iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000126804.13	ENST00000554015.5	ENSP00000451000.1
ENSG00000126804.13	ENST00000358738.3	ENSP00000351587.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.30e-12	48.8	24	87

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalf.lmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +D+++ +++ +f+ahk+vLaa+Ss+F+  f +++ +  +  +  ++k +++e+f  +l+F+Y gk+
   Q: 24   CDCCIAIDDIYFQAHKAVLAACSSYFRMFFmNHQHSTAQ-LNLSNMK-ISAECFDLILQFMYLGKI 87
           8*************************9999333333333.5555666.****************97 PP

Organism

Homo sapiens

Functional Description
(View)

Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity).

Protein Sequence
(Fasta)

MAKPSHSSYV LQQLNNQREW GFLCDCCIAI DDIYFQAHKA VLAACSSYFR MFFMNHQHST 60
AQLNLSNMKI SAECFDLILQ FMYLGKIMTA PSSFEQFKVA MNYLQLYNVP DCLEDIQDAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCAAGCCG CGCACTGCAA GCAGTGGCGC CGGCTCACGC ACCCCTCGGC CGCCTCTCGC 60
GCGGCTTCCC GCGCCGGCAG CCCGCGATGG CCCCACGTGA CCGCGTGTCT GGTAGCAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0221--Differentiation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR000877--Prot_inh_BBI
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0016604--C:nuclear body
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0030183--P:B cell differentiation
GO:0006974--P:cellular response to DNA damage stimulus
GO:0034644--P:cellular response to UV
GO:0006338--P:chromatin remodeling
GO:0006281--P:DNA repair
GO:0045087--P:innate immune response
GO:0042789--P:mRNA transcription from RNA polymerase II promoter
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032825--P:positive regulation of natural killer cell differentiation
GO:2000176--P:positive regulation of pro-T cell differentiation
GO:0045582--P:positive regulation of T cell differentiation
GO:0002711--P:positive regulation of T cell mediated immunity
GO:0051260--P:protein homooligomerization
GO:0033077--P:T cell differentiation in thymus
GO:0048538--P:thymus development
GO:0019985--P:translesion synthesis

KEGG

hsa:22890

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001844	Ailuropoda melanoleuca	97.05	0.00e+00	1352.00
IUUC-Apl-003725	Anas platyrhynchos	82.27	0.00e+00	1134.00
IUUC-Aca-004672	Anolis carolinensis	71.78	0.00e+00	952.00
IUUC-Ame-011859	Astyanax mexicanus	48.57	3.00e-179	622.00
IUUC-Bta-013323	Bos taurus	98.04	0.00e+00	1414.00
IUUC-Cja-018727	Callithrix jacchus	99.02	0.00e+00	1375.00
IUUC-Cfa-020390	Canis familiaris	97.05	0.00e+00	1360.00
IUUC-Cpo-022434	Cavia porcellus	96.35	0.00e+00	1385.00
IUUC-Csa-023909	Chlorocebus sabaeus	98.89	0.00e+00	1181.00
IUUC-Cho-024288	Choloepus hoffmanni	96.88	0.00e+00	954.00
IUUC-Dre-027623	Danio rerio	47.62	3.00e-179	622.00
IUUC-Dno-029224	Dasypus novemcinctus	98.04	0.00e+00	1412.00
IUUC-Ete-032672	Echinops telfairi	93.24	0.00e+00	989.00
IUUC-Eca-034361	Equus caballus	97.94	0.00e+00	1194.00
IUUC-Eeu-035254	Erinaceus europaeus	90.58	4.00e-157	548.00
IUUC-Fca-036217	Felis catus	96.77	0.00e+00	1394.00
IUUC-Fal-037026	Ficedula albicollis	78.16	0.00e+00	958.00
IUUC-Gga-040550	Gallus gallus	77.08	1.00e-142	499.00
IUUC-Gac-041379	Gasterosteus aculeatus	45.93	8.00e-170	590.00
IUUC-Ggo-044852	Gorilla gorilla	99.86	0.00e+00	1432.00
IUUC-Itr-048065	Ictidomys tridecemlineatus	97.19	0.00e+00	1395.00
IUUC-Lch-050025	Latimeria chalumnae	55.92	0.00e+00	786.00
IUUC-Loc-052590	Lepisosteus oculatus	50.41	0.00e+00	653.00
IUUC-Laf-054526	Loxodonta africana	96.77	0.00e+00	1377.00
IUUC-Mcc-055796	Macaca mulatta	99.02	0.00e+00	1355.00
IUUC-Mga-059889	Meleagris gallopavo	81.58	0.00e+00	1145.00
IUUC-Mmr-061304	Microcebus murinus	98.04	0.00e+00	1365.00
IUUC-Mdo-062964	Monodelphis domestica	89.06	0.00e+00	1279.00
IUUC-Mmu-064268	Mus musculus	94.96	0.00e+00	1355.00
IUUC-Mpu-065817	Mustela putorius furo	95.57	0.00e+00	1169.00
IUUC-Mlu-068225	Myotis lucifugus	97.48	0.00e+00	1380.00
IUUC-Nle-069390	Nomascus leucogenys	99.44	0.00e+00	1424.00
IUUC-Opr-070274	Ochotona princeps	95.79	0.00e+00	1338.00
IUUC-Ont-072145	Oreochromis niloticus	46.26	8.00e-172	597.00
IUUC-Oan-073144	Ornithorhynchus anatinus	84.91	0.00e+00	1026.00
IUUC-Ocu-074835	Oryctolagus cuniculus	89.90	0.00e+00	1240.00
IUUC-Ola-087520	Oryzias latipes	46.92	3.00e-170	592.00
IUUC-Oga-088605	Otolemur garnettii	97.34	0.00e+00	1395.00
IUUC-Oar-089788	Ovis aries	98.04	0.00e+00	1414.00
IUUC-Ptr-091274	Pan troglodytes	100.00	0.00e+00	1434.00
IUUC-Psi-093560	Pelodiscus sinensis	79.97	0.00e+00	1010.00
IUUC-Pfo-097221	Poecilia formosa	46.70	1.00e-168	587.00
IUUC-Pab-097799	Pongo abelii	99.53	0.00e+00	1254.00
IUUC-Pva-102769	Pteropus vampyrus	97.48	0.00e+00	1363.00
IUUC-Rno-105959	Rattus norvegicus	92.10	0.00e+00	1166.00
IUUC-Sha-106613	Sarcophilus harrisii	88.64	0.00e+00	1265.00
IUUC-Sar-112951	Sorex araneus	86.39	0.00e+00	1082.00
IUUC-Ssc-115673	Sus scrofa	97.76	0.00e+00	1361.00
IUUC-Tgu-116806	Taeniopygia guttata	80.19	0.00e+00	1103.00
IUUC-Tru-117544	Takifugu rubripes	43.21	3.00e-132	465.00
IUUC-Tsy-119233	Tarsius syrichta	90.88	0.00e+00	1241.00
IUUC-Tni-120273	Tetraodon nigroviridis	57.05	6.00e-101	361.00
IUUC-Tbe-128020	Tupaia belangeri	96.76	0.00e+00	1194.00
IUUC-Ttr-128357	Tursiops truncatus	97.76	0.00e+00	1350.00
IUUC-Vpa-130487	Vicugna pacos	98.04	0.00e+00	1413.00
IUUC-Xtr-132415	Xenopus tropicalis	58.08	0.00e+00	796.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence