iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000133884.9	ENST00000528416.5	ENSP00000436901.1
ENSG00000133884.9	ENST00000415073.6	ENSP00000399714.2
ENSG00000133884.9	ENST00000252268.8	ENSP00000252268.4
ENSG00000133884.9	ENST00000532102.5	ENSP00000434885.1
ENSG00000133884.9	ENST00000531989.1	ENSP00000435887.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
HINT	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	6.80e-11	43.8	342	388

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkC 51
           k C +Cg +++d+ +l+ C++C++ +H  Cl +s  +e p+ + w C  C
   Q: 342  KCCNICGTSENDD-QLLFCDDCDRGYHMYCLTPS-MSEPPEGS-WSCHLC 388
           78********987.7*******************.77777776.****** PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAAVVENVVK LLGEQYYKDA MEQCHNYNAR LCAERSVRLP FLDSQTGVAQ SNCYIWMEKR 60
HRGPGLASGQ LYSYPARRWR KKRRAHPPED PRLSFPSIKP DTDQTLKKEG LISQDGSSLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGCTCGCT CTAGTGCGCG CGCCCGGACG GCGCCTGCGC AGAGGGCAAG GAACCTGGTA 60
CCCCGGTGCG GTCCCGGCGC CTGCGCGCTG CGGACTGTGG GGCTTCTCGG CCCGAGGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025750--Requiem/DPF_N_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50016--ZF_PHD_2

Pfam

PF00628--PHD
PF14051--Requiem_N

SMART

SM00249--PHD

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011490	Astyanax mexicanus	75.20	2.00e-129	455.00
IUUC-Bta-012444	Bos taurus	96.05	0.00e+00	688.00
IUUC-Bdi-014990	Brachypodium distachyon	38.68	2.00e-07	50.10
IUUC-Cja-018790	Callithrix jacchus	98.77	0.00e+00	718.00
IUUC-Cfa-021170	Canis familiaris	100.00	0.00e+00	728.00
IUUC-Cpo-021708	Cavia porcellus	96.05	0.00e+00	687.00
IUUC-Csv-026070	Ciona savignyi	49.04	1.00e-54	206.00
IUUC-Dre-028764	Danio rerio	76.21	4.00e-149	521.00
IUUC-Dno-029032	Dasypus novemcinctus	99.01	0.00e+00	726.00
IUUC-Dor-030178	Dipodomys ordii	92.34	8.00e-113	400.00
IUUC-Dme-032134	Drosophila melanogaster	76.58	7.00e-52	198.00
IUUC-Eca-034080	Equus caballus	96.05	0.00e+00	686.00
IUUC-Fca-036246	Felis catus	100.00	0.00e+00	728.00
IUUC-Gmo-038909	Gadus morhua	73.38	1.00e-133	469.00
IUUC-Gga-041245	Gallus gallus	91.64	3.00e-178	617.00
IUUC-Gac-042460	Gasterosteus aculeatus	69.14	1.00e-138	486.00
IUUC-Ggo-045590	Gorilla gorilla	95.82	0.00e+00	684.00
IUUC-Itr-048034	Ictidomys tridecemlineatus	99.75	0.00e+00	727.00
IUUC-Laf-054024	Loxodonta africana	99.01	0.00e+00	726.00
IUUC-Mcc-055262	Macaca mulatta	100.00	0.00e+00	728.00
IUUC-Meu-056031	Macropus eugenii	93.40	0.00e+00	666.00
IUUC-Mmr-061145	Microcebus murinus	99.75	0.00e+00	726.00
IUUC-Mdo-062333	Monodelphis domestica	97.04	0.00e+00	713.00
IUUC-Mmu-063781	Mus musculus	98.52	0.00e+00	724.00
IUUC-Mpu-065905	Mustela putorius furo	99.75	0.00e+00	728.00
IUUC-Mlu-067867	Myotis lucifugus	93.81	0.00e+00	669.00
IUUC-Nle-069593	Nomascus leucogenys	96.30	0.00e+00	688.00
IUUC-Opr-070241	Ochotona princeps	92.59	0.00e+00	668.00
IUUC-Ont-071749	Oreochromis niloticus	77.91	1.00e-151	529.00
IUUC-Oan-072756	Ornithorhynchus anatinus	85.05	7.00e-156	543.00
IUUC-Ocu-074715	Oryctolagus cuniculus	98.74	0.00e+00	707.00
IUUC-Ola-086768	Oryzias latipes	80.20	3.00e-159	554.00
IUUC-Oga-088814	Otolemur garnettii	95.31	0.00e+00	683.00
IUUC-Oar-089928	Ovis aries	96.05	0.00e+00	688.00
IUUC-Ptr-090740	Pan troglodytes	100.00	0.00e+00	728.00
IUUC-Pan-092361	Papio anubis	100.00	0.00e+00	728.00
IUUC-Psi-093846	Pelodiscus sinensis	93.09	0.00e+00	668.00
IUUC-Pma-094466	Petromyzon marinus	70.90	2.00e-136	478.00
IUUC-Pfo-096452	Poecilia formosa	77.62	2.00e-148	518.00
IUUC-Pab-097789	Pongo abelii	100.00	0.00e+00	728.00
IUUC-Pva-103052	Pteropus vampyrus	95.80	0.00e+00	687.00
IUUC-Rno-105397	Rattus norvegicus	99.26	0.00e+00	727.00
IUUC-Sha-106820	Sarcophilus harrisii	94.32	0.00e+00	693.00
IUUC-Sar-113460	Sorex araneus	100.00	3.00e-81	295.00
IUUC-Ssc-116059	Sus scrofa	99.75	0.00e+00	728.00
IUUC-Tru-118006	Takifugu rubripes	80.24	3.00e-159	555.00
IUUC-Tni-120652	Tetraodon nigroviridis	77.72	9.00e-150	523.00
IUUC-Tbe-128093	Tupaia belangeri	93.83	0.00e+00	664.00
IUUC-Ttr-129279	Tursiops truncatus	96.05	0.00e+00	688.00
IUUC-Vpa-130748	Vicugna pacos	94.27	5.00e-136	477.00
IUUC-Xtr-131867	Xenopus tropicalis	86.15	6.00e-169	587.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence