iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045825

UUCD1 version

UUC-HoS-01168

Ensembl Protein ID

ENSP00000361506.3

UniProt Accession

Q9Y2K6; Q541F1; Q8IXQ1; Q96LG5; Q9UQN8; Q9UQP0; UBP20_HUMAN

Genbank Protein ID

AAL79676.1; BAA76847.2; CAC88170.1; EAW87914.1; AAH39593.1; CAB44350.1; CAB44352.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 20; Deubiquitinating enzyme 20; Ubiquitin thioesterase 20; Ubiquitin-specific-processing protease 20; VHL-interacting deubiquitinating enzyme 2

Genbank Nucleotide ID

AY074877; AB023220; AL158207; CH471090; BC039593; Y17457; Y17459

Gene Name

USP20; KIAA1003; LSFR3A; VDU2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000136878.12	ENST00000372429.7	ENSP00000361506.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	15933713

Classification

Family	E-value	Score	Start	End
DUB/USP	5.00e-111	372.8	145	684

Active Site

Position(s)	Description	Evidence
154	Nucleophile
643	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeqqD 91
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w k++ ++v p++l + +k ++++f+gy+qqD
   Q: 145  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhKKRPSYVVPTSLSHGIKLVNPMFRGYAQQD 231
           7******************************.....999999*******************99999************************** PP
   S: 92   aqEflaflldqleeelkk.............eknkpkeeeeeedkselsde......................................... 129
           +qEfl++l+dql+eelk+             +++++++e++e d+s ++de                                         
   Q: 232  TQEFLRCLMDQLHEELKEpvvatvalteardSDSSDTDEKREGDRSPSEDEflscdsssdrgegdgqgrgggssqaetellipdeagraise 323
           ****************99886666665555555555555555555555555***************************************** PP
   S: 130  ............................................................................................ 129
                                                                                                       
   Q: 324  kermkdrkfswgqqrtnseqvdedadvdtamaalddqpaeaqppsprssspcrtpepdndahlrsssrpcspvhhheghaklsssppraspv 415
           ******************************************************************************************** PP
   S: 130  .................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke................... 185
                            ++++k+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+                   
   Q: 416  rmapsyvlkkaqvlsagSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhsaiyqnvpakpgacgdsy 507
           ********************************************************************99888******************* PP
   S: 186  ..............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
                                         +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ +lPe+L++hLkRf  ++e + + 
   Q: 508  aaqgwlafiveyirrfvvsctpswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRF--RHEVMYSF 597
           **********************************************************************************..9999**** PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           kin++v+fple Ldl+pf+++++++q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+e+ v++   +++YvlfY++
   Q: 598  KINSHVSFPLEgLDLRPFLAKECTSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVHETVVQN---AEGYVLFYRK 684
           ***********************999..9**************************78999*******************...********98 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Protein Sequence
(Fasta)

MGDSRDLCPH LDSIGEVTKE DLLLKSKGTC QSCGVTGPNL WACLQVACPY VGCGESFADH 60
STIHAQAKKH NLTVNLTTFR LWCYACEKEV FLEQRLAAPL LGSSSKFSEQ DSPPPSHPLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTACCCACC TCACCCCGTT GGGCCTCTTC CTCAAGTTCT GTACCTCTCT GGTCTCTTCC 60
AGTTTTAATC TTTAAAAAGA AGAAGAAGCA GCAATGCATA AGCTGAGTGA TTCCCCGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0048471--C:perinuclear region of cytoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0001664--F:G-protein coupled receptor binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:10868

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	93.22	0.00e+00	1665.00
IUUC-Apl-003351	Anas platyrhynchos	86.40	0.00e+00	1563.00
IUUC-Aca-005077	Anolis carolinensis	76.62	0.00e+00	1117.00
IUUC-Ame-011777	Astyanax mexicanus	75.76	0.00e+00	1346.00
IUUC-Bta-013063	Bos taurus	93.88	0.00e+00	1668.00
IUUC-Cja-019868	Callithrix jacchus	97.16	0.00e+00	1770.00
IUUC-Cfa-020761	Canis familiaris	93.99	0.00e+00	1689.00
IUUC-Cpo-022267	Cavia porcellus	86.59	0.00e+00	1558.00
IUUC-Csa-024251	Chlorocebus sabaeus	98.69	0.00e+00	1790.00
IUUC-Cho-024483	Choloepus hoffmanni	95.28	5.00e-123	435.00
IUUC-Csv-025889	Ciona savignyi	43.71	2.00e-35	141.00
IUUC-Dre-028061	Danio rerio	74.17	0.00e+00	1218.00
IUUC-Dno-029423	Dasypus novemcinctus	95.40	0.00e+00	1717.00
IUUC-Dor-030877	Dipodomys ordii	91.67	0.00e+00	1095.00
IUUC-Dme-031837	Drosophila melanogaster	49.23	1.00e-137	484.00
IUUC-Ete-032802	Echinops telfairi	81.71	2.00e-135	476.00
IUUC-Eca-034283	Equus caballus	93.33	0.00e+00	1665.00
IUUC-Eeu-034620	Erinaceus europaeus	91.08	0.00e+00	1190.00
IUUC-Fca-036357	Felis catus	94.43	0.00e+00	1676.00
IUUC-Fal-037411	Ficedula albicollis	86.27	0.00e+00	1567.00
IUUC-Gga-041101	Gallus gallus	86.11	0.00e+00	1544.00
IUUC-Gac-041315	Gasterosteus aculeatus	73.85	0.00e+00	1324.00
IUUC-Ggo-045600	Gorilla gorilla	98.91	0.00e+00	1762.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	82.68	0.00e+00	1416.00
IUUC-Lch-050002	Latimeria chalumnae	75.84	0.00e+00	1326.00
IUUC-Loc-052574	Lepisosteus oculatus	77.67	0.00e+00	1413.00
IUUC-Laf-054428	Loxodonta africana	93.46	0.00e+00	1664.00
IUUC-Mcc-055736	Macaca mulatta	98.47	0.00e+00	1787.00
IUUC-Mga-059781	Meleagris gallopavo	85.78	0.00e+00	1546.00
IUUC-Mdo-063048	Monodelphis domestica	87.57	0.00e+00	1540.00
IUUC-Mmu-064079	Mus musculus	92.58	0.00e+00	1645.00
IUUC-Mpu-066616	Mustela putorius furo	92.80	0.00e+00	1704.00
IUUC-Mlu-067294	Myotis lucifugus	91.69	0.00e+00	1611.00
IUUC-Nle-070015	Nomascus leucogenys	98.91	0.00e+00	1729.00
IUUC-Opr-070328	Ochotona princeps	93.34	0.00e+00	1677.00
IUUC-Ont-071464	Oreochromis niloticus	74.51	0.00e+00	1315.00
IUUC-Oan-073259	Ornithorhynchus anatinus	79.35	0.00e+00	1316.00
IUUC-Ocu-074630	Oryctolagus cuniculus	91.37	0.00e+00	1605.00
IUUC-Ola-087240	Oryzias latipes	75.16	0.00e+00	1297.00
IUUC-Oga-088761	Otolemur garnettii	94.42	0.00e+00	1721.00
IUUC-Oar-089490	Ovis aries	88.51	0.00e+00	1502.00
IUUC-Ptr-091662	Pan troglodytes	99.56	0.00e+00	1776.00
IUUC-Pan-092199	Papio anubis	98.25	0.00e+00	1781.00
IUUC-Psi-093726	Pelodiscus sinensis	87.23	0.00e+00	1564.00
IUUC-Pma-094389	Petromyzon marinus	62.79	9.00e-100	356.00
IUUC-Pab-098632	Pongo abelii	99.12	0.00e+00	1763.00
IUUC-Pca-100614	Procavia capensis	86.25	0.00e+00	1293.00
IUUC-Pva-102922	Pteropus vampyrus	92.77	0.00e+00	988.00
IUUC-Rno-105215	Rattus norvegicus	92.24	0.00e+00	1647.00
IUUC-Sce-106176	Saccharomyces cerevisiae	32.96	3.00e-25	110.00
IUUC-Sha-106601	Sarcophilus harrisii	86.80	0.00e+00	1529.00
IUUC-Ssc-115533	Sus scrofa	92.11	0.00e+00	1641.00
IUUC-Tgu-117364	Taeniopygia guttata	86.56	0.00e+00	1543.00
IUUC-Tru-117770	Takifugu rubripes	72.75	0.00e+00	1291.00
IUUC-Tni-120001	Tetraodon nigroviridis	73.01	0.00e+00	1266.00
IUUC-Ttr-128732	Tursiops truncatus	94.32	0.00e+00	1680.00
IUUC-Xtr-132157	Xenopus tropicalis	76.89	0.00e+00	1367.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence