iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000134882.15	ENST00000355700.9	ENSP00000347928.5
ENSG00000134882.15	ENST00000403766.7	ENSP00000383911.3
ENSG00000134882.15	ENST00000376440.6	ENSP00000365623.2
ENSG00000134882.15	ENST00000457666.1	ENSP00000402249.1
ENSG00000134882.15	ENST00000474510.2	ENSP00000481260.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	23161479

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	9.70e-13	49.5	306	344

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +e++++ l+eMGF+r +al+aLra+nn+l++A+++Ll +
   Q: 306  SEEQVARLMEMGFSRGDALEALRASNNDLNVATNFLLQH 344
           79**********************************976 PP

Organism

Homo sapiens

Functional Description
(View)

Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets.

Protein Sequence
(Fasta)

MFTSTGSSGL YKAPLSKSLL LVPSALSLLL ALLLPHCQKL FVYDLHAVKN DFQIWRLICG 60
RIICLDLKDT FCSSLLIYNF RIFERRYGSR KFASFLLGSW VLSALFDFLL IEAMQYFFGI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGTTCGTCA GCGGCGAGTG GCCTCGCGGC GCCGGATTCG TCGCTCCGCC AAGAGTGCGC 60
CTGCGCGGTC GCTGGGGCTC GCACTTCAGC TTCCCCTCCC CCGGCGCCCT CTGGGGCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0472--Membrane
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR022764--Peptidase_S54_rhomboid_dom
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS50030--UBA

Pfam

PF00627--UBA

SMART

SM00165--UBA

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0043130--F:ubiquitin binding
GO:1904153--P:negative regulation of retrograde protein transport, ER to cytosol
GO:0070972--P:protein localization to endoplasmic reticulum

KEGG

hsa:337867

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002272	Ailuropoda melanoleuca	89.55	1.00e-161	561.00
IUUC-Atr-002884	Amborella trichopoda	31.03	2.00e-06	45.80
IUUC-Apl-004075	Anas platyrhynchos	80.23	1.00e-152	532.00
IUUC-Aca-004595	Anolis carolinensis	72.75	1.00e-131	462.00
IUUC-Aly-006411	Arabidopsis lyrata	28.28	4.00e-16	78.60
IUUC-Ath-007083	Arabidopsis thaliana	26.98	2.00e-21	95.90
IUUC-Ago-007789	Ashbya gossypii	28.43	2.00e-04	39.70
IUUC-Acl-008340	Aspergillus clavatus	29.47	4.00e-04	38.90
IUUC-Afu-009037	Aspergillus fumigatus	26.80	1.00e-04	40.80
IUUC-Ang-009777	Aspergillus niger	28.00	5.00e-06	44.70
IUUC-Ame-011242	Astyanax mexicanus	58.74	4.00e-53	201.00
IUUC-Bgr-012021	Blumeria graminis	27.48	2.00e-06	46.60
IUUC-Bta-013487	Bos taurus	87.25	1.00e-161	561.00
IUUC-Bci-013918	Botrytis cinerea	27.03	1.00e-09	57.00
IUUC-Bdi-014757	Brachypodium distachyon	30.77	3.00e-24	105.00
IUUC-Bol-015531	Brassica oleracea	30.82	3.00e-12	65.90
IUUC-Bra-017181	Brassica rapa	32.08	1.00e-13	70.10
IUUC-Cja-018818	Callithrix jacchus	97.68	2.00e-176	611.00
IUUC-Cfa-021174	Canis familiaris	88.99	9.00e-162	562.00
IUUC-Cpo-021964	Cavia porcellus	92.75	7.00e-164	569.00
IUUC-Cre-022898	Chlamydomonas reinhardtii	32.32	2.00e-08	53.10
IUUC-Csa-024015	Chlorocebus sabaeus	98.55	2.00e-177	614.00
IUUC-Cho-024706	Choloepus hoffmanni	82.90	6.00e-141	493.00
IUUC-Cgl-026433	Colletotrichum gloeosporioides	26.72	1.00e-09	57.00
IUUC-Cne-026916	Cryptococcus neoformans	28.14	1.00e-04	40.80
IUUC-Dre-027633	Danio rerio	59.54	4.00e-101	361.00
IUUC-Dno-029418	Dasypus novemcinctus	89.86	3.00e-163	567.00
IUUC-Dor-030432	Dipodomys ordii	88.99	4.00e-170	590.00
IUUC-Dse-031426	Dothistroma septosporum	23.81	2.00e-11	63.20
IUUC-Ete-032599	Echinops telfairi	75.65	6.00e-126	443.00
IUUC-Eca-034280	Equus caballus	89.35	5.00e-157	546.00
IUUC-Eeu-034998	Erinaceus europaeus	87.54	2.00e-159	555.00
IUUC-Fca-036332	Felis catus	86.26	1.00e-157	548.00
IUUC-Fal-036680	Ficedula albicollis	79.13	6.00e-151	526.00
IUUC-Fox-037932	Fusarium oxysporum	21.68	2.00e-07	49.30
IUUC-Fso-038343	Fusarium solani	39.02	2.00e-04	39.30
IUUC-Gmo-039606	Gadus morhua	58.38	1.00e-83	303.00
IUUC-Ggr-039926	Gaeumannomyces graminis	27.38	1.00e-04	40.40
IUUC-Gga-041116	Gallus gallus	76.30	9.00e-141	493.00
IUUC-Gac-041765	Gasterosteus aculeatus	55.20	1.00e-83	303.00
IUUC-Gma-043400	Glycine max	25.44	4.00e-15	75.10
IUUC-Ggo-045366	Gorilla gorilla	99.42	7.00e-179	619.00
IUUC-Hvu-047737	Hordeum vulgare	28.28	3.00e-11	62.40
IUUC-Itr-048679	Ictidomys tridecemlineatus	92.52	1.00e-77	281.00
IUUC-Lpe-051354	Leersia perrieri	31.21	7.00e-14	72.80
IUUC-Loc-052511	Lepisosteus oculatus	65.12	4.00e-109	387.00
IUUC-Laf-053414	Loxodonta africana	87.25	1.00e-158	552.00
IUUC-Mcc-055111	Macaca mulatta	99.13	2.00e-178	617.00
IUUC-Meu-056905	Macropus eugenii	78.00	2.00e-117	414.00
IUUC-Mor-057083	Magnaporthe oryzae	25.43	9.00e-06	43.90
IUUC-Mpo-057326	Magnaporthe poae	28.67	7.00e-05	41.20
IUUC-Mtr-057918	Medicago truncatula	26.37	1.00e-17	83.60
IUUC-Mla-058868	Melampsora laricipopulina	26.75	2.00e-04	39.70
IUUC-Mga-059639	Meleagris gallopavo	77.85	3.00e-63	233.00
IUUC-Mvi-060380	Microbotryum violaceum	34.04	6.00e-02	32.00
IUUC-Mmr-061267	Microcebus murinus	91.05	9.00e-144	502.00
IUUC-Mdo-062640	Monodelphis domestica	82.66	4.00e-152	530.00
IUUC-Mmu-063305	Mus musculus	88.99	2.00e-160	558.00
IUUC-Mac-064533	Musa acuminata	26.39	2.00e-10	59.70
IUUC-Mpu-066519	Mustela putorius furo	87.83	6.00e-163	566.00
IUUC-Mlu-067419	Myotis lucifugus	90.23	1.00e-103	368.00
IUUC-Nfi-068304	Neosartorya fischeri	27.37	1.00e-03	37.40
IUUC-Ncr-068703	Neurospora crassa	26.53	2.00e-06	46.20
IUUC-Nle-070130	Nomascus leucogenys	98.07	5.00e-156	543.00
IUUC-Opr-070252	Ochotona princeps	92.75	2.00e-168	584.00
IUUC-Ont-072624	Oreochromis niloticus	58.31	3.00e-103	368.00
IUUC-Oan-072843	Ornithorhynchus anatinus	83.15	2.00e-71	261.00
IUUC-Ocu-073940	Oryctolagus cuniculus	93.33	2.00e-167	581.00
IUUC-Oba-075875	Oryza barthii	31.88	2.00e-15	76.60
IUUC-Obr-076147	Oryza brachyantha	27.85	4.00e-22	98.60
IUUC-Ogl-077826	Oryza glaberrima	28.52	1.00e-21	97.10
IUUC-Ogu-078996	Oryza glumaepatula	28.67	1.00e-20	93.20
IUUC-Oin-079646	Oryza indica	31.88	1.00e-15	77.00
IUUC-Olo-081041	Oryza longistaminata	32.50	8.00e-15	75.50
IUUC-Ome-081238	Oryza meridionalis	29.29	3.00e-23	101.00
IUUC-Oni-082310	Oryza nivara	28.96	5.00e-20	91.30
IUUC-Opu-083821	Oryza punctata	31.25	1.00e-14	72.80
IUUC-Oru-084586	Oryza rufipogon	28.67	9.00e-21	94.00
IUUC-Osa-085823	Oryza sativa	32.54	5.00e-15	75.10
IUUC-Ola-086714	Oryzias latipes	50.14	3.00e-61	228.00
IUUC-Oga-088600	Otolemur garnettii	91.94	1.00e-163	568.00
IUUC-Oar-090421	Ovis aries	87.74	2.00e-156	545.00
IUUC-Ptr-091509	Pan troglodytes	100.00	1.00e-180	625.00
IUUC-Pan-092468	Papio anubis	99.03	5.00e-174	603.00
IUUC-Psi-093075	Pelodiscus sinensis	78.55	2.00e-145	508.00
IUUC-Pno-095028	Phaeosphaeria nodorum	29.79	3.00e-03	35.80
IUUC-Ppa-095918	Physcomitrella patens	26.39	2.00e-20	92.80
IUUC-Pfo-096398	Poecilia formosa	54.49	2.00e-85	309.00
IUUC-Pab-097915	Pongo abelii	99.35	4.00e-175	607.00
IUUC-Pop-098933	Populus trichocarpa	27.05	2.00e-20	92.80
IUUC-Pca-100602	Procavia capensis	76.52	4.00e-131	461.00
IUUC-Ppe-101164	Prunus persica	26.76	8.00e-20	90.90
IUUC-Pva-102466	Pteropus vampyrus	91.59	2.00e-161	561.00
IUUC-Pgr-103488	Puccinia graminis	28.00	6.00e-08	50.80
IUUC-Pte-104413	Pyrenophora teres	30.85	1.00e-04	40.40
IUUC-Pyt-104659	Pyrenophora triticirepentis	30.85	2.00e-04	39.30
IUUC-Rno-105226	Rattus norvegicus	88.99	6.00e-162	563.00
IUUC-Sce-106268	Saccharomyces cerevisiae	32.08	1.10e-02	34.30
IUUC-Sha-106739	Sarcophilus harrisii	82.39	1.00e-146	512.00
IUUC-Sja-107960	Schizosaccharomyces japonicus	25.31	3.00e-05	42.40
IUUC-Ssl-108440	Sclerotinia sclerotiorum	27.47	3.00e-11	62.00
IUUC-Smo-108945	Selaginella moellendorffii	28.44	7.00e-10	57.80
IUUC-Sit-110720	Setaria italica	28.90	8.00e-19	87.80
IUUC-Sly-111445	Solanum lycopersicum	25.81	4.00e-16	78.60
IUUC-Stu-112541	Solanum tuberosum	26.39	1.00e-15	77.40
IUUC-Sar-113380	Sorex araneus	71.92	3.00e-97	347.00
IUUC-Sbi-113779	Sorghum bicolor	25.67	7.00e-20	90.90
IUUC-Ssc-115286	Sus scrofa	92.59	2.00e-84	305.00
IUUC-Tgu-117075	Taeniopygia guttata	78.98	8.00e-146	509.00
IUUC-Tru-118110	Takifugu rubripes	55.21	7.00e-90	323.00
IUUC-Tsy-118933	Tarsius syrichta	82.07	5.00e-133	467.00
IUUC-Tni-119811	Tetraodon nigroviridis	55.87	2.00e-91	329.00
IUUC-Tca-121053	Theobroma cacao	27.80	4.00e-17	81.60
IUUC-Tre-122152	Trichoderma reesei	28.32	3.00e-08	52.00
IUUC-Tvi-122334	Trichoderma virens	31.48	3.00e-08	52.40
IUUC-Tae-125696	Triticum aestivum	28.57	2.00e-21	96.70
IUUC-Tur-126868	Triticum urartu	31.61	1.00e-14	73.20
IUUC-Tme-127059	Tuber melanosporum	26.15	2.00e-07	49.70
IUUC-Tbe-127867	Tupaia belangeri	57.97	3.00e-95	341.00
IUUC-Ttr-128543	Tursiops truncatus	91.59	9.00e-169	585.00
IUUC-Uma-129462	Ustilago maydis	25.10	1.00e-06	47.80
IUUC-Vda-129740	Verticillium dahliae	25.56	5.00e-08	51.60
IUUC-Vpa-130623	Vicugna pacos	78.84	4.00e-132	464.00
IUUC-Vvi-131299	Vitis vinifera	31.36	9.00e-15	74.30
IUUC-Xtr-132867	Xenopus tropicalis	57.00	2.00e-113	402.00
IUUC-Xma-133270	Xiphophorus maculatus	59.21	7.00e-87	313.00
IUUC-Yli-134415	Yarrowia lipolytica	26.42	1.00e-06	47.00
IUUC-Zma-135827	Zea mays	25.59	3.00e-20	92.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence