iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066328

Ensembl Protein ID

ENSMPUP00000003417.1

UniProt Accession

M3XWG7; M3XWG7_MUSPF

Genbank Protein ID

ENSMPUP00000003417

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01095847

Gene Name

USP30

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000003448.1	ENSMPUT00000003484.1	ENSMPUP00000003417.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-71	241.3	69	501

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw...kskkkavsprellkalkkeaeefsgy 87
           Gl NlgNtC+mNS+LQ Ls++p + + l e +++ ++++++  p++ l+ +l +l+++l     +++++ + + ll++l+++  ++s++
   Q: 69   GLVNLGNTCFMNSLLQGLSACPAFIKWLEEFTTQYTRDQKEAPPHQYLSLTLLHLLKALScqeVTDDEVLDASCLLDVLRMYRWQISSF 157
           9*****************************77788888888899***************888899999********************* PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..........aeekkkkknkslisdlFqgqlksqikclecdnvs.sr 165
           e+qDa+E+++++ ++le+e    ++ +++++++ ++ e++ e          + + ++++n+   ++ F+g+l+s+++c++c+++s +r
   Q: 158  EEQDAHELFHVITSSLEDER--DRQPRVTHLFDVHSLEQQPEitpkqitcrtRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSpVR 244
           *******************9..678889999999988888888999999999999********************************** PP
   S: 166  eepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekck...............kkqeaekklklkklPevLilhLkRfsf 239
           +++f +lsl++p  +  ++++l++cL++f + e++++   + c++c+               ++++ +k+lkl klP++L++hL+R s+
   Q: 245  FDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRD---VVCDNCTqieakgtlngekvehQRTTFVKQLKLGKLPQCLCIHLQRLSW 330
           ***********************************97...9******8888888888888777777*********************** PP
   S: 240  seeqksrekinkkvefpleLdlspfcts..............................................peekqke........ 274
           s++ + + k +++v+f++ L ++ +  +                                              +              
   Q: 331  SSH-GTPLKRQEHVQFNEFLMMDIYKYHllghkpgqpspkpseatgpaqdlqdrpvapapvlnqpagpkpqifmN-----Gacspsllp 413
           998.8888*********8888886666666788888777777666666666666666665555555555555550.....055555555 PP
   S: 275  ...................kkkYeLiavvvHsGslssGHYvayvkn.........ekgkWllfdDskVtevkeeevleetgstaYvlfY 335
                              ++ ++L+avvvH+G ++sGH+v+y ++         ++++Wl ++D++V++ + +evl+   s+aY+lfY
   Q: 414  plpaqmpfplpvvpdysssTYLFRLMAVVVHHGDMHSGHFVTYRRSppsaknplsTSNQWLWISDDTVRKASLQEVLS---SSAYLLFY 499
           55555555555555555559999***********************9999888888999*******************...******** PP
   S: 336  kr 337
           +r
   Q: 500  ER 501
           98 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MLSTRAQAAM TAADRAIQRF LRTGAAVRYR VMKNWGVIGG IAAALAAGIY VIWGPITERK 60
KRRKGLVPGL VNLGNTCFMN SLLQGLSACP AFIKWLEEFT TQYTRDQKEA PPHQYLSLTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTGAGCA CCCGGGCTCA GGCGGCGATG ACCGCGGCGG ACCGGGCCAT CCAGCGCTTC 60
CTGCGGACCG GGGCGGCCGT CAGGTGAGCC TTGGGGGGCG GGGCGGCCGG AGAGGCCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008053--P:mitochondrial fusion
GO:0000422--P:mitophagy
GO:0035871--P:protein K11-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000204	Aegilops tauschii	29.29	1.00e-16	80.90
IUUC-Aml-001733	Ailuropoda melanoleuca	95.58	0.00e+00	895.00
IUUC-Atr-002510	Amborella trichopoda	24.71	1.00e-21	98.20
IUUC-Apl-003645	Anas platyrhynchos	73.48	3.00e-107	381.00
IUUC-Aca-004583	Anolis carolinensis	68.42	1.00e-24	103.00
IUUC-Aly-005754	Arabidopsis lyrata	26.72	2.00e-23	103.00
IUUC-Ath-007622	Arabidopsis thaliana	26.68	1.00e-24	107.00
IUUC-Acl-008136	Aspergillus clavatus	22.18	9.00e-13	68.60
IUUC-Ame-010896	Astyanax mexicanus	63.08	1.00e-156	546.00
IUUC-Bgr-012133	Blumeria graminis	22.41	2.00e-10	60.80
IUUC-Bta-012321	Bos taurus	91.49	0.00e+00	860.00
IUUC-Bdi-014795	Brachypodium distachyon	27.27	9.00e-19	88.20
IUUC-Bol-015637	Brassica oleracea	25.99	4.00e-23	102.00
IUUC-Bra-016801	Brassica rapa	25.89	6.00e-24	105.00
IUUC-Cel-018308	Caenorhabditis elegans	28.54	4.00e-37	149.00
IUUC-Cja-018826	Callithrix jacchus	92.28	0.00e+00	911.00
IUUC-Cfa-021206	Canis familiaris	93.46	0.00e+00	901.00
IUUC-Cpo-021343	Cavia porcellus	91.42	0.00e+00	849.00
IUUC-Csa-023419	Chlorocebus sabaeus	92.46	0.00e+00	910.00
IUUC-Cho-024475	Choloepus hoffmanni	88.00	2.00e-135	475.00
IUUC-Cgl-026621	Colletotrichum gloeosporioides	21.95	9.00e-14	72.00
IUUC-Cne-027061	Cryptococcus neoformans	24.71	7.00e-10	59.30
IUUC-Dre-027563	Danio rerio	58.40	4.00e-158	551.00
IUUC-Dno-029929	Dasypus novemcinctus	90.72	0.00e+00	889.00
IUUC-Dor-030166	Dipodomys ordii	82.01	0.00e+00	739.00
IUUC-Dme-031627	Drosophila melanogaster	34.95	3.00e-35	143.00
IUUC-Ete-032634	Echinops telfairi	78.76	0.00e+00	681.00
IUUC-Eca-033968	Equus caballus	91.63	0.00e+00	828.00
IUUC-Eeu-035279	Erinaceus europaeus	82.32	1.00e-59	223.00
IUUC-Fca-036525	Felis catus	95.55	0.00e+00	918.00
IUUC-Fal-036606	Ficedula albicollis	77.60	5.00e-161	560.00
IUUC-Fso-038309	Fusarium solani	20.96	1.00e-09	58.50
IUUC-Gmo-038726	Gadus morhua	55.60	2.00e-143	502.00
IUUC-Gga-040718	Gallus gallus	75.06	2.00e-161	561.00
IUUC-Gac-042645	Gasterosteus aculeatus	57.66	7.00e-153	533.00
IUUC-Gma-042890	Glycine max	26.18	7.00e-27	115.00
IUUC-Ggo-045021	Gorilla gorilla	92.46	0.00e+00	908.00
IUUC-Hsa-045832	Homo sapiens	92.46	0.00e+00	908.00
IUUC-Itr-048392	Ictidomys tridecemlineatus	92.45	0.00e+00	843.00
IUUC-Lch-050662	Latimeria chalumnae	69.49	2.00e-178	618.00
IUUC-Lpe-051078	Leersia perrieri	25.96	5.00e-31	129.00
IUUC-Loc-052611	Lepisosteus oculatus	65.30	1.00e-179	622.00
IUUC-Lma-053048	Leptosphaeria maculans	20.63	5.00e-16	79.70
IUUC-Laf-053752	Loxodonta africana	91.84	0.00e+00	837.00
IUUC-Mcc-054892	Macaca mulatta	92.84	0.00e+00	914.00
IUUC-Meu-056673	Macropus eugenii	73.11	2.00e-159	554.00
IUUC-Mor-057143	Magnaporthe oryzae	20.92	7.00e-10	59.30
IUUC-Mtr-057976	Medicago truncatula	26.11	1.00e-32	134.00
IUUC-Mla-058970	Melampsora laricipopulina	23.47	1.00e-20	94.40
IUUC-Mga-059543	Meleagris gallopavo	76.92	0.00e+00	667.00
IUUC-Mmr-061534	Microcebus murinus	91.88	0.00e+00	876.00
IUUC-Mdo-062140	Monodelphis domestica	68.77	6.00e-167	580.00
IUUC-Mmu-063673	Mus musculus	88.59	0.00e+00	833.00
IUUC-Mlu-067938	Myotis lucifugus	93.42	0.00e+00	916.00
IUUC-Nle-069426	Nomascus leucogenys	91.86	0.00e+00	817.00
IUUC-Opr-070796	Ochotona princeps	85.60	3.00e-123	435.00
IUUC-Ont-072248	Oreochromis niloticus	58.17	1.00e-158	552.00
IUUC-Oan-072916	Ornithorhynchus anatinus	78.95	0.00e+00	759.00
IUUC-Ocu-074459	Oryctolagus cuniculus	85.64	0.00e+00	652.00
IUUC-Oba-075765	Oryza barthii	26.41	5.00e-30	125.00
IUUC-Obr-076005	Oryza brachyantha	26.95	5.00e-33	135.00
IUUC-Ogl-077916	Oryza glaberrima	27.20	6.00e-33	135.00
IUUC-Ogu-078263	Oryza glumaepatula	26.64	7.00e-31	128.00
IUUC-Oin-080096	Oryza indica	27.03	2.00e-24	106.00
IUUC-Ome-081928	Oryza meridionalis	27.25	4.00e-31	129.00
IUUC-Oni-082424	Oryza nivara	26.80	9.00e-31	128.00
IUUC-Oru-085117	Oryza rufipogon	26.80	9.00e-31	128.00
IUUC-Ola-087429	Oryzias latipes	56.41	4.00e-150	524.00
IUUC-Oga-087981	Otolemur garnettii	92.26	0.00e+00	871.00
IUUC-Oar-089927	Ovis aries	90.72	0.00e+00	852.00
IUUC-Ptr-090878	Pan troglodytes	92.46	0.00e+00	908.00
IUUC-Pan-092698	Papio anubis	92.84	0.00e+00	914.00
IUUC-Psi-093451	Pelodiscus sinensis	76.63	0.00e+00	719.00
IUUC-Ppa-096015	Physcomitrella patens	25.53	1.00e-09	58.90
IUUC-Pfo-096096	Poecilia formosa	58.27	2.00e-156	545.00
IUUC-Pab-098676	Pongo abelii	91.30	0.00e+00	887.00
IUUC-Pca-100418	Procavia capensis	95.40	2.00e-129	456.00
IUUC-Ppe-101898	Prunus persica	24.76	9.00e-26	111.00
IUUC-Pva-103018	Pteropus vampyrus	90.72	0.00e+00	869.00
IUUC-Pgr-103423	Puccinia graminis	25.26	7.00e-10	59.70
IUUC-Pte-104330	Pyrenophora teres	22.16	3.00e-15	77.00
IUUC-Pyt-104518	Pyrenophora triticirepentis	22.16	9.00e-18	85.50
IUUC-Rno-105708	Rattus norvegicus	88.20	0.00e+00	829.00
IUUC-Sha-106971	Sarcophilus harrisii	78.01	0.00e+00	760.00
IUUC-Ssl-108648	Sclerotinia sclerotiorum	22.00	7.00e-13	69.30
IUUC-Sit-110442	Setaria italica	26.02	5.00e-27	115.00
IUUC-Ssc-116397	Sus scrofa	90.91	0.00e+00	860.00
IUUC-Tgu-117446	Taeniopygia guttata	70.72	0.00e+00	644.00
IUUC-Tru-118268	Takifugu rubripes	58.80	1.00e-142	499.00
IUUC-Tsy-119484	Tarsius syrichta	89.76	1.00e-52	200.00
IUUC-Tni-119735	Tetraodon nigroviridis	54.67	1.00e-121	429.00
IUUC-Tca-121660	Theobroma cacao	25.19	1.00e-29	124.00
IUUC-Tae-125383	Triticum aestivum	28.40	2.00e-29	123.00
IUUC-Tur-126458	Triticum urartu	28.24	1.00e-27	117.00
IUUC-Tbe-127740	Tupaia belangeri	85.49	0.00e+00	783.00
IUUC-Ttr-129273	Tursiops truncatus	88.97	0.00e+00	834.00
IUUC-Vda-129789	Verticillium dahliae	22.34	1.00e-08	55.10
IUUC-Vvi-131177	Vitis vinifera	26.06	4.00e-27	115.00
IUUC-Xtr-132374	Xenopus tropicalis	66.20	5.00e-173	600.00
IUUC-Xma-133267	Xiphophorus maculatus	61.29	8.00e-160	556.00
IUUC-Yli-134571	Yarrowia lipolytica	24.10	1.00e-12	68.20
IUUC-Zma-135796	Zea mays	24.95	4.00e-24	106.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence