iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000123552.17	ENST00000500704.6	ENSP00000424372.1
ENSG00000123552.17	ENST00000496518.6	ENSP00000421248.1
ENSG00000123552.17	ENST00000369233.6	ENSP00000358236.2
ENSG00000123552.17	ENST00000506871.5	ENSP00000422460.1
ENSG00000123552.17	ENST00000511403.5	ENSP00000423374.1
ENSG00000123552.17	ENST00000496090.6	ENSP00000421706.1
ENSG00000123552.17	ENST00000507717.5	ENSP00000425876.1
ENSG00000123552.17	ENST00000329966.10	ENSP00000330540.5

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	14715245

Classification

Family	E-value	Score	Start	End
DUB/USP	6.30e-85	287.0	191	812

Active Site

Position(s)	Description	Evidence
199	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
746	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp..............kepkgellkslqklfeelwkskkkavsprellkal 77
           G++NlgNtC++N+v+Q L+++  l++l++e  +  ++++ +                 ++ g+l+++l  +++++ +++k+  sp+ l+++l
   Q: 191  GITNLGNTCFFNAVMQNLAQTYTLTDLMNEikE--SSTKLK-IfpssdsqldplvveLSRPGPLTSALFLFLHSMKETEKGPLSPKVLFNQL 279
           9*****************************542..333222.23445566666777777777****************************** PP
   S: 78   kkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikclecdnvs 163
           +++a++f+ ++qqD+qE+l++lld++++e +k+ + ++ +++++ ++++ d+      + + k+  + ++i+++F g+l+s+++c+ec+n+s
   Q: 280  CQKAPRFKDFQQQDSQELLHYLLDAVRTEETKRIQASILKAFNNPTTKTADDetrkkvKAYGKEGVKMNFIDRIFIGELTSTVMCEECANIS 371
           ******************************99888888888888877777773443335555555555************************ PP
   S: 164  sreepfldlslpvpgkeetkke...................................................................... 185
           + ++pf+d+slp+ +++ +k++                                                                      
   Q: 372  TVKDPFIDISLPIIEERVSKPLlwgrmnkyrslretdhdrysgnvtienihqpraakkhssskdksqlihdrkcirklssgetvtyqknenl 463
           *****************99888********************************************************************** PP
   S: 186  ............................................................................................ 185
                                                                                                       
   Q: 464  emngdslmfaslmnsesrlnesptddsekeashsesnvdadsepsesesaskqtglfrsssgsgvqpdgplyplsagkllytketdsgdkem 555
           ******************************************************************************************** PP
   S: 186  ...............................................................slqdcLesftkeeelegenkyycekckkk 214
                                                                          s+q+cL +ft+ e l g+nk+ ce+c+k+
   Q: 556  aeaiselrlsstvtgdqdfdrenqplnisnnlcflegkhlrsyspqnafqtlsqsyittskecSIQSCLYQFTSMELLMGNNKLLCENCTKN 647
           ******************************************************************************************88 PP
   S: 215  qe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYeLiavvv 285
           ++                   a+k+l ++ +P vLilhLkRf  ++++ s +k+n++v+fpl+Ldl+pfc+ ++++ ++  k+ Y L+++v 
   Q: 648  KQkyqeetsfaekkvegvytnARKQLLISAVPAVLILHLKRF--HQAGLSLRKVNRHVDFPLMLDLAPFCSATCKNASVgdKVLYGLYGIVE 737
           888999999999999999999*********************..9999************************88887667799********* PP
   S: 286  HsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           HsGs+++GHY+ayvk                           + g+W++++D++ ++v+e++ l+   ++aY+lfY+r
   Q: 738  HSGSMREGHYTAYVKVrtpsrklsehntkkknvpglkaadneSAGQWVHVSDTYLQVVPESRALS---AQAYLLFYER 812
           ****************999999999999999999999888777888*******************...********98 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MRVKDPTKAL PEKAKRSKRP TVPHDEDSSD DIAVGLTCQH VSHAISVNHV KRAIAENLWS 60
VCSECLKERR FYDGQLVLTS DIWLCLKCGF QGCGKNSESQ HSLKHFKSSR TEPHCIIINL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATAAAAGTT GGTGCTGGAG AGGCAGCATG CAAAGCGAAA AGAAGGGACT GCTTTGAGTT 60
CTAGACCCAA CGCCTCCGGT AACCACCTTC ATTTCTCTGG CTTCTGCTGG CTCATCGGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0070911--P:global genome nucleotide-excision repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:85015

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	73.51	0.00e+00	1088.00
IUUC-Apl-003512	Anas platyrhynchos	66.95	0.00e+00	1041.00
IUUC-Aca-004284	Anolis carolinensis	59.25	0.00e+00	938.00
IUUC-Ame-010735	Astyanax mexicanus	62.98	4.00e-85	308.00
IUUC-Bta-012880	Bos taurus	81.56	0.00e+00	1261.00
IUUC-Cja-019144	Callithrix jacchus	92.64	0.00e+00	1501.00
IUUC-Cfa-020971	Canis familiaris	82.86	0.00e+00	724.00
IUUC-Cpo-022497	Cavia porcellus	69.47	0.00e+00	1082.00
IUUC-Csa-023910	Chlorocebus sabaeus	94.16	0.00e+00	1443.00
IUUC-Cho-024358	Choloepus hoffmanni	61.90	1.00e-109	390.00
IUUC-Dre-028106	Danio rerio	61.17	6.00e-150	525.00
IUUC-Dno-029456	Dasypus novemcinctus	76.33	0.00e+00	702.00
IUUC-Dor-030438	Dipodomys ordii	63.53	0.00e+00	931.00
IUUC-Dme-031870	Drosophila melanogaster	46.71	2.00e-35	145.00
IUUC-Ete-032736	Echinops telfairi	64.34	0.00e+00	928.00
IUUC-Eca-034211	Equus caballus	82.66	0.00e+00	1330.00
IUUC-Eeu-034797	Erinaceus europaeus	81.01	3.00e-85	309.00
IUUC-Fca-035947	Felis catus	77.82	0.00e+00	1142.00
IUUC-Fal-037199	Ficedula albicollis	66.89	0.00e+00	918.00
IUUC-Gmo-039228	Gadus morhua	61.01	6.00e-140	491.00
IUUC-Gga-040823	Gallus gallus	63.06	2.00e-162	565.00
IUUC-Gac-042406	Gasterosteus aculeatus	59.52	6.00e-136	478.00
IUUC-Ggo-045402	Gorilla gorilla	98.90	0.00e+00	1623.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	81.07	0.00e+00	744.00
IUUC-Lch-049547	Latimeria chalumnae	57.89	0.00e+00	896.00
IUUC-Loc-052842	Lepisosteus oculatus	58.14	0.00e+00	880.00
IUUC-Laf-053988	Loxodonta africana	83.05	0.00e+00	1338.00
IUUC-Mcc-055491	Macaca mulatta	88.96	0.00e+00	1437.00
IUUC-Meu-056256	Macropus eugenii	63.49	3.00e-172	598.00
IUUC-Mtr-057945	Medicago truncatula	31.27	2.00e-33	137.00
IUUC-Mla-059026	Melampsora laricipopulina	30.73	3.00e-16	80.50
IUUC-Mga-059833	Meleagris gallopavo	59.60	6.00e-165	574.00
IUUC-Mmr-060952	Microcebus murinus	84.96	0.00e+00	1335.00
IUUC-Mdo-062642	Monodelphis domestica	69.77	0.00e+00	1068.00
IUUC-Mmu-063945	Mus musculus	77.53	0.00e+00	1209.00
IUUC-Mpu-065944	Mustela putorius furo	75.55	0.00e+00	1158.00
IUUC-Mlu-067049	Myotis lucifugus	80.98	0.00e+00	1258.00
IUUC-Nle-069828	Nomascus leucogenys	96.32	0.00e+00	1572.00
IUUC-Opr-070672	Ochotona princeps	70.73	4.00e-143	502.00
IUUC-Ont-072121	Oreochromis niloticus	58.78	1.00e-133	470.00
IUUC-Oan-073656	Ornithorhynchus anatinus	64.69	0.00e+00	1026.00
IUUC-Ocu-074323	Oryctolagus cuniculus	80.68	0.00e+00	1248.00
IUUC-Ola-087238	Oryzias latipes	59.66	4.00e-146	511.00
IUUC-Oga-088379	Otolemur garnettii	77.24	0.00e+00	1214.00
IUUC-Oar-089718	Ovis aries	81.85	0.00e+00	1261.00
IUUC-Ptr-091358	Pan troglodytes	99.02	0.00e+00	1629.00
IUUC-Pan-092023	Papio anubis	94.60	0.00e+00	1539.00
IUUC-Psi-093256	Pelodiscus sinensis	65.70	0.00e+00	969.00
IUUC-Pfo-097285	Poecilia formosa	51.95	1.00e-119	424.00
IUUC-Pab-098539	Pongo abelii	98.16	0.00e+00	1602.00
IUUC-Pca-100610	Procavia capensis	67.35	0.00e+00	916.00
IUUC-Pva-102985	Pteropus vampyrus	90.27	0.00e+00	695.00
IUUC-Rno-105538	Rattus norvegicus	77.08	0.00e+00	1215.00
IUUC-Sha-107022	Sarcophilus harrisii	72.62	1.00e-178	620.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	26.78	2.00e-19	91.70
IUUC-Spo-108149	Schizosaccharomyces pombe	30.19	5.00e-20	93.60
IUUC-Sar-113637	Sorex araneus	70.05	0.00e+00	1053.00
IUUC-Ssc-115870	Sus scrofa	81.54	0.00e+00	1305.00
IUUC-Tgu-116907	Taeniopygia guttata	67.52	0.00e+00	1048.00
IUUC-Tru-117835	Takifugu rubripes	51.96	2.00e-109	390.00
IUUC-Tsy-118869	Tarsius syrichta	78.06	0.00e+00	1211.00
IUUC-Tbe-128041	Tupaia belangeri	65.53	0.00e+00	945.00
IUUC-Ttr-128901	Tursiops truncatus	81.05	0.00e+00	1269.00
IUUC-Vpa-130331	Vicugna pacos	82.68	0.00e+00	1184.00
IUUC-Xtr-131794	Xenopus tropicalis	64.88	2.00e-145	509.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence