iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073306

UUCD1 version

UUC-OrA-00793

Ensembl Protein ID

ENSOANP00000020009.1

UniProt Accession

F7BTM7; F7BTM7_ORNAN

Protein Name

Uncharacterized protein

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000012650.3	ENSOANT00000020012.1	ENSOANP00000020009.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.50e-122	410.0	336	764

Active Site

Position(s)	Description	Evidence
517	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Q++++G + q+kl+++ ++lvGag++GcEllK+++++G+     g itv+Dmd +e snl rqFLfr++dv k+KAevaa+a+++l
   Q: 336  YDGQRAVFGTDFQKKLGRQCYFLVGAGAIGCELLKSFAMLGLgagpgGGITVTDMDSIERSNLCRQFLFRPQDVSKPKAEVAAAAARQL 424
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           np   v++h  ++ +++e+i+   Ff+ +++V++aldn+e r +v+++c+++ +p++esgt G+ G + v ++ lt  y+++   ++ t
   Q: 425  NPRLAVTPHVHRVGPDTESIFgddFFSGLHGVATALDNFEGRQYVADRCVHYLKPMLESGTQGTRGSAGVYLPFLTQRYRAPVVNTSPT 513
           ***************************************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafak 247
           +P+ctl+++p+a+eht++wa            + +  +l  e+++ e+le    ++ ++ ++    ++ + +++++ +++++a++ ++ 
   Q: 514  FPVCTLRHFPSAIEHTLQWArdefeglfrqpaETVHRYL-REPSFLETLE---GAQALTLLESL-YSSLTHRPQDWRDCVSWARRLWQL 597
           **********************99988877755555555.4444444444...34444444444.4446678***************** PP
   S: 248  ttinsikqllksfecdivtkskspfwv............................................................sf 276
            ++ +i+qll +f++++++++++pfw+                                                              
   Q: 598  HYHDGIRQLLLHFPPEKMSQDGVPFWSgtkrcpqpldfdhrnpthldyilaaanlyaqvyglsgsknrdalqallrelsvpafqpraDA 686
           **************************************************************999999988888888877755555533 PP
   S: 277  csnaealqvpekvekdeevvkasap...lylllralerfekk..kgrkpgelsfekddds..avdlvtaaanlraeslgiep 351
             +a+ +++ + + +d+ +     +   l+ l  ale+ +++  + ++++ l fekddds  ++d++ aa+nlrae++gi+p
   Q: 687  QIFASDQEMEQQAPEDFSTE----QekrLQELRGALEKQQETflHASPMKPLLFEKDDDSnfHMDFIVAASNLRAENYGIPP 764
           33333333334444444432....123477777777777764446777778*****************************98 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

ISSQFFLSEK DLGKNRAEVS QPHLAQLNSF VPIRIHTEPL TEAFLRGFQS ASYTALPTSR 60
GGILGTGATW GGAPWGKSRE GSGGLGQFGL EWKRDGCSQD PTEAEPVSAP IQHISQGSPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCTCCTCCC AGTTTTTTCT GTCAGAGAAG GATCTGGGGA AGAACCGGGC AGAGGTCTCT 60
CAACCGCACC TAGCTCAGCT CAACAGCTTC GTCCCCATCA GGATCCACAC GGAGCCCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR023318--Ub_act_enz_dom_a
IPR019572--UBA_E1_Cys
IPR033127--UBQ-activ_enz_E1_Cys_AS

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF00899--ThiF
PF10585--UBA_e1_thiolCys

Gene Ontology

GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001311	Ailuropoda melanoleuca	50.96	0.00e+00	763.00
IUUC-Aca-004620	Anolis carolinensis	48.02	0.00e+00	740.00
IUUC-Ame-010933	Astyanax mexicanus	48.40	0.00e+00	689.00
IUUC-Bta-012767	Bos taurus	49.81	0.00e+00	751.00
IUUC-Cja-019152	Callithrix jacchus	50.70	0.00e+00	758.00
IUUC-Cfa-020622	Canis familiaris	49.87	0.00e+00	719.00
IUUC-Cpo-022526	Cavia porcellus	50.19	0.00e+00	749.00
IUUC-Csa-023462	Chlorocebus sabaeus	54.52	0.00e+00	741.00
IUUC-Cho-024436	Choloepus hoffmanni	52.49	5.00e-58	218.00
IUUC-Dre-028149	Danio rerio	48.60	0.00e+00	726.00
IUUC-Dno-029347	Dasypus novemcinctus	55.92	0.00e+00	759.00
IUUC-Dor-030229	Dipodomys ordii	47.50	0.00e+00	704.00
IUUC-Ete-033124	Echinops telfairi	54.53	7.00e-172	597.00
IUUC-Eca-033929	Equus caballus	53.69	0.00e+00	780.00
IUUC-Eeu-034717	Erinaceus europaeus	53.00	3.00e-172	598.00
IUUC-Fca-036564	Felis catus	54.42	0.00e+00	767.00
IUUC-Fal-037445	Ficedula albicollis	48.54	0.00e+00	664.00
IUUC-Gmo-039338	Gadus morhua	47.23	0.00e+00	696.00
IUUC-Gga-040365	Gallus gallus	47.38	0.00e+00	637.00
IUUC-Ggo-045336	Gorilla gorilla	50.70	0.00e+00	753.00
IUUC-Hsa-045982	Homo sapiens	50.45	0.00e+00	749.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	50.83	0.00e+00	758.00
IUUC-Lch-050371	Latimeria chalumnae	48.66	0.00e+00	748.00
IUUC-Loc-052936	Lepisosteus oculatus	49.55	0.00e+00	748.00
IUUC-Laf-054119	Loxodonta africana	54.95	0.00e+00	777.00
IUUC-Mcc-055843	Macaca mulatta	50.70	0.00e+00	761.00
IUUC-Meu-056534	Macropus eugenii	59.70	0.00e+00	787.00
IUUC-Mga-060052	Meleagris gallopavo	47.04	8.00e-175	606.00
IUUC-Mmr-061405	Microcebus murinus	50.96	0.00e+00	744.00
IUUC-Mdo-063058	Monodelphis domestica	54.73	0.00e+00	818.00
IUUC-Mmu-063280	Mus musculus	49.94	0.00e+00	741.00
IUUC-Mpu-066255	Mustela putorius furo	53.94	0.00e+00	743.00
IUUC-Mlu-067217	Myotis lucifugus	50.58	0.00e+00	750.00
IUUC-Nle-070072	Nomascus leucogenys	50.51	0.00e+00	746.00
IUUC-Opr-070715	Ochotona princeps	49.94	0.00e+00	693.00
IUUC-Ont-071671	Oreochromis niloticus	48.71	0.00e+00	725.00
IUUC-Ocu-074162	Oryctolagus cuniculus	52.81	0.00e+00	729.00
IUUC-Ola-087002	Oryzias latipes	47.50	0.00e+00	724.00
IUUC-Oga-088594	Otolemur garnettii	50.70	0.00e+00	751.00
IUUC-Oar-090068	Ovis aries	49.81	0.00e+00	749.00
IUUC-Ptr-090581	Pan troglodytes	53.38	0.00e+00	703.00
IUUC-Pan-092458	Papio anubis	54.52	0.00e+00	737.00
IUUC-Pfo-097184	Poecilia formosa	47.12	0.00e+00	721.00
IUUC-Pab-098653	Pongo abelii	54.39	0.00e+00	743.00
IUUC-Pca-100347	Procavia capensis	51.43	0.00e+00	694.00
IUUC-Pva-102584	Pteropus vampyrus	49.62	0.00e+00	740.00
IUUC-Rno-105462	Rattus norvegicus	49.94	0.00e+00	742.00
IUUC-Sha-107368	Sarcophilus harrisii	58.01	0.00e+00	863.00
IUUC-Sar-113737	Sorex araneus	50.06	0.00e+00	748.00
IUUC-Ssc-115777	Sus scrofa	50.58	0.00e+00	758.00
IUUC-Tru-118742	Takifugu rubripes	47.95	0.00e+00	704.00
IUUC-Tni-120401	Tetraodon nigroviridis	47.89	0.00e+00	704.00
IUUC-Tbe-127587	Tupaia belangeri	56.99	0.00e+00	662.00
IUUC-Ttr-128422	Tursiops truncatus	53.76	0.00e+00	668.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence