iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045885

UUCD1 version

UUC-HoS-01187

Ensembl Protein ID

ENSP00000381717.3

UniProt Accession

P62837; D3DQC9; P51669; Q3MN78; Q96RP6; UB2D2_HUMAN

Genbank Protein ID

AAA91460.1; AAC41750.1; AAX35690.1; AAK93958.1; BAG50891.1; BAG50911.1; EAW62095.1; EAW62096.1; EAW62097.1; AAH33349.1

Protein Name

Ubiquitin-conjugating enzyme E2 D2; (E3-independent) E2 ubiquitin-conjugating enzyme D2; E2 ubiquitin-conjugating enzyme D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2; p53-regulated ubiquitin-conjugating enzyme 1

Genbank Nucleotide ID

U39317; L40146; AY651263; AF317220; AK001311; AK001428; AC010378; CH471062; CH471062; BC033349

Gene Name

UBE2D2; PUBC1; UBC4; UBC5B; UBCH4; UBCH5B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000131508.15	ENST00000398733.7	ENSP00000381717.3
ENSG00000131508.15	ENST00000253815.3	ENSP00000253815.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
DrugBank
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20704751; 20625400; 20145714; 18703417; 19690162; 19687296; 19578373; 19264966; 17786241; 18643997; 18633460; 18451177; 17604280; 17513889; 17341663; 16288031; 16203730; 12615916; 15920166; 11823428
UBD/UBC-like/UBD_UBC	UBD_UBC	22902369

Classification

Family	E-value	Score	Start	End
E2/UBC	1.90e-56	191.3	5	139
UBD/UBC-like/UBD_UBC	3.40e-85	284.8	5	142

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
           R++kel++l++dpp+++sa+pv + d+++w+++i+Gp+d+pY+ggvF l+i+fp+dYPfkPPkv f+t+i+hPn+++nG++Cl+il+  ++W
   Q: 5    RIHKELNDLARDPPAQCSAGPVGD-DMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILR--SQW 93
           99**********************.9************************************************************9..*** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           spal++++vllsi+sll++pnp++pl  e+a+++k++re+y++++r
   Q: 94   SPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAR 139
           ******************************************9987 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqwsaa 92
           ri+kel+dl+rd++aq+sa++v+dd+f+++ati+gp+dspy+ggvfflti++ptdypfkppkvaf+t+iyhpninsngsicldilrsqws+a
   Q: 5    RIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPA 96
           8******************************************************************************************* PP
   S: 93   ltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           lt+skvlls+csll+d++pddplv+eiariyktd+eky+riarewt
   Q: 97   LTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWT 142
           *********************************************8 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.

Protein Sequence
(Fasta)

MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY 60
PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATCCCTGTG GGGGACTCCG GCCAGCCTGA GTGACGCGAT CCAAAGAGCG CTCCCGGGTA 60
GGAAATTGCC CTGGTGGAAT GCCTCGCCAG AGCAGCGTGT AGCAGGCCCC CGCGGAGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
GO:0035666--P:TRIF-dependent toll-like receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:7322

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001778	Ailuropoda melanoleuca	100.00	1.00e-81	294.00
IUUC-Apl-003199	Anas platyrhynchos	100.00	3.00e-81	293.00
IUUC-Aca-005236	Anolis carolinensis	100.00	4.00e-86	309.00
IUUC-Ago-007967	Ashbya gossypii	80.95	2.00e-71	260.00
IUUC-Ang-009725	Aspergillus niger	84.80	4.00e-62	229.00
IUUC-Ame-011831	Astyanax mexicanus	96.60	3.00e-83	300.00
IUUC-Bgr-012238	Blumeria graminis	80.27	1.00e-69	254.00
IUUC-Bta-013158	Bos taurus	100.00	4.00e-86	309.00
IUUC-Cel-018362	Caenorhabditis elegans	93.88	2.00e-81	294.00
IUUC-Cja-019886	Callithrix jacchus	100.00	4.00e-86	309.00
IUUC-Cfa-020436	Canis familiaris	100.00	4.00e-86	309.00
IUUC-Cpo-021714	Cavia porcellus	97.96	3.00e-84	303.00
IUUC-Csa-023148	Chlorocebus sabaeus	95.27	5.00e-81	292.00
IUUC-Csv-026311	Ciona savignyi	85.62	9.00e-73	265.00
IUUC-Dre-027758	Danio rerio	98.64	6.00e-85	305.00
IUUC-Dno-028952	Dasypus novemcinctus	100.00	8.00e-82	295.00
IUUC-Dme-031594	Drosophila melanogaster	94.56	2.00e-81	293.00
IUUC-Ete-032295	Echinops telfairi	100.00	3.00e-81	293.00
IUUC-Eca-033293	Equus caballus	100.00	2.00e-81	294.00
IUUC-Fox-038021	Fusarium oxysporum	84.35	1.00e-73	268.00
IUUC-Ggr-039912	Gaeumannomyces graminis	79.61	2.00e-69	254.00
IUUC-Gga-040758	Gallus gallus	100.00	4.00e-86	309.00
IUUC-Gac-042231	Gasterosteus aculeatus	97.28	6.00e-84	302.00
IUUC-Ggo-045375	Gorilla gorilla	95.95	3.00e-82	296.00
IUUC-Itr-048882	Ictidomys tridecemlineatus	96.62	4.00e-82	296.00
IUUC-Lma-053121	Leptosphaeria maculans	84.35	4.00e-74	270.00
IUUC-Laf-053580	Loxodonta africana	100.00	1.00e-81	295.00
IUUC-Mcc-054673	Macaca mulatta	100.00	2.00e-81	294.00
IUUC-Mor-057235	Magnaporthe oryzae	83.67	5.00e-73	266.00
IUUC-Mpo-057596	Magnaporthe poae	79.61	5.00e-69	253.00
IUUC-Mvi-060397	Microbotryum violaceum	82.31	7.00e-72	262.00
IUUC-Mdo-062962	Monodelphis domestica	100.00	4.00e-86	309.00
IUUC-Mmu-063518	Mus musculus	100.00	4.00e-86	309.00
IUUC-Mpu-066604	Mustela putorius furo	95.89	3.00e-82	296.00
IUUC-Ont-071766	Oreochromis niloticus	98.64	4.00e-85	306.00
IUUC-Ocu-074315	Oryctolagus cuniculus	100.00	4.00e-86	309.00
IUUC-Ola-086331	Oryzias latipes	98.64	4.00e-85	306.00
IUUC-Ptr-090707	Pan troglodytes	100.00	4.00e-86	309.00
IUUC-Pan-092143	Papio anubis	100.00	4.00e-86	309.00
IUUC-Pma-094405	Petromyzon marinus	94.81	1.00e-75	274.00
IUUC-Pno-094765	Phaeosphaeria nodorum	84.35	4.00e-74	270.00
IUUC-Pfo-096753	Poecilia formosa	98.64	4.00e-85	306.00
IUUC-Pab-097764	Pongo abelii	100.00	4.00e-86	309.00
IUUC-Pgr-103381	Puccinia graminis	82.31	1.00e-69	256.00
IUUC-Ptt-103723	Puccinia triticina	77.86	2.00e-61	227.00
IUUC-Sce-106153	Saccharomyces cerevisiae	80.56	4.00e-70	256.00
IUUC-Sja-107729	Schizosaccharomyces japonicus	84.35	5.00e-73	266.00
IUUC-Sar-113302	Sorex araneus	100.00	3.00e-81	293.00
IUUC-Tru-118272	Takifugu rubripes	98.64	1.00e-84	305.00
IUUC-Tni-120056	Tetraodon nigroviridis	98.64	1.00e-84	305.00
IUUC-Tre-122125	Trichoderma reesei	82.31	2.00e-71	261.00
IUUC-Tvi-122296	Trichoderma virens	82.31	2.00e-71	261.00
IUUC-Tbe-127609	Tupaia belangeri	100.00	1.00e-67	247.00
IUUC-Uma-129648	Ustilago maydis	81.63	1.00e-71	261.00
IUUC-Vpa-130446	Vicugna pacos	99.29	2.00e-80	291.00
IUUC-Xtr-132329	Xenopus tropicalis	100.00	4.00e-86	309.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence