iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000134452.19	ENST00000379999.6	ENSP00000369335.5
ENSG00000134452.19	ENST00000397269.7	ENSP00000380439.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	15117950

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	29.67	5.00e-42	168.00	IUUC-Spo-108147

Organism

Homo sapiens

Functional Description
(View)

3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578).

Protein Sequence
(Fasta)

MSYEVTSGCH WTCQVPESCD NGLHCAGPLG HLHRRCQRTS AHLLVFTEHA EMRRFKRKHL 60
TAIDCQHLAR SHLAVTQPFG QRWTNRDPNH GLYPKPRTKR GSRGQGSQRC IPEFFLAGKQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGCTCGCG GAGGAAGTCG GCGGGCGTCT CGGGCTCCAG GTCCCGGCCA GAGGAGGAGC 60
TCGCTGCCGG GGGACGCTGG GCTGAGCGGC CGGCGGCGCG GGCCCGGCGG CGGCGGCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR014017--DNA_helicase_UvrD-like_C
IPR000212--DNA_helicase_UvrD/REP
IPR001810--F-box_dom
IPR027417--P-loop_NTPase

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF13361--UvrD_C

Gene Ontology

GO:0000785--C:chromatin
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0043138--F:3'-5' DNA helicase activity
GO:0005524--F:ATP binding
GO:0004003--F:ATP-dependent DNA helicase activity
GO:0003678--F:DNA helicase activity
GO:0015616--F:DNA translocase activity
GO:0003690--F:double-stranded DNA binding
GO:0003697--F:single-stranded DNA binding
GO:0008219--P:cell death
GO:0006974--P:cellular response to DNA damage stimulus
GO:0000737--P:DNA catabolic process, endonucleolytic
GO:0000724--P:double-strand break repair via homologous recombination
GO:0035562--P:negative regulation of chromatin binding
GO:2000042--P:negative regulation of double-strand break repair via homologous recombination
GO:1902231--P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0001934--P:positive regulation of protein phosphorylation
GO:0016567--P:protein ubiquitination
GO:0031297--P:replication fork processing
GO:0048478--P:replication fork protection
GO:0072429--P:response to intra-S DNA damage checkpoint signaling

KEGG

hsa:84893

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000424	Aegilops tauschii	43.48	1.00e-03	40.00
IUUC-Aml-001396	Ailuropoda melanoleuca	91.13	0.00e+00	1948.00
IUUC-Atr-002826	Amborella trichopoda	41.27	1.00e-03	39.70
IUUC-Apl-003317	Anas platyrhynchos	48.46	0.00e+00	951.00
IUUC-Aca-004498	Anolis carolinensis	54.06	0.00e+00	951.00
IUUC-Ath-007293	Arabidopsis thaliana	35.29	5.00e-03	37.40
IUUC-Ani-009226	Aspergillus nidulans	32.50	2.00e-06	48.50
IUUC-Ate-010526	Aspergillus terreus	38.24	1.00e-03	39.30
IUUC-Ame-011808	Astyanax mexicanus	59.34	1.00e-133	469.00
IUUC-Bta-013250	Bos taurus	88.81	0.00e+00	1891.00
IUUC-Bol-015348	Brassica oleracea	37.68	4.00e-03	37.70
IUUC-Cja-019638	Callithrix jacchus	97.13	0.00e+00	2113.00
IUUC-Cfa-020195	Canis familiaris	92.49	0.00e+00	1865.00
IUUC-Cpo-022269	Cavia porcellus	86.69	0.00e+00	1821.00
IUUC-Cre-022611	Chlamydomonas reinhardtii	40.28	3.00e-08	54.70
IUUC-Csa-024060	Chlorocebus sabaeus	98.04	0.00e+00	1875.00
IUUC-Cho-025003	Choloepus hoffmanni	88.89	0.00e+00	722.00
IUUC-Cin-025694	Ciona intestinalis	28.57	9.00e-32	131.00
IUUC-Cgl-026626	Colletotrichum gloeosporioides	45.71	1.70e-02	35.40
IUUC-Dre-028083	Danio rerio	49.72	0.00e+00	852.00
IUUC-Dno-029203	Dasypus novemcinctus	87.49	0.00e+00	1793.00
IUUC-Dor-030477	Dipodomys ordii	79.07	0.00e+00	794.00
IUUC-Ete-032861	Echinops telfairi	88.53	0.00e+00	1870.00
IUUC-Eca-033205	Equus caballus	92.07	0.00e+00	2002.00
IUUC-Eeu-034784	Erinaceus europaeus	85.78	0.00e+00	1211.00
IUUC-Fca-035797	Felis catus	90.84	0.00e+00	1961.00
IUUC-Gmo-038855	Gadus morhua	46.45	6.00e-125	442.00
IUUC-Gga-040326	Gallus gallus	50.91	0.00e+00	990.00
IUUC-Gac-042240	Gasterosteus aculeatus	42.27	0.00e+00	738.00
IUUC-Ggo-045050	Gorilla gorilla	94.53	0.00e+00	2082.00
IUUC-Itr-047965	Ictidomys tridecemlineatus	97.42	0.00e+00	780.00
IUUC-Lch-050231	Latimeria chalumnae	42.94	2.00e-171	596.00
IUUC-Loc-051884	Lepisosteus oculatus	50.00	0.00e+00	994.00
IUUC-Lma-053267	Leptosphaeria maculans	22.53	2.00e-04	42.00
IUUC-Laf-053843	Loxodonta africana	90.82	0.00e+00	1943.00
IUUC-Mcc-055570	Macaca mulatta	95.89	0.00e+00	2132.00
IUUC-Meu-056798	Macropus eugenii	67.68	6.00e-154	538.00
IUUC-Mtr-057915	Medicago truncatula	38.24	4.00e-05	44.70
IUUC-Mla-058841	Melampsora laricipopulina	34.55	3.00e-02	31.60
IUUC-Mga-059648	Meleagris gallopavo	51.82	0.00e+00	954.00
IUUC-Mmr-060757	Microcebus murinus	90.46	0.00e+00	1930.00
IUUC-Mdo-061913	Monodelphis domestica	69.75	0.00e+00	1387.00
IUUC-Mmu-064337	Mus musculus	89.87	0.00e+00	1943.00
IUUC-Mac-064479	Musa acuminata	36.92	3.00e-03	37.70
IUUC-Mpu-066483	Mustela putorius furo	90.14	0.00e+00	1954.00
IUUC-Mlu-068204	Myotis lucifugus	85.21	0.00e+00	1826.00
IUUC-Ncr-068735	Neurospora crassa	35.94	6.00e-03	37.00
IUUC-Nle-070053	Nomascus leucogenys	97.26	0.00e+00	2125.00
IUUC-Opr-070588	Ochotona princeps	83.96	0.00e+00	1817.00
IUUC-Ont-072655	Oreochromis niloticus	47.13	0.00e+00	762.00
IUUC-Oan-073351	Ornithorhynchus anatinus	63.02	0.00e+00	1338.00
IUUC-Ocu-074465	Oryctolagus cuniculus	90.65	0.00e+00	1864.00
IUUC-Obr-076710	Oryza brachyantha	35.29	4.00e-03	37.70
IUUC-Oin-079176	Oryza indica	23.62	3.00e-05	43.50
IUUC-Opu-083155	Oryza punctata	47.50	4.00e-03	37.40
IUUC-Olu-087831	Ostreococcus lucimarinus	32.14	4.00e-66	247.00
IUUC-Oga-089088	Otolemur garnettii	91.48	0.00e+00	1907.00
IUUC-Oar-089870	Ovis aries	87.95	0.00e+00	1846.00
IUUC-Ptr-090957	Pan troglodytes	98.16	0.00e+00	2164.00
IUUC-Pan-092632	Papio anubis	97.99	0.00e+00	2029.00
IUUC-Psi-093035	Pelodiscus sinensis	55.92	0.00e+00	1158.00
IUUC-Pno-094870	Phaeosphaeria nodorum	25.27	4.00e-05	43.90
IUUC-Ppa-095660	Physcomitrella patens	38.36	1.00e-03	40.00
IUUC-Pfo-096902	Poecilia formosa	44.66	0.00e+00	686.00
IUUC-Pab-098206	Pongo abelii	97.78	0.00e+00	1913.00
IUUC-Pop-098801	Populus trichocarpa	37.68	9.00e-05	43.10
IUUC-Pca-100238	Procavia capensis	83.53	0.00e+00	1842.00
IUUC-Ppe-101748	Prunus persica	33.82	4.00e-03	37.70
IUUC-Pva-103182	Pteropus vampyrus	86.46	0.00e+00	1872.00
IUUC-Pte-104033	Pyrenophora teres	24.29	2.00e-04	41.60
IUUC-Pyt-104599	Pyrenophora triticirepentis	24.29	2.00e-04	42.00
IUUC-Rno-105141	Rattus norvegicus	89.67	0.00e+00	1944.00
IUUC-Sce-106341	Saccharomyces cerevisiae	27.91	5.00e-03	36.60
IUUC-Sha-106827	Sarcophilus harrisii	67.87	0.00e+00	1451.00
IUUC-Sja-107882	Schizosaccharomyces japonicus	29.33	7.00e-43	169.00
IUUC-Spo-108147	Schizosaccharomyces pombe	29.67	2.00e-42	167.00
IUUC-Ssl-108584	Sclerotinia sclerotiorum	24.24	7.00e-04	39.70
IUUC-Sly-111170	Solanum lycopersicum	37.88	6.00e-03	36.20
IUUC-Sre-115025	Sporisorium reilianum	34.39	2.00e-38	154.00
IUUC-Ssc-116188	Sus scrofa	94.14	0.00e+00	1277.00
IUUC-Tgu-116612	Taeniopygia guttata	57.80	2.00e-163	568.00
IUUC-Tsy-119560	Tarsius syrichta	83.06	9.00e-117	415.00
IUUC-Tni-120734	Tetraodon nigroviridis	45.77	0.00e+00	707.00
IUUC-Tca-121338	Theobroma cacao	31.78	2.00e-03	38.50
IUUC-Tre-122089	Trichoderma reesei	35.82	2.00e-04	41.60
IUUC-Tae-125126	Triticum aestivum	36.23	1.00e-03	38.10
IUUC-Tme-127009	Tuber melanosporum	22.86	2.00e-04	42.00
IUUC-Tbe-127431	Tupaia belangeri	88.02	0.00e+00	1693.00
IUUC-Ttr-128744	Tursiops truncatus	85.39	0.00e+00	1852.00
IUUC-Uma-129536	Ustilago maydis	34.78	1.00e-39	159.00
IUUC-Vpa-130123	Vicugna pacos	69.31	2.00e-108	387.00
IUUC-Vvi-131025	Vitis vinifera	36.76	7.00e-04	40.00
IUUC-Xtr-132902	Xenopus tropicalis	58.37	0.00e+00	1017.00
IUUC-Xma-133978	Xiphophorus maculatus	45.94	9.00e-153	534.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence