iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-097845

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF185; RING finger protein 185; RING-type E3 ubiquitin transferase RNF185

Genbank Nucleotide ID

CR857146

Gene Name

RNF185

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000011729.1	ENSPPYT00000013617.1	ENSPPYP00000013084.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.80e-07	31.6	39	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+  kd  ++  CgH+f+  Cl++w        +++ CP+C+
   Q: 39   CNICLDTAKD-AVISLCGHLFCWPCLHQW---LETRPNRQVCPVCK 80
           99********.77788*************...666999999****7 PP

Organism

Pongo abelii

Functional Description
(View)

E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.

Protein Sequence
(Fasta)

MASKGPSASS SPENSSAGGP SGSSNGAGES GGQDSTFECN ICLDTAKDAV ISLCGHLFCW 60
PCLHQWLETR PNRQVCPVCK AGISRDKVIP LYGRGSTGQQ DPREKTPPRP QGQRPEPENR 120

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Nucleotide Sequence
(Fasta)

GGGGCGGCTC CGCGTCATGT GACTGGAGTC CGTGTAGGAG GGGTCGGAGG TCCTACCCAA 60
CAGATTGACG CGGCATTAGT ATTGGCCGTG TAGCCGAAAA ACTGATTGAC TGGGCTGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0051865--P:protein autoubiquitination

KEGG

pon:100171457

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001042	Aegilops tauschii	52.75	3.00e-24	105.00
IUUC-Aml-001875	Ailuropoda melanoleuca	100.00	3.00e-62	230.00
IUUC-Atr-002721	Amborella trichopoda	55.06	3.00e-25	107.00
IUUC-Apl-003744	Anas platyrhynchos	100.00	4.00e-40	155.00
IUUC-Aly-006065	Arabidopsis lyrata	56.98	1.00e-25	109.00
IUUC-Ath-007401	Arabidopsis thaliana	54.55	1.00e-24	105.00
IUUC-Ame-011667	Astyanax mexicanus	96.79	1.00e-52	198.00
IUUC-Bgr-012018	Blumeria graminis	40.98	2.00e-09	56.20
IUUC-Bta-012734	Bos taurus	100.00	6.00e-62	229.00
IUUC-Bci-013671	Botrytis cinerea	48.98	2.00e-09	57.00
IUUC-Cel-018228	Caenorhabditis elegans	70.59	2.00e-34	138.00
IUUC-Cja-019136	Callithrix jacchus	99.38	9.00e-62	229.00
IUUC-Cfa-020308	Canis familiaris	100.00	3.00e-62	230.00
IUUC-Cpo-021347	Cavia porcellus	98.75	2.00e-61	228.00
IUUC-Cre-022829	Chlamydomonas reinhardtii	56.32	3.00e-26	109.00
IUUC-Csa-023755	Chlorocebus sabaeus	100.00	3.00e-62	231.00
IUUC-Dre-028094	Danio rerio	96.86	3.00e-59	220.00
IUUC-Dno-029402	Dasypus novemcinctus	100.00	3.00e-62	230.00
IUUC-Dor-030373	Dipodomys ordii	100.00	3.00e-62	230.00
IUUC-Dme-031966	Drosophila melanogaster	60.98	8.00e-56	209.00
IUUC-Ete-032786	Echinops telfairi	99.38	4.00e-62	230.00
IUUC-Eca-034261	Equus caballus	100.00	3.00e-62	230.00
IUUC-Eeu-034614	Erinaceus europaeus	90.00	2.00e-49	187.00
IUUC-Fca-036049	Felis catus	100.00	3.00e-62	230.00
IUUC-Fal-037085	Ficedula albicollis	98.76	1.00e-61	228.00
IUUC-Gmo-039369	Gadus morhua	94.51	2.00e-55	207.00
IUUC-Gga-040514	Gallus gallus	99.38	2.00e-61	228.00
IUUC-Gac-041719	Gasterosteus aculeatus	95.73	2.00e-56	211.00
IUUC-Gma-043248	Glycine max	59.30	8.00e-27	113.00
IUUC-Ggo-044504	Gorilla gorilla	100.00	3.00e-62	230.00
IUUC-Hsa-045707	Homo sapiens	100.00	3.00e-62	230.00
IUUC-Hvu-047487	Hordeum vulgare	52.75	7.00e-24	103.00
IUUC-Itr-048343	Ictidomys tridecemlineatus	100.00	5.00e-62	229.00
IUUC-Lch-050658	Latimeria chalumnae	93.12	4.00e-59	220.00
IUUC-Loc-052118	Lepisosteus oculatus	96.95	3.00e-57	214.00
IUUC-Laf-054438	Loxodonta africana	100.00	3.00e-62	230.00
IUUC-Mcc-054641	Macaca mulatta	96.25	5.00e-55	206.00
IUUC-Meu-056828	Macropus eugenii	90.00	6.00e-33	131.00
IUUC-Mor-057077	Magnaporthe oryzae	37.29	2.00e-08	53.50
IUUC-Mpo-057431	Magnaporthe poae	35.29	7.00e-09	55.50
IUUC-Mtr-058107	Medicago truncatula	59.30	2.00e-26	112.00
IUUC-Mga-059554	Meleagris gallopavo	99.38	2.00e-61	228.00
IUUC-Mvi-060316	Microbotryum violaceum	50.88	6.00e-12	64.30
IUUC-Mmr-061662	Microcebus murinus	93.87	3.00e-53	201.00
IUUC-Mdo-062774	Monodelphis domestica	100.00	3.00e-62	230.00
IUUC-Mmu-063372	Mus musculus	100.00	7.00e-62	229.00
IUUC-Mpu-066033	Mustela putorius furo	100.00	1.00e-62	234.00
IUUC-Mlu-067254	Myotis lucifugus	100.00	3.00e-62	230.00
IUUC-Ncr-068628	Neurospora crassa	43.14	6.00e-10	58.50
IUUC-Nle-069850	Nomascus leucogenys	100.00	3.00e-62	230.00
IUUC-Opr-070197	Ochotona princeps	88.12	9.00e-58	215.00
IUUC-Ont-071950	Oreochromis niloticus	97.45	2.00e-58	217.00
IUUC-Oan-073480	Ornithorhynchus anatinus	100.00	3.00e-62	230.00
IUUC-Ocu-073878	Oryctolagus cuniculus	91.88	4.00e-62	230.00
IUUC-Oba-075248	Oryza barthii	55.84	2.00e-23	101.00
IUUC-Ola-086800	Oryzias latipes	97.50	2.00e-55	207.00
IUUC-Oga-088197	Otolemur garnettii	100.00	1.00e-64	239.00
IUUC-Ptr-091106	Pan troglodytes	100.00	3.00e-62	230.00
IUUC-Pan-092671	Papio anubis	100.00	3.00e-62	231.00
IUUC-Psi-093323	Pelodiscus sinensis	100.00	6.00e-62	229.00
IUUC-Pno-094942	Phaeosphaeria nodorum	42.68	4.00e-10	58.50
IUUC-Ppa-095474	Physcomitrella patens	55.91	4.00e-26	111.00
IUUC-Pfo-096943	Poecilia formosa	96.25	1.00e-54	205.00
IUUC-Ppe-102011	Prunus persica	58.14	3.00e-26	111.00
IUUC-Pva-102298	Pteropus vampyrus	100.00	4.00e-62	230.00
IUUC-Pyt-104640	Pyrenophora triticirepentis	37.50	7.00e-10	57.80
IUUC-Rno-105293	Rattus norvegicus	100.00	1.00e-62	231.00
IUUC-Sha-107361	Sarcophilus harrisii	100.00	3.00e-62	230.00
IUUC-Smo-109663	Selaginella moellendorffii	51.69	2.00e-23	100.00
IUUC-Sit-110376	Setaria italica	55.81	1.00e-24	106.00
IUUC-Sar-113669	Sorex araneus	100.00	1.00e-25	107.00
IUUC-Ssc-116228	Sus scrofa	100.00	3.00e-62	230.00
IUUC-Tgu-116886	Taeniopygia guttata	98.76	1.00e-61	228.00
IUUC-Tni-120909	Tetraodon nigroviridis	93.90	2.00e-56	211.00
IUUC-Tae-123670	Triticum aestivum	52.94	4.00e-23	100.00
IUUC-Tur-126676	Triticum urartu	52.94	3.00e-23	101.00
IUUC-Tbe-127360	Tupaia belangeri	100.00	4.00e-43	166.00
IUUC-Ttr-129044	Tursiops truncatus	100.00	3.00e-62	230.00
IUUC-Vda-129983	Verticillium dahliae	43.75	1.00e-08	52.80
IUUC-Vpa-130365	Vicugna pacos	99.38	2.00e-61	227.00
IUUC-Vvi-131449	Vitis vinifera	56.32	3.00e-26	111.00
IUUC-Xtr-131916	Xenopus tropicalis	93.59	3.00e-42	164.00
IUUC-Xma-133333	Xiphophorus maculatus	93.90	5.00e-55	206.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence