iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000122481.16	ENST00000370202.4	ENSP00000359221.4
ENSG00000122481.16	ENST00000263893.10	ENSP00000263893.6

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	microRNA
TRANSFAC	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWAS Central	OMIM
Post-translational Modifications (PTMs)
PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	20026589

Organism

Homo sapiens

Functional Description
(View)

Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.

Protein Sequence
(Fasta)

MAEPVQEELS VLAAIFCRPH EWEVLSRSET DGTVFRIHTK AEGFMDVDIP LELVFHLPVN 60
YPSCLPGISI NSEQLTRAQC VTVKENLLEQ AESLLSEPMV HELVLWIQQN LRHILSQPET 120

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Nucleotide Sequence
(Fasta)

AGTGCTGCTC CTGGCCGGTG GAGGCGGCGG CTGCGGCAGC GGAAGGGGAA GCGCTGAGGC 60
GGTGGGGCCC ACAGCCATGG CGGAGCCTGT GCAGGAGGAG CTCTCGGTCC TGGCCGCGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR006575--RWD-domain
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50908--RWD

Pfam

PF05773--RWD

SMART

SM00591--RWD

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:1902073--P:positive regulation of hypoxia-inducible factor-1alpha signaling pathway
GO:0033235--P:positive regulation of protein sumoylation

KEGG

hsa:25950

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001116	Aegilops tauschii	30.86	2.00e-03	37.40
IUUC-Aml-001708	Ailuropoda melanoleuca	78.65	4.00e-121	427.00
IUUC-Apl-003522	Anas platyrhynchos	68.06	6.00e-95	340.00
IUUC-Aca-004740	Anolis carolinensis	65.87	2.00e-94	338.00
IUUC-Ame-011185	Astyanax mexicanus	50.00	6.00e-63	233.00
IUUC-Bta-012741	Bos taurus	83.90	3.00e-131	460.00
IUUC-Cja-019852	Callithrix jacchus	94.01	6.00e-148	516.00
IUUC-Cfa-020650	Canis familiaris	90.91	9.00e-98	348.00
IUUC-Cpo-021315	Cavia porcellus	86.14	1.00e-132	465.00
IUUC-Cre-022814	Chlamydomonas reinhardtii	32.59	2.00e-14	75.50
IUUC-Csa-023248	Chlorocebus sabaeus	94.38	2.00e-148	518.00
IUUC-Cho-024592	Choloepus hoffmanni	73.03	2.00e-108	385.00
IUUC-Dno-029731	Dasypus novemcinctus	86.89	3.00e-138	484.00
IUUC-Dor-030629	Dipodomys ordii	81.51	7.00e-115	406.00
IUUC-Eca-033706	Equus caballus	77.69	5.00e-116	410.00
IUUC-Eeu-035055	Erinaceus europaeus	77.78	2.00e-73	267.00
IUUC-Fca-036331	Felis catus	86.61	2.00e-122	431.00
IUUC-Fal-037061	Ficedula albicollis	67.19	2.00e-88	318.00
IUUC-Gmo-039582	Gadus morhua	45.67	4.00e-24	105.00
IUUC-Gga-041275	Gallus gallus	69.17	5.00e-97	347.00
IUUC-Gac-041519	Gasterosteus aculeatus	39.42	9.00e-44	170.00
IUUC-Ggo-045321	Gorilla gorilla	98.13	2.00e-154	537.00
IUUC-Itr-048801	Ictidomys tridecemlineatus	87.27	1.00e-132	465.00
IUUC-Lch-049416	Latimeria chalumnae	59.68	7.00e-76	276.00
IUUC-Loc-052111	Lepisosteus oculatus	53.90	7.00e-63	233.00
IUUC-Laf-053356	Loxodonta africana	89.54	9.00e-127	445.00
IUUC-Mga-059513	Meleagris gallopavo	65.66	2.00e-92	331.00
IUUC-Mdo-062569	Monodelphis domestica	77.53	4.00e-116	410.00
IUUC-Mmu-063527	Mus musculus	78.65	7.00e-122	429.00
IUUC-Mpu-066086	Mustela putorius furo	84.15	2.00e-132	464.00
IUUC-Mlu-067896	Myotis lucifugus	66.67	2.00e-95	342.00
IUUC-Nle-069974	Nomascus leucogenys	97.07	2.00e-136	477.00
IUUC-Opr-070316	Ochotona princeps	79.40	4.00e-123	434.00
IUUC-Oan-073737	Ornithorhynchus anatinus	71.97	2.00e-92	332.00
IUUC-Ocu-074676	Oryctolagus cuniculus	77.15	4.00e-120	424.00
IUUC-Ogl-077649	Oryza glaberrima	25.56	5.00e-03	35.00
IUUC-Olu-087629	Ostreococcus lucimarinus	29.79	5.00e-08	51.20
IUUC-Oga-088240	Otolemur garnettii	85.02	5.00e-134	470.00
IUUC-Oar-090323	Ovis aries	82.71	4.00e-129	453.00
IUUC-Ptr-090606	Pan troglodytes	98.13	4.00e-154	536.00
IUUC-Pan-092703	Papio anubis	95.51	5.00e-151	526.00
IUUC-Psi-093692	Pelodiscus sinensis	73.22	5.00e-100	357.00
IUUC-Pma-094209	Petromyzon marinus	41.95	3.00e-51	194.00
IUUC-Pfo-097216	Poecilia formosa	37.27	3.00e-39	155.00
IUUC-Pab-098276	Pongo abelii	97.00	1.00e-152	531.00
IUUC-Pca-100393	Procavia capensis	86.55	2.00e-121	428.00
IUUC-Pva-103171	Pteropus vampyrus	85.77	2.00e-136	477.00
IUUC-Rno-106097	Rattus norvegicus	80.15	2.00e-125	441.00
IUUC-Sha-107558	Sarcophilus harrisii	83.43	3.00e-78	283.00
IUUC-Sar-113593	Sorex araneus	82.35	2.00e-112	397.00
IUUC-Ssc-116414	Sus scrofa	76.36	1.00e-117	415.00
IUUC-Tgu-116827	Taeniopygia guttata	81.60	2.00e-55	207.00
IUUC-Tsy-119601	Tarsius syrichta	85.59	1.00e-109	388.00
IUUC-Tni-120017	Tetraodon nigroviridis	40.07	3.00e-49	188.00
IUUC-Tbe-127311	Tupaia belangeri	86.05	6.00e-131	459.00
IUUC-Ttr-128974	Tursiops truncatus	87.64	8.00e-139	486.00
IUUC-Vpa-130461	Vicugna pacos	93.15	3.00e-75	273.00
IUUC-Xtr-131871	Xenopus tropicalis	57.37	1.00e-71	263.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence