iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000130177.14	ENST00000356221.7	ENSP00000348554.3
ENSG00000130177.14	ENST00000252457.9	ENSP00000252457.5
ENSG00000130177.14	ENST00000252458.6	ENSP00000252458.6

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C	APC_C	21107322; 16763193

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C	32.65	1.00e-75	278.00	IUUC-Sce-106205

Organism

Homo sapiens

Functional Description
(View)

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Protein Sequence
(Fasta)

MNLERLRKRV RQYLDQQQYQ SALFWADKVA SLSREPQDIY WLAQCLYLTA QYHRAAHALR 60
SRKLDKLYEA CRYLAARCHY AAKEHQQALD VLDMEEPINK RLFEKYLKDE SGFKDPSSDW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCCTGGGC AGTGCACGGG GCCTGGGTGG GGGGTGCGGG TGTGGGTGGG GACCTGCGGC 60
CTTCGAGTCC GCGGCCTTCG AGTCCTGGGG CGGCGGCGGC GGCTGCAGGC ACGGGCACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat

PROSITE

PS50005--TPR
PS50293--TPR_REGION

SMART

SM00028--TPR

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005819--C:spindle
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0008283--P:cell proliferation
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0007088--P:regulation of mitotic nuclear division
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

KEGG

hsa:8881

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000117	Aegilops tauschii	37.03	2.00e-76	280.00
IUUC-Aml-001382	Ailuropoda melanoleuca	96.08	0.00e+00	1201.00
IUUC-Atr-002720	Amborella trichopoda	42.03	5.00e-110	391.00
IUUC-Apl-003937	Anas platyrhynchos	92.18	0.00e+00	1102.00
IUUC-Aca-004235	Anolis carolinensis	85.44	0.00e+00	1105.00
IUUC-Aly-005937	Arabidopsis lyrata	42.45	4.00e-103	369.00
IUUC-Ath-006890	Arabidopsis thaliana	42.26	2.00e-100	359.00
IUUC-Ago-007821	Ashbya gossypii	35.95	4.00e-82	299.00
IUUC-Acl-008251	Aspergillus clavatus	31.60	3.00e-64	240.00
IUUC-Afl-008584	Aspergillus flavus	29.04	6.00e-50	192.00
IUUC-Afu-009095	Aspergillus fumigatus	30.65	3.00e-61	229.00
IUUC-Ani-009178	Aspergillus nidulans	31.71	7.00e-59	222.00
IUUC-Ang-009647	Aspergillus niger	32.59	1.00e-63	238.00
IUUC-Aor-010061	Aspergillus oryzae	29.85	2.00e-56	214.00
IUUC-Ate-010558	Aspergillus terreus	29.66	4.00e-55	209.00
IUUC-Ame-011880	Astyanax mexicanus	78.94	0.00e+00	1002.00
IUUC-Bgr-012022	Blumeria graminis	32.55	2.00e-78	286.00
IUUC-Bta-012343	Bos taurus	97.58	0.00e+00	1262.00
IUUC-Bci-013719	Botrytis cinerea	31.88	5.00e-76	278.00
IUUC-Bdi-014012	Brachypodium distachyon	41.92	1.00e-104	374.00
IUUC-Bol-015750	Brassica oleracea	41.17	4.00e-100	358.00
IUUC-Bra-017378	Brassica rapa	41.35	3.00e-101	362.00
IUUC-Cel-018178	Caenorhabditis elegans	28.71	7.00e-42	165.00
IUUC-Cja-019645	Callithrix jacchus	99.03	0.00e+00	1278.00
IUUC-Cfa-021173	Canis familiaris	97.74	0.00e+00	1236.00
IUUC-Cpo-022175	Cavia porcellus	97.26	0.00e+00	1193.00
IUUC-Csa-023470	Chlorocebus sabaeus	99.52	0.00e+00	1255.00
IUUC-Cho-024406	Choloepus hoffmanni	74.47	8.00e-180	623.00
IUUC-Cin-025267	Ciona intestinalis	59.95	8.00e-144	503.00
IUUC-Cgl-026539	Colletotrichum gloeosporioides	32.30	1.00e-75	277.00
IUUC-Cne-026856	Cryptococcus neoformans	30.54	1.00e-68	254.00
IUUC-Cme-027272	Cyanidioschyzon merolae	26.00	2.00e-27	117.00
IUUC-Dre-027977	Danio rerio	78.40	0.00e+00	974.00
IUUC-Dno-029872	Dasypus novemcinctus	86.71	0.00e+00	849.00
IUUC-Dor-030233	Dipodomys ordii	93.84	0.00e+00	658.00
IUUC-Dse-031306	Dothistroma septosporum	29.55	2.00e-70	260.00
IUUC-Dme-031877	Drosophila melanogaster	50.31	2.00e-92	333.00
IUUC-Ete-032688	Echinops telfairi	74.77	1.00e-139	490.00
IUUC-Eca-033845	Equus caballus	98.02	0.00e+00	1211.00
IUUC-Eeu-034744	Erinaceus europaeus	84.18	3.00e-92	332.00
IUUC-Fca-036291	Felis catus	97.58	0.00e+00	1236.00
IUUC-Fal-036779	Ficedula albicollis	91.48	0.00e+00	1183.00
IUUC-Fox-037869	Fusarium oxysporum	32.84	4.00e-75	275.00
IUUC-Fso-038267	Fusarium solani	33.33	3.00e-79	290.00
IUUC-Gmo-039534	Gadus morhua	77.90	0.00e+00	999.00
IUUC-Ggr-039826	Gaeumannomyces graminis	30.66	3.00e-72	266.00
IUUC-Gga-040228	Gallus gallus	90.69	0.00e+00	1175.00
IUUC-Gac-041593	Gasterosteus aculeatus	77.37	0.00e+00	980.00
IUUC-Gma-043291	Glycine max	40.82	2.00e-102	366.00
IUUC-Ggo-044491	Gorilla gorilla	99.68	0.00e+00	1257.00
IUUC-Hvu-047156	Hordeum vulgare	36.58	6.00e-40	157.00
IUUC-Itr-048812	Ictidomys tridecemlineatus	96.60	0.00e+00	1214.00
IUUC-Kpa-049186	Komagataella pastoris	31.39	2.00e-74	273.00
IUUC-Lch-050215	Latimeria chalumnae	81.83	0.00e+00	926.00
IUUC-Lpe-051395	Leersia perrieri	38.42	1.00e-86	315.00
IUUC-Loc-052340	Lepisosteus oculatus	73.13	0.00e+00	894.00
IUUC-Lma-053003	Leptosphaeria maculans	31.05	2.00e-73	270.00
IUUC-Laf-054125	Loxodonta africana	96.31	0.00e+00	1166.00
IUUC-Mcc-054598	Macaca mulatta	99.19	0.00e+00	1250.00
IUUC-Meu-056839	Macropus eugenii	76.02	0.00e+00	853.00
IUUC-Mor-056916	Magnaporthe oryzae	31.20	3.00e-78	286.00
IUUC-Mtr-057912	Medicago truncatula	40.67	8.00e-105	374.00
IUUC-Mla-058971	Melampsora laricipopulina	27.98	6.00e-64	239.00
IUUC-Mga-059655	Meleagris gallopavo	90.79	0.00e+00	1148.00
IUUC-Mvi-060246	Microbotryum violaceum	32.89	3.00e-74	273.00
IUUC-Mmr-060691	Microcebus murinus	92.10	0.00e+00	1139.00
IUUC-Mdo-061872	Monodelphis domestica	94.86	0.00e+00	1208.00
IUUC-Mmu-063256	Mus musculus	95.32	0.00e+00	1242.00
IUUC-Mac-064797	Musa acuminata	38.20	1.00e-95	343.00
IUUC-Mpu-066773	Mustela putorius furo	97.35	0.00e+00	1199.00
IUUC-Mlu-067237	Myotis lucifugus	97.26	0.00e+00	1230.00
IUUC-Nfi-068499	Neosartorya fischeri	30.83	1.00e-59	224.00
IUUC-Ncr-068893	Neurospora crassa	33.09	2.00e-81	296.00
IUUC-Nle-070117	Nomascus leucogenys	99.03	0.00e+00	1247.00
IUUC-Opr-070994	Ochotona princeps	97.03	0.00e+00	697.00
IUUC-Ont-072034	Oreochromis niloticus	78.46	0.00e+00	986.00
IUUC-Oan-072989	Ornithorhynchus anatinus	92.01	9.00e-177	612.00
IUUC-Ocu-074107	Oryctolagus cuniculus	89.71	0.00e+00	1121.00
IUUC-Oba-074985	Oryza barthii	41.33	4.00e-99	355.00
IUUC-Obr-076412	Oryza brachyantha	41.13	3.00e-96	346.00
IUUC-Ogl-077693	Oryza glaberrima	41.33	3.00e-99	356.00
IUUC-Ogu-078411	Oryza glumaepatula	41.40	9.00e-100	358.00
IUUC-Oin-079841	Oryza indica	41.07	1.00e-93	338.00
IUUC-Olo-080560	Oryza longistaminata	40.91	6.00e-92	331.00
IUUC-Ome-081660	Oryza meridionalis	41.40	2.00e-99	357.00
IUUC-Oni-082141	Oryza nivara	41.33	4.00e-99	355.00
IUUC-Opu-083634	Oryza punctata	41.14	3.00e-99	356.00
IUUC-Oru-084291	Oryza rufipogon	41.33	4.00e-99	355.00
IUUC-Osa-085547	Oryza sativa	41.40	5.00e-100	358.00
IUUC-Ola-086854	Oryzias latipes	76.75	0.00e+00	970.00
IUUC-Olu-087784	Ostreococcus lucimarinus	34.44	2.00e-68	253.00
IUUC-Oga-088800	Otolemur garnettii	98.55	0.00e+00	1143.00
IUUC-Oar-089669	Ovis aries	97.83	0.00e+00	1192.00
IUUC-Ptr-091251	Pan troglodytes	99.84	0.00e+00	1259.00
IUUC-Pan-092320	Papio anubis	95.65	0.00e+00	1195.00
IUUC-Psi-093847	Pelodiscus sinensis	91.49	0.00e+00	1174.00
IUUC-Pno-094804	Phaeosphaeria nodorum	32.91	5.00e-79	288.00
IUUC-Ppa-095889	Physcomitrella patens	41.96	2.00e-102	366.00
IUUC-Pfo-096273	Poecilia formosa	77.96	0.00e+00	986.00
IUUC-Pab-098108	Pongo abelii	91.94	0.00e+00	1135.00
IUUC-Pop-099818	Populus trichocarpa	41.19	5.00e-105	375.00
IUUC-Pca-100859	Procavia capensis	86.14	3.00e-102	365.00
IUUC-Pva-102413	Pteropus vampyrus	98.06	0.00e+00	1241.00
IUUC-Pgr-103689	Puccinia graminis	33.09	2.00e-51	197.00
IUUC-Ptt-103799	Puccinia triticina	32.20	4.00e-47	182.00
IUUC-Pte-104162	Pyrenophora teres	33.39	2.00e-76	280.00
IUUC-Pyt-104476	Pyrenophora triticirepentis	33.94	1.00e-78	287.00
IUUC-Rno-105403	Rattus norvegicus	95.81	0.00e+00	1220.00
IUUC-Sce-106205	Saccharomyces cerevisiae	32.65	2.00e-83	303.00
IUUC-Sha-107183	Sarcophilus harrisii	94.86	0.00e+00	1236.00
IUUC-Sja-107827	Schizosaccharomyces japonicus	37.48	1.00e-93	337.00
IUUC-Spo-108188	Schizosaccharomyces pombe	36.22	1.00e-86	314.00
IUUC-Ssl-108522	Sclerotinia sclerotiorum	35.66	2.00e-39	155.00
IUUC-Smo-109302	Selaginella moellendorffii	41.25	2.00e-100	360.00
IUUC-Sit-110486	Setaria italica	41.54	1.00e-101	364.00
IUUC-Sly-111083	Solanum lycopersicum	41.56	4.00e-105	375.00
IUUC-Sar-113712	Sorex araneus	93.78	0.00e+00	793.00
IUUC-Sbi-114145	Sorghum bicolor	40.75	7.00e-97	348.00
IUUC-Sre-115016	Sporisorium reilianum	31.26	3.00e-55	210.00
IUUC-Ssc-115757	Sus scrofa	96.60	0.00e+00	1209.00
IUUC-Tgu-116718	Taeniopygia guttata	91.65	0.00e+00	1187.00
IUUC-Tru-118018	Takifugu rubripes	77.42	0.00e+00	961.00
IUUC-Tsy-118804	Tarsius syrichta	97.65	0.00e+00	1103.00
IUUC-Tni-119767	Tetraodon nigroviridis	75.96	0.00e+00	961.00
IUUC-Tca-121364	Theobroma cacao	40.75	9.00e-104	370.00
IUUC-Tre-122067	Trichoderma reesei	33.21	2.00e-82	300.00
IUUC-Tvi-122461	Trichoderma virens	32.78	2.00e-78	287.00
IUUC-Tae-123368	Triticum aestivum	41.24	3.00e-109	389.00
IUUC-Tur-126602	Triticum urartu	44.13	3.00e-79	289.00
IUUC-Tme-126892	Tuber melanosporum	32.90	5.00e-80	292.00
IUUC-Tbe-127430	Tupaia belangeri	78.39	0.00e+00	929.00
IUUC-Ttr-128535	Tursiops truncatus	97.26	0.00e+00	1228.00
IUUC-Uma-129584	Ustilago maydis	31.26	1.00e-57	219.00
IUUC-Vda-129823	Verticillium dahliae	31.66	2.00e-83	303.00
IUUC-Vpa-130167	Vicugna pacos	90.52	0.00e+00	786.00
IUUC-Vvi-131646	Vitis vinifera	40.67	2.00e-98	352.00
IUUC-Xtr-131785	Xenopus tropicalis	87.74	0.00e+00	690.00
IUUC-Xma-133644	Xiphophorus maculatus	78.12	0.00e+00	988.00
IUUC-Yli-134405	Yarrowia lipolytica	34.86	4.00e-89	322.00
IUUC-Zma-135969	Zea mays	40.98	5.00e-101	362.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence