iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066123

Ensembl Protein ID

ENSMPUP00000002147.1

UniProt Accession

M3XSU7; M3XSU7_MUSPF

Genbank Protein ID

ENSMPUP00000002147

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01040772

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000002169.1	ENSMPUT00000002191.1	ENSMPUP00000002147.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-86	291.1	700	1022

Active Site

Position(s)	Description	Evidence
992	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++dl+++l+v+f+gE g+d gGv+ ef+++l++e+ +p++g+f+y e+ +++++p + ++    e+ ++F f+G+l+g++l++ ++ 
   Q: 700  NEDLRRELMVSFSGEIGHDSGGVKVEFFHCLFEEMTRPEYGMFMYPEEASYMWFPVRPKF----EKKRYF-FFGVLCGLSLFNFNVA 781
           6899*******************************************************9....567888.99************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++p++ +++k+ll++  sledl+e+ p l ksl+ +++ + +d  e  + + f     +  + ++++L+p+G+ + V ++Nk++Yv+
   Q: 782  NIPFPLALFKKLLNQTPSLEDLKELSPVLGKSLQTLLDDEGDDFGEV-FYIYFN----VHWDKNDTDLIPNGSCVIVDQTNKRDYVS 863
           *************************************8855555554.666665....566779999******************** PP
   S: 176  lvveyrlkegikeqveafreGfnev.iplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseer 261
           ++v+y+++ ++k  +e+f++Gf++v +++++++ F++eel+ +i G++++d+e+++k++ y++gy +++p+i +Fw++l++++ ee+
   Q: 864  KYVNYIFNISVKALYEEFQRGFYRVvCDKDIIEFFHPEELKDVIIGNTDYDWETFEKNAHYEEGYDNSHPTIVMFWKALHKLTLEEK 950
           ***********************9847888********************************************************* PP
   S: 262  kafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           k+fL F+Tg++r+ ++G++++k   f+++++ ++++ ++++TC+++L LP+Ys++e ++e L++Ai++++gF+
   Q: 951  KKFLVFLTGTDRIQVKGLKNMK-ITFCCPENVNEKDPIRAQTCISVLYLPKYSTMERVEEALQVAINNSRGFG 1022
           **********************.77999999****************************************96 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MEQRPRRRAR GGVRPVPGPD PPSRPAAPRR SAEPPGTQLW LFPSAAGLRR ALPQRTEATR 60
QMCCTRGRLV VLERGGAGVE VHQLPAGSDG AKKPKCIKLG KKMKIHSVDQ GAEHMLILSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCAGA GGCCGCGAAG GAGGGCTCGC GGCGGCGTGC GCCCGGTTCC CGGGCCGGAC 60
CCGCCGTCGC GACCCGCAGC GCCGCGGCGC TCCGCCGAGC CGCCGGGCAC TCAGCTCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	91.44	0.00e+00	1895.00
IUUC-Bta-012422	Bos taurus	76.90	0.00e+00	1472.00
IUUC-Cja-018751	Callithrix jacchus	75.17	0.00e+00	1535.00
IUUC-Cfa-020247	Canis familiaris	89.69	0.00e+00	1769.00
IUUC-Csa-023204	Chlorocebus sabaeus	76.00	0.00e+00	1367.00
IUUC-Cho-025101	Choloepus hoffmanni	66.53	0.00e+00	670.00
IUUC-Dno-029795	Dasypus novemcinctus	72.09	0.00e+00	1174.00
IUUC-Dor-030862	Dipodomys ordii	67.71	0.00e+00	1315.00
IUUC-Ete-032585	Echinops telfairi	59.29	0.00e+00	831.00
IUUC-Eca-034358	Equus caballus	81.37	0.00e+00	1595.00
IUUC-Eeu-035282	Erinaceus europaeus	70.79	0.00e+00	788.00
IUUC-Fca-036505	Felis catus	89.90	0.00e+00	1817.00
IUUC-Ggo-045445	Gorilla gorilla	74.08	0.00e+00	1439.00
IUUC-Hsa-046342	Homo sapiens	76.37	0.00e+00	1522.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	72.71	0.00e+00	1467.00
IUUC-Laf-053921	Loxodonta africana	74.10	0.00e+00	1509.00
IUUC-Mcc-054850	Macaca mulatta	76.10	0.00e+00	1373.00
IUUC-Mmr-060783	Microcebus murinus	66.84	0.00e+00	1216.00
IUUC-Mlu-067914	Myotis lucifugus	80.79	0.00e+00	1512.00
IUUC-Nle-069986	Nomascus leucogenys	75.86	0.00e+00	1515.00
IUUC-Opr-070513	Ochotona princeps	71.95	0.00e+00	1080.00
IUUC-Ocu-074305	Oryctolagus cuniculus	74.89	0.00e+00	1437.00
IUUC-Oar-089456	Ovis aries	83.63	0.00e+00	1668.00
IUUC-Ptr-091216	Pan troglodytes	76.15	0.00e+00	1321.00
IUUC-Pan-091706	Papio anubis	74.60	0.00e+00	1458.00
IUUC-Pca-100320	Procavia capensis	68.13	0.00e+00	1374.00
IUUC-Pva-102646	Pteropus vampyrus	85.55	0.00e+00	1755.00
IUUC-Sar-113605	Sorex araneus	77.84	2.00e-152	532.00
IUUC-Ssc-116076	Sus scrofa	84.07	0.00e+00	643.00
IUUC-Tsy-119240	Tarsius syrichta	64.92	0.00e+00	1224.00
IUUC-Tbe-127787	Tupaia belangeri	71.44	0.00e+00	1349.00
IUUC-Ttr-128191	Tursiops truncatus	80.85	0.00e+00	1602.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence