iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.40e-76	256.2	4553	4881

Active Site

Position(s)	Description	Evidence
4850	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrlldlplsksfy 97
           ++++v+fvgE++ d+gG  +e +a++++elqn +++l+ +++n++ +   n+d +l +p      ++++F+flG+l+g+a+++g +l ++l+++++
   Q: 4553 RVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPtlssvLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVW 4648
           4556****************************************************9999**9999****************************** PP
   S: 98   klllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveaf 193
           ++l g+ l   dl evd++++  l  i++++++    ++l+l fs+     ++++ +e   + + +++   N+ eYv+l + +rl+e ++eqv+a+
   Q: 4649 RQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFST-----SSARGHEVPLSTRYTHISPRNRAEYVRLALGFRLHE-FDEQVKAV 4738
           ******************************8887888899999994.....55788889999*************************.******** PP
   S: 194  reGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvi 289
           r+G+++vip  llslF++ el+ ++cG+++i +  lk+ ++ykg + ++s  + wFwev+eef+++er+ fL+Fv+g+ rlP + +a+++ r fv+
   Q: 4739 RDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKG-FDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLP-RTIADFRGRDFVL 4832
           ******************************************77.*************************************.7999999999988 PP
   S: 290  rk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +    +  d+ lP+s TCf++Lk+P+Ys k +l ekL yAi+ +k++++
   Q: 4833 QVlekNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSIDT 4881
           888768888***********************************99875 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MFNRQASGGA GSSGQGAGSS QTASAAPVSA GVGVGGGGGA SGAAAGAGSA AGSGSGSGSG 60
SAAPPSHSPD LYLRPLPFLD AKWLRADLIA SLRNAADGAV LWNHLIQDCE LVSSPTAPLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCAGTTTG CACCTCCCCC TGATATCGAT TGCCATCAAA CAATTTTATT TCATTTTAAA 60
ATAATTCCTT GATTTCAAAT TGCATTGTAC TGGTAACTGG CACTTCCAAT TGTGACCCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS50030--UBA

Pfam

PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM00119--HECTc

Gene Ontology

GO:0005814--C:centriole
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0016567--P:protein ubiquitination

KEGG

dme:Dmel_CG11734

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	59.72	0.00e+00	1561.00
IUUC-Atr-003065	Amborella trichopoda	34.11	7.00e-46	178.00
IUUC-Apl-003983	Anas platyrhynchos	60.45	0.00e+00	1574.00
IUUC-Aca-004300	Anolis carolinensis	60.26	0.00e+00	1575.00
IUUC-Aly-006545	Arabidopsis lyrata	35.22	1.00e-46	181.00
IUUC-Ath-007268	Arabidopsis thaliana	33.46	1.00e-28	121.00
IUUC-Ame-010621	Astyanax mexicanus	60.35	0.00e+00	1560.00
IUUC-Bta-013067	Bos taurus	60.17	0.00e+00	1551.00
IUUC-Bol-015203	Brassica oleracea	34.12	5.00e-49	189.00
IUUC-Bra-016737	Brassica rapa	34.88	8.00e-46	178.00
IUUC-Cja-019687	Callithrix jacchus	36.70	0.00e+00	1557.00
IUUC-Cfa-020672	Canis familiaris	59.72	0.00e+00	1563.00
IUUC-Cpo-021819	Cavia porcellus	70.52	0.00e+00	1272.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	38.65	2.00e-46	178.00
IUUC-Csa-023817	Chlorocebus sabaeus	59.80	0.00e+00	1535.00
IUUC-Cho-024387	Choloepus hoffmanni	43.41	0.00e+00	717.00
IUUC-Cin-025709	Ciona intestinalis	50.11	0.00e+00	1244.00
IUUC-Csv-026336	Ciona savignyi	50.49	0.00e+00	1253.00
IUUC-Dre-027717	Danio rerio	60.16	0.00e+00	1553.00
IUUC-Dno-029296	Dasypus novemcinctus	59.87	0.00e+00	1560.00
IUUC-Dor-030979	Dipodomys ordii	66.91	0.00e+00	757.00
IUUC-Ete-032687	Echinops telfairi	48.50	0.00e+00	648.00
IUUC-Eca-034046	Equus caballus	59.58	0.00e+00	1557.00
IUUC-Eeu-034859	Erinaceus europaeus	56.40	0.00e+00	895.00
IUUC-Fca-036262	Felis catus	59.65	0.00e+00	1560.00
IUUC-Fal-037562	Ficedula albicollis	60.45	0.00e+00	1574.00
IUUC-Gmo-038739	Gadus morhua	65.54	0.00e+00	749.00
IUUC-Gga-040359	Gallus gallus	60.31	0.00e+00	1570.00
IUUC-Gac-041879	Gasterosteus aculeatus	65.54	0.00e+00	766.00
IUUC-Gma-043616	Glycine max	37.73	3.00e-45	175.00
IUUC-Ggo-044692	Gorilla gorilla	59.50	0.00e+00	1524.00
IUUC-Hsa-045995	Homo sapiens	59.80	0.00e+00	1539.00
IUUC-Hvu-047529	Hordeum vulgare	34.27	4.00e-47	182.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	39.50	3.00e-168	585.00
IUUC-Lch-049808	Latimeria chalumnae	71.89	0.00e+00	1286.00
IUUC-Lpe-051165	Leersia perrieri	35.79	3.00e-43	168.00
IUUC-Loc-052685	Lepisosteus oculatus	71.44	0.00e+00	1282.00
IUUC-Laf-053372	Loxodonta africana	59.65	0.00e+00	1556.00
IUUC-Mcc-054693	Macaca mulatta	59.87	0.00e+00	1540.00
IUUC-Meu-056660	Macropus eugenii	64.32	0.00e+00	1335.00
IUUC-Mtr-058277	Medicago truncatula	30.25	5.00e-47	181.00
IUUC-Mga-059371	Meleagris gallopavo	71.86	0.00e+00	1289.00
IUUC-Mmr-060787	Microcebus murinus	59.80	0.00e+00	1549.00
IUUC-Mdo-062518	Monodelphis domestica	62.50	0.00e+00	1103.00
IUUC-Mmu-063690	Mus musculus	59.94	0.00e+00	1562.00
IUUC-Mpu-066478	Mustela putorius furo	59.65	0.00e+00	1550.00
IUUC-Mlu-067596	Myotis lucifugus	38.88	0.00e+00	1054.00
IUUC-Nle-069633	Nomascus leucogenys	39.55	1.00e-162	568.00
IUUC-Opr-070990	Ochotona princeps	61.30	0.00e+00	1523.00
IUUC-Ont-072285	Oreochromis niloticus	60.12	0.00e+00	1562.00
IUUC-Oan-072721	Ornithorhynchus anatinus	60.23	0.00e+00	1562.00
IUUC-Ocu-074273	Oryctolagus cuniculus	59.55	0.00e+00	1552.00
IUUC-Oba-075262	Oryza barthii	36.73	2.00e-43	169.00
IUUC-Obr-076115	Oryza brachyantha	37.86	6.00e-45	174.00
IUUC-Ogl-077586	Oryza glaberrima	36.73	2.00e-43	169.00
IUUC-Ogu-078796	Oryza glumaepatula	36.73	2.00e-43	169.00
IUUC-Oin-079298	Oryza indica	36.73	2.00e-43	169.00
IUUC-Olo-080768	Oryza longistaminata	34.24	1.00e-45	176.00
IUUC-Ome-081908	Oryza meridionalis	31.18	3.00e-43	168.00
IUUC-Oni-082049	Oryza nivara	36.73	2.00e-43	169.00
IUUC-Opu-083608	Oryza punctata	35.59	3.00e-43	168.00
IUUC-Oru-084712	Oryza rufipogon	36.73	2.00e-43	169.00
IUUC-Osa-086078	Oryza sativa	36.73	2.00e-43	169.00
IUUC-Ola-087346	Oryzias latipes	67.82	0.00e+00	890.00
IUUC-Oga-088742	Otolemur garnettii	56.14	0.00e+00	2191.00
IUUC-Oar-090093	Ovis aries	44.29	0.00e+00	2677.00
IUUC-Ptr-091034	Pan troglodytes	52.65	0.00e+00	1289.00
IUUC-Pan-092783	Papio anubis	59.87	0.00e+00	1538.00
IUUC-Psi-094027	Pelodiscus sinensis	72.04	0.00e+00	1291.00
IUUC-Pma-094275	Petromyzon marinus	39.35	2.00e-65	244.00
IUUC-Pfo-097354	Poecilia formosa	67.81	0.00e+00	778.00
IUUC-Pab-097760	Pongo abelii	39.93	1.00e-169	591.00
IUUC-Pop-099121	Populus trichocarpa	34.50	3.00e-46	179.00
IUUC-Pca-100465	Procavia capensis	40.00	5.00e-170	593.00
IUUC-Ppe-101345	Prunus persica	35.47	6.00e-46	179.00
IUUC-Pva-103147	Pteropus vampyrus	47.10	0.00e+00	670.00
IUUC-Rno-105458	Rattus norvegicus	59.87	0.00e+00	1560.00
IUUC-Sha-106959	Sarcophilus harrisii	55.77	0.00e+00	1370.00
IUUC-Smo-108827	Selaginella moellendorffii	34.79	4.00e-48	186.00
IUUC-Sly-111155	Solanum lycopersicum	33.82	1.00e-48	187.00
IUUC-Stu-112166	Solanum tuberosum	35.11	1.00e-44	174.00
IUUC-Sar-113532	Sorex araneus	48.73	2.00e-146	514.00
IUUC-Sbi-114352	Sorghum bicolor	33.42	9.00e-47	181.00
IUUC-Ssc-116304	Sus scrofa	67.30	0.00e+00	671.00
IUUC-Tgu-116789	Taeniopygia guttata	71.83	0.00e+00	1288.00
IUUC-Tru-118129	Takifugu rubripes	60.26	0.00e+00	1564.00
IUUC-Tsy-119302	Tarsius syrichta	46.78	1.00e-143	505.00
IUUC-Tni-120374	Tetraodon nigroviridis	60.03	0.00e+00	1557.00
IUUC-Tca-121094	Theobroma cacao	34.31	2.00e-48	187.00
IUUC-Tae-124157	Triticum aestivum	36.47	1.00e-48	187.00
IUUC-Tur-126300	Triticum urartu	34.27	1.00e-47	184.00
IUUC-Tbe-128137	Tupaia belangeri	64.73	9.00e-161	562.00
IUUC-Ttr-128273	Tursiops truncatus	55.68	0.00e+00	1383.00
IUUC-Vpa-130471	Vicugna pacos	43.29	4.00e-137	483.00
IUUC-Xtr-132185	Xenopus tropicalis	70.95	0.00e+00	1269.00
IUUC-Xma-133233	Xiphophorus maculatus	60.48	0.00e+00	1557.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence