iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000136045.11	ENST00000412830.7	ENSP00000387365.3
ENSG00000136045.11	ENST00000552760.5	ENSP00000448227.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.40e-22	79.7	254	287

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf....sdtllvsGsdDgtikvWDlr 31
           gHtd v +l++      + l+s+s D+t+ +WD++
   Q: 254  GHTDAVLDLSWnkliR-NVLASASADNTVILWDMS 287
           8**********77664.689*************86 PP

Organism

Homo sapiens

Functional Description
(View)

Belongs to the WD repeat PWP1 family.

Protein Sequence
(Fasta)

MNRSRQVTCV AWVRCGVAKE TPDKVELSKE EVKRLIAEAK EKLQEEGGGS DEEETGSPSE 60
DGMQSARTQA RPREPLEDGD PEDDRTLDDD ELAEYDLDKY DEEGDPDAET LGESLLGLTV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAATGACGT CTGAAATGAG CGCCGACGCT GCCCAAACAG GAGCCTGCGC ATGCGCTCTG 60
CCCTGGCAGC GGCCCTGTGC AGATCCCTGA GCGTGTGGCA GCAGTGCGGT CGTGGTCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0034773--P:histone H4-K20 trimethylation
GO:1903262--P:negative regulation of serine phosphorylation of STAT3 protein
GO:2000738--P:positive regulation of stem cell differentiation
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:11137

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000884	Aegilops tauschii	35.06	2.00e-57	216.00
IUUC-Aml-001975	Ailuropoda melanoleuca	97.21	0.00e+00	877.00
IUUC-Atr-002719	Amborella trichopoda	36.25	1.00e-53	203.00
IUUC-Apl-004171	Anas platyrhynchos	75.94	3.00e-178	617.00
IUUC-Aca-005184	Anolis carolinensis	72.63	0.00e+00	652.00
IUUC-Aly-005967	Arabidopsis lyrata	34.41	2.00e-61	229.00
IUUC-Ath-006878	Arabidopsis thaliana	35.22	9.00e-54	204.00
IUUC-Ago-007922	Ashbya gossypii	37.33	1.00e-54	207.00
IUUC-Acl-008064	Aspergillus clavatus	36.56	1.00e-79	290.00
IUUC-Afl-008590	Aspergillus flavus	40.82	3.00e-75	276.00
IUUC-Afu-009081	Aspergillus fumigatus	39.22	1.00e-86	314.00
IUUC-Ani-009187	Aspergillus nidulans	38.43	3.00e-81	295.00
IUUC-Aor-010018	Aspergillus oryzae	40.97	1.00e-74	273.00
IUUC-Ate-010542	Aspergillus terreus	42.38	1.00e-57	217.00
IUUC-Ame-011810	Astyanax mexicanus	65.69	0.00e+00	632.00
IUUC-Bgr-012023	Blumeria graminis	35.28	1.00e-69	257.00
IUUC-Bta-012671	Bos taurus	96.81	0.00e+00	884.00
IUUC-Bci-013981	Botrytis cinerea	34.54	5.00e-69	255.00
IUUC-Bdi-014598	Brachypodium distachyon	38.40	5.00e-66	245.00
IUUC-Bol-016451	Brassica oleracea	33.60	8.00e-62	231.00
IUUC-Bra-017210	Brassica rapa	33.73	3.00e-61	229.00
IUUC-Cel-018525	Caenorhabditis elegans	37.13	1.00e-64	241.00
IUUC-Cja-018931	Callithrix jacchus	96.61	0.00e+00	829.00
IUUC-Cfa-020421	Canis familiaris	97.60	0.00e+00	818.00
IUUC-Cpo-022066	Cavia porcellus	90.66	0.00e+00	861.00
IUUC-Cre-022807	Chlamydomonas reinhardtii	41.75	2.00e-75	276.00
IUUC-Csa-024120	Chlorocebus sabaeus	96.81	0.00e+00	861.00
IUUC-Cho-024765	Choloepus hoffmanni	79.87	2.00e-171	595.00
IUUC-Cin-025441	Ciona intestinalis	42.15	2.00e-71	263.00
IUUC-Csv-025867	Ciona savignyi	32.21	3.00e-22	98.20
IUUC-Cgl-026678	Colletotrichum gloeosporioides	39.18	2.00e-70	259.00
IUUC-Cne-026879	Cryptococcus neoformans	32.51	5.00e-58	219.00
IUUC-Cme-027322	Cyanidioschyzon merolae	24.79	2.00e-19	90.10
IUUC-Dre-027584	Danio rerio	68.04	0.00e+00	633.00
IUUC-Dno-029634	Dasypus novemcinctus	95.41	0.00e+00	919.00
IUUC-Dor-030767	Dipodomys ordii	93.92	0.00e+00	750.00
IUUC-Dse-031449	Dothistroma septosporum	34.40	1.00e-73	271.00
IUUC-Dme-032070	Drosophila melanogaster	35.53	3.00e-72	265.00
IUUC-Ete-032857	Echinops telfairi	87.41	2.00e-138	486.00
IUUC-Eca-033871	Equus caballus	91.24	0.00e+00	814.00
IUUC-Eeu-034899	Erinaceus europaeus	92.61	0.00e+00	867.00
IUUC-Fca-036260	Felis catus	97.41	0.00e+00	817.00
IUUC-Fal-036704	Ficedula albicollis	79.62	3.00e-179	621.00
IUUC-Fox-037875	Fusarium oxysporum	45.80	1.00e-46	180.00
IUUC-Fso-038104	Fusarium solani	40.98	4.00e-70	259.00
IUUC-Gmo-038715	Gadus morhua	72.49	4.00e-159	554.00
IUUC-Ggr-040060	Gaeumannomyces graminis	34.53	2.00e-69	256.00
IUUC-Gga-040402	Gallus gallus	72.65	0.00e+00	694.00
IUUC-Gac-042618	Gasterosteus aculeatus	69.25	4.00e-177	614.00
IUUC-Gma-044165	Glycine max	37.60	4.00e-63	235.00
IUUC-Ggo-044778	Gorilla gorilla	88.12	0.00e+00	805.00
IUUC-Hvu-047774	Hordeum vulgare	35.56	8.00e-34	137.00
IUUC-Itr-048829	Ictidomys tridecemlineatus	95.61	0.00e+00	818.00
IUUC-Kpa-049194	Komagataella pastoris	31.83	9.00e-54	204.00
IUUC-Lch-049524	Latimeria chalumnae	63.88	2.00e-165	575.00
IUUC-Lpe-050918	Leersia perrieri	36.45	3.00e-61	229.00
IUUC-Loc-051947	Lepisosteus oculatus	69.67	0.00e+00	664.00
IUUC-Lma-053310	Leptosphaeria maculans	34.78	7.00e-74	271.00
IUUC-Laf-053737	Loxodonta africana	95.41	0.00e+00	885.00
IUUC-Mcc-054770	Macaca mulatta	99.20	0.00e+00	869.00
IUUC-Meu-056892	Macropus eugenii	69.54	6.00e-120	424.00
IUUC-Mor-057110	Magnaporthe oryzae	39.31	8.00e-72	264.00
IUUC-Mpo-057610	Magnaporthe poae	38.52	1.00e-42	167.00
IUUC-Mtr-058677	Medicago truncatula	35.80	1.00e-70	260.00
IUUC-Mla-059056	Melampsora laricipopulina	32.63	9.00e-68	251.00
IUUC-Mga-059434	Meleagris gallopavo	76.41	3.00e-177	614.00
IUUC-Mvi-060307	Microbotryum violaceum	38.05	1.00e-73	271.00
IUUC-Mmr-061729	Microcebus murinus	97.41	0.00e+00	856.00
IUUC-Mdo-062905	Monodelphis domestica	75.31	0.00e+00	711.00
IUUC-Mmu-063191	Mus musculus	88.84	0.00e+00	852.00
IUUC-Mac-064937	Musa acuminata	40.27	1.00e-63	237.00
IUUC-Mpu-066036	Mustela putorius furo	97.41	0.00e+00	837.00
IUUC-Mlu-068240	Myotis lucifugus	94.82	0.00e+00	862.00
IUUC-Nfi-068446	Neosartorya fischeri	38.48	2.00e-81	296.00
IUUC-Ncr-068630	Neurospora crassa	41.76	1.00e-68	254.00
IUUC-Nle-069444	Nomascus leucogenys	100.00	0.00e+00	857.00
IUUC-Opr-070284	Ochotona princeps	87.21	0.00e+00	680.00
IUUC-Ont-071946	Oreochromis niloticus	68.27	3.00e-180	624.00
IUUC-Oan-073312	Ornithorhynchus anatinus	85.48	0.00e+00	666.00
IUUC-Ocu-074548	Oryctolagus cuniculus	95.21	0.00e+00	813.00
IUUC-Oba-075486	Oryza barthii	37.97	4.00e-59	222.00
IUUC-Obr-076759	Oryza brachyantha	39.20	1.00e-63	237.00
IUUC-Ogu-078324	Oryza glumaepatula	36.04	3.00e-50	192.00
IUUC-Oin-079455	Oryza indica	39.65	3.00e-69	256.00
IUUC-Olo-080518	Oryza longistaminata	37.82	3.00e-58	219.00
IUUC-Ome-081585	Oryza meridionalis	36.36	1.00e-54	207.00
IUUC-Oni-082084	Oryza nivara	38.64	8.00e-64	238.00
IUUC-Opu-084114	Oryza punctata	38.64	1.00e-63	237.00
IUUC-Oru-084211	Oryza rufipogon	38.64	8.00e-64	238.00
IUUC-Osa-085974	Oryza sativa	39.65	3.00e-69	256.00
IUUC-Ola-087544	Oryzias latipes	65.58	0.00e+00	630.00
IUUC-Olu-087732	Ostreococcus lucimarinus	37.67	1.00e-62	234.00
IUUC-Oga-088626	Otolemur garnettii	96.01	0.00e+00	858.00
IUUC-Oar-089641	Ovis aries	94.62	0.00e+00	888.00
IUUC-Ptr-091379	Pan troglodytes	100.00	0.00e+00	857.00
IUUC-Pan-092669	Papio anubis	89.88	0.00e+00	799.00
IUUC-Psi-093753	Pelodiscus sinensis	76.83	0.00e+00	656.00
IUUC-Pma-094478	Petromyzon marinus	70.42	3.00e-114	404.00
IUUC-Pno-095033	Phaeosphaeria nodorum	38.76	7.00e-73	268.00
IUUC-Ppa-095650	Physcomitrella patens	39.18	6.00e-76	278.00
IUUC-Pfo-097516	Poecilia formosa	66.60	0.00e+00	630.00
IUUC-Pab-097912	Pongo abelii	94.92	1.00e-122	432.00
IUUC-Pop-099606	Populus trichocarpa	35.85	3.00e-69	255.00
IUUC-Pca-100653	Procavia capensis	86.40	0.00e+00	648.00
IUUC-Ppe-101910	Prunus persica	36.96	1.00e-68	254.00
IUUC-Pva-103106	Pteropus vampyrus	96.21	0.00e+00	839.00
IUUC-Pgr-103382	Puccinia graminis	35.36	6.00e-69	255.00
IUUC-Ptt-103725	Puccinia triticina	36.08	2.00e-31	130.00
IUUC-Pte-104400	Pyrenophora teres	40.16	3.00e-72	266.00
IUUC-Pyt-104707	Pyrenophora triticirepentis	35.74	9.00e-73	267.00
IUUC-Rno-105173	Rattus norvegicus	89.22	0.00e+00	834.00
IUUC-Sce-106279	Saccharomyces cerevisiae	34.22	7.00e-56	211.00
IUUC-Sha-106556	Sarcophilus harrisii	77.39	0.00e+00	714.00
IUUC-Sja-107920	Schizosaccharomyces japonicus	36.14	8.00e-60	224.00
IUUC-Spo-108023	Schizosaccharomyces pombe	35.15	2.00e-65	243.00
IUUC-Ssl-108635	Sclerotinia sclerotiorum	34.82	5.00e-70	258.00
IUUC-Smo-109124	Selaginella moellendorffii	37.89	4.00e-65	241.00
IUUC-Sit-110604	Setaria italica	38.25	6.00e-70	258.00
IUUC-Sly-111400	Solanum lycopersicum	40.25	4.00e-63	235.00
IUUC-Stu-112208	Solanum tuberosum	39.46	1.00e-42	167.00
IUUC-Sar-113458	Sorex araneus	59.72	1.00e-99	356.00
IUUC-Sbi-114069	Sorghum bicolor	37.41	7.00e-68	251.00
IUUC-Sre-115034	Sporisorium reilianum	34.96	3.00e-67	249.00
IUUC-Ssc-115281	Sus scrofa	96.21	0.00e+00	844.00
IUUC-Tgu-117052	Taeniopygia guttata	64.90	2.00e-168	585.00
IUUC-Tru-118113	Takifugu rubripes	69.25	2.00e-180	625.00
IUUC-Tsy-119546	Tarsius syrichta	83.43	0.00e+00	757.00
IUUC-Tni-120562	Tetraodon nigroviridis	68.34	0.00e+00	626.00
IUUC-Tca-121431	Theobroma cacao	38.35	1.00e-76	280.00
IUUC-Tre-122165	Trichoderma reesei	41.38	6.00e-71	261.00
IUUC-Tvi-122282	Trichoderma virens	41.38	9.00e-71	261.00
IUUC-Tae-123805	Triticum aestivum	36.84	7.00e-65	241.00
IUUC-Tur-126252	Triticum urartu	34.24	8.00e-56	211.00
IUUC-Tme-127183	Tuber melanosporum	38.70	5.00e-63	235.00
IUUC-Tbe-128052	Tupaia belangeri	82.63	0.00e+00	656.00
IUUC-Ttr-129310	Tursiops truncatus	91.82	0.00e+00	773.00
IUUC-Uma-129566	Ustilago maydis	33.78	7.00e-60	225.00
IUUC-Vda-129705	Verticillium dahliae	40.91	6.00e-69	255.00
IUUC-Vpa-130511	Vicugna pacos	89.60	0.00e+00	724.00
IUUC-Vvi-131241	Vitis vinifera	38.27	1.00e-63	237.00
IUUC-Xtr-132170	Xenopus tropicalis	69.64	0.00e+00	680.00
IUUC-Xma-133266	Xiphophorus maculatus	66.74	2.00e-179	622.00
IUUC-Yli-134585	Yarrowia lipolytica	35.27	1.00e-65	244.00
IUUC-Zma-135830	Zea mays	38.15	4.00e-69	255.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence