iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000138134.11	ENST00000371926.7	ENSP00000360994.3
ENSG00000138134.11	ENST00000371927.7	ENSP00000360995.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/JAMM	JAMM	16716190

Classification

Family	E-value	Score	Start	End
UBD/Jab_MPN	1.10e-49	169.5	268	393

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Jab_MPN

   S: 5    vvvlpkrllkkflelsdvkiavavevyGlllgelvkdkevktvvlvpkqlagvgsvqvenvedvfdlldqeGlivlGWiHthpeelkflssv 96
            vvlp+ l++kfl+l+++++ +++e++G+l+g+l ++++++t+v+vpkq+ag +++++enve++f+++dq+ l +lGWiHthp++++flssv
   Q: 268  CVVLPEDLCHKFLQLAESNTVRGIETCGILCGKLTHNEFTITHVIVPKQSAGPDYCDMENVEELFNVQDQHDLLTLGWIHTHPTQTAFLSSV 359
           69****************************************************************************************** PP
   S: 97   dvathsslealkkrsvaivsspkfqelsafkltd 130
           d++th+s++ ++++ +aiv+spk +++++f+lt+
   Q: 360  DLHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLTN 393
           ********************************96 PP

Organism

Homo sapiens

Functional Description
(View)

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.

Protein Sequence
(Fasta)

MDQPFTVNSL KKLAAMPDHT DVSLSPEERV RALSKLGCNI TISEDITPRR YFRSGVEMER 60
MASVYLEEGN LENAFVLYNK FITLFVEKLP NHRDYQQCAV PEKQDIMKKL KEIAFPRTDE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAACATCCAG GAGATATTCT AATACTTCTT ATTTTCCAAG TACACACAAA TTGGGGGTAG 60
GGGGAAGGGC TAAGATGCTT AATAGTGGGC GTAGCCAGTT GTGGATAAAT ATCAAAAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR000555--JAMM/MPN+_dom
IPR007330--MIT
IPR015063--USP8_dimer

Pfam

PF01398--JAB
PF08969--USP8_dimer

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0016579--P:protein deubiquitination

KEGG

hsa:57559

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000506	Aegilops tauschii	50.57	8.00e-44	172.00
IUUC-Aml-001297	Ailuropoda melanoleuca	89.68	0.00e+00	776.00
IUUC-Apl-003560	Anas platyrhynchos	80.50	0.00e+00	700.00
IUUC-Aca-004523	Anolis carolinensis	81.92	0.00e+00	688.00
IUUC-Aly-005784	Arabidopsis lyrata	41.63	6.00e-44	172.00
IUUC-Ath-007385	Arabidopsis thaliana	41.63	6.00e-44	172.00
IUUC-Ang-009659	Aspergillus niger	44.24	1.00e-43	171.00
IUUC-Ame-011650	Astyanax mexicanus	65.53	7.00e-157	546.00
IUUC-Bgr-012260	Blumeria graminis	46.33	2.00e-41	163.00
IUUC-Bta-012468	Bos taurus	92.66	0.00e+00	847.00
IUUC-Bdi-014845	Brachypodium distachyon	50.00	1.00e-43	171.00
IUUC-Cja-019809	Callithrix jacchus	98.62	0.00e+00	863.00
IUUC-Cfa-020729	Canis familiaris	88.07	0.00e+00	767.00
IUUC-Cpo-022124	Cavia porcellus	93.35	0.00e+00	816.00
IUUC-Cre-022989	Chlamydomonas reinhardtii	47.78	1.00e-33	135.00
IUUC-Csa-023702	Chlorocebus sabaeus	94.39	0.00e+00	833.00
IUUC-Cho-024802	Choloepus hoffmanni	87.32	0.00e+00	718.00
IUUC-Dre-027852	Danio rerio	65.98	2.00e-164	572.00
IUUC-Dno-029491	Dasypus novemcinctus	95.50	0.00e+00	814.00
IUUC-Dor-030785	Dipodomys ordii	93.63	0.00e+00	765.00
IUUC-Dse-031153	Dothistroma septosporum	49.72	6.00e-40	159.00
IUUC-Dme-031787	Drosophila melanogaster	40.53	1.00e-79	290.00
IUUC-Ete-032842	Echinops telfairi	90.21	0.00e+00	795.00
IUUC-Eca-034082	Equus caballus	93.81	0.00e+00	855.00
IUUC-Eeu-034738	Erinaceus europaeus	76.74	3.00e-169	587.00
IUUC-Fca-036175	Felis catus	90.83	0.00e+00	790.00
IUUC-Fal-037252	Ficedula albicollis	81.19	0.00e+00	709.00
IUUC-Gga-041246	Gallus gallus	78.90	0.00e+00	688.00
IUUC-Ggo-044665	Gorilla gorilla	91.14	0.00e+00	771.00
IUUC-Itr-047930	Ictidomys tridecemlineatus	95.41	0.00e+00	835.00
IUUC-Kpa-049381	Komagataella pastoris	31.40	1.00e-49	190.00
IUUC-Lch-049954	Latimeria chalumnae	79.17	0.00e+00	699.00
IUUC-Loc-052178	Lepisosteus oculatus	67.66	3.00e-173	601.00
IUUC-Laf-053366	Loxodonta africana	95.18	0.00e+00	832.00
IUUC-Mcc-055560	Macaca mulatta	99.04	0.00e+00	830.00
IUUC-Mtr-057642	Medicago truncatula	48.52	1.00e-44	174.00
IUUC-Mga-059433	Meleagris gallopavo	79.13	0.00e+00	689.00
IUUC-Mmr-061327	Microcebus murinus	96.18	0.00e+00	802.00
IUUC-Mdo-062783	Monodelphis domestica	75.21	2.00e-147	514.00
IUUC-Mmu-064307	Mus musculus	91.06	0.00e+00	798.00
IUUC-Mac-065572	Musa acuminata	48.82	8.00e-44	171.00
IUUC-Mpu-066259	Mustela putorius furo	90.83	0.00e+00	792.00
IUUC-Mlu-067657	Myotis lucifugus	93.81	0.00e+00	818.00
IUUC-Nle-069180	Nomascus leucogenys	98.11	0.00e+00	832.00
IUUC-Opr-070830	Ochotona princeps	94.50	0.00e+00	788.00
IUUC-Ont-071929	Oreochromis niloticus	61.68	1.00e-147	516.00
IUUC-Oan-073314	Ornithorhynchus anatinus	80.31	2.00e-174	604.00
IUUC-Ocu-074386	Oryctolagus cuniculus	95.87	0.00e+00	837.00
IUUC-Oba-075358	Oryza barthii	50.00	1.00e-43	170.00
IUUC-Obr-076024	Oryza brachyantha	50.00	8.00e-45	174.00
IUUC-Ogl-077100	Oryza glaberrima	50.00	5.00e-43	169.00
IUUC-Ogu-078047	Oryza glumaepatula	50.00	1.00e-43	171.00
IUUC-Oin-079545	Oryza indica	50.00	1.00e-43	171.00
IUUC-Olo-080359	Oryza longistaminata	50.00	1.00e-43	171.00
IUUC-Ome-081619	Oryza meridionalis	50.00	1.00e-43	171.00
IUUC-Oni-082079	Oryza nivara	50.00	1.00e-43	171.00
IUUC-Opu-083914	Oryza punctata	50.00	6.00e-43	168.00
IUUC-Oru-085251	Oryza rufipogon	50.00	1.00e-43	171.00
IUUC-Osa-085426	Oryza sativa	50.00	1.00e-43	171.00
IUUC-Ola-087457	Oryzias latipes	71.94	2.00e-55	207.00
IUUC-Oga-088150	Otolemur garnettii	95.28	0.00e+00	805.00
IUUC-Oar-089824	Ovis aries	91.18	0.00e+00	840.00
IUUC-Ptr-090702	Pan troglodytes	99.77	0.00e+00	869.00
IUUC-Pan-091924	Papio anubis	99.31	0.00e+00	861.00
IUUC-Psi-093069	Pelodiscus sinensis	83.72	0.00e+00	698.00
IUUC-Ppa-095540	Physcomitrella patens	47.93	5.00e-44	172.00
IUUC-Pab-098080	Pongo abelii	98.85	0.00e+00	865.00
IUUC-Pca-100352	Procavia capensis	94.50	0.00e+00	793.00
IUUC-Rno-104938	Rattus norvegicus	90.83	0.00e+00	792.00
IUUC-Sha-107154	Sarcophilus harrisii	84.63	0.00e+00	774.00
IUUC-Sja-107679	Schizosaccharomyces japonicus	34.21	8.00e-53	201.00
IUUC-Sit-110118	Setaria italica	45.37	3.00e-45	176.00
IUUC-Sly-111816	Solanum lycopersicum	50.30	3.00e-44	172.00
IUUC-Stu-112240	Solanum tuberosum	50.30	3.00e-44	172.00
IUUC-Sar-112924	Sorex araneus	93.06	0.00e+00	756.00
IUUC-Sbi-114439	Sorghum bicolor	45.97	2.00e-44	173.00
IUUC-Ssc-115372	Sus scrofa	93.81	0.00e+00	822.00
IUUC-Tsy-119100	Tarsius syrichta	95.22	0.00e+00	634.00
IUUC-Tae-124826	Triticum aestivum	50.57	5.00e-44	172.00
IUUC-Tur-126001	Triticum urartu	50.57	6.00e-44	172.00
IUUC-Tme-126874	Tuber melanosporum	48.33	2.00e-45	177.00
IUUC-Tbe-127977	Tupaia belangeri	94.24	0.00e+00	650.00
IUUC-Ttr-128291	Tursiops truncatus	94.27	0.00e+00	715.00
IUUC-Vpa-130821	Vicugna pacos	95.59	0.00e+00	780.00
IUUC-Vvi-131576	Vitis vinifera	45.25	3.00e-45	176.00
IUUC-Xma-133318	Xiphophorus maculatus	60.94	3.00e-149	521.00
IUUC-Yli-134641	Yarrowia lipolytica	49.71	5.00e-47	182.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence