iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000124257.6	ENST00000545238.1	ENSP00000442383.1
ENSG00000124257.6	ENST00000372518.4	ENSP00000361596.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	InWeb_IM
Disease-associated Information
OMIM
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	14960280

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	5.80e-13	50.2	243	285

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 6    llrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           +l+   +SLq+LCRl+I+r++ ++    id+L+LPk+Lkd+++ye
   Q: 243  QLEYGLPSLQTLCRLVIQRSMVHRLA--IDGLHLPKELKDFCKYE 285
           5566689****************888..****************8 PP

Organism

Homo sapiens

Functional Description
(View)

Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).

Protein Sequence
(Fasta)

MAAASEPVDS GALWGLERPE PPPTRFHRVH GANIRVDPSG TRATRVESFA HGVCFSREPL 60
APGQVFLVEI EEKELGWCGH LRLGLTALDP ASLAPVPEFS LPDLVNLGHT WVFAITRHHN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCTCCCG CCCCTTCTTT GGTCCCTACG GACCTGGGGG GCGGTGGCGG TCAATGCCGG 60
GTCAAGGTCC GCGGGCCTCG CAGATCGTAG CCCGGGCGCA CGCGATCAGA TGATCCTGTT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR006573--NHR_dom
IPR001496--SOCS_box

PROSITE

PS51065--NHR
PS50225--SOCS

Pfam

PF07177--Neuralized
PF07525--SOCS_box

SMART

SM00588--NEUZ
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

hsa:140825

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001561	Ailuropoda melanoleuca	93.33	3.00e-154	537.00
IUUC-Aca-004460	Anolis carolinensis	74.34	3.00e-113	401.00
IUUC-Ame-011381	Astyanax mexicanus	62.69	3.00e-101	361.00
IUUC-Bta-012486	Bos taurus	93.68	1.00e-144	505.00
IUUC-Bci-013952	Botrytis cinerea	37.10	1.50e-01	31.20
IUUC-Cja-019245	Callithrix jacchus	93.03	3.00e-146	510.00
IUUC-Cfa-020571	Canis familiaris	93.33	3.00e-146	511.00
IUUC-Cpo-021996	Cavia porcellus	91.58	4.00e-143	500.00
IUUC-Csa-023472	Chlorocebus sabaeus	98.25	2.00e-148	518.00
IUUC-Cin-025368	Ciona intestinalis	35.61	4.00e-40	158.00
IUUC-Dre-028609	Danio rerio	63.02	4.00e-101	360.00
IUUC-Dno-029871	Dasypus novemcinctus	90.07	1.00e-129	455.00
IUUC-Dor-030463	Dipodomys ordii	84.91	1.00e-131	462.00
IUUC-Dme-031873	Drosophila melanogaster	37.74	4.00e-40	158.00
IUUC-Ete-032706	Echinops telfairi	88.42	2.00e-132	464.00
IUUC-Eca-034103	Equus caballus	92.25	6.00e-151	526.00
IUUC-Eeu-034855	Erinaceus europaeus	89.86	3.00e-141	494.00
IUUC-Fca-035442	Felis catus	93.68	7.00e-147	512.00
IUUC-Fal-036651	Ficedula albicollis	73.56	3.00e-110	390.00
IUUC-Gmo-038504	Gadus morhua	67.33	7.00e-34	137.00
IUUC-Gga-040928	Gallus gallus	74.16	2.00e-109	388.00
IUUC-Gac-041997	Gasterosteus aculeatus	60.70	3.00e-103	368.00
IUUC-Ggo-045554	Gorilla gorilla	98.95	4.00e-153	533.00
IUUC-Itr-048452	Ictidomys tridecemlineatus	91.29	1.00e-145	508.00
IUUC-Lch-050327	Latimeria chalumnae	68.18	7.00e-112	396.00
IUUC-Loc-052546	Lepisosteus oculatus	68.46	6.00e-102	363.00
IUUC-Laf-054489	Loxodonta africana	89.82	5.00e-140	490.00
IUUC-Meu-056619	Macropus eugenii	87.05	3.00e-104	370.00
IUUC-Mga-059826	Meleagris gallopavo	79.86	6.00e-62	229.00
IUUC-Mdo-062712	Monodelphis domestica	84.91	1.00e-134	471.00
IUUC-Mmu-064190	Mus musculus	90.53	5.00e-142	496.00
IUUC-Mpu-066287	Mustela putorius furo	92.98	3.00e-152	530.00
IUUC-Mlu-067381	Myotis lucifugus	93.33	2.00e-154	537.00
IUUC-Nle-069071	Nomascus leucogenys	97.89	5.00e-149	520.00
IUUC-Opr-071179	Ochotona princeps	92.31	8.00e-143	499.00
IUUC-Ont-072451	Oreochromis niloticus	63.12	2.00e-100	358.00
IUUC-Ocu-074047	Oryctolagus cuniculus	90.85	3.00e-145	507.00
IUUC-Ola-086786	Oryzias latipes	61.03	2.00e-93	335.00
IUUC-Oga-088222	Otolemur garnettii	89.82	9.00e-148	515.00
IUUC-Oar-089209	Ovis aries	90.88	5.00e-142	496.00
IUUC-Ptr-091394	Pan troglodytes	99.65	3.00e-152	530.00
IUUC-Pan-092410	Papio anubis	98.25	9.00e-149	519.00
IUUC-Psi-093087	Pelodiscus sinensis	80.00	8.00e-67	245.00
IUUC-Pma-094206	Petromyzon marinus	43.61	2.00e-59	221.00
IUUC-Pfo-096952	Poecilia formosa	61.51	2.00e-93	335.00
IUUC-Pab-097547	Pongo abelii	98.60	3.00e-151	527.00
IUUC-Pca-100811	Procavia capensis	89.82	8.00e-147	512.00
IUUC-Pva-102203	Pteropus vampyrus	91.93	3.00e-142	497.00
IUUC-Rno-105117	Rattus norvegicus	90.18	2.00e-146	511.00
IUUC-Sha-106495	Sarcophilus harrisii	86.69	1.00e-126	446.00
IUUC-Ssc-115387	Sus scrofa	92.28	4.00e-151	526.00
IUUC-Tgu-117336	Taeniopygia guttata	73.08	2.00e-107	382.00
IUUC-Tru-117643	Takifugu rubripes	60.89	2.00e-101	362.00
IUUC-Tni-119965	Tetraodon nigroviridis	63.46	1.00e-102	365.00
IUUC-Tbe-127810	Tupaia belangeri	93.68	6.00e-144	503.00
IUUC-Ttr-128525	Tursiops truncatus	93.33	2.00e-144	504.00
IUUC-Vpa-130813	Vicugna pacos	95.93	8.00e-109	385.00
IUUC-Xtr-132387	Xenopus tropicalis	67.42	1.00e-106	379.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence