iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Acl-008214

Ensembl Protein ID

CADACLAP00008452

UniProt Accession

A1CEK7; PAN2_ASPCL

Genbank Protein ID

EAW11306.1

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit pan2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

DS027052

Gene Name

ACLA_089990; pan2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADACLAG00008662	CADACLAT00008662	CADACLAP00008452

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.40e-10	39.0	485	820

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs......... 85
           Gl+ + +  + N++LQ L +ip +r+l l++  +++  e      ++ll+++  lf  l k + ++ + ++llka++++ e  +         
   Q: 485  GLETHIANSFTNALLQLLKFIPLVRNLALHHAASTCIYE------TCLLCEMGYLFDMLEKANGQNCQATNLLKAFSSYREASNlglleenlt 571
           788888899*********************888888765......7*******************************9999866443333333 PP
   S: 86   .gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl.....dl 172
            ++     q + +f+l+q+                          ++ +    +++ +++ +    +++i+c  c+n+ +r  + l     + 
   Q: 572  tKSLSSAIQSVNRFFLNQIA-------------------------HDFRMILPSSDDLDHRLATIASESIRCMFCQNEIVRPGNSLaneliYP 639
           22222333333333333333.........................34467777788888888999999*********9977654441111155 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilh......LkRfsfseeqksrekinkkvefpleL 259
            +++++ + +   +++++L++  ++e+ +   + +c+ c+++q+++ + +++++P vLil+      L R  +s  ++ +e i   ve  + +
   Q: 640  AIDIKQARRNPAFKFSNILRASIERETQN---RGWCNYCRRYQQVTIRKTVHRMPLVLILNaalnnpLCRRLWSIPGWLPEEIGIVVEGGQVM 729
           6788888888888************9987...59**************************855444456668999999999999999988765 PP
   S: 260  dls..pfctspeekqkekkkYeLiavvvHsG..slssGHYvayvkn........ekgkWllfdDskVtevkeeevleetg..staYvlfYk 336
             +  +  ++ ++k+ + + Y+L++ v      ++++ H v++++         +k +W lf+D  Vtev+++e l++++  + + vl Y+
   Q: 730  CYEgdELKAQVQNKVPNLVLYDLVGLVAEIDipEHQKAHLVSFINVsissreteSKSRWHLFNDFLVTEVDKDEALRFNQpwKIPCVLAYQ 820
           44444777888888888*********998887899***********888887765667******************998877666666665 PP

Organism

Aspergillus clavatus

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein pab1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.

Protein Sequence
(Fasta)

MEADWDELSR IPVPAPSSHG LPTIATTIAF DDVSELLWAG NEFGRITSFY GPELQRYTSV 60
RAHPVSDGPV RQILFHERGV ISLSPKSVHM ITRRGLSQWH IAHEEMTDLH CMSFTAQLNR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGCCG ATTGGGATGA ATTGTCGCGC ATTCCCGTGC CTGCTCCGAG CTCGCACGGC 60
TTGCCGACTA TCGCGACGAC GATAGCATTC GACGATGTCT CCGAATTGCT GTGGGCCGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening

KEGG

act:ACLA_089990

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	31.05	3.00e-154	537.00
IUUC-Apl-003500	Anas platyrhynchos	31.31	4.00e-138	484.00
IUUC-Aca-004930	Anolis carolinensis	30.99	4.00e-152	530.00
IUUC-Afu-009112	Aspergillus fumigatus	92.51	0.00e+00	2224.00
IUUC-Ang-009531	Aspergillus niger	87.86	0.00e+00	2114.00
IUUC-Ame-011259	Astyanax mexicanus	31.44	2.00e-152	531.00
IUUC-Bta-012371	Bos taurus	31.14	1.00e-153	535.00
IUUC-Bci-013684	Botrytis cinerea	49.18	0.00e+00	1064.00
IUUC-Cja-019297	Callithrix jacchus	30.67	1.00e-150	525.00
IUUC-Cfa-020489	Canis familiaris	31.22	2.00e-153	535.00
IUUC-Cpo-022392	Cavia porcellus	31.11	1.00e-154	539.00
IUUC-Csa-023220	Chlorocebus sabaeus	31.05	9.00e-153	532.00
IUUC-Csv-025841	Ciona savignyi	29.58	4.00e-123	434.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	51.19	0.00e+00	1154.00
IUUC-Cne-026932	Cryptococcus neoformans	34.03	3.00e-163	567.00
IUUC-Dre-028482	Danio rerio	28.67	3.00e-80	291.00
IUUC-Dno-029398	Dasypus novemcinctus	31.33	6.00e-154	536.00
IUUC-Dor-030307	Dipodomys ordii	31.44	4.00e-95	341.00
IUUC-Dme-032111	Drosophila melanogaster	28.70	8.00e-77	280.00
IUUC-Eca-033985	Equus caballus	31.22	1.00e-153	535.00
IUUC-Eeu-034928	Erinaceus europaeus	30.00	5.00e-40	158.00
IUUC-Fca-035587	Felis catus	30.93	1.00e-154	539.00
IUUC-Fal-037587	Ficedula albicollis	31.95	2.00e-152	532.00
IUUC-Fso-038133	Fusarium solani	45.69	0.00e+00	976.00
IUUC-Gmo-039076	Gadus morhua	28.79	8.00e-77	280.00
IUUC-Ggr-039957	Gaeumannomyces graminis	46.32	0.00e+00	1003.00
IUUC-Gga-040948	Gallus gallus	32.19	4.00e-152	530.00
IUUC-Gac-042396	Gasterosteus aculeatus	30.95	2.00e-148	518.00
IUUC-Ggo-045412	Gorilla gorilla	31.05	2.00e-153	535.00
IUUC-Hsa-046076	Homo sapiens	31.05	3.00e-153	534.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	29.67	5.00e-134	470.00
IUUC-Kpa-049178	Komagataella pastoris	32.78	1.00e-170	592.00
IUUC-Lch-050279	Latimeria chalumnae	38.57	1.00e-65	243.00
IUUC-Loc-052872	Lepisosteus oculatus	29.79	2.00e-81	296.00
IUUC-Lma-052986	Leptosphaeria maculans	51.93	0.00e+00	1198.00
IUUC-Laf-054181	Loxodonta africana	31.29	3.00e-151	527.00
IUUC-Mcc-054812	Macaca mulatta	31.25	3.00e-153	534.00
IUUC-Meu-056325	Macropus eugenii	31.22	1.00e-152	532.00
IUUC-Mor-057246	Magnaporthe oryzae	43.01	0.00e+00	871.00
IUUC-Mpo-057464	Magnaporthe poae	46.33	0.00e+00	1016.00
IUUC-Mla-058911	Melampsora laricipopulina	35.04	7.00e-168	583.00
IUUC-Mga-059335	Meleagris gallopavo	32.37	2.00e-152	531.00
IUUC-Mvi-060461	Microbotryum violaceum	34.70	9.00e-168	582.00
IUUC-Mmr-060636	Microcebus murinus	31.31	3.00e-152	531.00
IUUC-Mmu-063503	Mus musculus	31.16	3.00e-155	540.00
IUUC-Mpu-066670	Mustela putorius furo	30.96	1.00e-153	536.00
IUUC-Mlu-068119	Myotis lucifugus	31.26	6.00e-156	543.00
IUUC-Nfi-068398	Neosartorya fischeri	93.28	0.00e+00	2226.00
IUUC-Ncr-068927	Neurospora crassa	43.05	0.00e+00	892.00
IUUC-Nle-069651	Nomascus leucogenys	30.35	1.00e-144	506.00
IUUC-Opr-070614	Ochotona princeps	30.85	6.00e-151	526.00
IUUC-Ont-072433	Oreochromis niloticus	31.58	3.00e-150	524.00
IUUC-Oan-073283	Ornithorhynchus anatinus	35.66	2.00e-60	226.00
IUUC-Ocu-074401	Oryctolagus cuniculus	30.78	4.00e-153	534.00
IUUC-Ola-087522	Oryzias latipes	31.33	2.00e-152	531.00
IUUC-Oga-088226	Otolemur garnettii	30.90	4.00e-153	534.00
IUUC-Oar-089241	Ovis aries	31.54	9.00e-156	542.00
IUUC-Pan-092297	Papio anubis	30.86	1.00e-140	492.00
IUUC-Psi-094043	Pelodiscus sinensis	31.29	3.00e-143	501.00
IUUC-Pma-094394	Petromyzon marinus	30.82	4.00e-143	500.00
IUUC-Pno-095053	Phaeosphaeria nodorum	51.18	0.00e+00	1079.00
IUUC-Ppa-095188	Physcomitrella patens	28.50	1.00e-116	412.00
IUUC-Pfo-097517	Poecilia formosa	31.58	5.00e-154	537.00
IUUC-Pca-100471	Procavia capensis	31.49	3.00e-153	534.00
IUUC-Pva-102805	Pteropus vampyrus	31.54	2.00e-90	325.00
IUUC-Pte-104021	Pyrenophora teres	51.95	0.00e+00	1215.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	52.88	0.00e+00	1207.00
IUUC-Rno-105471	Rattus norvegicus	31.56	1.00e-156	546.00
IUUC-Sce-106235	Saccharomyces cerevisiae	31.64	2.00e-136	478.00
IUUC-Sha-106883	Sarcophilus harrisii	30.66	1.00e-146	512.00
IUUC-Spo-108169	Schizosaccharomyces pombe	35.69	0.00e+00	663.00
IUUC-Sar-113323	Sorex araneus	32.09	3.00e-124	437.00
IUUC-Sre-115075	Sporisorium reilianum	41.45	4.00e-67	248.00
IUUC-Ssc-116363	Sus scrofa	31.35	3.00e-155	541.00
IUUC-Tru-118427	Takifugu rubripes	29.55	2.00e-85	309.00
IUUC-Tni-120218	Tetraodon nigroviridis	29.55	3.00e-86	311.00
IUUC-Tre-122177	Trichoderma reesei	49.59	0.00e+00	1132.00
IUUC-Tme-127176	Tuber melanosporum	46.91	0.00e+00	936.00
IUUC-Tbe-127641	Tupaia belangeri	31.76	6.00e-27	114.00
IUUC-Ttr-128888	Tursiops truncatus	32.63	4.00e-103	367.00
IUUC-Uma-129361	Ustilago maydis	42.40	5.00e-67	248.00
IUUC-Xtr-132811	Xenopus tropicalis	29.17	2.00e-77	282.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence