iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074401

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

PAB-dependent poly(A)-specific ribonuclease subunit PAN2; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2

Genbank Nucleotide ID

AAGW02059147

Gene Name

PAN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000007227.3	ENSOCUT00000023668.1	ENSOCUP00000024202.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-21	77.6	525	914

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs............ 85
             Y+N+++Q+L++++++r+l+ +   + +++      + +l+++l  lf+ l  s+    + +++l+a++++ e               
   Q: 525  NAYCNCMIQVLYFLEPVRCLIQN---HLCQK------EFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASAlgliladsdeas 604
           56*********************...55654......57*************9*****************9999865766666666655 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             g+     q   +f+l ql++++           +e +  ++ ++a  +  ++++s+i +lF  ++++   c +c+++++r ++ l +
   Q: 605  gkGNLARLIQRWNRFILTQLHQDM-----------QELEVPQAYRSAGGSFCSSGDSVIGQLFSCEMENCSLC-RCGSETVRASSTLLF 681
           555555666667777777777777...........3333345667788899*****************99999.8************** PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+ p++++ k+ ++ ++L+     e+ +   + +c++c+k+q + ++  +++lP++L+++    s +e+   r   + +v f+  + +
   Q: 682  TLSYPEDKTGKNYDFAQVLKRSICLEQNT---QAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFWR--AQAEVAFK--MAM 763
           **********999**99999888766665...69*****************************99777776666..55666665..556 PP
   S: 262  spfcts.......................................................peekqke..................... 274
           +++  +                                                       +                           
   Q: 764  KKHGGEvvknkefaradrkevgspegallcpsmeelknvwlpfslrmkmtknkgldvcnwtD-----Geevlaawvppsqwgparaeee 847
           65555544446666666666666666666666666666666666666555555555555550.....0555555555555555555555 PP
   S: 275  ..kkkYeLiavvvHsG.slssGHYvayvkn...........ekgkWllfdDskVtevkeeevleetg 327
              + Y+L+a vvH   s  +G  va++k            ++++W+lf+D  +++++++e +++  
   Q: 848  hgVYVYDLMATVVHILdSRTGGSLVAHIKVgetyhqrkegvTHQQWYLFNDFLIEPIDKHEAVQFDM 914
           559*************9*************999988877777888************9999888654 PP

Organism

Oryctolagus cuniculus

Functional Description
(View)

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Protein Sequence
(Fasta)

MNFEGLDPGL AEYAPAMHST LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG 60
VYSELHSVVA EVGVPVSVSH FDLHEEMLWV GSHGGHATSF FGPALERYSS FQVNGNDDIR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACTTTG AGGGTCTGGA CCCTGGATTG GCAGAGTATG CTCCGGCTAT GCATTCCACC 60
CTGGACCCTG TCCTGGATGC CCACCTGAAC CCGAGTCTGC TACAGAATGT GGAGCTGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0507--mRNA processing
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR013520--Exonuclease_RNaseT/DNA_pol3
IPR030843--PAN2
IPR028881--PAN2_dom
IPR012337--RNaseH-like_dom
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

PROSITE

PS50235--USP_3

Pfam

PF00929--RNase_T
PF13423--UCH_1

SMART

SM00479--EXOIII

Gene Ontology

GO:0005634--C:nucleus
GO:0000932--C:P-body
GO:0031251--C:PAN complex
GO:0003676--F:nucleic acid binding
GO:0004535--F:poly(A)-specific ribonuclease activity
GO:0006397--P:mRNA processing
GO:0000289--P:nuclear-transcribed mRNA poly(A) tail shortening
GO:0010606--P:positive regulation of cytoplasmic mRNA processing body assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001273	Ailuropoda melanoleuca	96.45	0.00e+00	2314.00
IUUC-Apl-003500	Anas platyrhynchos	84.36	0.00e+00	1874.00
IUUC-Aca-004930	Anolis carolinensis	83.84	0.00e+00	2018.00
IUUC-Acl-008214	Aspergillus clavatus	30.98	1.00e-156	547.00
IUUC-Afu-009112	Aspergillus fumigatus	31.24	5.00e-146	512.00
IUUC-Ang-009531	Aspergillus niger	30.56	6.00e-148	518.00
IUUC-Ame-011259	Astyanax mexicanus	75.35	0.00e+00	1828.00
IUUC-Bta-012371	Bos taurus	96.52	0.00e+00	2315.00
IUUC-Bci-013684	Botrytis cinerea	43.35	2.00e-72	267.00
IUUC-Cja-019297	Callithrix jacchus	92.67	0.00e+00	2253.00
IUUC-Cfa-020489	Canis familiaris	96.35	0.00e+00	2302.00
IUUC-Cpo-022392	Cavia porcellus	95.54	0.00e+00	2314.00
IUUC-Csa-023220	Chlorocebus sabaeus	96.28	0.00e+00	2318.00
IUUC-Csv-025841	Ciona savignyi	45.46	0.00e+00	898.00
IUUC-Cgl-026534	Colletotrichum gloeosporioides	30.12	4.00e-88	319.00
IUUC-Cne-026932	Cryptococcus neoformans	42.94	5.00e-73	270.00
IUUC-Dre-028482	Danio rerio	73.28	0.00e+00	1778.00
IUUC-Dno-029398	Dasypus novemcinctus	95.77	0.00e+00	2292.00
IUUC-Dor-030307	Dipodomys ordii	89.12	0.00e+00	1299.00
IUUC-Dme-032111	Drosophila melanogaster	41.23	0.00e+00	884.00
IUUC-Eca-033985	Equus caballus	97.01	0.00e+00	2322.00
IUUC-Eeu-034928	Erinaceus europaeus	84.01	0.00e+00	775.00
IUUC-Fca-035587	Felis catus	96.45	0.00e+00	2315.00
IUUC-Fal-037587	Ficedula albicollis	83.63	0.00e+00	1976.00
IUUC-Fso-038133	Fusarium solani	29.22	9.00e-132	464.00
IUUC-Gmo-039076	Gadus morhua	73.16	0.00e+00	1747.00
IUUC-Ggr-039957	Gaeumannomyces graminis	31.84	4.00e-138	486.00
IUUC-Gga-040948	Gallus gallus	84.45	0.00e+00	2045.00
IUUC-Gac-042396	Gasterosteus aculeatus	73.92	0.00e+00	1797.00
IUUC-Ggo-045412	Gorilla gorilla	96.45	0.00e+00	2317.00
IUUC-Hsa-046076	Homo sapiens	96.45	0.00e+00	2320.00
IUUC-Itr-048143	Ictidomys tridecemlineatus	90.23	0.00e+00	2118.00
IUUC-Kpa-049178	Komagataella pastoris	40.48	8.00e-67	249.00
IUUC-Lch-050279	Latimeria chalumnae	72.48	0.00e+00	1708.00
IUUC-Loc-052872	Lepisosteus oculatus	75.88	0.00e+00	1825.00
IUUC-Lma-052986	Leptosphaeria maculans	31.22	1.00e-91	331.00
IUUC-Laf-054181	Loxodonta africana	95.27	0.00e+00	2300.00
IUUC-Mcc-054812	Macaca mulatta	96.77	0.00e+00	2321.00
IUUC-Meu-056325	Macropus eugenii	91.49	0.00e+00	2194.00
IUUC-Mor-057246	Magnaporthe oryzae	27.27	9.00e-65	242.00
IUUC-Mpo-057464	Magnaporthe poae	31.59	3.00e-138	486.00
IUUC-Mla-058911	Melampsora laricipopulina	40.77	1.00e-69	258.00
IUUC-Mga-059335	Meleagris gallopavo	84.76	0.00e+00	1997.00
IUUC-Mvi-060461	Microbotryum violaceum	34.20	3.00e-145	509.00
IUUC-Mmr-060636	Microcebus murinus	96.85	0.00e+00	2322.00
IUUC-Mmu-063503	Mus musculus	95.93	0.00e+00	2288.00
IUUC-Mpu-066670	Mustela putorius furo	97.01	0.00e+00	2322.00
IUUC-Mlu-068119	Myotis lucifugus	95.77	0.00e+00	2333.00
IUUC-Nfi-068398	Neosartorya fischeri	31.91	2.00e-155	543.00
IUUC-Ncr-068927	Neurospora crassa	29.35	3.00e-120	426.00
IUUC-Nle-069651	Nomascus leucogenys	92.57	0.00e+00	2218.00
IUUC-Opr-070614	Ochotona princeps	96.37	0.00e+00	2284.00
IUUC-Ont-072433	Oreochromis niloticus	74.84	0.00e+00	1850.00
IUUC-Oan-073283	Ornithorhynchus anatinus	74.02	0.00e+00	1425.00
IUUC-Ola-087522	Oryzias latipes	73.82	0.00e+00	1785.00
IUUC-Oga-088226	Otolemur garnettii	97.02	0.00e+00	2343.00
IUUC-Oar-089241	Ovis aries	96.12	0.00e+00	2332.00
IUUC-Pan-092297	Papio anubis	96.72	0.00e+00	2076.00
IUUC-Psi-094043	Pelodiscus sinensis	81.34	0.00e+00	1915.00
IUUC-Pma-094394	Petromyzon marinus	68.88	0.00e+00	1557.00
IUUC-Pno-095053	Phaeosphaeria nodorum	31.39	2.00e-81	297.00
IUUC-Ppa-095188	Physcomitrella patens	32.35	3.00e-158	552.00
IUUC-Pfo-097517	Poecilia formosa	74.96	0.00e+00	1851.00
IUUC-Pca-100471	Procavia capensis	95.78	0.00e+00	2160.00
IUUC-Pva-102805	Pteropus vampyrus	91.94	0.00e+00	1813.00
IUUC-Pte-104021	Pyrenophora teres	30.88	4.00e-94	339.00
IUUC-Pyt-104682	Pyrenophora triticirepentis	30.59	4.00e-93	336.00
IUUC-Rno-105471	Rattus norvegicus	95.44	0.00e+00	2281.00
IUUC-Sce-106235	Saccharomyces cerevisiae	37.76	3.00e-60	227.00
IUUC-Sha-106883	Sarcophilus harrisii	91.32	0.00e+00	2044.00
IUUC-Spo-108169	Schizosaccharomyces pombe	32.03	3.00e-141	496.00
IUUC-Sar-113323	Sorex araneus	94.44	0.00e+00	1696.00
IUUC-Sre-115075	Sporisorium reilianum	37.90	5.00e-61	230.00
IUUC-Ssc-116363	Sus scrofa	97.10	0.00e+00	2365.00
IUUC-Tru-118427	Takifugu rubripes	74.84	0.00e+00	1863.00
IUUC-Tni-120218	Tetraodon nigroviridis	74.92	0.00e+00	1866.00
IUUC-Tre-122177	Trichoderma reesei	28.21	1.00e-76	281.00
IUUC-Tme-127176	Tuber melanosporum	32.44	1.00e-139	490.00
IUUC-Tbe-127641	Tupaia belangeri	88.03	0.00e+00	802.00
IUUC-Ttr-128888	Tursiops truncatus	94.58	0.00e+00	1448.00
IUUC-Uma-129361	Ustilago maydis	38.42	2.00e-63	238.00
IUUC-Xtr-132811	Xenopus tropicalis	79.17	0.00e+00	1905.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence