iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000134574.11	ENST00000256996.8	ENSP00000256996.3
ENSG00000134574.11	ENST00000378601.7	ENSP00000367864.3
ENSG00000134574.11	ENST00000622090.4	ENSP00000479994.1
ENSG00000134574.11	ENST00000610805.4	ENSP00000478063.1
ENSG00000134574.11	ENST00000616278.4	ENSP00000478411.1
ENSG00000134574.11	ENST00000378600.7	ENSP00000367863.3
ENSG00000134574.11	ENST00000378603.7	ENSP00000367866.3
ENSG00000134574.11	ENST00000617847.4	ENSP00000482080.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	19109893; 15882621

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-10	42.9	241	274

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrt 32
           H+ +vt +a+    d++l+++s D t+k+WDlr+
   Q: 241  HKKKVTHVALnpcCDWFLATASVDQTVKIWDLRQ 274
           7888999999975559***************986 PP

Organism

Homo sapiens

Functional Description
(View)

Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.

Protein Sequence
(Fasta)

MAPKKRPETQ KTSEIVLRPR NKRSRSPLEL EPEAKKLCAK GSGPSRRCDS DCLWVGLAGP 60
QILPPCRSIV RTLHQHKLGR ASWPSVQQGL QQSFLHTLDS YRILQKAAPF DRRATSLAWH 120

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Nucleotide Sequence
(Fasta)

ACCCGCAGAG GCCTGGCAGC GCCGCGTTTG AGGAGGGTTC GTGTCAGGAA GTCAAGGCTG 60
GATGATCGCT TAAGCCCAGG AGTTAAAGAC CGGCCCGGAC AACAAAGCGA GACCCCGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0857--Xeroderma pigmentosum

Interpro

IPR033312--DDB2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0030054--C:cell junction
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0003684--F:damaged DNA binding
GO:0003677--F:DNA binding
GO:0006281--P:DNA repair
GO:0070911--P:global genome nucleotide-excision repair
GO:0035518--P:histone H2A monoubiquitination
GO:0006289--P:nucleotide-excision repair
GO:0000715--P:nucleotide-excision repair, DNA damage recognition
GO:0000717--P:nucleotide-excision repair, DNA duplex unwinding
GO:0033683--P:nucleotide-excision repair, DNA incision
GO:0006295--P:nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296--P:nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006294--P:nucleotide-excision repair, preincision complex assembly
GO:0006293--P:nucleotide-excision repair, preincision complex stabilization
GO:0051865--P:protein autoubiquitination
GO:0016579--P:protein deubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006290--P:pyrimidine dimer repair
GO:0009411--P:response to UV
GO:0070914--P:UV-damage excision repair

KEGG

hsa:1643

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000470	Aegilops tauschii	29.48	9.00e-31	128.00
IUUC-Aml-002203	Ailuropoda melanoleuca	86.85	0.00e+00	751.00
IUUC-Atr-002957	Amborella trichopoda	30.09	4.00e-35	142.00
IUUC-Apl-003832	Anas platyrhynchos	52.63	1.00e-124	440.00
IUUC-Aca-004358	Anolis carolinensis	52.99	9.00e-129	453.00
IUUC-Aly-006296	Arabidopsis lyrata	30.06	3.00e-34	140.00
IUUC-Ath-007115	Arabidopsis thaliana	30.06	2.00e-35	144.00
IUUC-Ame-010817	Astyanax mexicanus	51.26	2.00e-121	429.00
IUUC-Bta-012914	Bos taurus	84.78	0.00e+00	760.00
IUUC-Bdi-014261	Brachypodium distachyon	29.63	7.00e-31	129.00
IUUC-Bol-015317	Brassica oleracea	30.30	3.00e-35	143.00
IUUC-Bra-016848	Brassica rapa	30.30	3.00e-35	143.00
IUUC-Cja-018967	Callithrix jacchus	97.89	0.00e+00	844.00
IUUC-Cfa-021238	Canis familiaris	86.85	0.00e+00	722.00
IUUC-Cpo-022063	Cavia porcellus	79.67	0.00e+00	704.00
IUUC-Csa-023382	Chlorocebus sabaeus	98.36	0.00e+00	879.00
IUUC-Cho-024805	Choloepus hoffmanni	59.16	2.00e-90	325.00
IUUC-Dre-028732	Danio rerio	48.48	4.00e-106	378.00
IUUC-Dor-030461	Dipodomys ordii	80.71	1.00e-124	439.00
IUUC-Ete-033038	Echinops telfairi	73.77	0.00e+00	650.00
IUUC-Eca-033772	Equus caballus	87.12	0.00e+00	723.00
IUUC-Eeu-034662	Erinaceus europaeus	62.81	2.00e-65	243.00
IUUC-Fca-036095	Felis catus	86.22	0.00e+00	726.00
IUUC-Gmo-039683	Gadus morhua	49.44	1.00e-105	377.00
IUUC-Gga-040530	Gallus gallus	60.33	2.00e-125	442.00
IUUC-Gac-041517	Gasterosteus aculeatus	49.04	6.00e-98	351.00
IUUC-Gma-043378	Glycine max	31.02	2.00e-38	153.00
IUUC-Ggo-045364	Gorilla gorilla	99.77	0.00e+00	890.00
IUUC-Hvu-047151	Hordeum vulgare	30.82	7.00e-28	117.00
IUUC-Itr-048304	Ictidomys tridecemlineatus	86.40	0.00e+00	762.00
IUUC-Lpe-051256	Leersia perrieri	30.06	1.00e-30	127.00
IUUC-Loc-052398	Lepisosteus oculatus	58.29	9.00e-126	443.00
IUUC-Laf-053562	Loxodonta africana	84.31	0.00e+00	726.00
IUUC-Mcc-055197	Macaca mulatta	76.40	0.00e+00	635.00
IUUC-Meu-056151	Macropus eugenii	76.00	2.00e-121	428.00
IUUC-Mtr-057940	Medicago truncatula	30.79	6.00e-36	145.00
IUUC-Mga-059923	Meleagris gallopavo	60.33	2.00e-132	465.00
IUUC-Mmr-061465	Microcebus murinus	95.32	3.00e-161	561.00
IUUC-Mdo-063063	Monodelphis domestica	66.13	2.00e-160	558.00
IUUC-Mmu-064294	Mus musculus	78.45	0.00e+00	685.00
IUUC-Mac-065598	Musa acuminata	31.34	8.00e-33	135.00
IUUC-Mpu-066831	Mustela putorius furo	86.62	0.00e+00	751.00
IUUC-Mlu-067222	Myotis lucifugus	83.22	0.00e+00	735.00
IUUC-Nle-069581	Nomascus leucogenys	98.83	0.00e+00	885.00
IUUC-Opr-070644	Ochotona princeps	84.31	0.00e+00	734.00
IUUC-Ont-072605	Oreochromis niloticus	55.18	2.00e-115	409.00
IUUC-Oan-072973	Ornithorhynchus anatinus	71.35	7.00e-151	526.00
IUUC-Ocu-074615	Oryctolagus cuniculus	84.31	0.00e+00	760.00
IUUC-Oba-075283	Oryza barthii	29.63	2.00e-30	127.00
IUUC-Obr-076605	Oryza brachyantha	30.37	3.00e-32	133.00
IUUC-Ogl-077512	Oryza glaberrima	29.63	2.00e-30	127.00
IUUC-Ogu-078329	Oryza glumaepatula	29.63	1.00e-30	127.00
IUUC-Oin-079980	Oryza indica	29.63	2.00e-30	127.00
IUUC-Olo-080516	Oryza longistaminata	29.32	8.00e-31	128.00
IUUC-Ome-081415	Oryza meridionalis	29.63	2.00e-30	127.00
IUUC-Oni-082985	Oryza nivara	29.63	2.00e-30	127.00
IUUC-Opu-084159	Oryza punctata	29.94	7.00e-31	128.00
IUUC-Oru-085137	Oryza rufipogon	29.63	1.00e-30	128.00
IUUC-Osa-085614	Oryza sativa	29.63	8.00e-31	128.00
IUUC-Ola-087044	Oryzias latipes	46.43	4.00e-103	368.00
IUUC-Oga-088274	Otolemur garnettii	89.70	0.00e+00	784.00
IUUC-Oar-089826	Ovis aries	85.01	0.00e+00	768.00
IUUC-Ptr-091631	Pan troglodytes	100.00	0.00e+00	892.00
IUUC-Pan-092535	Papio anubis	98.83	0.00e+00	884.00
IUUC-Psi-093815	Pelodiscus sinensis	55.69	4.00e-126	444.00
IUUC-Pma-094474	Petromyzon marinus	48.05	1.00e-95	343.00
IUUC-Ppa-095414	Physcomitrella patens	27.20	7.00e-27	115.00
IUUC-Pfo-096559	Poecilia formosa	50.00	2.00e-102	366.00
IUUC-Pab-098528	Pongo abelii	99.06	0.00e+00	885.00
IUUC-Pop-100064	Populus trichocarpa	28.83	2.00e-34	140.00
IUUC-Pca-100803	Procavia capensis	81.50	0.00e+00	717.00
IUUC-Ppe-101966	Prunus persica	30.18	5.00e-36	145.00
IUUC-Pva-103213	Pteropus vampyrus	84.78	0.00e+00	721.00
IUUC-Rno-105087	Rattus norvegicus	78.91	0.00e+00	694.00
IUUC-Sha-107466	Sarcophilus harrisii	71.75	4.00e-155	541.00
IUUC-Smo-108958	Selaginella moellendorffii	28.06	4.00e-27	116.00
IUUC-Sit-109968	Setaria italica	29.01	4.00e-29	122.00
IUUC-Sly-111495	Solanum lycopersicum	30.46	3.00e-34	139.00
IUUC-Stu-112182	Solanum tuberosum	26.59	9.00e-14	72.40
IUUC-Sar-113272	Sorex araneus	78.47	5.00e-163	566.00
IUUC-Sbi-114706	Sorghum bicolor	27.81	4.00e-26	113.00
IUUC-Ssc-115437	Sus scrofa	86.65	0.00e+00	762.00
IUUC-Tgu-116602	Taeniopygia guttata	58.97	1.00e-122	433.00
IUUC-Tru-118698	Takifugu rubripes	49.58	7.00e-99	354.00
IUUC-Tsy-119027	Tarsius syrichta	89.21	0.00e+00	723.00
IUUC-Tni-119787	Tetraodon nigroviridis	48.88	4.00e-103	368.00
IUUC-Tca-121447	Theobroma cacao	29.73	7.00e-37	148.00
IUUC-Tae-125839	Triticum aestivum	29.79	4.00e-31	129.00
IUUC-Tur-126724	Triticum urartu	29.79	4.00e-31	129.00
IUUC-Tbe-127680	Tupaia belangeri	84.73	3.00e-139	488.00
IUUC-Ttr-128201	Tursiops truncatus	76.81	0.00e+00	652.00
IUUC-Vpa-130451	Vicugna pacos	69.60	3.00e-108	385.00
IUUC-Vvi-131001	Vitis vinifera	30.40	2.00e-36	147.00
IUUC-Xtr-132266	Xenopus tropicalis	62.40	1.00e-130	459.00
IUUC-Xma-133034	Xiphophorus maculatus	53.68	2.00e-114	405.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence