iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/PRU	99.42	6.00e-84	308.00	IUUC-Mmu-063167
UBD/PRU	26.21	2.00e-02	35.00	IUUC-Sce-106377

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and thus activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.

Protein Sequence
(Fasta)

MTTSGALFPS LVPGSRGSST KYLVEFRAGK MSLKGTTVTP DKRKGLVYIQ QTDDSLIHFC 60
WKDRTSGTVE DDLIIFPDDC EFKRVPQCPS GRVYVLKFKA GSKRLFFWMQ EPKTDQDEEH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAGGCCCG GCAGGCGCCG AGGAGGAAGA GCGAGCCCGG ACGGTGCCCC TAGGCCGAGT 60
GTGAGCGCGG CCAGGTAGGG GCCCGGTGGC GGCAGCGGCG GCATAGGGGC ACGCGGCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR006773--26S_Psome_Ubiquitin-recp_Rpn13
IPR032368--RPN13_C

Pfam

PF04683--Proteasom_Rpn13
PF16550--RPN13_C

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0000502--C:proteasome complex
GO:0008541--C:proteasome regulatory particle, lid subcomplex
GO:0061133--F:endopeptidase activator activity
GO:0070628--F:proteasome binding
GO:0043130--F:ubiquitin binding
GO:0043248--P:proteasome assembly
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:65138

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000735	Aegilops tauschii	39.01	3.00e-23	102.00
IUUC-Aml-002306	Ailuropoda melanoleuca	97.09	2.00e-83	302.00
IUUC-Atr-002494	Amborella trichopoda	52.25	5.00e-33	134.00
IUUC-Apl-003608	Anas platyrhynchos	89.94	2.00e-65	242.00
IUUC-Aca-004810	Anolis carolinensis	91.76	8.00e-79	287.00
IUUC-Aly-006501	Arabidopsis lyrata	48.30	2.00e-35	142.00
IUUC-Ath-007220	Arabidopsis thaliana	50.00	1.00e-36	146.00
IUUC-Ago-007904	Ashbya gossypii	32.35	7.00e-09	52.80
IUUC-Acl-008240	Aspergillus clavatus	36.63	8.00e-13	68.20
IUUC-Afl-008673	Aspergillus flavus	36.63	3.00e-13	69.30
IUUC-Afu-009026	Aspergillus fumigatus	52.38	4.00e-03	35.40
IUUC-Ani-009170	Aspergillus nidulans	37.11	1.00e-12	67.40
IUUC-Ang-009696	Aspergillus niger	34.26	2.00e-12	66.60
IUUC-Aor-009975	Aspergillus oryzae	36.63	3.00e-13	69.30
IUUC-Ate-010404	Aspergillus terreus	36.63	5.00e-13	68.60
IUUC-Ame-011726	Astyanax mexicanus	87.12	2.00e-65	243.00
IUUC-Bgr-012116	Blumeria graminis	35.29	1.00e-13	70.90
IUUC-Bta-012686	Bos taurus	97.09	2.00e-83	302.00
IUUC-Bci-013772	Botrytis cinerea	33.98	1.00e-10	60.50
IUUC-Bdi-014600	Brachypodium distachyon	52.34	1.00e-30	126.00
IUUC-Bol-015418	Brassica oleracea	52.25	1.00e-31	130.00
IUUC-Bra-018022	Brassica rapa	52.25	4.00e-32	131.00
IUUC-Cja-019223	Callithrix jacchus	95.35	9.00e-82	296.00
IUUC-Cfa-020426	Canis familiaris	95.93	2.00e-85	308.00
IUUC-Cpo-021820	Cavia porcellus	97.09	2.00e-86	312.00
IUUC-Csa-023622	Chlorocebus sabaeus	97.09	3.00e-83	301.00
IUUC-Cin-025475	Ciona intestinalis	65.58	1.00e-57	216.00
IUUC-Csv-026094	Ciona savignyi	73.83	3.00e-49	188.00
IUUC-Cgl-026557	Colletotrichum gloeosporioides	39.22	5.00e-14	72.00
IUUC-Cne-026937	Cryptococcus neoformans	36.61	1.00e-18	86.70
IUUC-Cme-027138	Cyanidioschyzon merolae	41.59	1.00e-25	110.00
IUUC-Dre-027576	Danio rerio	87.65	2.00e-69	256.00
IUUC-Dno-029119	Dasypus novemcinctus	98.26	4.00e-85	308.00
IUUC-Dor-030837	Dipodomys ordii	97.01	2.00e-72	266.00
IUUC-Dse-031557	Dothistroma septosporum	40.40	1.00e-16	80.90
IUUC-Dme-031872	Drosophila melanogaster	67.50	8.00e-51	194.00
IUUC-Ete-032654	Echinops telfairi	94.97	2.00e-72	265.00
IUUC-Eca-034182	Equus caballus	95.93	5.00e-81	294.00
IUUC-Eeu-035242	Erinaceus europaeus	96.51	9.00e-83	300.00
IUUC-Fca-036448	Felis catus	97.09	2.00e-83	303.00
IUUC-Fal-036857	Ficedula albicollis	91.76	3.00e-82	298.00
IUUC-Fox-037975	Fusarium oxysporum	29.92	9.00e-12	64.70
IUUC-Fso-038361	Fusarium solani	35.29	6.00e-12	65.10
IUUC-Gmo-038621	Gadus morhua	86.98	8.00e-69	254.00
IUUC-Ggr-039789	Gaeumannomyces graminis	33.65	2.00e-10	60.50
IUUC-Gga-040784	Gallus gallus	91.28	1.00e-82	300.00
IUUC-Gac-041531	Gasterosteus aculeatus	82.14	2.00e-76	279.00
IUUC-Gma-044281	Glycine max	45.31	9.00e-31	126.00
IUUC-Ggo-044790	Gorilla gorilla	97.09	4.00e-83	301.00
IUUC-Hsa-046024	Homo sapiens	97.09	4.00e-83	301.00
IUUC-Hvu-047480	Hordeum vulgare	45.39	6.00e-33	134.00
IUUC-Itr-048195	Ictidomys tridecemlineatus	97.67	5.00e-84	304.00
IUUC-Kpa-049226	Komagataella pastoris	25.96	3.00e-07	47.00
IUUC-Lch-049418	Latimeria chalumnae	87.65	4.00e-75	275.00
IUUC-Lpe-050742	Leersia perrieri	48.23	1.00e-35	143.00
IUUC-Loc-052496	Lepisosteus oculatus	88.10	1.00e-68	253.00
IUUC-Lma-053330	Leptosphaeria maculans	36.61	1.00e-13	69.30
IUUC-Laf-053604	Loxodonta africana	97.67	3.00e-85	308.00
IUUC-Mcc-055359	Macaca mulatta	97.09	3.00e-83	301.00
IUUC-Meu-056243	Macropus eugenii	92.16	1.00e-66	246.00
IUUC-Mor-057247	Magnaporthe oryzae	36.70	1.00e-09	57.80
IUUC-Mpo-057457	Magnaporthe poae	34.62	6.00e-11	61.60
IUUC-Mtr-058738	Medicago truncatula	55.05	1.00e-32	133.00
IUUC-Mla-059042	Melampsora laricipopulina	35.29	1.00e-14	73.60
IUUC-Mga-059762	Meleagris gallopavo	88.68	2.00e-65	241.00
IUUC-Mvi-060526	Microbotryum violaceum	42.59	3.00e-20	92.40
IUUC-Mmr-061152	Microcebus murinus	96.51	1.00e-85	310.00
IUUC-Mdo-062086	Monodelphis domestica	93.53	4.00e-80	291.00
IUUC-Mmu-063167	Mus musculus	99.42	7.00e-86	310.00
IUUC-Mpu-066924	Mustela putorius furo	96.43	8.00e-73	266.00
IUUC-Mlu-068064	Myotis lucifugus	96.51	4.00e-83	301.00
IUUC-Nfi-068545	Neosartorya fischeri	35.64	6.00e-12	65.10
IUUC-Ncr-068847	Neurospora crassa	35.29	6.00e-12	65.10
IUUC-Nle-069563	Nomascus leucogenys	94.77	4.00e-81	295.00
IUUC-Ont-072472	Oreochromis niloticus	83.53	7.00e-71	261.00
IUUC-Oan-072770	Ornithorhynchus anatinus	92.94	9.00e-80	290.00
IUUC-Oba-075129	Oryza barthii	46.10	7.00e-33	134.00
IUUC-Obr-076216	Oryza brachyantha	46.81	2.00e-34	139.00
IUUC-Ogl-077663	Oryza glaberrima	46.10	7.00e-33	134.00
IUUC-Oin-079928	Oryza indica	46.10	7.00e-33	134.00
IUUC-Ome-081406	Oryza meridionalis	39.01	6.00e-23	100.00
IUUC-Oni-083080	Oryza nivara	46.10	7.00e-33	134.00
IUUC-Opu-083569	Oryza punctata	45.39	3.00e-32	132.00
IUUC-Osa-085922	Oryza sativa	46.10	7.00e-33	134.00
IUUC-Ola-087324	Oryzias latipes	82.94	1.00e-72	266.00
IUUC-Oga-089045	Otolemur garnettii	97.67	1.00e-83	303.00
IUUC-Oar-090402	Ovis aries	97.09	2.00e-83	302.00
IUUC-Ptr-090578	Pan troglodytes	96.92	1.00e-76	280.00
IUUC-Pan-092872	Papio anubis	97.09	3.00e-83	301.00
IUUC-Psi-093198	Pelodiscus sinensis	91.76	2.00e-78	286.00
IUUC-Pno-095051	Phaeosphaeria nodorum	33.94	3.00e-12	65.10
IUUC-Ppa-095547	Physcomitrella patens	54.13	3.00e-32	132.00
IUUC-Pfo-096879	Poecilia formosa	86.90	2.00e-65	243.00
IUUC-Pab-098731	Pongo abelii	95.93	5.00e-79	288.00
IUUC-Pca-100816	Procavia capensis	95.95	6.00e-70	258.00
IUUC-Ppe-101400	Prunus persica	53.15	1.00e-32	133.00
IUUC-Pva-103198	Pteropus vampyrus	95.60	2.00e-74	272.00
IUUC-Pgr-103494	Puccinia graminis	38.39	3.00e-19	89.00
IUUC-Ptt-103732	Puccinia triticina	30.59	1.00e-04	38.90
IUUC-Pte-104034	Pyrenophora teres	36.94	1.00e-13	70.50
IUUC-Pyt-104724	Pyrenophora triticirepentis	36.04	4.00e-13	68.90
IUUC-Sce-106377	Saccharomyces cerevisiae	35.90	1.00e-02	32.70
IUUC-Sha-106986	Sarcophilus harrisii	94.12	4.00e-80	291.00
IUUC-Sja-107713	Schizosaccharomyces japonicus	41.29	2.00e-28	119.00
IUUC-Spo-108172	Schizosaccharomyces pombe	45.69	2.00e-26	113.00
IUUC-Ssl-108639	Sclerotinia sclerotiorum	34.95	8.00e-10	57.00
IUUC-Smo-109349	Selaginella moellendorffii	25.83	1.00e-03	38.90
IUUC-Sly-111320	Solanum lycopersicum	54.13	3.00e-31	128.00
IUUC-Sbi-114588	Sorghum bicolor	54.13	4.00e-33	135.00
IUUC-Tgu-116881	Taeniopygia guttata	88.61	8.00e-82	295.00
IUUC-Tru-118602	Takifugu rubripes	82.94	1.00e-64	240.00
IUUC-Tni-119694	Tetraodon nigroviridis	84.12	2.00e-65	242.00
IUUC-Tca-121244	Theobroma cacao	35.11	9.00e-27	114.00
IUUC-Tre-122090	Trichoderma reesei	37.25	9.00e-12	64.70
IUUC-Tvi-122267	Trichoderma virens	36.54	2.00e-12	66.60
IUUC-Tae-124010	Triticum aestivum	46.10	3.00e-33	135.00
IUUC-Tur-126552	Triticum urartu	38.30	7.00e-23	100.00
IUUC-Tme-126941	Tuber melanosporum	35.83	1.00e-18	87.00
IUUC-Tbe-127777	Tupaia belangeri	92.48	7.00e-63	233.00
IUUC-Ttr-128473	Tursiops truncatus	96.51	6.00e-99	354.00
IUUC-Vda-129665	Verticillium dahliae	36.00	9.00e-13	68.20
IUUC-Vvi-131383	Vitis vinifera	51.35	7.00e-33	134.00
IUUC-Xma-133590	Xiphophorus maculatus	86.23	1.00e-66	246.00
IUUC-Yli-134627	Yarrowia lipolytica	35.00	6.00e-13	67.80
IUUC-Zma-134939	Zea mays	53.70	2.00e-32	132.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence