iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000136451.8	ENST00000258963.7	ENSP00000258963.3
ENSG00000136451.8	ENST00000584396.5	ENSP00000464687.1
ENSG00000136451.8	ENST00000581208.1	ENSP00000462337.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2	LncRNADisease
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/UBZ	1.80e-07	32.9	176	192

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/UBZ

   S: 4    CPvCqkm.vdqtdfeeH 19
           C++C+k+  d++++++H
   Q: 176  CEMCGKAfRDVYHLNRH 192
           ***************** PP

Organism

Homo sapiens

Functional Description
(View)

Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3.

Protein Sequence
(Fasta)

MEANWTAFLF QAHEASHHQQ QAAQNSLLPL LSSAVEPPDQ KPLLPIPITQ KPQGAPETLK 60
DAIGIKKEKP KTSFVCTYCS KAFRDSYHLR RHESCHTGIK LVSRPKKTPT TVVPLISTIA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAAGTGGC CGCGCTCGGC GCTGCCATGT TGAGGAGCCG CCGCTGCCGT TGCCGCCGCC 60
GCCGCCGCCG CTTTGTTGTC GCCTCCTCCG GCTGAGGAGG CTCCCCGAGC GGGGGGAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR023413--GFP-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR013087--Znf_C2H2_type
IPR001781--Znf_LIM

PROSITE

PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

SMART

SM00355--ZnF_C2H2

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0001525--P:angiogenesis
GO:0006968--P:cellular defense response
GO:0001885--P:endothelial cell development
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter

KEGG

hsa:7716

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002029	Ailuropoda melanoleuca	95.55	0.00e+00	753.00
IUUC-Apl-003373	Anas platyrhynchos	89.31	0.00e+00	725.00
IUUC-Aca-005340	Anolis carolinensis	94.06	4.00e-153	533.00
IUUC-Ame-011155	Astyanax mexicanus	56.41	5.00e-151	527.00
IUUC-Bta-012345	Bos taurus	98.39	0.00e+00	770.00
IUUC-Cja-019080	Callithrix jacchus	94.36	0.00e+00	756.00
IUUC-Cfa-021007	Canis familiaris	95.63	0.00e+00	779.00
IUUC-Cpo-021494	Cavia porcellus	94.24	0.00e+00	768.00
IUUC-Csa-023995	Chlorocebus sabaeus	99.23	0.00e+00	791.00
IUUC-Cho-024441	Choloepus hoffmanni	97.79	0.00e+00	765.00
IUUC-Dre-027737	Danio rerio	53.58	4.00e-138	484.00
IUUC-Dno-029621	Dasypus novemcinctus	97.89	0.00e+00	785.00
IUUC-Eca-033916	Equus caballus	98.24	0.00e+00	792.00
IUUC-Eeu-035069	Erinaceus europaeus	95.50	2.00e-180	625.00
IUUC-Fca-036019	Felis catus	95.01	0.00e+00	770.00
IUUC-Fal-036792	Ficedula albicollis	89.25	0.00e+00	745.00
IUUC-Gmo-038865	Gadus morhua	48.78	8.00e-120	423.00
IUUC-Gga-040650	Gallus gallus	90.09	0.00e+00	752.00
IUUC-Gac-041688	Gasterosteus aculeatus	56.09	7.00e-147	514.00
IUUC-Ggo-044834	Gorilla gorilla	99.23	0.00e+00	764.00
IUUC-Itr-048584	Ictidomys tridecemlineatus	98.59	0.00e+00	766.00
IUUC-Lch-050011	Latimeria chalumnae	67.76	9.00e-172	596.00
IUUC-Loc-052051	Lepisosteus oculatus	55.43	1.00e-147	516.00
IUUC-Laf-053768	Loxodonta africana	94.37	0.00e+00	782.00
IUUC-Mcc-055529	Macaca mulatta	99.20	0.00e+00	771.00
IUUC-Meu-055911	Macropus eugenii	90.29	5.00e-172	597.00
IUUC-Mga-060192	Meleagris gallopavo	90.00	0.00e+00	754.00
IUUC-Mmr-060984	Microcebus murinus	96.74	0.00e+00	767.00
IUUC-Mdo-062265	Monodelphis domestica	92.91	0.00e+00	795.00
IUUC-Mmu-063475	Mus musculus	97.89	0.00e+00	792.00
IUUC-Mpu-066117	Mustela putorius furo	96.16	0.00e+00	748.00
IUUC-Mlu-067275	Myotis lucifugus	95.39	0.00e+00	793.00
IUUC-Nle-069246	Nomascus leucogenys	98.59	0.00e+00	758.00
IUUC-Opr-070726	Ochotona princeps	97.59	0.00e+00	763.00
IUUC-Ont-072277	Oreochromis niloticus	59.46	8.00e-151	526.00
IUUC-Oan-072979	Ornithorhynchus anatinus	91.88	0.00e+00	769.00
IUUC-Ocu-073937	Oryctolagus cuniculus	98.19	0.00e+00	764.00
IUUC-Ola-087493	Oryzias latipes	68.10	2.00e-116	412.00
IUUC-Oga-088803	Otolemur garnettii	98.08	0.00e+00	780.00
IUUC-Oar-089981	Ovis aries	98.39	0.00e+00	768.00
IUUC-Ptr-091099	Pan troglodytes	99.40	0.00e+00	745.00
IUUC-Pan-092907	Papio anubis	99.04	0.00e+00	791.00
IUUC-Psi-093337	Pelodiscus sinensis	90.06	0.00e+00	733.00
IUUC-Pfo-096575	Poecilia formosa	53.01	5.00e-142	498.00
IUUC-Pva-102541	Pteropus vampyrus	97.12	0.00e+00	815.00
IUUC-Rno-105906	Rattus norvegicus	98.46	0.00e+00	776.00
IUUC-Sha-106911	Sarcophilus harrisii	95.17	0.00e+00	758.00
IUUC-Ssl-108572	Sclerotinia sclerotiorum	37.25	1.70e-01	30.00
IUUC-Sar-113280	Sorex araneus	91.75	0.00e+00	695.00
IUUC-Ssc-116365	Sus scrofa	98.66	0.00e+00	787.00
IUUC-Tgu-116650	Taeniopygia guttata	93.39	0.00e+00	724.00
IUUC-Tru-117810	Takifugu rubripes	56.72	8.00e-149	520.00
IUUC-Tsy-119364	Tarsius syrichta	94.58	0.00e+00	714.00
IUUC-Tni-120633	Tetraodon nigroviridis	56.83	2.00e-149	522.00
IUUC-Tbe-127293	Tupaia belangeri	98.59	0.00e+00	761.00
IUUC-Ttr-128189	Tursiops truncatus	93.16	0.00e+00	724.00
IUUC-Xtr-131813	Xenopus tropicalis	76.04	0.00e+00	674.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence