iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000130024.14	ENST00000366780.8	ENSP00000355743.4
ENSG00000130024.14	ENST00000339209.8	ENSP00000341805.4
ENSG00000130024.14	ENST00000612128.1	ENSP00000479515.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	5.40e-13	50.6	434	480

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           k C +Cg+++++e +++ C+ C++ +H  C++l      p+   wiC  C++
   Q: 434  KTCIICGQPHHEE-EMMFCDMCDRGYHTFCVGLG---AIPSGR-WICDCCQR 480
           78*********88.5*******************...999996.******86 PP

Organism

Homo sapiens

Functional Description
(View)

Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Protein Sequence
(Fasta)

MAAAAGPGAA LSPRPCDSDP ATPGAQSPKD DNEDNSNDGT QPSKRRRMGS GDSSRSCETS 60
SQDLGFSYYP AENLIEYKWP PDETGEYYML QEQVSEYLGV TSFKRKYPDL ERRDLSHKEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGACAAGAA GTGCGGCGGA AGCTTACACC TGCACGTGGT GGGACAGAGG CAAGAACGGA 60
TGGTCTGGCT GAGGCTGAGA GAACCAAGCT GGATTAGGAT CGGCTTGAGG GCCCGGCGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00628--PHD

SMART

SM00249--PHD

Gene Ontology

GO:0071564--C:npBAF complex
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0007399--P:nervous system development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:55274

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001967	Ailuropoda melanoleuca	97.01	0.00e+00	829.00
IUUC-Apl-003184	Anas platyrhynchos	90.28	0.00e+00	701.00
IUUC-Aca-005357	Anolis carolinensis	86.68	0.00e+00	768.00
IUUC-Ame-011482	Astyanax mexicanus	74.31	0.00e+00	630.00
IUUC-Bta-013488	Bos taurus	93.17	0.00e+00	636.00
IUUC-Cel-018612	Caenorhabditis elegans	31.99	1.00e-59	223.00
IUUC-Cja-018959	Callithrix jacchus	96.91	0.00e+00	845.00
IUUC-Cfa-020275	Canis familiaris	97.17	0.00e+00	808.00
IUUC-Cpo-021997	Cavia porcellus	97.07	0.00e+00	744.00
IUUC-Csa-024058	Chlorocebus sabaeus	99.56	0.00e+00	834.00
IUUC-Cin-025585	Ciona intestinalis	54.05	9.00e-66	244.00
IUUC-Csv-026176	Ciona savignyi	52.70	6.00e-63	235.00
IUUC-Dre-027911	Danio rerio	73.15	0.00e+00	633.00
IUUC-Dno-028846	Dasypus novemcinctus	98.09	0.00e+00	839.00
IUUC-Dor-030929	Dipodomys ordii	96.83	0.00e+00	735.00
IUUC-Dme-032114	Drosophila melanogaster	31.03	3.00e-32	135.00
IUUC-Ete-032648	Echinops telfairi	91.12	7.00e-94	337.00
IUUC-Eca-034382	Equus caballus	95.85	0.00e+00	728.00
IUUC-Eeu-035027	Erinaceus europaeus	95.85	0.00e+00	731.00
IUUC-Fca-036040	Felis catus	93.56	0.00e+00	756.00
IUUC-Fal-037535	Ficedula albicollis	90.40	0.00e+00	777.00
IUUC-Gmo-038527	Gadus morhua	72.68	3.00e-147	514.00
IUUC-Gga-040769	Gallus gallus	82.65	0.00e+00	640.00
IUUC-Gac-042584	Gasterosteus aculeatus	67.71	4.00e-149	521.00
IUUC-Ggo-045145	Gorilla gorilla	99.51	0.00e+00	747.00
IUUC-Itr-047896	Ictidomys tridecemlineatus	97.65	0.00e+00	828.00
IUUC-Lch-050598	Latimeria chalumnae	69.87	9.00e-174	603.00
IUUC-Loc-052902	Lepisosteus oculatus	82.21	0.00e+00	674.00
IUUC-Laf-053764	Loxodonta africana	91.77	0.00e+00	676.00
IUUC-Mcc-055088	Macaca mulatta	97.53	0.00e+00	848.00
IUUC-Meu-056586	Macropus eugenii	95.28	1.00e-66	246.00
IUUC-Mga-059912	Meleagris gallopavo	81.14	0.00e+00	655.00
IUUC-Mmr-061508	Microcebus murinus	95.93	0.00e+00	844.00
IUUC-Mdo-062561	Monodelphis domestica	95.90	0.00e+00	826.00
IUUC-Mmu-063445	Mus musculus	96.31	0.00e+00	859.00
IUUC-Mpu-066775	Mustela putorius furo	95.85	0.00e+00	731.00
IUUC-Mlu-067747	Myotis lucifugus	94.36	0.00e+00	778.00
IUUC-Nle-069553	Nomascus leucogenys	99.80	0.00e+00	912.00
IUUC-Opr-071037	Ochotona princeps	71.30	2.00e-74	271.00
IUUC-Ont-072137	Oreochromis niloticus	75.73	9.00e-179	619.00
IUUC-Oan-073733	Ornithorhynchus anatinus	95.34	0.00e+00	805.00
IUUC-Ocu-074802	Oryctolagus cuniculus	95.52	0.00e+00	784.00
IUUC-Ola-086309	Oryzias latipes	74.36	2.00e-151	528.00
IUUC-Oga-088663	Otolemur garnettii	97.33	0.00e+00	864.00
IUUC-Oar-089478	Ovis aries	93.25	0.00e+00	765.00
IUUC-Ptr-091474	Pan troglodytes	99.79	0.00e+00	866.00
IUUC-Pan-092456	Papio anubis	98.97	0.00e+00	868.00
IUUC-Psi-093676	Pelodiscus sinensis	91.39	0.00e+00	775.00
IUUC-Pfo-096908	Poecilia formosa	75.27	4.00e-177	614.00
IUUC-Pab-097820	Pongo abelii	99.39	0.00e+00	878.00
IUUC-Pca-100174	Procavia capensis	91.99	0.00e+00	674.00
IUUC-Pva-102571	Pteropus vampyrus	84.63	1.00e-174	605.00
IUUC-Rno-105400	Rattus norvegicus	97.56	0.00e+00	744.00
IUUC-Sha-107024	Sarcophilus harrisii	95.79	0.00e+00	796.00
IUUC-Ssc-115799	Sus scrofa	90.47	0.00e+00	717.00
IUUC-Tgu-116658	Taeniopygia guttata	92.44	0.00e+00	696.00
IUUC-Tru-118269	Takifugu rubripes	69.40	9.00e-142	496.00
IUUC-Tsy-119389	Tarsius syrichta	97.32	0.00e+00	699.00
IUUC-Tni-119914	Tetraodon nigroviridis	71.04	2.00e-143	501.00
IUUC-Tbe-128154	Tupaia belangeri	81.51	0.00e+00	664.00
IUUC-Ttr-129016	Tursiops truncatus	95.60	0.00e+00	702.00
IUUC-Xtr-132371	Xenopus tropicalis	70.97	3.00e-169	588.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence