iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RBR	RBR	17367545; 20615966; 20300062; 20864535

Classification

Family	E-value	Score	Start	End
E3 activity/RBR	1.20e-51	176.0	30	222

Active Site

Position(s)	Description	Evidence
206	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpek..leeseikellveeelykryekllleevveadaal 88
           Ck+Cl+e+s +++t+l+eC+++fC++Clkqy++l+i+eg+ + i+cp++ c ++  l+e+ei++ lv  ++++ y++l++e++v+ d+ +
   Q: 30   CKLCLCEQSLDKMTTLQECQCIFCTACLKQYMQLAIREGCGSPITCPDMVCLNHgtLQEAEIAC-LVPVDQFQLYQRLKFEREVHLDPYR 118
           ***************************************************9988899******.6999********************* PP
   S: 89   kwcpapdCslvvllekea..eklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyiekneg 176
           +wcp +dC++v+ +++++  + + vec++c+ +fC++Ck++wH+++sC++ +  +  te   ++a   + +ea +k+Cp C+vyie+neg
   Q: 119  TWCPVADCQTVCPVASSDpgQPVLVECPSCHLKFCSCCKDAWHAEVSCRDSQPIVLPTE---HRALFGTDAEAPIKQCPVCRVYIERNEG 205
           *************9998877899999*****************************9999...99************************** PP
   S: 177  CnhmtCakCkaefCwlC 193
           C++m+C++Ck++fCw+C
   Q: 206  CAQMMCKNCKHTFCWYC 222
           ***************** PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.

Protein Sequence
(Fasta)

MGSAGRLHYL AMTAENPTPG DLAPAPLITC KLCLCEQSLD KMTTLQECQC IFCTACLKQY 60
MQLAIREGCG SPITCPDMVC LNHGTLQEAE IACLVPVDQF QLYQRLKFER EVHLDPYRTW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCTGTGCC CCACGCTCCC GCTGCAACAG TCCCGGGCAT CGCAGCTGCC AGTCAAGGCT 60
AGGAGGCGGT CGGGGACTCC GCCTCCTCCC GACCCGTAGG TCTGGGAGCG CAAGTCCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1

Pfam

PF01485--IBR

SMART

SM00647--IBR
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0031966--C:mitochondrial membrane
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:255488

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001257	Ailuropoda melanoleuca	94.39	4.00e-171	593.00
IUUC-Apl-004112	Anas platyrhynchos	81.85	8.00e-130	456.00
IUUC-Aca-004533	Anolis carolinensis	76.57	3.00e-137	481.00
IUUC-Bta-012641	Bos taurus	94.41	3.00e-169	587.00
IUUC-Cja-019626	Callithrix jacchus	82.84	2.00e-145	508.00
IUUC-Cfa-020702	Canis familiaris	95.38	9.00e-173	598.00
IUUC-Cpo-022147	Cavia porcellus	95.71	2.00e-170	591.00
IUUC-Csa-023473	Chlorocebus sabaeus	98.35	3.00e-178	617.00
IUUC-Cho-024298	Choloepus hoffmanni	91.05	1.00e-140	492.00
IUUC-Dre-028099	Danio rerio	65.41	2.00e-91	328.00
IUUC-Dno-029122	Dasypus novemcinctus	88.49	6.00e-158	550.00
IUUC-Dor-030669	Dipodomys ordii	96.14	3.00e-133	467.00
IUUC-Ete-033141	Echinops telfairi	80.53	1.00e-131	462.00
IUUC-Eca-034360	Equus caballus	97.36	2.00e-175	607.00
IUUC-Eeu-034538	Erinaceus europaeus	73.24	7.00e-85	306.00
IUUC-Fca-036055	Felis catus	93.73	1.00e-169	588.00
IUUC-Fal-037339	Ficedula albicollis	80.65	2.00e-132	464.00
IUUC-Gmo-038780	Gadus morhua	61.17	3.00e-86	311.00
IUUC-Gga-040256	Gallus gallus	79.72	4.00e-132	464.00
IUUC-Gac-042127	Gasterosteus aculeatus	62.24	4.00e-94	337.00
IUUC-Ggo-044867	Gorilla gorilla	99.67	1.00e-179	622.00
IUUC-Hvu-047484	Hordeum vulgare	30.14	1.00e-17	84.00
IUUC-Itr-048250	Ictidomys tridecemlineatus	97.41	7.00e-110	389.00
IUUC-Lch-050168	Latimeria chalumnae	73.44	6.00e-132	463.00
IUUC-Loc-052150	Lepisosteus oculatus	60.93	4.00e-87	314.00
IUUC-Laf-053967	Loxodonta africana	94.72	1.00e-170	592.00
IUUC-Mcc-055898	Macaca mulatta	98.35	3.00e-178	617.00
IUUC-Meu-056628	Macropus eugenii	97.44	2.00e-43	168.00
IUUC-Mtr-057989	Medicago truncatula	26.76	4.00e-19	88.60
IUUC-Mga-059820	Meleagris gallopavo	78.65	3.00e-130	457.00
IUUC-Mmr-060680	Microcebus murinus	94.39	5.00e-170	590.00
IUUC-Mdo-062839	Monodelphis domestica	85.86	4.00e-154	536.00
IUUC-Mmu-063339	Mus musculus	87.79	2.00e-148	518.00
IUUC-Mac-065414	Musa acuminata	28.44	1.00e-19	90.90
IUUC-Mpu-065973	Mustela putorius furo	93.73	4.00e-171	593.00
IUUC-Mlu-067112	Myotis lucifugus	95.38	1.00e-163	568.00
IUUC-Nle-069795	Nomascus leucogenys	99.67	3.00e-180	624.00
IUUC-Opr-070390	Ochotona princeps	88.45	6.00e-154	536.00
IUUC-Ont-072329	Oreochromis niloticus	64.73	3.00e-90	324.00
IUUC-Oan-072980	Ornithorhynchus anatinus	77.92	6.00e-137	479.00
IUUC-Ocu-073845	Oryctolagus cuniculus	94.72	2.00e-170	591.00
IUUC-Ola-086872	Oryzias latipes	61.80	9.00e-86	310.00
IUUC-Oga-088954	Otolemur garnettii	95.38	4.00e-172	597.00
IUUC-Oar-089879	Ovis aries	95.07	3.00e-170	590.00
IUUC-Ptr-090685	Pan troglodytes	100.00	4.00e-180	623.00
IUUC-Pan-092086	Papio anubis	98.02	5.00e-178	616.00
IUUC-Psi-093481	Pelodiscus sinensis	81.52	5.00e-138	483.00
IUUC-Pfo-096065	Poecilia formosa	65.15	4.00e-92	331.00
IUUC-Pab-098031	Pongo abelii	99.34	5.00e-179	619.00
IUUC-Pca-100936	Procavia capensis	91.75	3.00e-165	573.00
IUUC-Pva-102864	Pteropus vampyrus	85.81	8.00e-150	522.00
IUUC-Rno-105503	Rattus norvegicus	87.79	5.00e-148	516.00
IUUC-Sha-107425	Sarcophilus harrisii	86.51	4.00e-155	540.00
IUUC-Stu-112736	Solanum tuberosum	28.30	3.00e-19	89.00
IUUC-Ssc-115458	Sus scrofa	93.49	1.00e-158	551.00
IUUC-Tgu-117226	Taeniopygia guttata	79.57	4.00e-132	464.00
IUUC-Tru-118362	Takifugu rubripes	65.04	1.00e-94	339.00
IUUC-Tsy-119255	Tarsius syrichta	96.70	2.00e-174	604.00
IUUC-Tni-120140	Tetraodon nigroviridis	61.73	4.00e-88	317.00
IUUC-Tae-124420	Triticum aestivum	31.82	3.00e-18	87.00
IUUC-Tbe-127306	Tupaia belangeri	94.72	2.00e-170	591.00
IUUC-Ttr-128923	Tursiops truncatus	95.07	1.00e-158	552.00
IUUC-Vpa-130148	Vicugna pacos	94.72	5.00e-170	589.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence