iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/NEDD8	2.60e-42	143.2	1	76
ULD/UDP/UBQ/UBQ_PIM	5.90e-22	77.7	1	71

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/NEDD8

   S: 1    mlikvktLtgkeieieieesdtierikerveekeGiPPsqqrliyaGkqleddktaadynlekgsvLhLvLaLrGG 76
           mlikvktLtgkeie++ie+ d++erike+veekeGiPP qqrli+aGkq++ddktaady++ +gsvLhLvLaLrGG
   Q: 1    MLIKVKTLTGKEIELDIEPNDRVERIKEKVEEKEGIPPPQQRLIFAGKQMNDDKTAADYKVLGGSVLHLVLALRGG 76
           89*************************************************************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvv 71
           m ++vktl+gke+el+++++d ve+ Kek++++ g+pp qq+LI+aGk+++Dd+t  ++++  gsv+hlv+
   Q: 1    MLIKVKTLTGKEIELDIEPNDRVERIKEKVEEKEGIPPPQQRLIFAGKQMNDDKTAADYKVLGGSVLHLVL 71
           789******************************************************************97 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex uba-3-ula-1 and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

Protein Sequence
(Fasta)

MLIKVKTLTG KEIELDIEPN DRVERIKEKV EEKEGIPPPQ QRLIFAGKQM NDDKTAADYK 60
VLGGSVLHLV LALRGGF 77

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTACTTCA TTCGCTTTTC TTTCGTCTTG ACGAACGGTG AGCAATTTTC TATCTCATTT 60
CTTGAATTTT TCTTCTTCTT TTCTCAATAA TATATTTCAT AGCTATGAGA ACTTTTAATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

PRINTS

PR00348--UBIQUITIN

SMART

SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0007275--P:multicellular organism development
GO:0043066--P:negative regulation of apoptotic process
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0010629--P:negative regulation of gene expression
GO:0043065--P:positive regulation of apoptotic process

KEGG

cel:CELE_F45H11.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001930	Ailuropoda melanoleuca	83.33	1.00e-18	82.40
IUUC-Atr-003172	Amborella trichopoda	78.95	4.00e-32	127.00
IUUC-Ago-008002	Ashbya gossypii	64.47	1.00e-24	102.00
IUUC-Acl-008037	Aspergillus clavatus	80.26	5.00e-31	123.00
IUUC-Afu-008979	Aspergillus fumigatus	75.00	2.00e-29	118.00
IUUC-Ani-009466	Aspergillus nidulans	80.26	5.00e-31	123.00
IUUC-Ang-009839	Aspergillus niger	78.95	1.00e-30	122.00
IUUC-Ame-011045	Astyanax mexicanus	86.84	2.00e-27	112.00
IUUC-Bgr-011975	Blumeria graminis	75.00	5.00e-28	113.00
IUUC-Bta-013565	Bos taurus	81.25	6.00e-20	87.00
IUUC-Bci-013689	Botrytis cinerea	71.43	2.00e-20	88.60
IUUC-Cja-019714	Callithrix jacchus	86.15	1.00e-21	92.40
IUUC-Cfa-020576	Canis familiaris	83.33	1.00e-18	82.40
IUUC-Cpo-022447	Cavia porcellus	80.00	1.00e-19	86.30
IUUC-Csa-023443	Chlorocebus sabaeus	84.21	3.00e-34	134.00
IUUC-Cho-024788	Choloepus hoffmanni	88.16	6.00e-28	113.00
IUUC-Cin-025290	Ciona intestinalis	89.47	4.00e-29	117.00
IUUC-Cgl-026712	Colletotrichum gloeosporioides	73.68	8.00e-28	112.00
IUUC-Cme-027142	Cyanidioschyzon merolae	75.00	1.00e-24	103.00
IUUC-Dre-028273	Danio rerio	86.84	2.00e-27	111.00
IUUC-Dor-030213	Dipodomys ordii	88.16	4.00e-28	114.00
IUUC-Dse-031407	Dothistroma septosporum	76.32	1.00e-29	119.00
IUUC-Dme-031610	Drosophila melanogaster	89.47	1.00e-35	139.00
IUUC-Ete-032442	Echinops telfairi	88.16	8.00e-28	113.00
IUUC-Eca-033619	Equus caballus	86.15	1.00e-21	92.40
IUUC-Eeu-035250	Erinaceus europaeus	86.15	1.00e-21	92.40
IUUC-Fca-036565	Felis catus	81.97	8.00e-19	83.20
IUUC-Fal-036836	Ficedula albicollis	77.27	9.00e-19	83.20
IUUC-Fox-037878	Fusarium oxysporum	76.32	8.00e-29	116.00
IUUC-Fso-038359	Fusarium solani	76.32	8.00e-29	116.00
IUUC-Gmo-038699	Gadus morhua	84.62	8.00e-21	89.70
IUUC-Ggr-039872	Gaeumannomyces graminis	78.95	7.00e-30	120.00
IUUC-Gga-041132	Gallus gallus	86.30	2.00e-25	106.00
IUUC-Gac-042098	Gasterosteus aculeatus	86.84	3.00e-27	111.00
IUUC-Ggo-044777	Gorilla gorilla	84.75	2.00e-18	82.00
IUUC-Hsa-045911	Homo sapiens	86.15	1.00e-21	92.40
IUUC-Hvu-047076	Hordeum vulgare	78.95	2.00e-23	98.20
IUUC-Itr-048900	Ictidomys tridecemlineatus	88.16	4.00e-28	114.00
IUUC-Lch-050564	Latimeria chalumnae	86.84	2.00e-27	111.00
IUUC-Lma-053069	Leptosphaeria maculans	77.63	3.00e-30	121.00
IUUC-Laf-053906	Loxodonta africana	84.21	5.00e-26	107.00
IUUC-Mcc-054619	Macaca mulatta	72.13	4.00e-21	90.90
IUUC-Meu-056784	Macropus eugenii	84.62	7.00e-21	90.10
IUUC-Mor-057128	Magnaporthe oryzae	81.58	6.00e-31	123.00
IUUC-Mpo-057329	Magnaporthe poae	80.26	3.00e-30	121.00
IUUC-Mla-058992	Melampsora laricipopulina	72.37	8.00e-22	93.20
IUUC-Mvi-060369	Microbotryum violaceum	73.68	1.00e-27	112.00
IUUC-Mdo-062773	Monodelphis domestica	81.67	7.00e-18	80.10
IUUC-Mmu-063552	Mus musculus	86.36	4.00e-22	94.40
IUUC-Mpu-065984	Mustela putorius furo	85.92	5.00e-25	103.00
IUUC-Nfi-068282	Neosartorya fischeri	75.00	2.00e-29	118.00
IUUC-Ncr-068922	Neurospora crassa	78.95	5.00e-30	120.00
IUUC-Nle-069841	Nomascus leucogenys	85.48	4.00e-19	86.70
IUUC-Ocu-074716	Oryctolagus cuniculus	86.15	1.00e-21	92.40
IUUC-Opu-083943	Oryza punctata	59.46	9.00e-22	92.80
IUUC-Olu-087844	Ostreococcus lucimarinus	82.67	6.00e-23	97.10
IUUC-Oar-089805	Ovis aries	83.33	1.00e-18	82.40
IUUC-Pan-092763	Papio anubis	86.15	1.00e-21	92.40
IUUC-Pno-095039	Phaeosphaeria nodorum	77.92	6.00e-31	123.00
IUUC-Pfo-096478	Poecilia formosa	86.84	1.00e-27	112.00
IUUC-Pab-098633	Pongo abelii	84.62	6.00e-21	90.10
IUUC-Pca-100180	Procavia capensis	86.15	1.00e-21	92.40
IUUC-Pva-102640	Pteropus vampyrus	86.15	1.00e-21	92.40
IUUC-Pgr-103621	Puccinia graminis	68.42	6.00e-27	110.00
IUUC-Pte-104313	Pyrenophora teres	77.92	1.00e-31	125.00
IUUC-Pyt-104549	Pyrenophora triticirepentis	76.62	4.00e-31	124.00
IUUC-Rno-105633	Rattus norvegicus	86.36	4.00e-22	94.40
IUUC-Sha-107504	Sarcophilus harrisii	80.26	4.00e-25	104.00
IUUC-Sja-107751	Schizosaccharomyces japonicus	82.89	1.00e-32	129.00
IUUC-Spo-108180	Schizosaccharomyces pombe	82.89	2.00e-32	128.00
IUUC-Smo-108916	Selaginella moellendorffii	72.22	7.00e-24	100.00
IUUC-Sar-113327	Sorex araneus	86.15	1.00e-21	92.40
IUUC-Sre-114970	Sporisorium reilianum	81.58	9.00e-32	126.00
IUUC-Ssc-115698	Sus scrofa	79.69	5.00e-19	84.00
IUUC-Tru-118771	Takifugu rubripes	86.84	1.00e-27	112.00
IUUC-Tsy-118907	Tarsius syrichta	86.15	1.00e-21	92.40
IUUC-Tni-120371	Tetraodon nigroviridis	86.84	2.00e-27	111.00
IUUC-Tre-122155	Trichoderma reesei	76.32	1.00e-28	115.00
IUUC-Tvi-122440	Trichoderma virens	76.32	5.00e-29	117.00
IUUC-Tme-126933	Tuber melanosporum	75.00	3.00e-29	117.00
IUUC-Ttr-128587	Tursiops truncatus	82.61	1.00e-20	89.40
IUUC-Uma-129335	Ustilago maydis	79.22	2.00e-31	124.00
IUUC-Vda-129767	Verticillium dahliae	75.00	4.00e-28	114.00
IUUC-Vpa-130121	Vicugna pacos	84.62	1.00e-20	89.00
IUUC-Xtr-132345	Xenopus tropicalis	86.84	2.00e-27	111.00
IUUC-Xma-134074	Xiphophorus maculatus	84.51	2.00e-24	101.00
IUUC-Yli-134497	Yarrowia lipolytica	64.47	3.00e-25	104.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence