iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040514

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF185; RING finger protein 185; RING-type E3 ubiquitin transferase RNF185

Genbank Nucleotide ID

AJ720715

Gene Name

RNF185; RCJMB04_23p11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000006960.4	ENSGALT00000011276.3	ENSGALP00000011262.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.30e-07	31.6	41	82

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+  kd  ++  CgH+f+  Cl++w        +++ CP+C+
   Q: 41   CNICLDTAKD-AVISLCGHLFCWPCLHQW---LETRPNRQVCPVCK 82
           99********.77788*************...666999999****7 PP

Organism

Gallus gallus

Functional Description
(View)

E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.

Protein Sequence
(Fasta)

MASKGPTTSA STKSSSTGGT SGSSSSNGAG DNTNQDNTFE CNICLDTAKD AVISLCGHLF 60
CWPCLHQWLE TRPNRQVCPV CKAGISRDKV IPLYGRGSTG QQDPREKTPP RPQGQRPEPE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCGGGGC GATCAGGTGA CGGCGGCCGC GGGCAGGGAG CGGCTCCGCG GGTCTCCGGG 60
AGCGCCGGTG AGCACAGCCG AGCGAGTCCG GGTCCGGATC CGAGTCCGGG TCCGGCTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0044390--F:ubiquitin-like protein conjugating enzyme binding
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

gga:416965

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001042	Aegilops tauschii	50.00	2.00e-24	105.00
IUUC-Aml-001875	Ailuropoda melanoleuca	99.38	8.00e-62	229.00
IUUC-Atr-002721	Amborella trichopoda	54.65	1.00e-24	105.00
IUUC-Apl-003744	Anas platyrhynchos	100.00	3.00e-40	156.00
IUUC-Aca-004254	Anolis carolinensis	73.49	1.00e-34	138.00
IUUC-Aly-005785	Arabidopsis lyrata	55.95	4.00e-24	103.00
IUUC-Ath-007401	Arabidopsis thaliana	54.55	2.00e-24	105.00
IUUC-Ame-011667	Astyanax mexicanus	96.79	1.00e-52	198.00
IUUC-Bgr-012018	Blumeria graminis	40.68	4.00e-09	55.10
IUUC-Bta-012734	Bos taurus	99.38	2.00e-61	228.00
IUUC-Bci-013671	Botrytis cinerea	48.98	2.00e-09	57.00
IUUC-Bdi-014313	Brachypodium distachyon	51.76	1.00e-22	99.80
IUUC-Bol-016132	Brassica oleracea	56.18	2.00e-26	111.00
IUUC-Bra-017631	Brassica rapa	33.49	2.00e-26	111.00
IUUC-Cel-018228	Caenorhabditis elegans	67.03	4.00e-35	140.00
IUUC-Cja-019136	Callithrix jacchus	98.75	3.00e-61	227.00
IUUC-Cfa-020308	Canis familiaris	99.38	8.00e-62	229.00
IUUC-Cpo-021347	Cavia porcellus	98.12	6.00e-61	226.00
IUUC-Cre-022829	Chlamydomonas reinhardtii	55.17	6.00e-26	108.00
IUUC-Csa-023755	Chlorocebus sabaeus	99.38	6.00e-62	229.00
IUUC-Cme-027164	Cyanidioschyzon merolae	46.15	1.00e-16	80.10
IUUC-Dre-028094	Danio rerio	96.23	8.00e-59	219.00
IUUC-Dno-029402	Dasypus novemcinctus	99.38	8.00e-62	229.00
IUUC-Dor-030373	Dipodomys ordii	99.38	8.00e-62	229.00
IUUC-Dme-031966	Drosophila melanogaster	60.37	1.00e-55	209.00
IUUC-Ete-032786	Echinops telfairi	98.75	9.00e-62	228.00
IUUC-Eca-034261	Equus caballus	99.38	8.00e-62	229.00
IUUC-Eeu-034614	Erinaceus europaeus	89.38	6.00e-49	186.00
IUUC-Fca-036049	Felis catus	99.38	8.00e-62	229.00
IUUC-Fal-037085	Ficedula albicollis	100.00	1.00e-62	231.00
IUUC-Fso-038195	Fusarium solani	45.28	3.00e-09	56.20
IUUC-Gmo-039369	Gadus morhua	91.67	5.00e-55	206.00
IUUC-Gac-041719	Gasterosteus aculeatus	95.15	2.00e-56	211.00
IUUC-Gma-043248	Glycine max	59.30	6.00e-27	114.00
IUUC-Ggo-044504	Gorilla gorilla	99.38	8.00e-62	229.00
IUUC-Hsa-045707	Homo sapiens	99.38	8.00e-62	229.00
IUUC-Hvu-047487	Hordeum vulgare	51.04	2.00e-24	105.00
IUUC-Itr-048343	Ictidomys tridecemlineatus	99.38	1.00e-61	228.00
IUUC-Lch-050658	Latimeria chalumnae	92.50	9.00e-59	219.00
IUUC-Lpe-051034	Leersia perrieri	55.29	8.00e-25	106.00
IUUC-Loc-052118	Lepisosteus oculatus	96.34	3.00e-57	213.00
IUUC-Laf-054438	Loxodonta africana	99.38	9.00e-62	229.00
IUUC-Mcc-054641	Macaca mulatta	95.62	1.00e-54	204.00
IUUC-Meu-056828	Macropus eugenii	88.57	1.00e-32	130.00
IUUC-Mpo-057431	Magnaporthe poae	35.82	8.00e-09	54.70
IUUC-Mtr-058107	Medicago truncatula	59.30	2.00e-26	112.00
IUUC-Mga-059554	Meleagris gallopavo	100.00	6.00e-62	229.00
IUUC-Mvi-060316	Microbotryum violaceum	50.88	4.00e-12	64.30
IUUC-Mmr-061662	Microcebus murinus	93.25	7.00e-53	199.00
IUUC-Mdo-062774	Monodelphis domestica	99.38	8.00e-62	229.00
IUUC-Mmu-063372	Mus musculus	99.38	2.00e-61	228.00
IUUC-Mac-065053	Musa acuminata	54.76	6.00e-23	100.00
IUUC-Mpu-066033	Mustela putorius furo	99.38	4.00e-62	233.00
IUUC-Mlu-067254	Myotis lucifugus	99.38	8.00e-62	229.00
IUUC-Ncr-068628	Neurospora crassa	41.18	1.00e-09	57.80
IUUC-Nle-069850	Nomascus leucogenys	99.38	8.00e-62	229.00
IUUC-Opr-070197	Ochotona princeps	87.50	2.00e-57	214.00
IUUC-Ont-071950	Oreochromis niloticus	97.45	3.00e-58	217.00
IUUC-Oan-073480	Ornithorhynchus anatinus	99.38	8.00e-62	229.00
IUUC-Ocu-073878	Oryctolagus cuniculus	91.25	1.00e-61	228.00
IUUC-Oba-075248	Oryza barthii	51.25	6.00e-24	103.00
IUUC-Obr-076382	Oryza brachyantha	54.12	2.00e-24	105.00
IUUC-Ogl-077553	Oryza glaberrima	50.53	2.00e-26	112.00
IUUC-Ogu-078463	Oryza glumaepatula	50.53	1.00e-26	112.00
IUUC-Oin-080177	Oryza indica	50.53	2.00e-26	112.00
IUUC-Olo-080378	Oryza longistaminata	51.76	1.00e-22	99.40
IUUC-Ome-081605	Oryza meridionalis	51.06	3.00e-26	111.00
IUUC-Oni-082458	Oryza nivara	50.53	4.00e-26	111.00
IUUC-Opu-083362	Oryza punctata	55.29	8.00e-25	107.00
IUUC-Oru-084757	Oryza rufipogon	50.53	2.00e-26	112.00
IUUC-Osa-086198	Oryza sativa	48.00	2.00e-26	112.00
IUUC-Ola-086800	Oryzias latipes	96.88	5.00e-55	206.00
IUUC-Olu-087623	Ostreococcus lucimarinus	43.66	4.00e-15	74.30
IUUC-Oga-088197	Otolemur garnettii	97.02	2.00e-64	237.00
IUUC-Oar-090284	Ovis aries	70.83	4.00e-45	173.00
IUUC-Ptr-091106	Pan troglodytes	99.38	8.00e-62	229.00
IUUC-Pan-092671	Papio anubis	99.38	6.00e-62	229.00
IUUC-Psi-093323	Pelodiscus sinensis	99.38	1.00e-61	228.00
IUUC-Pno-094942	Phaeosphaeria nodorum	43.90	1.00e-10	60.50
IUUC-Ppa-095474	Physcomitrella patens	54.17	6.00e-27	114.00
IUUC-Pfo-096943	Poecilia formosa	95.62	3.00e-54	204.00
IUUC-Pab-097845	Pongo abelii	99.38	8.00e-62	229.00
IUUC-Pop-098988	Populus trichocarpa	52.08	2.00e-26	112.00
IUUC-Pca-100319	Procavia capensis	71.67	8.00e-46	176.00
IUUC-Ppe-102011	Prunus persica	55.21	5.00e-28	117.00
IUUC-Pva-102298	Pteropus vampyrus	99.38	1.00e-61	228.00
IUUC-Pte-104163	Pyrenophora teres	42.53	6.00e-10	57.40
IUUC-Pyt-104640	Pyrenophora triticirepentis	38.46	2.00e-10	59.70
IUUC-Rno-105293	Rattus norvegicus	99.38	4.00e-62	230.00
IUUC-Sha-107361	Sarcophilus harrisii	99.38	8.00e-62	229.00
IUUC-Smo-109663	Selaginella moellendorffii	52.94	3.00e-23	99.80
IUUC-Sit-110376	Setaria italica	55.81	9.00e-25	106.00
IUUC-Sly-111909	Solanum lycopersicum	54.65	7.00e-24	103.00
IUUC-Stu-112801	Solanum tuberosum	54.65	3.00e-24	104.00
IUUC-Sar-113669	Sorex araneus	100.00	1.00e-25	107.00
IUUC-Sbi-114275	Sorghum bicolor	51.76	1.00e-22	99.40
IUUC-Ssc-116228	Sus scrofa	99.38	8.00e-62	229.00
IUUC-Tgu-116886	Taeniopygia guttata	100.00	1.00e-62	231.00
IUUC-Tru-118679	Takifugu rubripes	65.75	2.00e-22	97.80
IUUC-Tsy-119615	Tarsius syrichta	71.67	4.00e-46	176.00
IUUC-Tni-120909	Tetraodon nigroviridis	91.62	1.00e-56	211.00
IUUC-Tca-121830	Theobroma cacao	53.76	4.00e-26	110.00
IUUC-Tre-122215	Trichoderma reesei	42.86	5.00e-09	56.20
IUUC-Tae-123670	Triticum aestivum	52.94	3.00e-23	101.00
IUUC-Tur-126676	Triticum urartu	52.94	2.00e-23	101.00
IUUC-Tbe-127360	Tupaia belangeri	99.22	1.00e-42	165.00
IUUC-Ttr-129044	Tursiops truncatus	99.38	8.00e-62	229.00
IUUC-Vda-129983	Verticillium dahliae	43.75	1.00e-08	52.80
IUUC-Vpa-130365	Vicugna pacos	98.75	7.00e-61	226.00
IUUC-Vvi-131449	Vitis vinifera	56.98	2.00e-26	111.00
IUUC-Xtr-131916	Xenopus tropicalis	91.14	4.00e-42	163.00
IUUC-Xma-133333	Xiphophorus maculatus	93.90	6.00e-55	206.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence