSP00000095670.2
ENSMUSG00000030779.15	ENSMUST00000071590.5	ENSMUSP00000071519.5
ENSMUSG00000030779.15	ENSMUST00000205495.1	ENSMUSP00000145759.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/DWNN	DWNN	16396680

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.60e-09	38.8	254	327
E3 activity/RING/RING	0.057	15.1	260	300

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlp.sGitydrssIekwl.asggktcPvtrqpl.teedlvPnltlrrliqawceen 72
           +p+e+lC I +++M+d vv+p +G +y  ++I+  l +s+++tcP+++q   +++ l+ n++lr+ ++++ +e 
   Q: 254  IPDELLCLICKDIMTDAVVIPcCGNSYCDECIRTALlESDEHTCPTCHQNDvSPDALIANKFLRQAVNNFKNET 327
           8********************************998677777*****9975599999*********99998765 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlp.CgHvfhadClqkwpglknssskefrCPlC 45
           C+iC++ + d  +v p Cg  ++ +C+        ++s e +CP+C
   Q: 260  CLICKDIMTD-AVVIPcCGNSYCDECIRTA----LLESDEHTCPTC 300
           ********99.55566589********544....57********** PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation (PubMed:17470788). Regulates DNA-replication and common fragile sites (CFS) stability in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).

Protein Sequence
(Fasta)

MSCVHYKFSS KLNYDTVTFD GLHISLCDLK KQIMGREKLK AADSDLQITN AQTKEEYTDD 60
NALIPKNSSV IVRRIPIGGV KSTSKTYVIS RTEPVMGTTK AIDDASASIS LAQLTKTANL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGCTTACT TCTTTGGGAT TCCAGCTTTT ACTGAAGACC AGCTGAGACA TTGAGCCTCA 60
TGGACTGAGC AACGTTGGAT TCTTGAACTT TCCATTCATA GTCAGACATG ACTGGATTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0227--DNA damage
KW-0235--DNA replication
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR014891--DWNN_domain
IPR033489--RBBP6
IPR003613--Ubox_domain
IPR025829--Zn_knuckle_CX2CX3GHX4C
IPR001878--Znf_CCHC
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51282--DWNN
PS50158--ZF_CCHC
PS50089--ZF_RING_2

Pfam

PF08783--DWNN
PF04564--U-box
PF13696--zf-CCHC_2

SMART

SM01180--DWNN
SM00184--RING
SM00343--ZnF_C2HC

Gene Ontology

GO:0005694--C:chromosome
GO:0005737--C:cytoplasm
GO:0005815--C:microtubule organizing center
GO:0005730--C:nucleolus
GO:0003723--F:RNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006260--P:DNA replication
GO:0048568--P:embryonic organ development
GO:0001701--P:in utero embryonic development
GO:0006397--P:mRNA processing
GO:0035264--P:multicellular organism growth
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006275--P:regulation of DNA replication
GO:0061053--P:somite development

KEGG

mmu:19647

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000195	Aegilops tauschii	35.71	4.00e-16	80.50
IUUC-Aml-001655	Ailuropoda melanoleuca	79.54	0.00e+00	1061.00
IUUC-Atr-002768	Amborella trichopoda	38.69	9.00e-18	85.50
IUUC-Apl-004100	Anas platyrhynchos	65.36	0.00e+00	834.00
IUUC-Aca-004345	Anolis carolinensis	66.67	2.00e-113	403.00
IUUC-Aly-006036	Arabidopsis lyrata	30.54	2.00e-34	141.00
IUUC-Ath-006684	Arabidopsis thaliana	31.13	2.00e-34	141.00
IUUC-Ago-007949	Ashbya gossypii	29.13	6.00e-35	141.00
IUUC-Acl-008118	Aspergillus clavatus	31.01	2.00e-26	114.00
IUUC-Afl-008408	Aspergillus flavus	32.08	6.00e-16	79.00
IUUC-Afu-008777	Aspergillus fumigatus	31.88	1.00e-34	141.00
IUUC-Ani-009426	Aspergillus nidulans	30.83	3.00e-35	143.00
IUUC-Ang-009735	Aspergillus niger	30.08	3.00e-32	133.00
IUUC-Aor-010213	Aspergillus oryzae	31.53	4.00e-34	139.00
IUUC-Ate-010474	Aspergillus terreus	30.64	1.00e-31	131.00
IUUC-Ame-010679	Astyanax mexicanus	82.69	1.00e-164	575.00
IUUC-Bgr-012229	Blumeria graminis	32.84	5.00e-38	152.00
IUUC-Bta-012672	Bos taurus	80.48	0.00e+00	1161.00
IUUC-Bci-013880	Botrytis cinerea	31.41	9.00e-35	141.00
IUUC-Bdi-014250	Brachypodium distachyon	28.00	2.00e-35	144.00
IUUC-Bol-015602	Brassica oleracea	31.28	3.00e-39	157.00
IUUC-Bra-016670	Brassica rapa	31.28	5.00e-39	156.00
IUUC-Cel-018532	Caenorhabditis elegans	36.15	2.00e-54	207.00
IUUC-Cja-018843	Callithrix jacchus	80.37	0.00e+00	1213.00
IUUC-Cfa-021107	Canis familiaris	80.09	0.00e+00	1162.00
IUUC-Cre-022712	Chlamydomonas reinhardtii	40.00	7.00e-11	62.00
IUUC-Csa-023397	Chlorocebus sabaeus	79.93	0.00e+00	1220.00
IUUC-Cho-024327	Choloepus hoffmanni	96.15	0.00e+00	946.00
IUUC-Cin-025439	Ciona intestinalis	47.01	1.00e-47	182.00
IUUC-Csv-026162	Ciona savignyi	54.98	1.00e-55	209.00
IUUC-Cgl-026629	Colletotrichum gloeosporioides	30.40	3.00e-28	120.00
IUUC-Cne-026921	Cryptococcus neoformans	28.46	5.00e-39	155.00
IUUC-Cme-027244	Cyanidioschyzon merolae	45.05	6.00e-18	86.70
IUUC-Dre-028023	Danio rerio	83.04	2.00e-161	564.00
IUUC-Dno-029430	Dasypus novemcinctus	79.52	0.00e+00	1142.00
IUUC-Dor-030406	Dipodomys ordii	80.87	0.00e+00	1155.00
IUUC-Dse-031312	Dothistroma septosporum	30.61	6.00e-38	152.00
IUUC-Dme-032133	Drosophila melanogaster	43.07	2.00e-74	274.00
IUUC-Ete-032466	Echinops telfairi	77.02	0.00e+00	1065.00
IUUC-Eca-034174	Equus caballus	80.71	0.00e+00	941.00
IUUC-Eeu-034677	Erinaceus europaeus	94.04	0.00e+00	827.00
IUUC-Fca-035439	Felis catus	79.76	0.00e+00	1120.00
IUUC-Fal-037230	Ficedula albicollis	64.17	0.00e+00	724.00
IUUC-Fox-037976	Fusarium oxysporum	30.32	9.00e-35	141.00
IUUC-Fso-038202	Fusarium solani	28.89	4.00e-34	139.00
IUUC-Gmo-038618	Gadus morhua	67.15	2.00e-74	272.00
IUUC-Ggr-040035	Gaeumannomyces graminis	27.88	3.00e-31	130.00
IUUC-Gga-040908	Gallus gallus	65.58	0.00e+00	729.00
IUUC-Gac-041718	Gasterosteus aculeatus	70.72	6.00e-86	310.00
IUUC-Gma-044229	Glycine max	31.71	3.00e-40	160.00
IUUC-Ggo-044567	Gorilla gorilla	79.93	0.00e+00	1171.00
IUUC-Hsa-046849	Homo sapiens	80.37	0.00e+00	1178.00
IUUC-Hvu-047050	Hordeum vulgare	25.49	3.00e-23	103.00
IUUC-Itr-048832	Ictidomys tridecemlineatus	81.10	0.00e+00	1110.00
IUUC-Kpa-049323	Komagataella pastoris	30.91	2.00e-34	140.00
IUUC-Lch-050524	Latimeria chalumnae	67.28	0.00e+00	700.00
IUUC-Lpe-050947	Leersia perrieri	29.57	1.00e-29	125.00
IUUC-Loc-052709	Lepisosteus oculatus	82.54	6.00e-167	582.00
IUUC-Lma-053186	Leptosphaeria maculans	33.93	8.00e-36	145.00
IUUC-Laf-054472	Loxodonta africana	78.98	0.00e+00	1134.00
IUUC-Mcc-055743	Macaca mulatta	78.08	0.00e+00	1220.00
IUUC-Meu-056399	Macropus eugenii	77.02	0.00e+00	731.00
IUUC-Mor-057073	Magnaporthe oryzae	30.06	6.00e-32	132.00
IUUC-Mpo-057378	Magnaporthe poae	27.58	1.00e-30	128.00
IUUC-Mtr-058761	Medicago truncatula	31.37	1.00e-32	135.00
IUUC-Mla-058840	Melampsora laricipopulina	36.73	1.00e-24	108.00
IUUC-Mga-060129	Meleagris gallopavo	64.64	0.00e+00	795.00
IUUC-Mvi-060424	Microbotryum violaceum	35.85	1.00e-24	108.00
IUUC-Mmr-061295	Microcebus murinus	80.87	0.00e+00	1177.00
IUUC-Mdo-062295	Monodelphis domestica	69.99	0.00e+00	978.00
IUUC-Mac-065479	Musa acuminata	35.63	4.00e-24	107.00
IUUC-Mpu-065875	Mustela putorius furo	81.37	0.00e+00	1171.00
IUUC-Mlu-066941	Myotis lucifugus	79.19	0.00e+00	1067.00
IUUC-Nfi-068518	Neosartorya fischeri	32.17	1.00e-35	144.00
IUUC-Ncr-068886	Neurospora crassa	28.61	1.00e-31	131.00
IUUC-Nle-069717	Nomascus leucogenys	96.73	0.00e+00	973.00
IUUC-Opr-070280	Ochotona princeps	94.38	0.00e+00	689.00
IUUC-Ont-071462	Oreochromis niloticus	66.31	8.00e-140	492.00
IUUC-Oan-073300	Ornithorhynchus anatinus	69.56	0.00e+00	895.00
IUUC-Ocu-074124	Oryctolagus cuniculus	80.11	0.00e+00	1221.00
IUUC-Oba-075756	Oryza barthii	30.75	3.00e-30	127.00
IUUC-Obr-076580	Oryza brachyantha	29.87	2.00e-28	121.00
IUUC-Ogl-077759	Oryza glaberrima	32.35	2.00e-36	147.00
IUUC-Ogu-078657	Oryza glumaepatula	31.10	6.00e-30	126.00
IUUC-Oin-079481	Oryza indica	32.47	2.00e-31	131.00
IUUC-Olo-081062	Oryza longistaminata	36.31	1.00e-22	102.00
IUUC-Ome-081813	Oryza meridionalis	30.83	1.00e-29	125.00
IUUC-Oni-083007	Oryza nivara	30.83	1.00e-29	125.00
IUUC-Opu-083385	Oryza punctata	29.84	2.00e-29	124.00
IUUC-Oru-084861	Oryza rufipogon	30.83	1.00e-29	125.00
IUUC-Osa-085896	Oryza sativa	32.18	4.00e-36	145.00
IUUC-Ola-086693	Oryzias latipes	62.67	5.00e-126	445.00
IUUC-Olu-087631	Ostreococcus lucimarinus	47.30	2.00e-14	70.10
IUUC-Oga-088262	Otolemur garnettii	80.22	0.00e+00	1158.00
IUUC-Oar-089658	Ovis aries	79.28	0.00e+00	1221.00
IUUC-Ptr-091311	Pan troglodytes	80.26	0.00e+00	1182.00
IUUC-Pan-091925	Papio anubis	80.04	0.00e+00	1221.00
IUUC-Psi-093605	Pelodiscus sinensis	65.36	0.00e+00	809.00
IUUC-Pma-094163	Petromyzon marinus	72.81	3.00e-98	350.00
IUUC-Pno-094790	Phaeosphaeria nodorum	29.79	1.00e-24	108.00
IUUC-Ppa-095943	Physcomitrella patens	30.41	7.00e-45	176.00
IUUC-Pfo-096581	Poecilia formosa	69.41	7.00e-134	472.00
IUUC-Pab-098229	Pongo abelii	79.61	0.00e+00	1172.00
IUUC-Pop-099160	Populus trichocarpa	30.40	1.00e-39	158.00
IUUC-Pca-100875	Procavia capensis	75.08	0.00e+00	749.00
IUUC-Ppe-101658	Prunus persica	36.47	3.00e-17	84.30
IUUC-Pva-102343	Pteropus vampyrus	91.91	0.00e+00	926.00
IUUC-Pgr-103275	Puccinia graminis	36.24	5.00e-18	87.00
IUUC-Ptt-104004	Puccinia triticina	40.00	3.00e-10	60.50
IUUC-Pte-104161	Pyrenophora teres	31.99	7.00e-30	125.00
IUUC-Pyt-104576	Pyrenophora triticirepentis	32.41	2.00e-30	127.00
IUUC-Rno-105264	Rattus norvegicus	92.46	0.00e+00	1287.00
IUUC-Sce-106138	Saccharomyces cerevisiae	31.20	2.00e-38	153.00
IUUC-Sha-107497	Sarcophilus harrisii	69.57	0.00e+00	1000.00
IUUC-Sja-107991	Schizosaccharomyces japonicus	34.03	6.00e-44	171.00
IUUC-Spo-108257	Schizosaccharomyces pombe	34.12	2.00e-46	179.00
IUUC-Ssl-108581	Sclerotinia sclerotiorum	29.74	3.00e-37	149.00
IUUC-Smo-109358	Selaginella moellendorffii	29.95	3.00e-34	139.00
IUUC-Sit-109920	Setaria italica	31.99	7.00e-37	149.00
IUUC-Sly-111616	Solanum lycopersicum	38.10	1.00e-26	115.00
IUUC-Stu-112648	Solanum tuberosum	32.37	3.00e-11	63.20
IUUC-Sar-113120	Sorex araneus	75.39	0.00e+00	1016.00
IUUC-Sbi-113881	Sorghum bicolor	30.87	4.00e-38	153.00
IUUC-Sre-115127	Sporisorium reilianum	30.46	3.00e-47	183.00
IUUC-Ssc-116147	Sus scrofa	80.96	0.00e+00	1161.00
IUUC-Tgu-117215	Taeniopygia guttata	64.07	0.00e+00	714.00
IUUC-Tru-118525	Takifugu rubripes	63.83	2.00e-132	465.00
IUUC-Tsy-119160	Tarsius syrichta	81.84	0.00e+00	1198.00
IUUC-Tni-119816	Tetraodon nigroviridis	68.52	4.00e-82	297.00
IUUC-Tca-121727	Theobroma cacao	30.83	2.00e-32	134.00
IUUC-Tre-122181	Trichoderma reesei	28.92	2.00e-35	144.00
IUUC-Tvi-122316	Trichoderma virens	28.27	2.00e-35	143.00
IUUC-Tae-125227	Triticum aestivum	36.31	3.00e-17	84.00
IUUC-Tur-126827	Triticum urartu	36.31	2.00e-16	81.30
IUUC-Tme-126984	Tuber melanosporum	30.46	1.00e-44	174.00
IUUC-Tbe-127263	Tupaia belangeri	76.35	0.00e+00	874.00
IUUC-Ttr-128498	Tursiops truncatus	78.04	0.00e+00	1196.00
IUUC-Uma-129457	Ustilago maydis	30.63	7.00e-45	175.00
IUUC-Vda-129986	Verticillium dahliae	28.95	1.00e-34	141.00
IUUC-Vpa-130795	Vicugna pacos	89.78	0.00e+00	760.00
IUUC-Vvi-131146	Vitis vinifera	36.31	7.00e-17	82.80
IUUC-Xtr-132789	Xenopus tropicalis	65.35	0.00e+00	647.00
IUUC-Xma-133011	Xiphophorus maculatus	68.71	3.00e-132	465.00
IUUC-Yli-134516	Yarrowia lipolytica	32.49	1.00e-39	157.00
IUUC-Zma-134699	Zea mays	30.00	1.00e-36	148.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence