iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000013798.8	ENSRNOT00000055669.4	ENSRNOP00000052531.4
ENSRNOG00000013798.8	ENSRNOT00000019244.6	ENSRNOP00000019244.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-10	41.0	543	595

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           ++++y++++ n+++L +k+G+v+++i +e++  gW ++ +  +g +G +P  ++ 
   Q: 543  CKAIYPFDGHNEGTLAMKEGEVLYII-EEDKGDGWTRA-RRQNGEEGYVPTTYID 595
           99************************.999999*****.59**********9996 PP

Organism

Rattus norvegicus

Functional Description
(View)

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similarity). May negatively regulate neurite extension and axon branching in developing neurons.

Protein Sequence
(Fasta)

MSWGTELWDQ FDSLDKHTQW GIDFLERYAK FVKERIEIEQ NYAKQLRNLV KKYCPKRSSK 60
DEEPRFTSCI AFFNILNELN DYAGQREVVA EEMAHRVYGE LMRYAHDLKT ERKMHLQEGR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCGGGGAC GCGGCGGCAG CTCGCTTCAG TCGTGTCTCT CTCACTCACT GGGGAACCCG 60
GTGGTGGCGG CAGCTTTCGA GGCAGACACT TGCCGGCCCG GTCCTGAGAA GGGAAAGTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR027267--AH/BAR-dom
IPR031160--F_BAR
IPR001060--FCH_dom
IPR030116--FNBP1L
IPR011072--HR1_rho-bd
IPR001452--SH3_domain

PROSITE

PS51741--F_BAR
PS50002--SH3

Pfam

PF00611--FCH
PF00018--SH3_1

SMART

SM00055--FCH
SM00326--SH3

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0005856--C:cytoskeleton
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0008289--F:lipid binding
GO:0006914--P:autophagy
GO:0030154--P:cell differentiation
GO:0060271--P:cilium assembly
GO:0072583--P:clathrin-dependent endocytosis
GO:0006900--P:membrane budding
GO:0010324--P:membrane invagination
GO:0007399--P:nervous system development
GO:0097320--P:plasma membrane tubulation
GO:0051491--P:positive regulation of filopodium assembly
GO:0030050--P:vesicle transport along actin filament

KEGG

rno:310839

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002284	Ailuropoda melanoleuca	97.36	0.00e+00	1176.00
IUUC-Apl-003448	Anas platyrhynchos	91.07	0.00e+00	1105.00
IUUC-Acl-008089	Aspergillus clavatus	24.02	2.00e-13	71.60
IUUC-Afl-008472	Aspergillus flavus	23.77	1.00e-11	65.50
IUUC-Afu-009118	Aspergillus fumigatus	24.43	8.00e-16	79.00
IUUC-Ang-009697	Aspergillus niger	22.61	5.00e-11	63.20
IUUC-Aor-010089	Aspergillus oryzae	24.05	4.00e-13	70.10
IUUC-Ate-010418	Aspergillus terreus	22.65	4.00e-11	63.50
IUUC-Bgr-012268	Blumeria graminis	24.51	2.00e-14	74.70
IUUC-Bta-013289	Bos taurus	87.09	0.00e+00	1042.00
IUUC-Bci-013658	Botrytis cinerea	26.55	9.00e-09	55.80
IUUC-Cja-019157	Callithrix jacchus	97.32	0.00e+00	1159.00
IUUC-Cfa-021263	Canis familiaris	97.00	0.00e+00	1157.00
IUUC-Cpo-022162	Cavia porcellus	96.82	0.00e+00	1141.00
IUUC-Csa-024094	Chlorocebus sabaeus	87.60	0.00e+00	1055.00
IUUC-Cho-024432	Choloepus hoffmanni	83.31	0.00e+00	1003.00
IUUC-Dno-030053	Dasypus novemcinctus	87.60	0.00e+00	1037.00
IUUC-Dor-030954	Dipodomys ordii	87.60	0.00e+00	1021.00
IUUC-Dse-031554	Dothistroma septosporum	23.91	8.00e-08	52.40
IUUC-Ete-033202	Echinops telfairi	80.66	0.00e+00	961.00
IUUC-Eca-034433	Equus caballus	97.15	0.00e+00	1153.00
IUUC-Fca-036316	Felis catus	97.35	0.00e+00	1172.00
IUUC-Fal-037482	Ficedula albicollis	81.15	0.00e+00	870.00
IUUC-Fox-037938	Fusarium oxysporum	24.56	6.00e-14	72.80
IUUC-Fso-038099	Fusarium solani	26.45	3.00e-14	73.90
IUUC-Ggr-040011	Gaeumannomyces graminis	23.77	5.00e-11	63.20
IUUC-Gga-040893	Gallus gallus	83.14	0.00e+00	1006.00
IUUC-Ggo-045368	Gorilla gorilla	97.03	0.00e+00	1175.00
IUUC-Hsa-046014	Homo sapiens	97.52	0.00e+00	1187.00
IUUC-Itr-048450	Ictidomys tridecemlineatus	96.18	0.00e+00	888.00
IUUC-Lch-049559	Latimeria chalumnae	78.08	0.00e+00	638.00
IUUC-Laf-053633	Loxodonta africana	96.03	0.00e+00	1159.00
IUUC-Mcc-055726	Macaca mulatta	97.69	0.00e+00	1189.00
IUUC-Mor-057091	Magnaporthe oryzae	25.00	3.00e-10	60.50
IUUC-Mpo-057513	Magnaporthe poae	23.36	2.00e-10	61.60
IUUC-Mla-059151	Melampsora laricipopulina	22.43	1.00e-10	62.00
IUUC-Mga-059482	Meleagris gallopavo	80.99	0.00e+00	972.00
IUUC-Mmr-061011	Microcebus murinus	97.19	0.00e+00	1181.00
IUUC-Mdo-062199	Monodelphis domestica	95.85	0.00e+00	1159.00
IUUC-Mmu-064089	Mus musculus	98.51	0.00e+00	1199.00
IUUC-Mpu-065924	Mustela putorius furo	87.77	0.00e+00	1055.00
IUUC-Mlu-068188	Myotis lucifugus	91.40	0.00e+00	1092.00
IUUC-Nfi-068456	Neosartorya fischeri	24.43	6.00e-16	79.30
IUUC-Ncr-068849	Neurospora crassa	22.82	1.00e-10	61.60
IUUC-Nle-070050	Nomascus leucogenys	97.15	0.00e+00	1162.00
IUUC-Opr-071010	Ochotona princeps	82.06	5.00e-120	424.00
IUUC-Oan-073051	Ornithorhynchus anatinus	93.40	0.00e+00	1116.00
IUUC-Ocu-074906	Oryctolagus cuniculus	97.85	0.00e+00	1189.00
IUUC-Oba-075410	Oryza barthii	34.21	8.50e-01	29.30
IUUC-Ogl-077729	Oryza glaberrima	34.21	8.50e-01	29.30
IUUC-Ogu-077953	Oryza glumaepatula	34.21	8.50e-01	29.60
IUUC-Oin-079638	Oryza indica	36.11	2.00e-01	28.90
IUUC-Oru-084884	Oryza rufipogon	34.21	8.50e-01	29.30
IUUC-Osa-085690	Oryza sativa	34.21	8.50e-01	29.30
IUUC-Oga-088792	Otolemur garnettii	96.05	0.00e+00	1154.00
IUUC-Oar-090267	Ovis aries	96.85	0.00e+00	1162.00
IUUC-Ptr-091071	Pan troglodytes	97.69	0.00e+00	1188.00
IUUC-Pan-092738	Papio anubis	87.44	0.00e+00	1040.00
IUUC-Psi-093274	Pelodiscus sinensis	84.09	0.00e+00	1002.00
IUUC-Pab-098294	Pongo abelii	97.85	0.00e+00	1189.00
IUUC-Pgr-103504	Puccinia graminis	20.95	6.00e-11	62.80
IUUC-Pyt-104583	Pyrenophora triticirepentis	24.24	4.00e-08	53.50
IUUC-Sce-106410	Saccharomyces cerevisiae	20.93	1.00e-11	65.10
IUUC-Sha-107064	Sarcophilus harrisii	93.96	0.00e+00	1082.00
IUUC-Ssl-108508	Sclerotinia sclerotiorum	25.00	4.00e-09	57.00
IUUC-Ssc-116115	Sus scrofa	95.76	0.00e+00	1157.00
IUUC-Tgu-117005	Taeniopygia guttata	90.97	0.00e+00	1093.00
IUUC-Tsy-119510	Tarsius syrichta	87.63	0.00e+00	943.00
IUUC-Tre-122218	Trichoderma reesei	24.48	9.00e-12	65.90
IUUC-Tvi-122448	Trichoderma virens	24.17	3.00e-12	67.00
IUUC-Tme-126925	Tuber melanosporum	23.29	5.00e-09	56.60
IUUC-Ttr-128761	Tursiops truncatus	80.33	0.00e+00	957.00
IUUC-Vda-129874	Verticillium dahliae	24.50	1.00e-13	71.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence