iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046215

UUCD1 version

UUC-HoS-01251

Ensembl Protein ID

ENSP00000380336.3

UniProt Accession

Q2TAY7; B4E3L0; Q9BU59; Q9HA96; Q9NVD1; SMU1_HUMAN

Genbank Protein ID

BAA91822.1; BAG65522.1; CAI15554.1; AAH02876.1; AAI10655.1

Protein Name

WD40 repeat-containing protein SMU1; Smu-1 suppressor of mec-8 and unc-52 protein homolog; WD40 repeat-containing protein SMU1, N-terminally processed

Genbank Nucleotide ID

AK001667; AK022032; AL162590; BC002876; BC110654

Gene Name

SMU1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000122692.8	ENST00000397149.3	ENSP00000380336.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.10e-35	118.8	265	300
UBD/Beta-Prp	2.50e-55	189.4	213	512

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 4    dsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           d v c++f  d  +l++G+ Dg+ikvW + +g +l+
   Q: 265  DAVLCMCFsRDtEMLATGAQDGKIKVWKIQSGQCLR 300
           6799*****777********************9986 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl.sgheae.......vtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk. 91
           +ks + c  fspd+++l+tgs dg i+vw++ttgk  + l ++ ++        v +++fs+d+++l+tg++D+ ikvw +++g+c++ ++ 
   Q: 213  QKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLkYQAQDNfmmmddaVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFEr 304
           678899******************************666644444446666666************************************98 PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.....tgg 178
           +h++ v++lsfs++++ ++s+s d+tir+  l++g+ l+  ++gh+++vn +++ +dg +++s+s D+tv++W++kt ++  t+     t g
   Q: 305  AHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLK-EFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFkslgsTAG 395
           9**************************************.********************************************88887555 PP
   S: 179  htdsvysls.fdsngkelvsgsldgtvklwdlqtgecvrtlnght...dnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnss 266
            +  v+s++ + +n +++v + + +tv + ++q g++vr++   +     + + ++sp++e+++++++D +++++ + +g+l +tl+ h++ 
   Q: 396  TDITVNSVIlLPKNPEHFVVCNRSNTVVIMNMQ-GQIVRSFSSGKregGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKD 486
           777778887666666*****************5.66888888766566566678999*********************************** PP
   S: 267  visvavlsfgdnvlvlgsedskvniwk 293
           vi +a+ ++ +n +++ sed+ +++wk
   Q: 487  VIGIAH-HPHQNLIATYSEDGLLKLWK 512
           ******.*******************8 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSIEIESSDV IRLIMQYLKE NSLHRALATL QEETTVSLNT VDSIESFVAD INSGHWDTVL 60
QAIQSLKLPD KTLIDLYEQV VLELIELREL GAARSLLRQT DPMIMLKQTQ PERYIHLENL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGACTGGC CTTGAGGGAG AGCTGGGGCC TGCTCCCGGA GAGATACGGC TATGTCGATC 60
GAAATCGAAT CTTCGGAGTG AGTCCTGCGG TGGGGATGTT CGCGCCTTGC CGGGGGCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR006595--CTLH_C
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50897--CTLH
PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00668--CTLH
SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus

KEGG

hsa:55234

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000857	Aegilops tauschii	60.27	1.00e-48	185.00
IUUC-Aml-001330	Ailuropoda melanoleuca	100.00	0.00e+00	1071.00
IUUC-Atr-002570	Amborella trichopoda	66.21	0.00e+00	724.00
IUUC-Apl-003826	Anas platyrhynchos	99.19	0.00e+00	1027.00
IUUC-Aca-005183	Anolis carolinensis	99.22	0.00e+00	1064.00
IUUC-Aly-005632	Arabidopsis lyrata	64.72	0.00e+00	720.00
IUUC-Ath-007219	Arabidopsis thaliana	64.72	0.00e+00	715.00
IUUC-Ame-011374	Astyanax mexicanus	95.91	0.00e+00	1042.00
IUUC-Bta-012890	Bos taurus	100.00	0.00e+00	1071.00
IUUC-Bdi-014061	Brachypodium distachyon	65.04	0.00e+00	728.00
IUUC-Bol-016332	Brassica oleracea	65.04	0.00e+00	722.00
IUUC-Bra-017612	Brassica rapa	64.91	0.00e+00	723.00
IUUC-Cel-018238	Caenorhabditis elegans	62.04	0.00e+00	678.00
IUUC-Cja-019336	Callithrix jacchus	100.00	0.00e+00	1071.00
IUUC-Cfa-021108	Canis familiaris	99.81	0.00e+00	1070.00
IUUC-Cpo-022052	Cavia porcellus	100.00	0.00e+00	1071.00
IUUC-Cre-022595	Chlamydomonas reinhardtii	59.77	0.00e+00	658.00
IUUC-Csa-023488	Chlorocebus sabaeus	100.00	0.00e+00	1071.00
IUUC-Cho-025010	Choloepus hoffmanni	89.86	0.00e+00	944.00
IUUC-Cin-025251	Ciona intestinalis	82.10	0.00e+00	901.00
IUUC-Csv-026092	Ciona savignyi	75.66	0.00e+00	827.00
IUUC-Dre-027382	Danio rerio	95.71	0.00e+00	1034.00
IUUC-Dno-029007	Dasypus novemcinctus	99.81	0.00e+00	1071.00
IUUC-Dor-030180	Dipodomys ordii	86.51	0.00e+00	697.00
IUUC-Dme-031762	Drosophila melanogaster	77.97	0.00e+00	869.00
IUUC-Ete-032933	Echinops telfairi	99.77	0.00e+00	892.00
IUUC-Eca-033864	Equus caballus	100.00	0.00e+00	1054.00
IUUC-Eeu-034635	Erinaceus europaeus	89.36	0.00e+00	788.00
IUUC-Fca-036119	Felis catus	100.00	0.00e+00	1071.00
IUUC-Fal-037396	Ficedula albicollis	99.60	0.00e+00	1042.00
IUUC-Gmo-038962	Gadus morhua	93.37	0.00e+00	1019.00
IUUC-Gga-040134	Gallus gallus	99.61	0.00e+00	1069.00
IUUC-Gac-041630	Gasterosteus aculeatus	93.76	0.00e+00	1019.00
IUUC-Gma-043928	Glycine max	66.21	0.00e+00	734.00
IUUC-Ggo-045061	Gorilla gorilla	99.61	0.00e+00	1066.00
IUUC-Hvu-047799	Hordeum vulgare	66.67	5.00e-148	516.00
IUUC-Itr-048826	Ictidomys tridecemlineatus	100.00	0.00e+00	1071.00
IUUC-Lch-050209	Latimeria chalumnae	92.02	0.00e+00	976.00
IUUC-Lpe-050740	Leersia perrieri	65.23	0.00e+00	726.00
IUUC-Loc-052739	Lepisosteus oculatus	88.82	0.00e+00	954.00
IUUC-Laf-053895	Loxodonta africana	99.81	0.00e+00	1067.00
IUUC-Mcc-055183	Macaca mulatta	100.00	0.00e+00	1071.00
IUUC-Mtr-057730	Medicago truncatula	65.23	0.00e+00	712.00
IUUC-Mga-059222	Meleagris gallopavo	99.52	0.00e+00	881.00
IUUC-Mmr-061749	Microcebus murinus	99.03	0.00e+00	1057.00
IUUC-Mdo-062920	Monodelphis domestica	99.61	0.00e+00	1069.00
IUUC-Mmu-063228	Mus musculus	100.00	0.00e+00	1071.00
IUUC-Mac-065084	Musa acuminata	66.41	0.00e+00	740.00
IUUC-Mpu-066162	Mustela putorius furo	100.00	0.00e+00	1071.00
IUUC-Mlu-067471	Myotis lucifugus	99.03	0.00e+00	1064.00
IUUC-Nle-070129	Nomascus leucogenys	100.00	0.00e+00	1071.00
IUUC-Opr-071176	Ochotona princeps	100.00	0.00e+00	1054.00
IUUC-Ont-071830	Oreochromis niloticus	95.13	0.00e+00	1033.00
IUUC-Oan-072778	Ornithorhynchus anatinus	99.61	0.00e+00	1070.00
IUUC-Ocu-074570	Oryctolagus cuniculus	100.00	0.00e+00	1071.00
IUUC-Oba-075507	Oryza barthii	65.23	0.00e+00	728.00
IUUC-Obr-076672	Oryza brachyantha	65.62	0.00e+00	732.00
IUUC-Ogl-077110	Oryza glaberrima	65.23	0.00e+00	728.00
IUUC-Ogu-077976	Oryza glumaepatula	65.23	0.00e+00	728.00
IUUC-Oin-079525	Oryza indica	65.23	0.00e+00	728.00
IUUC-Olo-080391	Oryza longistaminata	63.57	0.00e+00	719.00
IUUC-Oni-082778	Oryza nivara	65.23	0.00e+00	728.00
IUUC-Opu-083710	Oryza punctata	65.43	0.00e+00	729.00
IUUC-Oru-084250	Oryza rufipogon	65.23	0.00e+00	728.00
IUUC-Osa-085363	Oryza sativa	65.23	0.00e+00	728.00
IUUC-Ola-087092	Oryzias latipes	94.74	0.00e+00	1026.00
IUUC-Olu-087753	Ostreococcus lucimarinus	50.39	2.00e-140	493.00
IUUC-Oga-088278	Otolemur garnettii	91.31	0.00e+00	957.00
IUUC-Oar-089664	Ovis aries	99.42	0.00e+00	1066.00
IUUC-Ptr-090991	Pan troglodytes	100.00	0.00e+00	1071.00
IUUC-Pan-092697	Papio anubis	100.00	0.00e+00	1071.00
IUUC-Psi-093204	Pelodiscus sinensis	100.00	0.00e+00	1045.00
IUUC-Ppa-095325	Physcomitrella patens	66.02	0.00e+00	738.00
IUUC-Pfo-096988	Poecilia formosa	94.93	0.00e+00	1034.00
IUUC-Pab-098288	Pongo abelii	100.00	0.00e+00	1071.00
IUUC-Pop-098787	Populus trichocarpa	66.28	0.00e+00	739.00
IUUC-Pca-100583	Procavia capensis	93.06	0.00e+00	957.00
IUUC-Ppe-101307	Prunus persica	65.43	0.00e+00	731.00
IUUC-Pva-102711	Pteropus vampyrus	100.00	0.00e+00	1071.00
IUUC-Rno-105614	Rattus norvegicus	100.00	0.00e+00	1071.00
IUUC-Sha-107017	Sarcophilus harrisii	99.81	0.00e+00	1071.00
IUUC-Smo-109547	Selaginella moellendorffii	63.55	0.00e+00	677.00
IUUC-Sit-110278	Setaria italica	65.23	0.00e+00	708.00
IUUC-Sly-111777	Solanum lycopersicum	67.19	0.00e+00	740.00
IUUC-Stu-112293	Solanum tuberosum	66.99	0.00e+00	738.00
IUUC-Sar-112955	Sorex araneus	89.88	0.00e+00	947.00
IUUC-Sbi-114802	Sorghum bicolor	65.43	0.00e+00	703.00
IUUC-Ssc-116054	Sus scrofa	100.00	0.00e+00	1071.00
IUUC-Tgu-116909	Taeniopygia guttata	98.44	0.00e+00	1056.00
IUUC-Tru-118195	Takifugu rubripes	94.54	0.00e+00	1030.00
IUUC-Tsy-119420	Tarsius syrichta	92.20	0.00e+00	969.00
IUUC-Tni-120416	Tetraodon nigroviridis	94.15	0.00e+00	1024.00
IUUC-Tca-121653	Theobroma cacao	66.28	0.00e+00	712.00
IUUC-Tae-125609	Triticum aestivum	64.65	0.00e+00	725.00
IUUC-Tur-126197	Triticum urartu	66.12	3.00e-155	540.00
IUUC-Tbe-128009	Tupaia belangeri	100.00	0.00e+00	716.00
IUUC-Ttr-128719	Tursiops truncatus	91.42	0.00e+00	964.00
IUUC-Vpa-130579	Vicugna pacos	99.61	0.00e+00	1063.00
IUUC-Vvi-131127	Vitis vinifera	66.99	0.00e+00	739.00
IUUC-Xtr-132950	Xenopus tropicalis	91.88	0.00e+00	978.00
IUUC-Xma-133537	Xiphophorus maculatus	94.93	0.00e+00	1034.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence