iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.60e-14	53.1	164	218

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v++ ++++ +n+deL+  kGd+++v     +++gW++g  +l+g+ G fP+n+v++++
   Q: 164  IVKARFNFKQTNEDELSVCKGDIIYVT--RVEEGGWWEG--TLNGRTGWFPSNYVREIK 218
           68999*********************7..999*******..8**************997 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1 (By similarity). Interacts with PARVB. Interacts with BIN2. Identified in a complex with BIN2 and GIT2.

Protein Sequence
(Fasta)

MNPEEQIVTW LISLGVLESP KKTICDPEEF LKSSLKNGVV LCKLINRLMP GSVEKFCLDP 60
QTEADCINNI NDFLKGCATL QVEIFDPDDL YSGVNFSKVL STLLAVNKAT EDQLSERPCG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTAAAGTTG GCCTTATCAT AAATTTCCCA ATAGTATGCC TATTTCAAGT GGTTCTGAAA 60
ATGTTTGAGA ATGATGAAGA TCTCTTGTTA TAGACAGTTT TTTTTTCAGA GCAGTATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0991--Mental retardation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain
IPR003096--SM22_calponin

PROSITE

PS50021--CH
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0030027--C:lamellipodium
GO:0005096--F:GTPase activator activity
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0006915--P:apoptotic process
GO:0007254--P:JNK cascade
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0035023--P:regulation of Rho protein signal transduction
GO:0051056--P:regulation of small GTPase mediated signal transduction

KEGG

hsa:9459

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001631	Ailuropoda melanoleuca	79.35	0.00e+00	1265.00
IUUC-Apl-003960	Anas platyrhynchos	75.00	0.00e+00	1122.00
IUUC-Aca-004988	Anolis carolinensis	69.79	0.00e+00	1040.00
IUUC-Ame-011546	Astyanax mexicanus	63.13	0.00e+00	951.00
IUUC-Bta-013527	Bos taurus	94.59	0.00e+00	1412.00
IUUC-Cja-018935	Callithrix jacchus	97.94	0.00e+00	1457.00
IUUC-Cfa-021269	Canis familiaris	93.81	0.00e+00	1399.00
IUUC-Cpo-021620	Cavia porcellus	88.09	0.00e+00	1306.00
IUUC-Csa-023415	Chlorocebus sabaeus	98.58	0.00e+00	1464.00
IUUC-Dre-028580	Danio rerio	62.88	0.00e+00	964.00
IUUC-Dno-029201	Dasypus novemcinctus	89.88	0.00e+00	1368.00
IUUC-Dor-030868	Dipodomys ordii	75.13	0.00e+00	1028.00
IUUC-Eca-033500	Equus caballus	94.59	0.00e+00	1392.00
IUUC-Eeu-035269	Erinaceus europaeus	81.61	3.00e-164	572.00
IUUC-Fca-035683	Felis catus	93.56	0.00e+00	1370.00
IUUC-Fal-037611	Ficedula albicollis	75.13	0.00e+00	1123.00
IUUC-Gmo-038980	Gadus morhua	61.02	0.00e+00	917.00
IUUC-Gga-040940	Gallus gallus	74.06	0.00e+00	1119.00
IUUC-Gac-042203	Gasterosteus aculeatus	59.87	0.00e+00	936.00
IUUC-Ggo-044755	Gorilla gorilla	99.48	0.00e+00	1478.00
IUUC-Lch-049517	Latimeria chalumnae	69.03	0.00e+00	1038.00
IUUC-Loc-052393	Lepisosteus oculatus	63.98	0.00e+00	1011.00
IUUC-Laf-054196	Loxodonta africana	91.87	0.00e+00	1330.00
IUUC-Mcc-055716	Macaca mulatta	98.58	0.00e+00	1464.00
IUUC-Meu-056285	Macropus eugenii	72.29	0.00e+00	671.00
IUUC-Mtr-058576	Medicago truncatula	44.62	4.00e-11	62.00
IUUC-Mga-060029	Meleagris gallopavo	74.87	0.00e+00	1138.00
IUUC-Mmr-060803	Microcebus murinus	94.85	0.00e+00	1404.00
IUUC-Mdo-062654	Monodelphis domestica	78.92	0.00e+00	1210.00
IUUC-Mmu-063479	Mus musculus	91.23	0.00e+00	1332.00
IUUC-Mpu-066065	Mustela putorius furo	93.17	0.00e+00	1364.00
IUUC-Mlu-068222	Myotis lucifugus	92.79	0.00e+00	1353.00
IUUC-Nle-069379	Nomascus leucogenys	99.23	0.00e+00	1474.00
IUUC-Opr-070687	Ochotona princeps	73.68	0.00e+00	826.00
IUUC-Ont-072240	Oreochromis niloticus	58.39	0.00e+00	912.00
IUUC-Oan-073067	Ornithorhynchus anatinus	80.15	0.00e+00	1216.00
IUUC-Ocu-074852	Oryctolagus cuniculus	93.69	0.00e+00	1378.00
IUUC-Oga-089048	Otolemur garnettii	88.07	0.00e+00	1211.00
IUUC-Oar-089339	Ovis aries	94.72	0.00e+00	1409.00
IUUC-Pan-092666	Papio anubis	96.02	0.00e+00	1410.00
IUUC-Psi-093116	Pelodiscus sinensis	75.16	0.00e+00	1164.00
IUUC-Pfo-097394	Poecilia formosa	62.13	0.00e+00	930.00
IUUC-Pab-098567	Pongo abelii	99.23	0.00e+00	1475.00
IUUC-Pca-100997	Procavia capensis	79.25	0.00e+00	1105.00
IUUC-Pva-102500	Pteropus vampyrus	92.27	0.00e+00	1335.00
IUUC-Rno-104974	Rattus norvegicus	91.48	0.00e+00	1313.00
IUUC-Sar-113420	Sorex araneus	88.02	0.00e+00	1285.00
IUUC-Ssc-115679	Sus scrofa	94.65	0.00e+00	1247.00
IUUC-Tgu-117069	Taeniopygia guttata	74.61	0.00e+00	1119.00
IUUC-Tru-118488	Takifugu rubripes	56.14	0.00e+00	823.00
IUUC-Tsy-119243	Tarsius syrichta	87.18	0.00e+00	963.00
IUUC-Tni-120584	Tetraodon nigroviridis	60.08	0.00e+00	920.00
IUUC-Tbe-127994	Tupaia belangeri	78.61	0.00e+00	1134.00
IUUC-Ttr-128839	Tursiops truncatus	92.53	0.00e+00	1338.00
IUUC-Vpa-130144	Vicugna pacos	85.47	0.00e+00	1199.00
IUUC-Xtr-132624	Xenopus tropicalis	70.82	0.00e+00	1078.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence