iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000127837.9	ENST00000248450.8	ENSP00000248450.4
ENSG00000127837.9	ENST00000444053.5	ENSP00000403343.1
ENSG00000127837.9	ENST00000420660.5	ENSP00000416394.1
ENSG00000127837.9	ENST00000422731.1	ENSP00000396295.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	CircNet	miRTarBase	microRNA
TRANSFAC	RepTar	SomamiR	miRcode
RAID2	LncRNADisease
Protein-protein Interaction
HINT	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.10e-32	110.8	91	128
UBD/Beta-Prp	1.30e-48	167.4	90	299

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrtgvll 36
           H++sv+c+++   ++tl v+G+ D +  vW+l++g ll
   Q: 91   HSASVFCVSLdpkTNTLAVTGGEDDKAFVWRLSDGELL 128
           99*********8655999**************999875 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkf.spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
            h  sv  cv    + ++l +tg++d++  vw++++g ll +  gh++ vt+  fs+d+ + +tg   +++kvw ++t + v +++    ++
   Q: 90   LHSASVF-CVSLdPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFE--AGDL 178
           4444455.577735556666899************************************9**************************..8999 PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tgghtdsvysls 187
             ++++p   +l++G++d    +w++++g c   t++g +   +c +v pdg+  v G  D+t+r+Wdlk+g+ ++ l  t+gh+++ ++++
   Q: 179  EWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK--TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLkgTEGHQGPLTCVA 268
           9******************************9..7*******************************************99677********* PP
   S: 188  fdsngkelvsgsldgtvklwdlqtgecvrtl 218
            +++g  +++gs d + kl++  tg++v  +
   Q: 269  ANQDGSLILTGSVDCQAKLVSATTGKVVGVF 299
           **************************99876 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP ADDLAQEMED VDFEEEEEEE 60
GNEEGWVLEP QEGVVGSMEG PDDSEVTFAL HSASVFCVSL DPKTNTLAVT GGEDDKAFVW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCCAGCC AACCTTCGTA GCTATTGGCC GAACGGCCGT CGCTCTTCCT GCTGGGGAGT 60
CGCCTACGCC TACTTCCTGC CGGGAGGAGG GGCTCGAGTT CCGCGTCGTC GCGCAGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0045171--C:intercellular bridge
GO:0015630--C:microtubule cytoskeleton

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000794	Aegilops tauschii	34.91	4.00e-57	216.00
IUUC-Aml-001781	Ailuropoda melanoleuca	96.10	0.00e+00	750.00
IUUC-Atr-003169	Amborella trichopoda	35.82	8.00e-61	227.00
IUUC-Apl-003939	Anas platyrhynchos	66.96	6.00e-115	406.00
IUUC-Aca-004594	Anolis carolinensis	83.62	1.00e-175	609.00
IUUC-Aly-006277	Arabidopsis lyrata	31.25	8.00e-48	184.00
IUUC-Ath-007701	Arabidopsis thaliana	33.43	4.00e-56	211.00
IUUC-Ame-011651	Astyanax mexicanus	55.84	6.00e-134	470.00
IUUC-Bgr-012118	Blumeria graminis	22.82	1.00e-17	85.10
IUUC-Bta-012833	Bos taurus	98.16	0.00e+00	752.00
IUUC-Bdi-014289	Brachypodium distachyon	35.21	4.00e-62	231.00
IUUC-Bol-015313	Brassica oleracea	32.29	9.00e-53	201.00
IUUC-Bra-017115	Brassica rapa	31.43	6.00e-43	168.00
IUUC-Cel-018305	Caenorhabditis elegans	33.14	6.00e-38	151.00
IUUC-Cja-019433	Callithrix jacchus	99.31	0.00e+00	758.00
IUUC-Cfa-020093	Canis familiaris	96.09	0.00e+00	761.00
IUUC-Cpo-021742	Cavia porcellus	95.86	0.00e+00	754.00
IUUC-Cre-022781	Chlamydomonas reinhardtii	33.24	2.00e-42	166.00
IUUC-Csa-023498	Chlorocebus sabaeus	99.54	0.00e+00	757.00
IUUC-Cho-024628	Choloepus hoffmanni	93.59	6.00e-176	610.00
IUUC-Cin-025244	Ciona intestinalis	46.44	4.00e-85	308.00
IUUC-Csv-026218	Ciona savignyi	46.44	8.00e-88	317.00
IUUC-Cne-026911	Cryptococcus neoformans	27.23	4.00e-26	112.00
IUUC-Dre-028528	Danio rerio	65.25	2.00e-139	488.00
IUUC-Dno-029297	Dasypus novemcinctus	97.25	0.00e+00	758.00
IUUC-Dor-030543	Dipodomys ordii	97.16	1.00e-65	243.00
IUUC-Dme-031587	Drosophila melanogaster	30.73	2.00e-45	177.00
IUUC-Ete-033100	Echinops telfairi	97.02	5.00e-125	440.00
IUUC-Eca-034277	Equus caballus	95.76	0.00e+00	733.00
IUUC-Eeu-035052	Erinaceus europaeus	98.07	5.00e-106	377.00
IUUC-Fca-036115	Felis catus	96.09	0.00e+00	759.00
IUUC-Fal-036864	Ficedula albicollis	82.09	2.00e-177	615.00
IUUC-Gmo-039090	Gadus morhua	60.95	6.00e-99	353.00
IUUC-Gga-040545	Gallus gallus	79.38	0.00e+00	626.00
IUUC-Gac-042027	Gasterosteus aculeatus	60.84	1.00e-141	496.00
IUUC-Gma-044168	Glycine max	35.92	1.00e-57	217.00
IUUC-Ggo-045036	Gorilla gorilla	100.00	0.00e+00	761.00
IUUC-Hvu-047217	Hordeum vulgare	34.96	7.00e-59	221.00
IUUC-Itr-048114	Ictidomys tridecemlineatus	96.09	0.00e+00	755.00
IUUC-Kpa-049147	Komagataella pastoris	25.20	5.00e-24	105.00
IUUC-Lch-049747	Latimeria chalumnae	65.45	7.00e-138	483.00
IUUC-Lpe-051433	Leersia perrieri	32.73	2.00e-53	202.00
IUUC-Loc-052406	Lepisosteus oculatus	68.90	6.00e-160	556.00
IUUC-Lma-053153	Leptosphaeria maculans	27.75	5.00e-15	75.90
IUUC-Laf-053901	Loxodonta africana	96.09	0.00e+00	754.00
IUUC-Mcc-054990	Macaca mulatta	99.73	0.00e+00	710.00
IUUC-Meu-056844	Macropus eugenii	86.94	0.00e+00	653.00
IUUC-Mtr-057759	Medicago truncatula	37.18	6.00e-59	221.00
IUUC-Mla-058856	Melampsora laricipopulina	29.17	1.00e-36	147.00
IUUC-Mga-059749	Meleagris gallopavo	81.20	2.00e-177	615.00
IUUC-Mvi-060237	Microbotryum violaceum	31.15	6.00e-44	171.00
IUUC-Mmr-061270	Microcebus murinus	91.81	0.00e+00	740.00
IUUC-Mdo-062965	Monodelphis domestica	86.70	0.00e+00	662.00
IUUC-Mmu-064081	Mus musculus	97.71	0.00e+00	761.00
IUUC-Mac-065236	Musa acuminata	33.43	4.00e-56	211.00
IUUC-Mpu-066355	Mustela putorius furo	96.55	0.00e+00	762.00
IUUC-Mlu-067630	Myotis lucifugus	95.18	0.00e+00	746.00
IUUC-Nle-069701	Nomascus leucogenys	99.31	0.00e+00	761.00
IUUC-Opr-070337	Ochotona princeps	89.43	0.00e+00	687.00
IUUC-Ont-072614	Oreochromis niloticus	69.71	7.00e-148	516.00
IUUC-Ocu-073912	Oryctolagus cuniculus	97.02	0.00e+00	749.00
IUUC-Oba-075195	Oryza barthii	32.44	6.00e-54	204.00
IUUC-Obr-076059	Oryza brachyantha	31.90	2.00e-55	209.00
IUUC-Ogl-077318	Oryza glaberrima	32.18	5.00e-56	211.00
IUUC-Ogu-078579	Oryza glumaepatula	32.05	6.00e-54	204.00
IUUC-Oin-079340	Oryza indica	32.18	5.00e-56	211.00
IUUC-Olo-080813	Oryza longistaminata	32.64	2.00e-54	206.00
IUUC-Ome-081420	Oryza meridionalis	33.04	2.00e-54	206.00
IUUC-Oni-082650	Oryza nivara	32.44	6.00e-54	204.00
IUUC-Opu-083832	Oryza punctata	33.04	8.00e-56	211.00
IUUC-Oru-084207	Oryza rufipogon	32.44	6.00e-54	204.00
IUUC-Osa-085708	Oryza sativa	32.18	5.00e-56	211.00
IUUC-Ola-087164	Oryzias latipes	70.57	3.00e-148	518.00
IUUC-Olu-087824	Ostreococcus lucimarinus	37.60	9.00e-51	194.00
IUUC-Oga-088864	Otolemur garnettii	97.02	0.00e+00	752.00
IUUC-Oar-090115	Ovis aries	98.85	0.00e+00	758.00
IUUC-Ptr-091398	Pan troglodytes	99.54	0.00e+00	762.00
IUUC-Pan-092002	Papio anubis	99.77	0.00e+00	758.00
IUUC-Psi-093979	Pelodiscus sinensis	86.90	1.00e-88	318.00
IUUC-Pma-094618	Petromyzon marinus	61.11	2.00e-128	452.00
IUUC-Ppa-095351	Physcomitrella patens	37.71	2.00e-66	246.00
IUUC-Pfo-097078	Poecilia formosa	72.57	1.00e-150	525.00
IUUC-Pab-098540	Pongo abelii	99.31	0.00e+00	761.00
IUUC-Pop-099140	Populus trichocarpa	35.53	5.00e-58	218.00
IUUC-Pca-101072	Procavia capensis	90.34	0.00e+00	701.00
IUUC-Ppe-101979	Prunus persica	36.34	7.00e-59	221.00
IUUC-Pva-102400	Pteropus vampyrus	88.05	0.00e+00	673.00
IUUC-Pgr-103362	Puccinia graminis	29.06	2.00e-43	170.00
IUUC-Ptt-103756	Puccinia triticina	31.93	1.00e-32	134.00
IUUC-Rno-105672	Rattus norvegicus	95.86	0.00e+00	766.00
IUUC-Sja-107693	Schizosaccharomyces japonicus	29.36	4.00e-44	172.00
IUUC-Spo-108208	Schizosaccharomyces pombe	29.66	2.00e-47	182.00
IUUC-Smo-109168	Selaginella moellendorffii	34.99	2.00e-57	216.00
IUUC-Sit-109978	Setaria italica	33.05	7.00e-56	211.00
IUUC-Sly-111316	Solanum lycopersicum	36.00	9.00e-60	224.00
IUUC-Stu-111956	Solanum tuberosum	37.32	7.00e-62	231.00
IUUC-Sbi-114189	Sorghum bicolor	33.05	1.00e-53	203.00
IUUC-Sre-115029	Sporisorium reilianum	33.14	6.00e-41	161.00
IUUC-Ssc-116045	Sus scrofa	88.51	6.00e-168	583.00
IUUC-Tgu-117514	Taeniopygia guttata	81.54	2.00e-176	611.00
IUUC-Tru-117851	Takifugu rubripes	67.14	5.00e-142	497.00
IUUC-Tsy-119140	Tarsius syrichta	89.43	0.00e+00	689.00
IUUC-Tni-120248	Tetraodon nigroviridis	67.71	2.00e-142	498.00
IUUC-Tca-121686	Theobroma cacao	32.59	3.00e-55	209.00
IUUC-Tae-123968	Triticum aestivum	34.96	5.00e-59	221.00
IUUC-Tur-126174	Triticum urartu	35.21	6.00e-57	214.00
IUUC-Tme-127079	Tuber melanosporum	27.92	2.00e-13	70.90
IUUC-Tbe-127476	Tupaia belangeri	97.58	2.00e-106	379.00
IUUC-Ttr-128182	Tursiops truncatus	97.24	0.00e+00	762.00
IUUC-Uma-129624	Ustilago maydis	32.55	5.00e-44	172.00
IUUC-Vpa-130605	Vicugna pacos	90.10	9.00e-172	596.00
IUUC-Vvi-131319	Vitis vinifera	34.01	8.00e-57	214.00
IUUC-Xtr-132193	Xenopus tropicalis	69.64	3.00e-164	571.00
IUUC-Xma-133880	Xiphophorus maculatus	71.71	3.00e-150	524.00
IUUC-Yli-134520	Yarrowia lipolytica	28.69	1.00e-26	114.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence