iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-070072

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01063432

Gene Name

UBA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000003096.2	ENSNLET00000004035.1	ENSNLEP00000003842.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.50e-209	696.3	451	931

Active Site

Position(s)	Description	Evidence
632	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Q++++G++ qekl+++k++lvGag++GcEllKn++++G+     g+i v+Dmdt+e+snlnrqFLfr++dv k K+++aa+a++++
   Q: 451  YDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLgcgegGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVHQM 539
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           np+++v++h++++ +++e+i+   Ff+++d+V++aldn++ar++++r+c+++r+pl+esgtlG++G+v+v+i+ lte+ys+s+dpp+k+
   Q: 540  NPHIRVTSHQNRVGPDTERIYdddFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKS 628
           ***************************************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafak 247
           iP+ctlk++pna+eht++wa            + +n++l ++++++e++ +l+ ++++e++++v+++l+ ++++++++++++a++++++
   Q: 629  IPICTLKNFPNAIEHTLQWArdefeglfkqpaENVNQYL-TDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHT 716
           ***************************************.999999******************************************* PP
   S: 248  ttinsikqllksfecdivtkskspfwv..........................................sfcsnaealqvp........ 286
           +++n+i+qll++f++d++t+s++pfw+                                           + ++ +++qvp        
   Q: 717  QYSNNIRQLLHNFPPDQLTSSGAPFWSgpkrcphpltfdvnnplhldyvmaaanlfaqtygltgsqdraAVATLLQSVQVPeftpksgv 805
           *****************************************************************999966666666666655555555 PP
   S: 287  ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipa 368
           + +++d+e ++a+a+     l+ l+++l + +k +g k++ ++fekddds  ++d++ aa+nlrae+++i+p +d+++ k iag+iipa
   Q: 806  KIHVSDQELQSANASvddsrLEELKATLPSPDKLPGFKMYPIDFEKDDDSnfHMDFIVAASNLRAENYDIPP-ADRHKSKLIAGKIIPA 893
           66666666666666688889****************************************************.**************** PP
   S: 369  iattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           iatt+a+v Gl+++E++Kvv+g  + + +kn fl++a+
   Q: 894  IATTTAAVVGLVCLELYKVVQGhrQLDSYKNGFLNLAL 931
           **********************999*********9875 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MSSSPLSKKR RVSGPDPKPG SNCSPAQSVL SEVPSVPTNG MAKNGSEADI DEGLYSRQLS 60
GAKAGLRGVG WDIERIGLGG AGPDLDTFPP FPIPEAPPFL VPQPFHLFPY CTPLQFYLRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAGCT CGCCGCTGTC CAAGAAACGT CGCGTGTCCG GGCCTGATCC AAAGCCGGGT 60
TCTAACTGCT CCCCTGCCCA GTCCGTGTTG TCCGAAGTGC CCTCGGTGCC AACCAACGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005829--C:cytosol
GO:0030057--C:desmosome
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0000792--C:heterochromatin
GO:0005765--C:lysosomal membrane
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0030867--C:rough endoplasmic reticulum membrane
GO:0005524--F:ATP binding
GO:0003723--F:RNA binding
GO:0004839--F:ubiquitin activating enzyme activity
GO:0006974--P:cellular response to DNA damage stimulus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000367	Aegilops tauschii	43.74	0.00e+00	790.00
IUUC-Aml-001311	Ailuropoda melanoleuca	91.27	0.00e+00	1969.00
IUUC-Atr-002684	Amborella trichopoda	43.18	0.00e+00	823.00
IUUC-Aca-004620	Anolis carolinensis	76.68	0.00e+00	1675.00
IUUC-Aly-005515	Arabidopsis lyrata	42.91	0.00e+00	836.00
IUUC-Ath-006891	Arabidopsis thaliana	43.50	0.00e+00	847.00
IUUC-Ago-007873	Ashbya gossypii	52.21	0.00e+00	1003.00
IUUC-Acl-008181	Aspergillus clavatus	51.27	0.00e+00	1003.00
IUUC-Afl-008455	Aspergillus flavus	53.10	0.00e+00	978.00
IUUC-Afu-009065	Aspergillus fumigatus	50.93	0.00e+00	1009.00
IUUC-Ani-009371	Aspergillus nidulans	50.97	0.00e+00	989.00
IUUC-Ang-009737	Aspergillus niger	51.41	0.00e+00	1007.00
IUUC-Aor-010007	Aspergillus oryzae	53.10	0.00e+00	978.00
IUUC-Ate-010466	Aspergillus terreus	51.58	0.00e+00	1027.00
IUUC-Ame-010933	Astyanax mexicanus	75.14	0.00e+00	1576.00
IUUC-Bgr-012281	Blumeria graminis	50.98	0.00e+00	1012.00
IUUC-Bta-012767	Bos taurus	91.52	0.00e+00	1978.00
IUUC-Bci-013721	Botrytis cinerea	51.76	0.00e+00	959.00
IUUC-Bdi-014843	Brachypodium distachyon	43.15	0.00e+00	798.00
IUUC-Bol-015665	Brassica oleracea	41.82	0.00e+00	825.00
IUUC-Bra-017522	Brassica rapa	44.50	0.00e+00	826.00
IUUC-Cel-018260	Caenorhabditis elegans	47.09	0.00e+00	874.00
IUUC-Cja-019152	Callithrix jacchus	93.29	0.00e+00	2008.00
IUUC-Cfa-020622	Canis familiaris	90.21	0.00e+00	1897.00
IUUC-Cpo-022526	Cavia porcellus	91.89	0.00e+00	1956.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	43.35	0.00e+00	772.00
IUUC-Csa-023780	Chlorocebus sabaeus	93.38	0.00e+00	2009.00
IUUC-Cho-024896	Choloepus hoffmanni	87.45	3.00e-118	419.00
IUUC-Cin-025790	Ciona intestinalis	60.23	0.00e+00	1273.00
IUUC-Csv-026084	Ciona savignyi	58.16	0.00e+00	1254.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	51.27	0.00e+00	1019.00
IUUC-Cne-026960	Cryptococcus neoformans	53.25	0.00e+00	1043.00
IUUC-Cme-027290	Cyanidioschyzon merolae	43.69	0.00e+00	793.00
IUUC-Dre-028149	Danio rerio	74.86	0.00e+00	1604.00
IUUC-Dno-028884	Dasypus novemcinctus	91.71	0.00e+00	1989.00
IUUC-Dor-030229	Dipodomys ordii	87.33	0.00e+00	1868.00
IUUC-Dse-031524	Dothistroma septosporum	49.95	0.00e+00	1010.00
IUUC-Dme-032045	Drosophila melanogaster	57.96	0.00e+00	1198.00
IUUC-Ete-032544	Echinops telfairi	96.12	0.00e+00	807.00
IUUC-Eca-033330	Equus caballus	92.54	0.00e+00	2001.00
IUUC-Fca-036255	Felis catus	92.54	0.00e+00	1972.00
IUUC-Fal-037445	Ficedula albicollis	49.51	0.00e+00	854.00
IUUC-Fox-038007	Fusarium oxysporum	54.19	2.00e-168	585.00
IUUC-Fso-038339	Fusarium solani	51.80	0.00e+00	990.00
IUUC-Gmo-039338	Gadus morhua	71.72	0.00e+00	1506.00
IUUC-Ggr-039823	Gaeumannomyces graminis	51.51	0.00e+00	1038.00
IUUC-Gga-040365	Gallus gallus	47.46	0.00e+00	819.00
IUUC-Gac-041773	Gasterosteus aculeatus	71.75	0.00e+00	1508.00
IUUC-Gma-043198	Glycine max	41.72	0.00e+00	803.00
IUUC-Ggo-045336	Gorilla gorilla	94.22	0.00e+00	2002.00
IUUC-Hsa-045982	Homo sapiens	94.04	0.00e+00	1996.00
IUUC-Hvu-047418	Hordeum vulgare	43.42	0.00e+00	808.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	92.54	0.00e+00	1998.00
IUUC-Kpa-049112	Komagataella pastoris	49.61	0.00e+00	956.00
IUUC-Lch-050371	Latimeria chalumnae	75.98	0.00e+00	1664.00
IUUC-Lpe-051299	Leersia perrieri	42.36	0.00e+00	827.00
IUUC-Loc-052936	Lepisosteus oculatus	76.91	0.00e+00	1654.00
IUUC-Lma-053315	Leptosphaeria maculans	49.53	0.00e+00	1015.00
IUUC-Laf-053948	Loxodonta africana	89.38	0.00e+00	1926.00
IUUC-Mcc-055843	Macaca mulatta	93.66	0.00e+00	2019.00
IUUC-Meu-056258	Macropus eugenii	83.04	0.00e+00	1801.00
IUUC-Mor-057269	Magnaporthe oryzae	51.46	0.00e+00	1016.00
IUUC-Mpo-057435	Magnaporthe poae	51.66	0.00e+00	1004.00
IUUC-Mtr-058572	Medicago truncatula	41.51	0.00e+00	786.00
IUUC-Mla-059176	Melampsora laricipopulina	53.72	0.00e+00	1029.00
IUUC-Mga-060052	Meleagris gallopavo	50.24	0.00e+00	748.00
IUUC-Mvi-060437	Microbotryum violaceum	51.67	0.00e+00	1002.00
IUUC-Mmr-061405	Microcebus murinus	90.49	0.00e+00	1938.00
IUUC-Mdo-062032	Monodelphis domestica	84.22	0.00e+00	1828.00
IUUC-Mmu-063280	Mus musculus	90.59	0.00e+00	1942.00
IUUC-Mac-065505	Musa acuminata	43.58	0.00e+00	815.00
IUUC-Mpu-066409	Mustela putorius furo	92.36	0.00e+00	1996.00
IUUC-Mlu-067217	Myotis lucifugus	90.77	0.00e+00	1958.00
IUUC-Nfi-068407	Neosartorya fischeri	51.12	0.00e+00	998.00
IUUC-Ncr-068698	Neurospora crassa	52.52	0.00e+00	1030.00
IUUC-Ont-071671	Oreochromis niloticus	74.65	0.00e+00	1584.00
IUUC-Oan-073306	Ornithorhynchus anatinus	49.56	0.00e+00	723.00
IUUC-Ocu-074544	Oryctolagus cuniculus	91.99	0.00e+00	1990.00
IUUC-Oba-075120	Oryza barthii	43.17	0.00e+00	811.00
IUUC-Obr-076557	Oryza brachyantha	43.68	0.00e+00	804.00
IUUC-Ogl-077887	Oryza glaberrima	43.17	0.00e+00	813.00
IUUC-Ogu-078305	Oryza glumaepatula	41.75	0.00e+00	817.00
IUUC-Oin-079370	Oryza indica	42.83	0.00e+00	811.00
IUUC-Olo-081089	Oryza longistaminata	41.84	0.00e+00	818.00
IUUC-Ome-081942	Oryza meridionalis	43.17	0.00e+00	810.00
IUUC-Oni-082365	Oryza nivara	43.07	0.00e+00	812.00
IUUC-Opu-083977	Oryza punctata	43.33	0.00e+00	812.00
IUUC-Oru-084469	Oryza rufipogon	41.84	0.00e+00	821.00
IUUC-Osa-085949	Oryza sativa	43.47	0.00e+00	822.00
IUUC-Ola-087002	Oryzias latipes	73.80	0.00e+00	1572.00
IUUC-Olu-087687	Ostreococcus lucimarinus	41.91	0.00e+00	746.00
IUUC-Oga-088594	Otolemur garnettii	92.36	0.00e+00	1962.00
IUUC-Oar-090068	Ovis aries	91.25	0.00e+00	1972.00
IUUC-Pan-092114	Papio anubis	93.66	0.00e+00	2020.00
IUUC-Pno-095154	Phaeosphaeria nodorum	49.95	0.00e+00	1023.00
IUUC-Ppa-095416	Physcomitrella patens	43.32	0.00e+00	826.00
IUUC-Pfo-097184	Poecilia formosa	73.61	0.00e+00	1566.00
IUUC-Pab-097861	Pongo abelii	93.94	0.00e+00	1985.00
IUUC-Pop-098934	Populus trichocarpa	42.47	0.00e+00	845.00
IUUC-Pca-100347	Procavia capensis	91.87	0.00e+00	1649.00
IUUC-Ppe-102012	Prunus persica	42.12	0.00e+00	830.00
IUUC-Pva-102584	Pteropus vampyrus	92.36	0.00e+00	2011.00
IUUC-Pgr-103336	Puccinia graminis	52.35	0.00e+00	991.00
IUUC-Ptt-103939	Puccinia triticina	51.92	0.00e+00	996.00
IUUC-Pte-104200	Pyrenophora teres	50.53	0.00e+00	1014.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	49.67	0.00e+00	1002.00
IUUC-Rno-105462	Rattus norvegicus	91.52	0.00e+00	1935.00
IUUC-Sce-106245	Saccharomyces cerevisiae	50.05	0.00e+00	1017.00
IUUC-Sha-107142	Sarcophilus harrisii	82.95	0.00e+00	1816.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	53.52	0.00e+00	1074.00
IUUC-Spo-108034	Schizosaccharomyces pombe	51.53	0.00e+00	1009.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	51.75	0.00e+00	978.00
IUUC-Smo-109211	Selaginella moellendorffii	43.60	0.00e+00	819.00
IUUC-Sit-110281	Setaria italica	43.34	0.00e+00	826.00
IUUC-Sly-110914	Solanum lycopersicum	42.18	0.00e+00	827.00
IUUC-Stu-112109	Solanum tuberosum	42.27	0.00e+00	835.00
IUUC-Sar-113737	Sorex araneus	91.15	0.00e+00	1964.00
IUUC-Sbi-114520	Sorghum bicolor	42.97	0.00e+00	824.00
IUUC-Sre-115148	Sporisorium reilianum	52.78	0.00e+00	1025.00
IUUC-Ssc-115777	Sus scrofa	92.46	0.00e+00	1993.00
IUUC-Tru-118742	Takifugu rubripes	73.61	0.00e+00	1519.00
IUUC-Tni-120401	Tetraodon nigroviridis	74.43	0.00e+00	1522.00
IUUC-Tca-121672	Theobroma cacao	42.31	0.00e+00	831.00
IUUC-Tre-122009	Trichoderma reesei	50.97	0.00e+00	970.00
IUUC-Tvi-122259	Trichoderma virens	51.27	0.00e+00	966.00
IUUC-Tae-125113	Triticum aestivum	43.78	0.00e+00	791.00
IUUC-Tur-126189	Triticum urartu	43.34	0.00e+00	788.00
IUUC-Tme-127055	Tuber melanosporum	51.27	0.00e+00	946.00
IUUC-Tbe-127487	Tupaia belangeri	86.57	0.00e+00	924.00
IUUC-Ttr-128331	Tursiops truncatus	91.52	0.00e+00	1964.00
IUUC-Uma-129387	Ustilago maydis	52.99	0.00e+00	1027.00
IUUC-Vda-129977	Verticillium dahliae	51.12	0.00e+00	935.00
IUUC-Vvi-130857	Vitis vinifera	42.70	0.00e+00	832.00
IUUC-Xtr-132026	Xenopus tropicalis	60.56	0.00e+00	1171.00
IUUC-Xma-133805	Xiphophorus maculatus	73.42	0.00e+00	1543.00
IUUC-Yli-134547	Yarrowia lipolytica	51.38	0.00e+00	1025.00
IUUC-Zma-135052	Zea mays	43.22	0.00e+00	828.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence